Articles tagged with Hiv Research
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A new HIV antibody, 10-1074, has been successfully tested on humans, demonstrating high antiviral activity and favourable pharmacokinetic properties. The trial also investigated the development of resistant HIV variants, providing valuable insights into the potential treatment approach.
Researchers identified a molecular signaling pathway that promotes sensory neuron growth and prevents or reverses peripheral neuropathy in cell and rodent models of type 1 and 2 diabetes, chemotherapy-induced neuropathy, and HIV. Anti-muscarinic drugs already approved for other conditions may offer new treatment options.
Researchers found that women with pro-inflammatory bacterial species were at a 4-fold higher risk of acquiring HIV than those with healthy vaginal bacteria. The study suggests specific genital bacteria can increase HIV risk by making it easier for the virus to find a foothold.
A new study from UCLA suggests modifying federal health guidelines to use a risk calculator that takes into account more factors, potentially increasing effectiveness of PrEP in preventing HIV transmission. The calculator uses real-world data and is expected to be useful for gay and bisexual men who have sex with men.
Researchers found that temporarily blocking type I interferon can restore immune function and speed up viral suppression in HIV-infected mice. This approach may help eradicate HIV throughout the body when combined with antiretroviral therapy.
A study conducted by New York University researchers found that individuals with substance use disorders face significant challenges transitioning from long-term residential treatment to the community. Common barriers include unmet basic needs, strained relationships, and lack of support networks.
A recent study found significant increases in past-year alcohol use, binge drinking, and alcohol use disorders among older adults, particularly women. The researchers highlight the need for healthcare providers to screen for unhealthy alcohol use in this population.
Researchers found that peer-referral strategies outperformed traditional methods in detecting undiagnosed HIV among high-risk heterosexuals. The study suggests a new approach for identifying and treating undiagnosed HIV cases in the US, with potential to reduce transmission rates.
A new study aims to explore the challenges faced by teenagers at high risk for HIV who are required to obtain parental permission to participate in prevention trials. The research will examine parents' views on consent and teens' willingness to engage their parents in the process.
A cross-sectional study found that HIV-positive patients with chronic pain did not experience significant functional interference, maintaining high activity levels. This contradicts previous assumptions and highlights the complex relationship between HIV-related pain and physical activity.
The HVTN 702 study is the largest and most advanced HIV vaccine clinical trial in South Africa, testing a new experimental vaccine regimen. The study aims to enroll 5,400 men and women and provide greater protection against HIV infection than previous vaccines.
Researchers at Centre for Genomic Regulation develop new technology to detect latent HIV, shedding light on expression landscape of the virus in human genome. The technology shows that different HIV reactivation drugs target different locations within chromosome, leading to more selective treatment.
A new approach to an HIV vaccine has been developed by combining a common cold virus with a DNA-based vaccine, resulting in specific immune responses in mice. The vaccine targets the Tat protein that helps the virus replicate, preventing infection and replication.
Researchers developed genetically engineered T cells armed with a fusion inhibitor to disrupt HIV's entry process. The C34 peptide was shown to be potent and effective against diverse HIV strains, including those resistant to existing drugs.
George Washington University researchers received a $2.2 million grant from the National Cancer Institute to investigate the role of human endogenous retroviruses (HERVs) in cancer development. They plan to use a novel computational pathway program, Telescope, to pinpoint HERV expression in various cancers.
Scientists from the National Institutes of Health identified an antibody, named N6, that potently neutralized 98 percent of HIV isolates tested. The researchers also tracked the evolution of N6 to understand how it developed its ability to neutralize nearly all HIV strains, which will inform vaccine design.
A Drexel University study shows that accounting for stigmatizing behaviors and substance use reduces the racial disparity in HIV risk between black and white men. Key findings reveal higher rates of HIV prevalence among black non-MSM and white MSM engaging in risky behavior, particularly amphetamine use.
Immunotherapy has shown modest control of HIV and identified pre-existing drug resistance as an important barrier to antibody-based treatments. The study used broadly neutralizing HIV antibodies, but suppression did not surpass 8 weeks in most participants.
Researchers found that a therapeutic vaccine and immune stimulator combination improved virologic control and delayed viral rebound in non-human primates infected with SIV. The study showed promise for achieving long-term viral suppression without antiretroviral therapy.
Researchers developed a vaccine combining with an innate immune stimulant to target dormant HIV cells. The combination showed reduced viral loads and delayed rebound in animal trials, offering hope for ART-free, long-term viral suppression.
Antibodies from Ebola survivors can strongly neutralize the virus and protect mice from a lethal challenge. The study found these protective antibodies using a new technology called Immune Repertoire Capture°0niversity.
A new study proves that Gaétan Dugas was one of many thousands infected in the years before HIV was recognized. The term 'Patient Zero' was created inadvertently in the earliest years of investigating AIDS, and Dugas's global defamation is attributed to this mistake.
Using a high-throughput cell-editing platform, researchers have successfully mutated genes in human immune cells to make them resistant to HIV infection. The new system enables the rapid testing of gene mutations that confer resistance, which could potentially accelerate the quest for an HIV cure.
Researchers developed a novel water dispersible nanotherapy for paediatric HIV patients, removing the need for high ethanol concentrations. The new approach has the potential to overcome challenges with current antiretroviral therapy, including administration of high doses and urgent need for better formulations.
Participants were highly adherent to using the gel before and after sex (93%) as they were to taking daily oral Truvada (94%). The study found that most participants used the gel 80% of the time or more, suggesting a potential alternative for HIV prevention.
Scientists at Binghamton University are developing a high-performance sensor to improve hearing aids, addressing limitations in microphone technology and noise understanding. The research aims to create more sensitive MEMS microphones for improved sound detection.
Researchers found no differences in HIV drug resistance between women using dapivirine and placebo rings in the ASPIRE trial. The dapivirine ring was safe and helped protect against HIV, with an overall risk reduction of 27%.
The experimental vaginal ring had little effect on sexual intercourse, with most women reporting no interference. However, some women experienced diminished pleasure due to worry about their partner noticing the ring, and those facing intimate partner violence or social harms were more likely to have low adherence.
A large HIV prevention trial found that women experiencing intimate partner violence were less likely to use a vaginal ring, with improved adherence after disclosure. Counseling and support can help these women adhere to the ring, improving their protection against HIV.
Researchers will examine the intersection of alcohol use and comorbidities in people living with HIV, including tuberculosis, cardiovascular disease, and falls. The five-year grants aim to improve health outcomes for alcohol-using individuals living with HIV.
Researchers developed a technology to generate mouse models quickly testing and tweaking potential HIV vaccines. The goal is to create broadly neutralizing antibodies able to fight any mutant HIV strain, which would be the 'holy grail' of AIDS vaccines.
Researchers describe a potential vaccination strategy to jump-start the selection and evolution of broadly effective antibodies against HIV. They plan to test this approach in an upcoming human clinical trial, promising progress toward a human vaccine.
Researchers have developed a new approach to creating human vaccines against HIV using Kymouse, a genetically modified mouse that mimics human antibody responses. The study found that Kymouse can produce antibodies of the type needed for protection, suggesting ways to improve immunization regimes.
Scientists describe a multi-step method to produce broadly neutralizing antibodies in genetically engineered mice, which can recognize multiple HIV mutations. This approach offers a starting point for developing an HIV vaccine that could prevent infection or cure the systemic illness.
A single HIV mutation was found to induce two different outcomes in T cell adaptation, revealing a complex co-evolution between the virus and human immune cells. This finding has significant implications for the development of T cell-mediated AIDS vaccines.
A new metric called the Relative Citation Ratio (RCR) allows researchers to evaluate article influence regardless of publication or field. RCR is benchmarked to a peer comparison group, providing a more accurate measure of an article's impact.
Researchers discovered that some monkeys with depleted immune systems still had a second line of defense against tuberculosis, targeting CD8 and B cells. This finding could lead to more effective vaccines for TB, which affects people co-infected with HIV.
A study by Stanford University researchers found that physicians provide inconsistent and varied advice on e-cigarettes to patients. The study analyzed over 500 online interactions between doctors and patients discussing e-cigarettes and identified significant knowledge gaps in the medical community.
Scientists developed a reductionist approach to HIV vaccine design by engineering broadly neutralizing antibodies with minimized rare features. The resulting antibodies retained their specificity for HIV while exhibiting excellent neutralization breadth, offering promising leads for HIV vaccine development.
Researchers found that nearly a third of HIV's immune target sites were 'pre-adapted' to the newly-infected partner, suggesting vaccine designers focus on conserved viral proteins. The study builds upon previous research using computer models and emphasizes the importance of finding this balance in vaccine development.
A recent study found that a UB-developed smartphone app can improve antiretroviral therapy adherence among people living with HIV. Participants reported high compliance with daily report completion, citing the app's ease of use and text reminders as key factors.
Despite limited safety data, investigators face significant challenges to conducting HIV research in pregnant women, including complex ethical and legal concerns. To address these gaps, Dr. Anne Lyerly is leading the PHASES Project to develop guidance for ethically advancing HIV research in pregnant women.
A research team led by Rebecca Schnall is developing a mobile app using existing in-person intervention MyPEEPS to deliver HIV prevention information to diverse young men. The five-year clinical trial will test the effectiveness of the mobile version among 700 racially and ethnically diverse adolescent MSM.
The Einstein-Montefiore and CUNY research team will use the data for their own research projects, addressing scientific clinical and healthcare delivery questions that inform care in Central Africa and beyond. The ongoing study involves over 50,000 HIV-positive children and adults taking anti-retroviral therapy.
A research team from Penn Nursing, University of Michigan School of Nursing and Emory's School of Public Health is awarded a $9 million grant to test an HIV prevention intervention for adolescent men who have sex with men. The iCON intervention offers life skills training and community-based resources through an online app.
A new study published in Nature Medicine found that over 90% of latent HIV 'provirus' genomes are genetic duds, unable to replicate and cause disease. This challenges the current methods for measuring the size of the reservoir, highlighting a need for more accurate counting methods.
A New York University study found that marijuana use is associated with increased feelings of self-attractiveness, sociability, and boldness, while also being linked to vaginal dryness. In contrast, alcohol use was more commonly associated with social outgoingness and atypical partner choice, as well as post-sex regret.
Researchers have successfully tested two Zika vaccine candidates in nonhuman primates, demonstrating robust protection against both Brazilian and Puerto Rican strains of the virus. The findings support the advancement of these vaccine candidates to human trials, with phase 1 clinical testing expected to begin later this year.
A cardiac imaging study showed a correlation between higher inflammatory biomarkers and an increased prevalence of coronary artery disease in men infected with human immunodeficiency virus (HIV). Researchers used computed tomography (CT) angiography to detect signs of subclinical CAD, such as narrowed arteries and the amount, density a...
Scientists have discovered specialized killer T cells that can migrate into lymphoid tissue to control hidden infections like HIV and glandular fever. This breakthrough discovery could lead to new therapies to treat chronic infections.
A recent study conducted in Tanzania found that an infection with the filarial nematode Wuchereria bancrofti increases the risk of HIV infection by two to three fold. The study revealed a significant association between filarial infections and increased risk of HIV infection, particularly among adolescents and young adults.
Researchers found that early antiretroviral therapy significantly reduces total HIV DNA levels in the body, which may predict time to viral load rebound after treatment cessation. The study suggests that people with a smaller HIV reservoir size have a greater chance of achieving long-term HIV remission.
Researchers at the University of North Carolina and partner institutions have made significant strides in understanding HIV latency, a key obstacle to eradicating the virus. The team has developed effective strategies, including histone deacetylase inhibitors, to reverse latency and boost the immune system.
Drs. Henry Boom and Moses Joloba at Case Western Reserve University and Makerere University, respectively, have received a $1.5 million five-year grant to strengthen Ugandan biomedical research capacity. The program aims to provide PhD-level training in microbiology and immunology to talented young Ugandan scientists.
The study confirms on-demand PrEP is a highly effective method of reducing the risk of HIV infection. The results show an incidence rate of 0.19 infections per 100 person-years of follow-up, with a significant drop in condom use among participants.
The ANRS 162-4D trial found that patients on a 4-day a week regimen had undetectable viral loads for most of the study period. The innovative strategy aims to improve adherence and reduce drug burden, but more research is needed to confirm its efficacy.
Using a drug-infused vaginal ring most of the time significantly reduced HIV infection risk in women by at least 56 percent, according to an exploratory analysis of data from the ASPIRE study. High adherence was associated with a risk reduction of potentially 75 percent or more.
The HOPE study will build on the ASPIRE trial results, gathering more information on the dapivirine ring's safety and effectiveness in reducing HIV risk. The study aims to understand why the ring works for some women but not others.
Researchers found that using the dapivirine ring consistently provided significant protection against HIV, with high adherence associated with better HIV protection. The study's results coincide with the start of the HOPE open-label study, which will gather additional information on the ring's safety and effectiveness.
Researchers from UCLA have discovered a type of cell called chimeric antigen receptors that can be used to kill HIV-infected cells. CARs are artificially created immune T cells engineered to produce receptors designed to target and kill specific cells containing viruses or tumor proteins.