Articles tagged with Hiv Research
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Researchers found a 60-fold increase in dormant HIV proviruses, potentially making it harder to find a cure. The latent reservoir is thought to contain functional proviruses that can reactivate and resume infection if antiretroviral therapy is stopped or interrupted.
A new HIV vaccine has demonstrated partial protection against simian-human immunodeficiency virus in rhesus monkeys, with an 87-90% reduction in infection rate. The vaccine uses optimized antigens that mount antibody and cellular immune responses to diverse strains of the virus.
The V-SmartTM therapeutic delivered tenofovir at levels considerably above therapeutic concentrations, overcoming the challenge of delivering HIV drugs through the BBB. The successful outcome confirms the strong potential of the delivery system to treat neuro-HIV and improve lives of AIDS patients.
The McGill/MUHC research team developed an innovative oral self-test screening strategy and interactive website/app called HIVSmart to address the stigma associated with HIV testing. The award-winning strategy aims to improve access to care by allowing individuals to be tested in the privacy of their own homes.
Researchers will investigate links between substance abuse and HIV among Latino and African-American men who have sex with men. The MASCULINE study aims to determine how substance use affects HIV transmission and treatment outcomes.
A new study published in The Lancet Infectious Diseases found that HIV-negative partners who know they are protected from HIV transmission do not engage in significantly more risky sexual behavior. The researchers analyzed data from over 3,000 participants and found no increase in unprotected sex, despite knowledge of protection.
The grant aims to investigate the effects of HIV-related changes on oral bacterial communities and their relationship to various oral infections in HIV disease. Researchers will explore how these changes affect conditions like oral candidiasis, periodontal disease, and cavities.
South Africa has made significant progress in reducing child mortality rates, mainly due to improved HIV/AIDS care. The country's under-five mortality rate has decreased by six to 10 percent per year since 2006, with the proportion of deaths due to AIDS falling from 39% to between 11 and 24%.
A Phase II clinical trial is underway to test the safety and acceptability of a reduced glycerin gel formulation of tenofovir in preventing HIV transmission through unprotected anal sex. The study aims to determine whether rectal microbicides can be used as an additional tool to reduce HIV risk.
The NIH has awarded $17 million to support genomics research in Africa, enhancing the continent's research capacity and training African genomic scientists. The new grants will study various health conditions important in Africa, including neurological disorders and respiratory diseases.
Researchers found that early diagnosis of HIV increases lifetime costs but improves length and quality of life. Activated B cells are identified as an early sign of AIDS-related lymphoma, while new circumcision devices need further development to increase circumcision rates in Africa.
Researchers will examine alcohol marketing and its role in early alcohol use among African youth acquiring HIV in Uganda. The project aims to develop communication messages and materials for a counter marketing campaign to reduce the risk of HIV transmission.
Researchers at NYU College of Dentistry have discovered a new way HIV-1 reproduces itself without integrating its genetic material into cell DNA, allowing the virus to persist in vivo and evade antiviral drugs. This finding may lead to the development of new treatments aimed at eliminating the virus from infected individuals.
Researchers discovered that levels of certain fats in cerebral spinal fluid can predict cognitive decline in HIV patients. The findings suggest that these fat markers reflect changes in brain metabolism, disrupting the 'garbage disposals' and leading to cognitive declines.
Researchers at Oregon Health & Science University have developed an HIV/AIDS vaccine candidate that appears to completely clear the AIDS-causing virus from the body. The vaccine uses a modified form of cytomegalovirus to generate T-cells capable of targeting and eliminating infected cells.
A substudy found that pre-exposure prophylaxis (PrEP) can be highly effective in preventing HIV infection with high adherence rates. Participants who received counseling and support showed 100% efficacy, while those who did not showed significantly lower rates of adherence.
The Malawi-Liverpool-Wellcome Trust Clinical Research Programme will receive £14 million over five years to continue its focus on infectious diseases and training local doctors. The program will also investigate the growing epidemic of non-communicable diseases in Africa, including diabetes and chronic lung disease.
A UCLA study demonstrates that combining behavioral science with social media and online communities can lead to increased HIV testing and encouraged significant behavioral change among high-risk groups. The approach proved to be one of the best HIV-prevention methods on the Internet, with high retention rates and successful engagement.
Three NIH scientists, Drs. Warner Greene, Richard Sutton, and Timothy Cardozo, receive $500,000 each to support groundbreaking HIV/AIDS research. Their projects focus on modifying the immune response to prevent further CD4 T-cell loss, identifying protective genes against HIV infection, and developing a combined cocaine/HIV vaccine.
A new study found no link between distrust in medical research and willingness to participate in related studies, contrary to popular belief. African Americans and Mexican Americans were more likely to endorse HIV conspiracy beliefs but significantly more willing to volunteer for HIV vaccine research.
Researchers at George Mason University have discovered that genistein, found in soybeans, can inhibit HIV infection by blocking cellular signals. The study's early findings suggest that genistein may be used as a complement treatment for HIV infection, potentially addressing drug toxicity issues.
A study found that both web-based and print-based decision aids significantly improved prostate cancer knowledge and reduced decisional conflict among patients. The tools offered flexibility for patients and providers, with increased satisfaction reported among those using print decision aids up to 13 months after treatment.
A team of researchers has developed a strategy for inducing a key part of an effective immune response to HIV by tracing the evolution of HIV-recognizing molecules. The study suggests that a future vaccine against HIV could combine multiple biological components to give broad protection against the virus.
A University of Missouri researcher has developed an intervention to help adults with hearing impairments acclimate to hearing aids. The intervention aims to reduce the stigma associated with wearing hearing aids and increase their use among this population.
A study published in Menopause found that women with HIV suffer from moderate to severe hot flashes, which significantly impact their daily functioning and overall well-being. The study also highlighted the potential risks of hot flashes on their health, HIV treatment, and ability to abstain from drugs and alcohol.
Researchers have discovered that a reduced daily dose of the antiretroviral medication efavirenz is both safe and effective in suppressing HIV. The findings could lead to lower treatment costs and increased access to life-saving therapy for millions worldwide.
AIDSVu, a detailed publicly available view of HIV prevalence in the US, has released updated maps displaying 2010 data and recent national HIV prevalence data. The new maps highlight urban cores with higher HIV rates and show disparities among black and Hispanic/Latino Americans.
Researchers found that work provides emotional support and extra financial resources for women with HIV, enabling them to better self-manage daily tasks. The study also highlights the importance of job training programs and microenterprises in improving the lives of these women.
A new intervention program in rural India has shown significant improvements in HIV/AIDS patients' lives by training lay women as social health activists. The program improved therapy adherence, immune-cell counts, and nutrition levels among patients.
Baligh Yehia has received the 2013 ICAAC Young Investigator Award for his pioneering work in HIV health services and quality research. He is recognized for his contributions to developing policies on healthcare reform, access to medical care, and performance measurement.
Research suggests that improved training in communication and interpersonal skills may help improve health, immune function, and reduce the spread of HIV. Patients who feel respected by their physicians are more likely to keep scheduled appointments and adhere to medical regimens.
A survey of adult South African men found that approximately one in 20 reported consensual sex with a man, while one in ten reported being sexually assaulted by another man. The study highlights the need for targeted HIV prevention messages and addressing male-on-male sexual violence.
A new study found that a daily oral dose of tenofovir significantly reduces the risk of HIV infection in people who inject drugs, with 17 participants infected out of 1204 on the drug versus 33 on placebo. Adherence to the treatment was key to its effectiveness.
Scientists have determined the precise chemical structure of the HIV capsid using a supercomputer on a 64 million-atom sample. The discovery has provided valuable insights into the development of new antiretroviral drugs that can suppress the HIV virus and stop AIDS progression.
Scientists have determined the precise chemical structure of the HIV capsid using a combination of laboratory techniques and computational simulations. The resulting structure revealed 216 protein hexagons and 12 protein pentagons, which work together to form the cone-shaped capsid.
Recent research at the University of Missouri discovered that listening to upbeat music can successfully try to be happier. Participants improved their moods after being instructed to attempt to do so, especially when listening to Copland's music, and reported higher levels of happiness over a two-week period.
The University of Rochester has been designated a Center for AIDS Research by the National Institutes of Health, with $7.5 million in new funding to advance HIV/AIDS research. The CFAR will focus on brain and aging effects, as well as RNA biology, with collaborations between departments.
Researchers developed a mathematical model to represent HIV-infected cell reproduction, revealing significant uncontrolled replication in sanctuary sites. The discovery implies current antiretroviral therapies may not be as complete in suppressing HIV as previously thought.
Researchers analyzed data from the RV144 HIV vaccine trial, which showed a 31% protection rate. They found that specific antibodies may interfere with the protective effects of other antibodies, reducing the vaccine's efficacy. This discovery can inform future vaccine development strategies to overcome these limitations.
Scientists analyzed patent medicines from the Henry Ford Museum collection to identify potentially toxic substances like arsenic, mercury and lead. The study found that some ingredients were actually healthy and mainstays in modern dietary supplements, while others posed significant health risks.
Researchers have identified a key player in the development of broadly neutralizing antibodies against HIV, paving the way for potential vaccine discovery. By studying the co-evolution of HIV and an individual's immune response, scientists can identify target proteins to include in vaccines.
Researchers have discovered that broadly neutralizing antibodies (bNAbs) can handle HIV's high mutation rate, offering a promising strategy for vaccine development. The study found that mutations in framework regions strengthened the antibodies' antiviral activity while conserving key structural features.
Researchers from Ragon Institute develop a computational method to analyze viral protein sequences, identifying vulnerabilities that could be exploited for vaccine development. The approach uses spin glass models and fitness landscapes to predict the prevalence of mutant proteins, providing a new way to design effective HIV vaccines.
A new paper highlights how political conflict can lead to disrupted treatment, promoting resistance to antiretroviral drugs and treatment failure. The authors call for further research and planning to mitigate the effects of treatment interruption in strife-prone nations with high rates of HIV infection.
A new study suggests that current CDC guidelines for HIV screening are too restrictive, recommending less frequent testing for both high- and low-risk groups. More frequent screenings, up to every three months for high-risk individuals and every three years for low-risk groups, would be cost-effective in the long run.
A study published in AIDS journal reports that patients with undetectable viral loads and near-normal immune cell counts on antiretroviral therapy have similar mortality rates to the general population. However, those with lower CD4+ cell counts were at increased risk of death.
A multi-site study led by a Miriam Hospital researcher reveals that treatment-experienced HIV patients can safely achieve viral suppression without incorporating the traditional class of HIV medications into their treatment regimen. This new approach could change treatment guidelines, lessen side effects, and increase adherence rates.
Researchers orally disseminated their HIV research findings to 477 participants, who enthusiastically received the information and identified new areas for investigation. The dissemination conference was funded by several organizations, including the National Institutes of Health.
A new study found that community-based HIV-prevention efforts can significantly increase testing rates and reduce new infections. The trial demonstrated a 14% reduction in new HIV infections compared to control communities.
A new report by researchers from the London School of Hygiene & Tropical Medicine highlights significant confusion among health and social care professionals about criminal prosecutions for HIV transmission. The study recommends improving best practice, training, and online resources to reduce stigma and promote public health.
A two-year-old child was treated with antiretroviral drugs from birth and later showed no detectable levels of virus or disease symptoms without treatment. Researchers are exploring the possibility of replicating this outcome in clinical trials involving other HIV-exposed children.
The VOICE study found that daily dosing of tenofovir gel was not effective in reducing HIV acquisition due to low adherence rates. In contrast, coital dosing, where women use the product around the time of sex, showed a significant reduction in HIV infections and herpes genital infections.
The study demonstrates that community efforts can significantly increase HIV testing rates, especially among men and young individuals. The intervention communities showed a 45% higher rate of testing for men compared to control communities, leading to a 14% reduction in new HIV infections.
A team of researchers describes the first case of a functional HIV cure in an infant, achieved through prompt antiviral therapy within 30 hours of birth. The infant remained virus-free for over a year without treatment.
Scientists at Johns Hopkins Medicine have identified 25 human proteins that may be critical to HIV-1's ability to infect new cells. These proteins are found in viruses from two different types of infected cells, providing a potential target for diagnosis and treatment.
Research suggests a significant proportion of HIV positive patients are not disclosing their infection to NHS staff, potentially skewing estimates of undiagnosed HIV. This phenomenon may be linked to fear of judgment or stigma, highlighting the need for further study and education.
Researchers at UCLA have identified a natural protein called cholesterol-25-hydroxylase (CH25H) that can block the entry of HIV and other deadly viruses into cells. The protein, which is activated by interferon, produces an oxysterol that can permeate cell walls and inhibit viral growth.
Researchers led by Ken Williams are studying cell types that contribute to an HIV viral reservoir and developing new therapies to control the virus's debilitating effects. The team aims to target specific cells and cellular activity linked to conditions like dementia, cardiovascular disease, and nerve damage.
Researchers found that African American and Latino men who have sex with men voluntarily used health-related Facebook groups to discuss HIV knowledge, stigma, and prevention, leading to increased requests for home-based HIV tests. The study suggests social media can be a useful tool for collecting and analyzing data, saving money and i...
A recent study found that tenofovir gel achieves substantially higher concentrations of active drug in vaginal tissue than the oral tablet, suggesting it should be highly effective in protecting women against HIV transmitted through vaginal sex. However, this has not been borne out in HIV prevention trials to date.