Articles tagged with Dementia
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Early stage clinical studies confirm 40Hz sensory stimulation is safe, with no serious adverse effects. The therapy also showed significant neurological and behavioral benefits, including improved brain activity, reduced brain atrophy, and better sleep patterns.
Researchers found that a gene mutation in mice resulted in increased plaque deposits and larger clumps, suggesting the gene plays a critical role in immune defenses. The study may lead to new therapies targeting this gene mutation to slow progression of Alzheimer's disease.
Researchers identify INPP5D as a key player in the inflammation process contributing to Alzheimer's disease, which may offer new potential targets for therapies. The study found that mice with inactivated INPP5D gene had more plaques covered by microglia, suggesting unexpected results when modulating inflammation genes.
A study published in Neurology found that people with higher scores for subjective cognitive decline were more likely to develop dementia. The study, which followed participants over five years, found that every additional point on the scale increased dementia risk by 8.5%.
Research finds that individuals with dementia who receive care from an interprofessional team are more likely to visit the emergency department than those cared for by a physician-only practice. However, this team-based approach does not appear to reduce hospitalization rates.
A recent clinical trial found that the Green Mediterranean diet reduced visceral adipose tissue by 14%, outperforming both the traditional Mediterranean diet and a healthy diet. The new diet incorporates dietary polyphenols and lower red meat intake, resulting in significant weight loss benefits.
A Cornell-led collaboration used machine learning to predict Alzheimer's progression in cognitively normal and mildly impaired individuals. The modeling showed that MRI scans are most informative for asymptomatic cases, while PET scans are more effective for those with mild cognitive impairment.
Recent studies from the University of Eastern Finland found that lower education levels and previous traumatic brain injuries may increase the risk of frontotemporal dementia (FTD). FTD patients were more likely to have cardiac disease and develop the condition earlier if they had a history of head injury.
A new biomarker has been identified with up to 89% accuracy for corticobasal degeneration, a primary tauopathy. The discovery could accelerate progress toward therapies for this rare brain disease, which is often misdiagnosed due to similar symptoms.
Scientists at Texas A&M University found that transplanting intestinal epithelial stem cells can repair the gut and reduce inflammation, potentially preserving cognitive function after a stroke. The study suggests that targeting gut health may be key to developing more effective stroke therapies.
A new study published in the journal Nature has identified medin as a key player in Alzheimer's therapies. Medin, a protein that accumulates in the blood vessels of the brain, promotes vascular pathology and cognitive decline. The researchers hope to develop a treatment targeting medin to prevent vascular damage and cognitive decline.
A recent study by Brigham and Women's Hospital reveals that patients with Alzheimer's dementia and related disorders who also experience delirium incur significantly higher healthcare costs. The average additional cost for one delirium ADRD patient's year of care is $34,828 more than non-delirium ADRD counterparts.
Scientists at WashU Medicine have discovered that immune cells surrounding the brain play a crucial role in clearing toxic clusters of proteins. Treating old mice with an immune-stimulating compound rejuvenates these cells, improving waste clearance and holding promise for treating neurodegenerative diseases like Alzheimer's.
A study published in the Journal of the American Geriatrics Society found that antiepileptic prescribing to US nursing home residents with Alzheimer's Disease and dementia increased between 2015 and 2019. In contrast, antipsychotic and opioid prescribing rates declined during this period
Researchers have identified a new gene, NUCL-1, in the transparent roundworm C. elegans, which is linked to human neurodegenerative diseases such as ALS and Alzheimer's. The discovery challenges recent theories on the role of nuclear structures in these disorders.
The age-adjusted prevalence of dementia declined from 12.2% to 8.5% among people over 65 between 2000 and 2016. Education was a key factor in the reduction, explaining 40% of the decline among men and 20% among women.
Researchers at UQ's Queensland Brain Institute found a causal relationship between lack of oxygen to the brain during sleep and Alzheimer's disease in mice. CPAP treatment for obstructive sleep apnea may prevent cognitive impairment and neuron death, reducing dementia risk.
Researchers discovered Fyn enzyme clusters when immobilized in synapses, forming toxic 'protein clumps' linked to dementia. Targeting Tau biomolecular condensates may prevent dementia progression.
A new study published in Alzheimer's & Dementia found that telmisartan, a blood pressure medication, is associated with lower risk of Alzheimer's specifically in Black patients over 60. The study analyzed data from over 5 million patients and suggests that future clinical trials should prioritize minority populations to find or reinfor...
A new poll finds that more than half of people over 50 have helped at least one person over 65 with various tasks, including health care needs, home repairs, and finances. The experience can be rewarding but also challenging, especially for those helping individuals with complex needs.
A study published in the Journal of Alzheimer's Disease found that analyzing patients' drawing tests can help diagnose Alzheimer's disease (AD) and distinguish it from dementia with Lewy bodies (DLB). The researchers discovered that DLB patients showed differences in speed-, pressure-, and pause-related features, whereas AD patients sh...
A study published in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring found that analyzing patients' speech can distinguish between different types of dementia. The research team developed a machine learning model using speech features to identify Alzheimer's disease and Lewy body dementia.
A new study found that only 12% of middle-aged adults are willing to participate in dementia prevention drug trials, citing concerns over the risks involved. The study suggests prioritizing those with a family history or perceived personal risk for dementia and communicating about trial safety could increase participation.
Scientists have developed a new mathematical model to understand the formation of amyloid protein clusters in the brain, which are linked to Alzheimer's disease. The study reveals that these clusters form through a process called liquid-liquid phase separation and can impact normal brain activity.
A new funding grant will be used to investigate the effectiveness of 'Fastball EEG' in detecting three major types of dementia, including frontotemporal dementia and Vascular Dementia. The technology has shown high accuracy in picking up small changes in brain waves associated with memory recall.
Researchers at Harvard Medical School have made progress in understanding the mechanism underlying a type of dementia that strikes early in life. A genetic form of frontotemporal dementia is associated with accumulation of specific lipids in the brain, which results from a protein deficiency that interferes with cell metabolism.
A team of researchers at USC is launching a comprehensive study to investigate the connection between type 2 diabetes and dementia in adults with Hispanic ancestry. The five-year study will examine brain structure and activity, blood flow, blood glucose and insulin levels, and cognitive functioning in 200 participants.
A new study published in NEJM Evidence found that crossword puzzle training significantly improved cognitive function and daily activities, reducing brain shrinkage in individuals with mild cognitive impairment. The findings suggest that engaging with familiar activities like crossword puzzles may be more effective than computerized co...
Researchers at Penn State aim to create a minimally invasive system using machine learning and multimodal biosensing platforms to detect Alzheimer's disease in its early stages. The system has the potential to improve detection accuracy and reduce false positives.
A meta-analysis published in Neurology found an association between traffic-related air pollution and an increased risk of dementia. Fine particulate matter exposure was linked to a 3% increase in dementia risk, highlighting the importance of reducing air pollution to prevent this disease.
A global study of over 28,000 people found that lowering blood pressure can significantly reduce the risk of dementia. The researchers analyzed five double-blind placebo-controlled trials and discovered a broad linear relationship between blood pressure reduction and lower dementia risk.
A recent US study of nearly 3,500 individuals aged 65+ found that 10% had dementia and 22% mild cognitive impairment (MCI), with disparities seen among racial and educational groups. The results highlight the disproportionate burden of dementia on older Black adults and MCI among Hispanic adults with lower education levels.
A recent study found that nearly 10% of US adults aged 65 and older have dementia, while another 22% have mild cognitive impairment. The prevalence of dementia and mild cognitive impairment increases with age, affecting individuals from diverse backgrounds differently.
Researchers found lower serum TDP-43 levels in patients with C9orf72 repeat expansion or motoneuron disease, distinguishing them from other FTD subtypes. This study suggests TDP-43 as a potential biomarker for diagnosing specific FTD subtypes, enabling patient-specific interventions.
Scientists at NTU Singapore have found that a stress response in cells, when 'switched on' at a post-reproductive age, could be the key to slowing down aging. The study showed that this stress response extended the lifespan of roundworms fed a high-glucose diet.
A population-based analysis of 1,193 major surgeries found that 13.4% of patients died within a year, with frail and dementia-affected individuals facing significantly higher mortality rates
A new study found that timely treatment of depression can reduce the risk of dementia by about 30% in certain patient groups. The study, published in Biological Psychiatry, analyzed data from over 350,000 participants and found that depression elevated the risk of dementia by 51%, but treatment reduced this risk. Those with increasing ...
A new study aims to diagnose severe neurodegenerative diseases like ALS and FTD with the help of speech tests. AI can analyze subtle nuances of speech patterns, including pauses, speed, and melodic aspects, to detect early changes.
A new study by UCL researchers found that talking therapies on the NHS can improve the mental health of people with dementia, with 63% experiencing a reduction in symptoms. The therapy proved clinically beneficial, even though response rates were lower than those without dementia.
A new study published in Neurology found that following a Mediterranean diet did not decrease the risk of dementia. The study, which followed 28,000 participants over 20 years, found no link between adhering to conventional dietary recommendations or the Mediterranean diet and reduced risk of dementia.
A recent UK Biobank study found that Black participants are at a higher risk of developing dementia compared to White participants, with an HR of 1.43. South Asians also have a similar risk to White participants. The study included 294,000 volunteers, but the results may not be representative of the wider UK population.
A recent study analyzed the records of over 33,000 dementia patients in Wales and found that those closest to their diagnosis were taking an average of three or more medications. This suggests a possible link between polypharmacy and the development of dementia.
Researchers have identified cognitive impairment in patients with dementia-related diseases up to 9 years before diagnosis, raising hope for earlier interventions and clinical trial recruitment. The study analyzed UK Biobank data and found subtle impairments in problem-solving and memory across various conditions.
Researchers found that higher levels of cell-free DNA in the blood are associated with increased cognitive decline and worsening frailty over an eight-year period. The study suggests that a simple blood test could detect risk of Alzheimer's disease and other forms of cognitive decline, potentially leading to early interventions.
A Baycrest study found that the gut microbiome plays a role in how diet and exercise affect brain health and dementia risk. Lifestyle interventions like Mediterranean-style diets can improve cognition and promote healthier microbiomes.
A long-term study found that older patients with type 2 diabetes treated with glitazones had a 22% lower risk of developing dementia. These drugs may effectively prevent dementia in high-risk patients and are now worth prioritizing for future clinical studies.
Researchers found positive correlations between lipoxin A4 and cognitive brain functions, as well as its potential to potentiate the endocannabinoid system. The study suggests that reducing levels of this substance may weaken the body's defenses against neurodegeneration.
Researchers analyzing over 3,000 blood samples from Alzheimer's patients and healthy individuals to identify reliable biomarkers. They investigate how well blood tests can diagnose Alzheimer's disease and predict its progression.
A new study found that caregivers, particularly women, experience higher odds of health-related vulnerabilities such as food insecurity and financial strain. Caregivers must balance their own lives with those of their dependents, finding ways to care for themselves while dedicating time to caring for loved ones.
A systematic review and meta-analysis found that psychotic disorders like schizophrenia are associated with a higher risk of developing dementia. People with psychotic disorders are 2.5 times more likely to develop dementia than those without a psychotic disorder, according to the review.
A study published in Nature has identified 61 additional genetic loci associated with stroke and six genes that are potential targets for drug therapy. The research also found a significant overlap between stroke and dementia, suggesting common biology between the two conditions.
Researchers at Lancaster University found that 3D printed flavor-based cues can stimulate rich sensory accounts and strong emotional connections in older adults, recalling memories from their youth. This technology has potential applications for dementia care, allowing individuals to relive cherished moments through the power of smell.
The I-CARE 2 trial will measure the impact of Brain CareNotes on informal caregivers and patients with Alzheimer's disease and related dementia. The randomized clinical trial aims to improve caregiver burden, depressive symptoms, and healthcare outcomes.
Research has found that former Scottish international rugby union players are at a significantly increased risk of developing neurodegenerative diseases, including dementia and motor neurone disease. The study's findings suggest that strategies to reduce head impact and traumatic brain injury in all sports are necessary.
A nationally representative study of 594,000 persons in England found an increased risk of suicide associated with dementia diagnosis before age 65. The study identified younger patients diagnosed within the 3-month post-diagnostic period as high-risk groups for suicidal thoughts and behaviors.
A new study found that fewer Asian, Black, and Hispanic patients qualify for anti-amyloid monoclonal antibody treatments, which may slow Alzheimer's progression. The treatment's effectiveness depends on the presence of amyloid plaques, with lower incidence in minorities.
A study by Queen Mary University of London and University of Nottingham found that patients with young onset dementia are at a high risk of suicide, particularly if under 65 or have psychiatric illness. Early recognition and support after diagnosis are crucial in reducing distress caused by this devastating condition.
A Rutgers study found that racial and ethnic minorities with dementia receive more intensive end-of-life care. This disparity may be attributed to systemic racism, discrimination, or poor physician communication. The researchers suggest improving end-of-life care and outcomes for people with dementia through initiatives like advance ca...
Researchers developed a machine learning model to quickly recognize predictive risk factors and their importance for undesirable hospitalization outcomes. The model achieved an accuracy of 95.6% and identified modifiable risk factors that can be mitigated through clinical interventions.
The National Institutes of Health has awarded a $10.7 million grant to Cleveland Clinic to expand a national research consortium focused on improving diagnosis and treatments for Dementia with Lewy Bodies. The consortium, which includes multiple clinical sites, aims to identify biomarkers for disease and develop new therapies.