Articles tagged with Depression
A 64-year-old woman with severe depression was treated with deep brain stimulation of the habenula, showing significant improvement and long-term remission. The procedure is a new treatment option for therapy-resistant depression, building on existing knowledge of the habenula's role in the condition.
Researchers found that expressing mutant DISC1 during prenatal periods, postnatal periods, or both led to distinct brain alterations and behaviors resembling schizophrenia or mood disorders. The study suggests that manipulating DISC1 expression timing may help develop new therapies for psychiatric disorders.
A meta-analysis of randomized trials found that antidepressant medications provide substantial benefit for patients with very severe depression, but little to no benefit for those with mild or moderate symptoms. The study suggests that the efficacy of these medications largely depends on the severity of depression symptoms.
A study found that many Americans with major depression do not receive adequate treatment, with racial and ethnic groups facing disparities. Psychotherapy is more commonly used than pharmacotherapy, but individuals with specific ethnic backgrounds have lower odds of receiving concordant care.
A study of over 15,659 adolescents found that those with earlier parental set bedtimes were less likely to suffer from depression and suicidal ideation. The association was most pronounced among adolescents who slept for five hours or fewer per night.
A new study at the University of Wisconsin-Madison suggests that depressed patients struggle to sustain activity in brain areas related to positive emotion and reward. Researchers found that despite normal initial levels of activity, depression impairs ability to maintain them over time.
Researchers pinpointed prime factors identifying elderly persons at high risk for developing major depression, including low-level depressive symptoms and poor social support. Preventive treatments hold promise for providing the greatest health benefit at the lowest cost.
Researcher Brandon Gibb is studying the causes of mental-health problems in kids and defining trajectories of risk for depression. He hopes to identify genetic, environmental, and psychological variables that contribute to depression in children.
A new study found that physical activity increases self-efficacy, which in turn reduces disease-related depression and fatigue. Higher levels of physical activity correspond to higher self-efficacy and lower levels of depression and fatigue, but the effect is reduced when controlling for self-efficacy.
Researchers found that antidepressant medications can substantially change patients' personalities, particularly those with high neuroticism and low extraversion. Personality changes were linked to long-term improvements in mood, suggesting a potential mechanism for modern antidepressants.
Postmenopausal women taking antidepressants may be at higher risk of stroke and death compared to those not taking the medication. Researchers emphasize the need for individualized risk assessment and further study to determine the exact association.
A new study reveals that most antidepressants miss the mark on a key brain protein called monoamine oxidase A (MAO-A), which is highly elevated during clinical depression. This finding has important implications for understanding why antidepressants don't always work, with potential benefits for developing more effective treatments.
USF researchers Paul Sanberg and Douglas Shytle developed TC-5214, a promising alternative to antidepressants, which has shown effectiveness in treating treatment-resistant depression. The $1B deal with AstraZeneca could generate substantial revenue for the university.
A study found that antidepressants can change personality traits like neuroticism and extraversion while alleviating depressive symptoms. Individuals taking the medication reported significant decreases in neuroticism and increases in extraversion compared to those receiving placebo or cognitive therapy.
Researchers found that anxiety sensitivity significantly predicted depression symptoms in above-average worriers. The fear of cognitive dyscontrol and publically observable anxiety symptoms specifically correlated with depression. Understanding this link may lead to new depression treatments by addressing anxiety sensitivity.
Researchers found that depressed women had no significant difference in weight loss success compared to non-depressed women. The key factor was attendance at a minimum of 12 sessions, regardless of depression status.
A Mayo Clinic-led study found that nearly 9% of US surgeons reported making a major error in the past three months, with burnout and depression being key factors. The researchers suggest that reducing work hours may not be enough to limit errors unless addressing burnout is also prioritized.
A recent study by Johns Hopkins Medicine suggests that burned-out and depressed surgeons are more likely to report major medical errors. The research found a significant association between burnout, depression, and self-reported medical errors, highlighting the need for better support for surgeons struggling with mental health.
Researchers found that children whose mothers had more depressive symptoms experienced more frequent asthma symptoms, while those with fewer depressive symptoms had less frequent symptoms. The study suggests maternal depression is an independent risk factor for childhood asthma symptoms.
A new study published in the American Journal of Hypertension found that Transcendental Meditation significantly reduces blood pressure, anxiety and depression in young adults at risk for hypertension. The three-month intervention program showed a 52% lower risk of developing hypertension in later years.
A motivationally-enhanced cardiac rehabilitation program for women with coronary heart disease significantly improves depressive symptoms and adherence rates compared to traditional programs. The intervention, tailored to the needs of women and their stage of readiness, led to sustained improvements at a 6-month follow-up period.
A study found that depression increases mortality risk similar to smoking, but anxiety reduces it when combined with depression. Researchers suggest that help-seeking behavior may explain this pattern, and highlight the need for more attention on physical health in people with mental disorders.
A study published in JAMA found that telephone-delivered collaborative care for post-CABG depression significantly improved mental HRQL, physical functioning, and mood symptoms. Intervention patients reported a 50% or greater reduction in mood symptoms compared to those receiving usual care.
A study found that a nurse-led telephone care program for depression post-bypass surgery improved mental health-related quality of life and physical functioning in CABG patients. The intervention showed significant reductions in mood symptoms, with men particularly benefiting from the treatment.
A large-scale meta-analysis has found a clear connection between depression and reduced bone density, increasing the risk of osteoporosis. The study, conducted by Hebrew University researchers, reveals that young women are particularly at risk, especially those with clinical depression.
A recent study found that head injuries can amplify the psychological impact of torture on survivors, with structural brain changes and more severe depression symptoms reported in those who experienced both. The research suggests that physical effects may help explain why standard therapies often don't work for torture survivors.
The new TMS clinic offers a safe and effective, non-drug treatment for major depression. TMS therapy stimulates the brain linked to depression by delivering magnetic field pulses, providing an alternative for those not responding to traditional treatments.
A new study from University of Bonn suggests that deep brain stimulation can significantly improve depression in half of patients, who had previously not responded to other therapies. The treatment involves implanting electrodes in the nucleus accumbens, a key area of the brain's reward system.
A new study has found that pregnant women with a history of depression who use psychiatric medication are at increased risk of delivering prematurely. The research analyzed data from nearly 3,000 women and showed that medication use and depression were strongly linked to preterm delivery before 35 weeks' gestation.
A new study found that depressed pregnant women have a stronger biological reaction to the seasonal flu vaccine than those with lower depression levels, suggesting immune system dysfunction. This immune dysregulation could affect symptom severity among infected women, highlighting the importance of flu vaccination during pregnancy.
A recent study published in Psychosomatic Medicine found that individuals with depression tend to overreport physical symptoms. Researchers attribute this phenomenon to depressed individuals' recall of experiences differently, tending to ruminate and exaggerate negative emotions.
Researchers found that depression-related genes and stress-related genes have almost no overlap, indicating that chronic stress does not cause the same molecular changes as depression. This finding challenges the long-held belief that stressful life events are a major cause of depression.
A study by Ohio State University researchers found that mice housed in a lighted room for 24 hours a day exhibited more depressive symptoms than those with normal light-dark cycles. However, mice that lived in constant light but could escape showed less evidence of depressive symptoms.
New research suggests that augmenting antidepressant therapy with omega-3 fatty acid supplements does not provide benefit for patients with coronary heart disease and depression. The study found no difference in improvement between groups on the Beck Depression Inventory-II scores.
Researchers found that an intervention called IMPACT improved depression symptoms, quality of life, and functional impairment in older cancer patients. After six months, 55% of IMPACT participants showed a 50% or greater reduction in depression symptoms.
In the Phase 2b trial, TC-5214 outperformed placebo in treating major depressive disorder, achieving high statistical significance on all secondary outcome measures. The study demonstrated a favorable tolerability profile and potential as an augmentation treatment for SSRI-resistant depression.
Researchers at Medical University of South Carolina pioneer bilateral epidural prefrontal cortical stimulation, providing significant improvement in depressive symptoms. Five patients showed average improvement of 54.9% after seven months, including three who reached remission.
A large study found that individuals following a Mediterranean diet, rich in fruits, vegetables, and whole grains, were less likely to develop depression. The diet's high intake of monounsaturated fatty acids from olive oil may be protective against depressive symptoms.
Research at AAO-HNSF Annual Meeting & OTO EXPO finds depression prevalence in CRS patients to be 20.5%, significantly impacting QOL measures. Physicians should screen for both CRS and depression to optimize patient health.
A new study found that depressive symptoms are associated with increased levels of interleukin-6, an inflammatory protein predicting cardiovascular events. In contrast, levels of interleukin-6 were not related to later increases in depressive symptoms among healthy adults.
A Mediterranean diet rich in fruits, nuts, and fish has been associated with a reduced risk of depression. The study found that individuals who closely followed the diet had a greater than 30 percent reduction in depression risk compared to those who did not adhere to it.
Studies found that antidepressant medication exposure during pregnancy is associated with an increased risk of preterm birth and low five-minute Apgar scores. Exposure was also linked to a higher risk of admission to the neonatal intensive care unit (NICU). The study suggests that treatment of depression during pregnancy may be warrant...
A recent study from Family Relations reveals that parents in low-income environments are more prone to depression when they lack social support. This is particularly true in rural regions where mental health resources may be scarce. Social support mechanisms can help mitigate negative thinking and promote healthy parental practices.
A study published in Family Relations found that parents in low-income environments with limited social support are more prone to depression. Social connections, such as community groups and school activities, can help mitigate negative thinking and promote healthy parenting practices.
The Weill Cornell Institute of Geriatric Psychiatry has received a $10 million grant from the National Institute of Mental Health to advance research on geriatric depression. The team will focus on understanding the biological, medical, cognitive, and psychosocial aspects of depression in older adults.
A recent study published in the Journal of Child Psychology and Psychiatry suggests that adolescent depression and anxiety disorders are not the same thing. The research, led by Dr. William W. Hale III, found that these two conditions have different symptoms and characteristics, contrary to current classification in the DSM-V.
A Mayo Clinic study found that distress and fatigue among medical residents significantly contribute to self-perceived medical errors. The research used standardized survey tools to measure burnout, symptoms of depression, sleepiness, and fatigue, and found that both factors increased the risk of errors.
Researchers found that nearly half of young adult women met the criteria for depression, obesity, or alcohol abuse at multiple time points. The study also discovered a significant link between obesity and depression in women, with those experiencing weight issues more likely to report depression later on.
Researchers developed a model to diagnose postnatal depression with an 80% predictive power, identifying risk factors such as social support and family history. The study also uncovered two protection factors: age and work during pregnancy, which reduce the risk of depression.
A recent meta-analysis published in Cancer found that depression is associated with a higher risk of death in cancer patients, with death rates up to 25% higher for those experiencing depressive symptoms. The study highlights the need for systematic screening and treatment of psychological distress in cancer patients.
A longitudinal study of over 1,000 New Zealanders from birth to age 32 found that people underreport mental illness, and the actual rate of anxiety, depression, and substance dependency may be higher. The study's findings challenge current diagnostic standards and suggest that mental illness may be more common than previously thought.
In a preliminary study, intravenous ketamine was found to acutely reduce suicidal thoughts in treatment-resistant depression patients. The reduction in suicidality was maintained when patients received repeated doses over two weeks, suggesting potential as an attractive treatment option for high-risk suicidal patients.
Researchers at UT Southwestern Medical Center found a significant link between depression and early-stage chronic kidney disease, with 57 out of 272 participants identified as depressed. The study suggests that depression screening should be considered for patients in the early stages of chronic kidney disease.
Researchers at Ohio State University found that a psychological therapy significantly relieved depressive symptoms and reduced markers of inflammation in breast cancer patients. The study published in Psychosomatic Medicine showed that treating depression can also lead to less inflammation, highlighting the importance of including psyc...
A new study published in the Journal of Child Psychology and Psychiatry found that up to 15 percent of preschoolers have atypically high levels of depression and anxiety. The investigation also revealed that children with atypically high depression and anxiety levels are more likely to have mothers with a history of depression.
A randomised controlled trial found online CBT to be more effective than usual care in treating depression. After 8 months, 42% of patients had recovered, compared to 26% in the control group.
A five-year study by UT Southwestern Medical Center researcher Dr. Uma Rao found that adolescents with shorter rapid-eye-movement (REM) sleep latency are more likely to develop depression. These teens reached the REM stage earlier in their sleep cycles, indicating a greater risk for depression.
Researchers discovered that individuals with anhedonia, a core symptom of major depressive disorder, are less willing to make choices requiring greater effort in exchange for greater reward. This finding suggests a plausible connection between dopamine deficiency and reward processing in depression.
Researchers found that teaching resilience and a sense of purpose in schools can reduce depressive symptoms, increase optimism, and boost learning. The Penn Resiliency Program and Positive Psychology Program were successful in improving life satisfaction and academic performance.
A new study found that adding psychosocial therapy to medication can improve depression scores short-term and long-term in stroke patients, leading to better perceived recovery, physical condition, and social participation. Depression following stroke is a significant public health problem affecting one-third of patients.