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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

How learning influences smell

Researchers found that prolonged exposure to one odorant improves differentiation among related odors and reveals increased response in brain areas. The study suggests that humans naturally learn to identify thousands of different smells through experience-dependent neural plasticity.

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Tiny inhaled particles take easy route from nose to brain

Tiny airborne particles, similar to nanoparticles, follow a rapid and efficient pathway from the nasal cavity to various regions of the brain in rats. The study found increased gene expression signaling inflammation and cellular stress response, but it is unclear if ultrafine particle buildup causes brain damage.

Quick -- what’s that smell?

Taking slightly longer to smell an odor can lead to more accurate identification, a discovery that sheds light on the brain's olfactory processing. The study, published in Neuron, reveals a clear relationship between sampling time and accuracy, implications for understanding human olfaction.

Researchers show how brain decodes complex smells

In a breakthrough study, researchers found that nerve cells in the olfactory bulb detect individual chemical compounds in odors, rather than perceiving complex mixtures as single objects. The brain integrates these signals to form a recognizable scent, much like combining multiple melodies to hear a symphony.

New groundbreaking findings in taste, smell and chemical irritation

Researchers present new discoveries on topics ranging from molecular biology to clinical diagnosis and treatment of smell and taste disorders. Key findings include zebrafish exhibiting robust light responses, flavor and fragrance scientists working to uncover basic science behind sensory delights.

When mice choose mates, experience counts

In a series of experiments, female mice were exposed to odors of either a male mouse alone or a male mouse with a female. The females consistently preferred the scent of males linked to other females. This finding suggests that female mice may use social cues, such as olfactory information, to inform their mate choice.

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Duck-billed dino crests not linked to sense of smell

A University of Toronto study has ruled out the theory that duck-billed dinosaurs' crests were linked to their sense of smell. The research, led by David Evans, found that the brain changed little from non-crested dinosaur ancestors, suggesting the crests may have been used for visual display or attracting mates.

Evolutionary shifts in olfactory sensitivities in fruit flies

Researchers found that fruit fly species D. sechellia develops a specialized olfactory system to detect the morinda fruit, which is toxic to other species. This unique system involves increased numbers and sensitivity of specific olfactory hairs, suggesting an evolutionary adaptation in just a limited time span.

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New study examines how sense of smell affects mating and aggression in mice

A new study published in Nature Neuroscience found that male mice require intact functioning of the main olfactory epithelium (MOE) to detect pheromones that elicit sexual behavior and fighting. The MOE plays a crucial role in regulating mating and aggression in mice, highlighting the importance of this sensory system.

Neurons generated in the adult brain learn to respond to novel stimuli

Researchers found that newly generated olfactory neurons in the adult brain can specialize in detecting previously unencountered odors and respond strongly to those smells. This suggests a unique role for these new cells in learning and memory functions, which may be important for repairing diseased brain tissue.

Olfactory input dominates reproductive behavior in mice

Researchers found that almost all neurons feeding into the LHRH-making region of the hypothalamus originated in the mouse nose. Mice with compromised olfactory function show dramatically impaired mating behavior, highlighting the essential role of olfactory activity in eliciting male mating behavior.

Olfactory system detects pheromones that control reproduction

Scientists used a genetically altered virus to trace connections between olfactory neurons and LHRH-producing neurons in mice. They found that the main olfactory epithelium sends signals to LHRH neurons, controlling puberty, ovulation, and testosterone production. The study challenges traditional views on pheromone communication systems.

Study shows humans have ability to track odors, much like bloodhounds

Researchers at UC Berkeley found that humans can reliably discern the source of an odor when presented with it through one nostril. The brain's primary olfactory cortex is divided into separate areas for each nostril, allowing for accurate localization. This ability has implications for various fields, including truffle hunting.

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Nose odors and mouth odors: The brain distinguishes

Researchers found that brain responds differently to odors introduced through the nose versus the mouth, with distinct brain regions activated. The study suggests that olfactory referral illusion is robust and cognitively impenetrable, and may play a role in flavor perception.

How a baby's nose knows Mom's scent

Newborn rats' brains show decreased NMDA receptor activity in olfactory-deprived side, leading to increased neuronal activation and saliency of early odors. This critical period affects olfactory development and learning.

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Fighting malaria by manipulating mosquitoes' sense of smell

Researchers at Vanderbilt University aim to develop powerful chemical repellents and attractants to interfere with malaria mosquitoes' ability to find human targets. The project uses genetic engineering, molecular biology, and field-based studies to establish an effective strategy for reducing malaria spread.

Decoding the logic of olfaction

The study found that individual odors stimulate a small subset of neurons across a large area in the cortex. Different odorants exhibit similar patterns of activation, but with partial overlaps. This suggests a complex logic to the way information is mapped onto the cortex.

Words influence smells

Subjects rated odors more pleasant when labeled with positive words like 'cheddar cheese', whereas unpleasant labels had the opposite effect. The study also found that brain regions processing odors were activated by word labels, highlighting high-level cognitive inputs' impact on sensory perception.

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'Blinding' an insect's sense of smell may be the best repellent

Scientists have discovered a gene responsible for an insect's sense of smell, which is highly conserved across four different species, including pests that target crops and human health. This finding could lead to the development of new pesticides and disease-controlling insect repellents by targeting the insects' sense of smell.

Cracking the olfactory code in bees

Bees' brains process scents in a complex system that correlates with behavioral responses, suggesting a species-specific code for odor recognition. The study's findings improve understanding of animal perception and memory, paving the way for further research.

It came from the sea: 'Monster' crabs evolve a bug's nose

Land-living crabs, descended from marine ancestors, have developed a sophisticated sense of smell similar to insects. The robber crab's olfactory system is highly sensitive and has adopted strategies used by insects to navigate its air-filled terrestrial environment.

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Genetic discovery paves way to decode sense of smell in mammals

Researchers discovered two proteins that chaperone odorant receptors to the surface of olfactory nerves in mice, enabling them to match nearly 1,000 different mouse odorant receptors with specific chemicals. This breakthrough opens up new possibilities for understanding the mechanisms underlying our sense of smell.

Olfactory bulb stem cells and Lou Gehrig's disease

Researchers transplanted adult olfactory bulb stem cells into genetically engineered mice with ALS, showing a significant delay in disease symptoms and improved functional outcomes. The study suggests these stem cells may hold potential for treating ALS, but further laboratory work is needed.

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That stinks: People with rare obesity syndrome can't sense odors

Researchers have found that people with the rare genetic disorder BBS syndrome are unable to detect odors due to faulty cilia in their olfactory system. The study, led by Johns Hopkins Medicine researchers, used mice models to prove that ciliary problems caused by BBS-causing genes lead to impaired sense of smell.

Biologists deciphering complex lemur scent language

Researchers at Duke University have been studying ring-tailed lemurs' scent language to understand their complex chemical communications. The scientists found that lemurs use 'scentences', combinations of scents extending their chemical messages, and identified specific compounds in their scent profiles.

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Yale scientists decipher odor code

Researchers at Yale University have created a detailed map of the relationship between odor receptors and neurons in fruit flies. The study reveals that different receptors respond to varying numbers of odors and can even be inhibited by certain smells, providing valuable insights into the human olfactory system.

Olfactory system matures in different stages

The study established four principles of olfactory system development: without sensory activity there is no full maturation, a sensitive period influences organization maturation, sensitive periods occur at different times for different receptors, and glomeruli may be innervated by multiple nerves during early development.

Odorants enhance survival of olfactory neurons

Olfactory sensory neurons can adapt to odorant stimulation, but the ability to enhance long-term survival after stimulation has been unclear. Researchers found that odorants stimulate the Erk/MAP kinase/CREB pathway, leading to cell survival and dynamic long-term adjustment to sensory information.

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Impaired sense of smell increases risk for certain hazards

A study of 445 patients with chronic olfactory dysfunction found a significant link between impaired sense of smell and an increased risk of cooking-related incidents, gas leaks, and fire detection. Otolaryngologists must be aware of these risks to provide proper diagnosis and counseling for patients.

Loss of smell linked to key protein in Alzheimer's disease

Researchers found a link between olfactory dysfunction and excess tau proteins in brain structures important for smelling. The study used genetically engineered mice to evaluate the effect of tau protein overexpression on smell perception.

Mice cloned from olfactory cells

Researchers successfully cloned mice from olfactory cell nuclei, demonstrating totipotent development and normal brain function. The study expands understanding of neuronal diversity and offers insights into reprogramming mature cells.

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Progress in probing the mosquito's sense of smell

Scientists at Vanderbilt University have verified that female Anopheles mosquitoes contain receptors responding to one of the chemical compounds found in human sweat. This discovery may lead to better ways to repel deadly insects and uncover additional chemicals that either attract or repel them.

New studies of smell uncover effects of aging on working memory

Researchers found that odor working memory is impaired by aging, while semantic memory remains relatively intact. The study suggests that different brain regions handle working and semantic memory, which may explain why odors are more vulnerable to age-related decline.

Evidence that neurons prune only 'twigs' to rewire themselves

Researchers studied neurons in the olfactory bulb and found that they only undergo subtle changes in response to environmental stimuli. These findings challenge previous theories of brain rewiring and may offer insights into disorders such as epilepsy and Alzheimer's disease.

AmScope B120C-5M Compound Microscope

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Geneticists show ripple effects of gene mutations

Researchers at North Carolina State University found that changes to genes regulating olfactory behavior in fruit flies have far-reaching implications. The study used a model organism to quantify the extent of ripples in the genome affecting behavior, revealing that two-thirds of affected genes impact olfactory behavior.

Smell, emotion processor in brain may be altered in depressed patients

A study found that depressed patients' brains respond differently to smells and visual stimuli compared to healthy individuals. The researchers suggest that alterations in the orbitofrontal cortex and amygdala may contribute to the reduced sense of smell and intensified emotions in depression.

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Metal ions may play big role in how we sense smells

Scientists propose a new mechanism for passing information through cell membranes via a shuttlecock motion involving metalloproteins. This theory explains why dietary zinc deficiencies lead to a loss of smell and has significant implications for understanding the sense of smell.

How the nose knows a rose-or a mate

A new study reveals that the human brain can distinguish between thousands of chemicals using a 'fingerprint' pattern, while another discovery sheds light on pheromone-detecting neurons in mice that identify potential mates and social status. These findings may also aid in understanding animal communication and behavior.

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Palm leaves act like flowers

Researchers discovered that palm leaves emit specific floral notes to attract pollinating weevils during the flowering season. This finding suggests a shift in flower-to-leaf function in plants, opening new questions about pollination system evolution.

The brain risks of binge drinking

A new study confirms that binge drinking can cause neuronal damage in the brain. Damage to the olfactory bulb occurred after just two days of 'binge drinking', while other regions were damaged after four days. The study suggests that alcohol-induced brain damage occurs during intoxication, not withdrawal.

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University of Warwick researchers in nose-on-a-chip-project

Researchers from the University of Warwick, Leicester, and Edinburgh are developing a nanotechnology-based electronic nose that mimics human olfactory sensors. The device aims to improve the sensitivity and processing power of existing electronic noses, allowing for real-time monitoring of environmental pollutants and food safety.

Exposing insects' sense of smell

A protein in an insect's antenna picks up chemical signals called pheromones and changes its shape to eject them onto sensitive nerve endings. This discovery could lead to the development of insecticides that prevent insects from detecting other chemical signals, essential for their survival.

Assaulting the mosquito’s sense of smell

Researchers at Vanderbilt University have identified four genes in the Anopheles gambiae mosquito that code for odorant receptors similar to those found in fruit flies. These genes are only expressed in the antennae and maxillary palps, indicating that mosquitoes use a conserved chemosensory system to track human body odor.

Does the Pill affect libido by blunting a woman’s sense of smell?

Researchers found that women taking oral contraceptives showed no change in their ability to detect odors, compared to the natural clime of the luteal phase. The study suggests that iatrogenic steroids may affect changes in smell sensitivity, and further research is needed to investigate this phenomenon.

Gene found responsible for social amnesia

Scientists at Emory University Health Sciences Center have discovered that the oxytocin gene is necessary for forming social memories, allowing individuals to recognize familiar faces. The study found that mice lacking this gene exhibited social memory deficits, which were restored with oxytocin treatment.

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Creating a standard spectrum of smell

Researchers at Cornell University have developed a standard spectrum of smell to identify individuals with specific anosmia, which can distort data in sensory research labs. The new approach uses gas chromatography olfactometry to categorize people into three sensitivity levels: hyperosmic, hyposmic, and anosmic.

Scientists can now see sense of smell

Neurobiologists at Duke University Medical Center have captured the first detailed images of the living brain in action, revealing how it recognizes specific odor molecules. The imaging technique can provide new insights into the machinery of learning and help decipher the brain's internal 'language' of smell.