Psychotic Disorders
Articles tagged with Psychotic Disorders
The boy on the balcony who never came outside
Dr. Dilek Colak's journey began with a childhood observation of a boy with mental illness, which inspired her to pursue a career in neuroscience. Her current work focuses on understanding autism and schizophrenia through the study of human brain organoids.
Bullying and adverse social climate take measurable toll on mental health of gender-diverse youth
Research found that gender-diverse teens reported higher rates of psychological stress and psychotic-like experiences, which can lead to depression, anxiety, and other serious mental health disorders. Bullying and unsupportive legislation drove these findings.
Bullying, state policy, and mental health symptoms in gender-diverse youths
A cohort study found that bullying and restrictive legislation were associated with higher rates of psychotic-like experiences in gender-diverse youths. The study suggests that supportive environments and policies can help alleviate mental health concerns among this population.
Scientists engineer a tool to “edit” brain circuits and enhance memory
Researchers develop molecular tool called SynTrogo, which enables selective dismantling of synaptic connections in brain circuits. By harnessing astrocytes, the system reduces synapse number while strengthening remaining connections, leading to enhanced long-term potentiation and improved memory.
TikTok’s mental health ‘minefield’
A systematic review of social media platforms reveals that TikTok contains a substantial proportion of misleading information about mental health and neurodivergence, with higher rates of misinformation than other platforms. The study emphasizes the importance of credible sources and evidence-based content to combat spreading false ide...
For the first time, Robert A. Winn Career Development Award opens to neuropsychiatry investigator-physicians
The Robert A. Winn Excellence in Clinical Trials Award Program is expanding its career development award to include neuropsychiatry researcher-physicians. This expansion aims to improve clinical trial enrollment and represent diverse patient populations affected by complex disorders.
Schizophrenia study finds new biomarker, drug candidate to treat cognitive symptoms
A new Northwestern University study has discovered a novel biomarker of schizophrenia that could also serve as a new drug candidate to treat the cognitive symptoms of the disorder. The study found that levels of the protein Cacna2d1 signal are reduced in patients with schizophrenia, resulting in overactive brain circuits.
PsyMetRiC – a new tool to predict physical health risks in young people with psychosis
PsyMetRiC, a new web-based risk prediction tool, forecasts cardiometabolic disorders in young people with psychosis. The algorithm predicts significant weight gain, metabolic syndrome, and type 2 diabetes within specific time frames, enabling meaningful discussions and interventions.
Dysregulation of the immune system differentiates depression and psychosis in young adulthood
A study found distinct inflammatory biomarkers and brain signatures for early-stage depression and psychosis, differing even in the earliest stages. These findings support customized therapies and may reduce risk of severe progression.
University of Houston professor warns of nerve stimulation during MRI
Researchers found that implanted cuff electrodes can trigger unintended nerve stimulation during MRI, causing discomfort or pain. The study recommends more refined guidelines and careful safety considerations to mitigate this risk.
Adolescent cannabis use and risk of psychotic, bipolar, depressive, and anxiety disorders
A cohort study found that adolescent cannabis use is associated with an increased risk of developing psychiatric disorders, particularly psychotic and bipolar conditions. The study's results inform the development of interventions and policies to prevent or delay adolescent cannabis use.
Key alterations in the cerebral cortex of people with psychosis
The study reveals that psychosis does not follow a single trajectory but is influenced by individual differences and treatment. It shows that cortical volume reduction, particularly in regions with high serotonin and dopamine receptor density, is a hallmark of the disease.
Brexpiprazole as an adjunct therapy for cognitive dysfunction in schizophrenia
Researchers found that brexpiprazole significantly improved information processing speed without worsening psychiatric symptoms in patients with schizophrenia. Cognitive dysfunction is a persistent challenge, affecting daily functioning and social participation.
Psychosis rates increasing in more recent generations
A large study of over 12 million people in Ontario found that psychosis rates are increasing in more recent generations, with higher rates among younger individuals. The study suggests that factors such as substance use, socioeconomic stress, and negative childhood experiences may contribute to these rising trends.
How bacteria in the mouth may offer new clues to cognitive dysfunction in people with schizophrenia
Research suggests that lower oral microbiota diversity is associated with poorer cognitive function in people with schizophrenia. The study also identified specific microbial metabolic pathways potentially linked to this relationship.
Updated "Treating and Preventing Adolescent Mental Health Disorders" published by Oxford
The updated edition provides a comprehensive overview of major mental health conditions that emerge during adolescence, discussing treatment strategies and prevention methods. The book emphasizes the importance of addressing stigma, promoting evidence-based treatments, and integrating positive youth development into policy agendas.
Psychosis patients ‘living in metaphor’ -- new study radically shifts ideas about delusions
New study finds psychosis delusions emerge from emotional experiences, bodily reactions, and linguistic fabric. Participants described intense emotional embodiment and disembodiment, with some experiencing positive feelings of awe and love.
Schizophrenia and osteoporosis share 195 genetic loci, highlighting unexpected biological bridges between brain and bone
A comprehensive genetic investigation by Dr. Feng Liu and collaborators identifies shared genetic loci between schizophrenia and osteoporosis, suggesting overlapping biological pathways. The study found that psychiatric patients face elevated fracture risks due to these molecular connections.
Schizophrenia-linked genetic variant renders key brain receptor completely unresponsive to both natural and therapeutic compounds
Researchers at Flinders University discover a genetic mutation that silences a brain receptor, rendering it unresponsive to both natural trace amines and clinical drug candidates. The C182F variant eliminates receptor signaling and reduces cell surface expression, with profound implications for emerging psychiatric treatments.
Researchers from NUS Medicine and the Institute of Mental Health detect early brain changes linked to future psychosis development
The study used advanced neuroimaging methods to identify early, network-level changes in over 3,000 individuals at varying levels of risk for psychosis. Individuals at high clinical risk exhibited early disruptions in brain network organisation despite mild clinical symptoms.
Antipsychotic medication use by older adults
A growing trend of antipsychotic medication prescription increases in older U.S. adults, with long-term care pharmacies being a primary source. Non-psychiatrist prescribers contribute to the trend, highlighting concerns over medication accessibility and oversight.
Increased use of cannabis seen among adolescents with psychiatric illnesses after cannabis sales became legal
After cannabis sales became legal, rates of cannabis use and cannabis-related disorders increased significantly among adolescents aged 12 to 17 presenting for psychiatric emergencies. The study found a fourfold increase in cannabis use and a similar rise in cannabis-related disorders among this age group.
The most affected regions of the brain identified in patients in early stages of schizophrenia spectrum disorders
A study from the University of Seville found that patients with schizophrenia spectrum disorders show significant reductions in structural similarity between different brain regions, particularly in the temporal, cingulate, and insular lobes. These alterations are associated with cognitive deficits and severe symptoms.
Artificial intelligence can improve psychiatric diagnosis
Large language models can help improve psychological questionnaires by avoiding redundant items and making diagnosis more efficient. The study found that LLMs recognize common symptom associations and can be used to develop precise and efficient questionnaires.
DNA methylation patterns in newborns point to susceptibility to schizophrenia
Researchers identified distinct epigenetic signatures in cord blood linked to increased schizophrenia and other neurodevelopmental conditions. Newborns with higher genetic susceptibility showed differences in DNA methylation patterns, especially in immune-related regions.
A small area of the brain may be associated with schizophrenia risk, new research finds
Researchers found that many schizophrenia-related molecular changes are specific to the habenula brain region, which regulates motivation and mood. The study identified genes with altered expression patterns in the habenula that overlap with those associated with schizophrenia risk.
No benefit of ketamine for patients hospitalised with depression, clinical trial reports
A randomized clinical trial found that repeated ketamine infusions provided no additional benefit to standard care for inpatients with serious depression. The study, led by Declan McLoughlin and Ana Jelovac, highlights the need for recalibrated expectations in clinical practice and underscores the importance of blinding in trials.
People with dark personality traits use touch to manipulate their partners
A new study by Binghamton University reveals that individuals with narcissistic, psychopathic, and Machiavellian personality traits exploit touch as a means of control in romantic relationships. They tend to have short-term, tumultuous relationships, often accompanied by violence.
Neighborhood trust benefits some more than others
A new study from Karolinska Institutet and UCL found that living in a safe neighborhood with high personal trust reduces psychosis risk among Swedish or European origin residents, but increases it for North African or Middle Eastern origin individuals. The researchers emphasize the need for inclusive environments to promote mental heal...
Brain scan as a BMI oracle for people with mental disorders
Researchers developed a machine learning model that uses MRI scans to predict which patients with mental illnesses will gain weight after diagnosis, and which ones won't. The BMIgap tool has the potential to prevent future weight gain and reduce the risk of metabolic diseases.
Brain cell discoveries reshape understanding of psychiatric disorders
Groundbreaking research by Dr. Bruce M. Cohen has uncovered critical abnormalities in energy metabolism and cellular connectivity that contribute to psychiatric disorders. The study's findings suggest therapeutic avenues that may be better targeted and more effective than current treatments.
Skin symptoms may forewarn mental health risks
Researchers found that 14.5% of patients with a first episode of psychosis had dermatological symptoms, which were linked to higher levels of depression and risk of suicide. The study suggests that skin conditions may serve as an advance marker for mental health risk, similar to blood tests for cancer or heart disease.
Researchers uncover how brain’s social skills impact recovery from early schizophrenia
A study by researchers at Case Western Reserve University found that teaching patients to better understand social cues through targeted training programs can be more effective than traditional approaches. The study identified the crucial role of social inference skills in determining functional recovery from early schizophrenia.
Tiny sugars in the brain disrupt emotional circuits, fueling depression
Researchers identify abnormal sugar modifications linked to depressive behaviors, offering potential diagnostic and therapeutic targets. Chronic stress disrupts sugar chains in the prefrontal cortex, triggering depression.
Lack of resources in neighborhoods linked to higher chance of certain mental illnesses
A recent study from the University of Georgia found that living in neighborhoods with lower incomes and high crime rates is associated with a 79% higher rate of psychotic disorders. This suggests that environmental factors can play a significant role in shaping an individual's risk for developing these conditions.
Racial discrimination may increase psychosis risk
A major review of international evidence found that racial discrimination contributes to the development of psychosis, with people experiencing discrimination being 77% more likely to develop psychotic symptoms. The study highlights the need for public health action to tackle systemic racism and its impact on mental health disparities.
Racial/ethnic discrimination might be a factor in disparities in psychosis risk
A systematic review of 23 primary studies found a positive association between racial/ethnic discrimination and psychosis risk. The largest effect sizes were observed in non-clinical settings, suggesting that experiences of racism may play a role in the development of psychosis.
Sugary drinks influence the psyche via the intestine
A new study found a correlation between sugary drink consumption and depression symptoms in women, suggesting the influence of the intestinal microbiome. The researchers identified an increased number of Eggerthella bacteria in women with high soft drink intake.
Mexican neuroscientist identifies glutamate biomarker predicting schizophrenia treatment success
Dr. Camilo de la Fuente-Sandoval has developed a groundbreaking approach to schizophrenia treatment prediction using neuroimaging and comprehensive clinical care. His team's research reveals elevated glutamate levels in the associative striatum that normalize with effective antipsychotic treatment.
Astrocytes identified as hidden culprit behind PTSD
Researchers at the Institute for Basic Science have discovered that excessive GABA produced by astrocytes impairs fear extinction in PTSD. A new brain-permeable drug called KDS2010 has reversed PTSD-like symptoms in mice, providing a promising therapeutic approach.
Treatment with Virtual Reality works quickly and effectively for psychosis
A recent study suggests that virtual reality therapy is effective in treating psychosis, working faster than current cognitive behavioral therapy. The treatment involves exposing patients to simulated social situations to reduce avoidance behavior and anxiety.
Dr. Deanna L. Kelly named Director of the Maryland Psychiatric Research Center
Dr. Deanna L. Kelly has been named Director of the Maryland Psychiatric Research Center, building on her expertise in schizophrenia treatments and nutrition. She continues to advance personalized treatment options, including effective medications and innovative dietary interventions.
Grip strength gives researchers a new handle on psychosis
A new study explores the connection between grip strength and psychosis, finding that impaired grip strength and well-being share common patterns of brain connectivity. The research provides a unifying brain circuit explanation for psychosis and identifies potential brain targets for new treatments.
University of Houston researchers find that females with flexible personalities have fewer eating disorders
Researchers at the University of Houston found that females with more psychologically flexible personalities have fewer signs of eating disorders. The study suggests a personalized approach to therapy may be most effective for preventing eating disorders when using Acceptance and Commitment Therapy.
Once-a-week pill for schizophrenia shows promise in clinical trials
Researchers have developed a once-a-week pill that can be taken orally to deliver medication to patients with schizophrenia. The treatment maintains consistent levels of the drug in the body and controls symptoms, making it easier for patients to adhere to their medication regimen.
Brain mechanisms that distinguish imagination from reality discovered
A new study published in Neuron has identified a brain region, the fusiform gyrus, as key to distinguishing between real and imagined experiences. The region's strength of activity can predict whether someone judges an experience as real or imagined.
June issues of APA journals feature new research on treatment for depression and psychosis and more
The June issues of The American Journal of Psychiatry and Psychiatric Services feature new research on treating depression and psychosis, as well as studies exploring postpartum mental health risks. These studies highlight the importance of predicting postpartum depression and developing effective treatment models.
Women whose sister experienced postpartum psychosis are more than 10 times as likely to experience it themselves, according to new research
Research found that women whose sister experienced postpartum psychosis are over 10 times more likely to experience it themselves. The study highlights genetic and shared environmental influences and suggests early recognition and prevention are crucial.
Medicaid unwinding disrupted kids’ and young adults’ access to chronic disease medicine
A new study finds that Medicaid unwinding disrupted kids' and young adults' access to chronic disease medication, particularly for those living in states with the largest drops in Medicaid enrollment. The disruptions led to increased use of private insurance or cash for prescriptions, exacerbating health issues.
Why does one person develop schizophrenia while another does not? A leading psychiatric geneticist investigates the answer
Dr. Consuelo Walss-Bass shares her groundbreaking research on schizophrenia, emphasizing the importance of considering both genetic predisposition and environmental factors. She also discusses her work with induced pluripotent stem cells to develop personalized psychiatry and reduce stigma around mental health.
Mutation increases enzyme in mouse brains linked to schizophrenia behaviors
Researchers discovered a genetic mutation that increases glycine decarboxylase enzyme, linked to schizophrenia behaviors in mice. The study provides a direct genetic link to psychosis and sheds light on the biochemical pathways involved.
Medical researcher explores economic impact of psychedelic therapy implementation
Emory University MD candidate Fayzan Rab's research investigates the economic and public health implications of psychedelic therapy implementation. His work emphasizes making these innovative treatments accessible to traditionally underserved communities.
Researchers uncover potential new biomarker for psychosis diagnosis
Researchers at the University of Rochester Medical Center have discovered a potential biomarker for psychosis diagnosis by analyzing brain connectivity patterns. The 'somato-visual' biomarker shows promise in predicting psychosis onset and stratifying patients into clinically meaningful subgroups.
Obesity in mums doubles the risk of autism in babies
A systematic review and meta-analysis of over 3.6 million mother-child pairs found that maternal obesity during pregnancy significantly linked with psychiatric and behavioral problems in children later in life, including autism spectrum disorder and attention deficit hyperactivity disorder.
Cannabis laws and utilization of medications for the treatment of mental health disorders
A cross-sectional study of commercially insured patients suggests that there may be meaningful heterogeneous associations between cannabis policy and state-level outcomes, as well as between cannabis policy and drug class, with implications for patient substance use and mental health outcomes.
Pink elephants in the brain?
A study published in Neuron reveals that neurons are wired to connect seemingly unrelated concepts, enhancing the brain's ability to predict what we see based on past experiences. Visual experience influences the organisation of feedback projections, which store information about the world.
Antipsychotic medications don’t just stop working below the neck
A potential new strategy for reducing diabetes risk associated with antipsychotic medications involves co-administering drugs that block dopamine receptors in the brain alongside those that stop these same receptors in the pancreas. This approach may limit metabolic side effects and improve glucose metabolism.
New evidence suggests link between teen cannabis use and psychotic disorders may be stronger than previously thought
A new study suggests that teens using cannabis are at an 11 times higher risk of developing a psychotic disorder compared to those not using cannabis. The research found a strong association between cannabis use and risk of psychotic disorder in adolescence, but not in young adulthood.
People with depression see no immediate change from common GP assessment, study shows
A new study by the University of Southampton found that a commonly used questionnaire for monitoring depression treatment in primary care does not provide immediate benefits. However, patients who tracked their scores reported improved overall wellbeing and quality of life after six months.