Articles tagged with Psychotic Disorders
Benzodiazepine prescriptions have decreased by 26.7% over the past decade, with the largest decline observed among young adults between ages 18 and 29. The average dose per prescription also decreased by 18.3%, suggesting more selective prescribing practices.
Researchers at UCI are developing a countywide system of care to identify youth at risk of psychosis and connect them with support, with the goal of preventing first episodes. The four-year initiative aims to provide treatment and coordinated care to over 150 young people, with outreach to families, schools, and community organizations.
Consuelo Walss-Bass's family was affected by schizophrenia, yet her sister was spared. Her laboratory addresses the genetic gap by exploring signaling alterations in neurons derived from affected sibling pairs, identifying convergent abnormalities in PI3K/GSK3 signaling.
Researchers aim to identify biological differences among patients to guide treatment with precision therapeutics and computational approaches. The goal is to improve treatment outcomes for schizophrenia, a condition that affects perception of reality.
A study found that the FKBP5 gene, regulating stress hormones, is 'stuck on' in schizophrenia brains, leading to increased stress response and vulnerability to psychiatric conditions. The research suggests new treatment targets, targeting the gene, may develop to address this altered stress response.
Researchers found that cannabis users develop psychosis an average of two-and-a-half years earlier than non-users, with the difference increasing with age. The study, which examined 149 studies involving over 71,000 people, suggests a cumulative effect of cannabis use that builds over time.
A large study found a significant association between severe mental illness and dementia at every age, with adults aged 30-39 showing a 20-fold increased risk of dementia. The study also found a higher risk of stroke in early and middle adulthood, particularly in those with severe mental illness.
A retrospective cohort study found that patients treated with aripiprazole had a lower risk of hyponatremia than those on olanzapine. This association could inform clinical decision-making for high-risk patients, despite residual confounding considerations.
Researchers identified subtle brain differences in children at increased risk of schizophrenia, even before symptoms emerge. The study suggests that early screening and personalized intervention strategies can help detect the disorder's progression.
The latest APA journal issues feature research on schizophrenia, combined treatments and involuntary psychiatric detentions trends. Combined treatment approaches are presented as a promising emerging field to improve patient outcomes.
Researchers at Salk Institute create a body-wide single-cell atlas of two major epigenetic systems, revealing that cell-type-specific epigenetic features can affect disease risk. The study identifies over 1.36 million differentially methylated regions and 283,606 differential chromatin loops across the human body's cell types.
A first-of-its-kind randomized controlled trial demonstrates rapid metabolic improvements with a ketogenic diet compared to diet-as-usual, leading to correlations between ketone levels and reduced blood glucose and depression symptoms. The study also shows sustained metabolic improvements alongside significant reductions in schizophren...
Researchers developed a groundbreaking approach to prioritize schizophrenia-associated genes by analyzing genetic data from over 102,000 individuals. This study uncovered 641 previously unrecognized genes associated with schizophrenia, shedding light on the complex interactions between distant genetic variants.
Global analysis finds that removing criminal penalties for cannabis possession does not increase levels of use, but commercial sale of cannabis is associated with higher rates of addiction and health risks. Tightly controlled legalisation, such as in Uruguay, shows little evidence of changes in cannabis use.
A team studied 173 multiplex families from the Azores and Madeira islands, finding a single broken gene that travels through three generations and causes different illnesses. The CHD2 mutation is rare and affects schizophrenia, mood disorder, and autism in different family members.
A new framework, criticome, integrates experience until age 25, reframing autism, schizophrenia, depression, and trauma as developmental disorders. The study suggests that screen-saturated childhoods may produce adult dysfunction, highlighting the importance of early experience in brain development.
Researchers at UCLA Health have identified a brain region called the ventromedial prefrontal cortex (vmPFC) that regulates memory integration. The vmPFC acts as a quality control checkpoint, preventing memories from getting mixed up when they are significantly different or far apart in time.
A new study found that nearly 8 in 10 college students with psychosis needed mental health support, but only 4 in 10 received the recommended combination of therapy and antipsychotic medication. This indicates potential barriers to accessing care, including stigma.
Researchers discovered that KD025 restored neural connections and improved memory and visual recognition in mice with schizophrenia-associated gene variants. The drug also reduced ROCK2 overactivity without causing serious side effects common to current medications.
Dr. Dilek Colak's journey began with a childhood observation of a boy with mental illness, which inspired her to pursue a career in neuroscience. Her current work focuses on understanding autism and schizophrenia through the study of human brain organoids.
Research found that gender-diverse teens reported higher rates of psychological stress and psychotic-like experiences, which can lead to depression, anxiety, and other serious mental health disorders. Bullying and unsupportive legislation drove these findings.
A cohort study found that bullying and restrictive legislation were associated with higher rates of psychotic-like experiences in gender-diverse youths. The study suggests that supportive environments and policies can help alleviate mental health concerns among this population.
Researchers develop molecular tool called SynTrogo, which enables selective dismantling of synaptic connections in brain circuits. By harnessing astrocytes, the system reduces synapse number while strengthening remaining connections, leading to enhanced long-term potentiation and improved memory.
A systematic review of social media platforms reveals that TikTok contains a substantial proportion of misleading information about mental health and neurodivergence, with higher rates of misinformation than other platforms. The study emphasizes the importance of credible sources and evidence-based content to combat spreading false ide...
The Robert A. Winn Excellence in Clinical Trials Award Program is expanding its career development award to include neuropsychiatry researcher-physicians. This expansion aims to improve clinical trial enrollment and represent diverse patient populations affected by complex disorders.
A new Northwestern University study has discovered a novel biomarker of schizophrenia that could also serve as a new drug candidate to treat the cognitive symptoms of the disorder. The study found that levels of the protein Cacna2d1 signal are reduced in patients with schizophrenia, resulting in overactive brain circuits.
PsyMetRiC, a new web-based risk prediction tool, forecasts cardiometabolic disorders in young people with psychosis. The algorithm predicts significant weight gain, metabolic syndrome, and type 2 diabetes within specific time frames, enabling meaningful discussions and interventions.
A study found distinct inflammatory biomarkers and brain signatures for early-stage depression and psychosis, differing even in the earliest stages. These findings support customized therapies and may reduce risk of severe progression.
Researchers found that implanted cuff electrodes can trigger unintended nerve stimulation during MRI, causing discomfort or pain. The study recommends more refined guidelines and careful safety considerations to mitigate this risk.
A cohort study found that adolescent cannabis use is associated with an increased risk of developing psychiatric disorders, particularly psychotic and bipolar conditions. The study's results inform the development of interventions and policies to prevent or delay adolescent cannabis use.
The study reveals that psychosis does not follow a single trajectory but is influenced by individual differences and treatment. It shows that cortical volume reduction, particularly in regions with high serotonin and dopamine receptor density, is a hallmark of the disease.
Researchers found that brexpiprazole significantly improved information processing speed without worsening psychiatric symptoms in patients with schizophrenia. Cognitive dysfunction is a persistent challenge, affecting daily functioning and social participation.
A large study of over 12 million people in Ontario found that psychosis rates are increasing in more recent generations, with higher rates among younger individuals. The study suggests that factors such as substance use, socioeconomic stress, and negative childhood experiences may contribute to these rising trends.
Research suggests that lower oral microbiota diversity is associated with poorer cognitive function in people with schizophrenia. The study also identified specific microbial metabolic pathways potentially linked to this relationship.
The updated edition provides a comprehensive overview of major mental health conditions that emerge during adolescence, discussing treatment strategies and prevention methods. The book emphasizes the importance of addressing stigma, promoting evidence-based treatments, and integrating positive youth development into policy agendas.
New study finds psychosis delusions emerge from emotional experiences, bodily reactions, and linguistic fabric. Participants described intense emotional embodiment and disembodiment, with some experiencing positive feelings of awe and love.
A comprehensive genetic investigation by Dr. Feng Liu and collaborators identifies shared genetic loci between schizophrenia and osteoporosis, suggesting overlapping biological pathways. The study found that psychiatric patients face elevated fracture risks due to these molecular connections.
Researchers at Flinders University discover a genetic mutation that silences a brain receptor, rendering it unresponsive to both natural trace amines and clinical drug candidates. The C182F variant eliminates receptor signaling and reduces cell surface expression, with profound implications for emerging psychiatric treatments.
The study used advanced neuroimaging methods to identify early, network-level changes in over 3,000 individuals at varying levels of risk for psychosis. Individuals at high clinical risk exhibited early disruptions in brain network organisation despite mild clinical symptoms.
A growing trend of antipsychotic medication prescription increases in older U.S. adults, with long-term care pharmacies being a primary source. Non-psychiatrist prescribers contribute to the trend, highlighting concerns over medication accessibility and oversight.
After cannabis sales became legal, rates of cannabis use and cannabis-related disorders increased significantly among adolescents aged 12 to 17 presenting for psychiatric emergencies. The study found a fourfold increase in cannabis use and a similar rise in cannabis-related disorders among this age group.
A study from the University of Seville found that patients with schizophrenia spectrum disorders show significant reductions in structural similarity between different brain regions, particularly in the temporal, cingulate, and insular lobes. These alterations are associated with cognitive deficits and severe symptoms.
Large language models can help improve psychological questionnaires by avoiding redundant items and making diagnosis more efficient. The study found that LLMs recognize common symptom associations and can be used to develop precise and efficient questionnaires.
Researchers identified distinct epigenetic signatures in cord blood linked to increased schizophrenia and other neurodevelopmental conditions. Newborns with higher genetic susceptibility showed differences in DNA methylation patterns, especially in immune-related regions.
Researchers found that many schizophrenia-related molecular changes are specific to the habenula brain region, which regulates motivation and mood. The study identified genes with altered expression patterns in the habenula that overlap with those associated with schizophrenia risk.
A randomized clinical trial found that repeated ketamine infusions provided no additional benefit to standard care for inpatients with serious depression. The study, led by Declan McLoughlin and Ana Jelovac, highlights the need for recalibrated expectations in clinical practice and underscores the importance of blinding in trials.
A new study by Binghamton University reveals that individuals with narcissistic, psychopathic, and Machiavellian personality traits exploit touch as a means of control in romantic relationships. They tend to have short-term, tumultuous relationships, often accompanied by violence.
Researchers developed a machine learning model that uses MRI scans to predict which patients with mental illnesses will gain weight after diagnosis, and which ones won't. The BMIgap tool has the potential to prevent future weight gain and reduce the risk of metabolic diseases.
A new study from Karolinska Institutet and UCL found that living in a safe neighborhood with high personal trust reduces psychosis risk among Swedish or European origin residents, but increases it for North African or Middle Eastern origin individuals. The researchers emphasize the need for inclusive environments to promote mental heal...
Groundbreaking research by Dr. Bruce M. Cohen has uncovered critical abnormalities in energy metabolism and cellular connectivity that contribute to psychiatric disorders. The study's findings suggest therapeutic avenues that may be better targeted and more effective than current treatments.
Researchers found that 14.5% of patients with a first episode of psychosis had dermatological symptoms, which were linked to higher levels of depression and risk of suicide. The study suggests that skin conditions may serve as an advance marker for mental health risk, similar to blood tests for cancer or heart disease.
A study by researchers at Case Western Reserve University found that teaching patients to better understand social cues through targeted training programs can be more effective than traditional approaches. The study identified the crucial role of social inference skills in determining functional recovery from early schizophrenia.
Researchers identify abnormal sugar modifications linked to depressive behaviors, offering potential diagnostic and therapeutic targets. Chronic stress disrupts sugar chains in the prefrontal cortex, triggering depression.
A major review of international evidence found that racial discrimination contributes to the development of psychosis, with people experiencing discrimination being 77% more likely to develop psychotic symptoms. The study highlights the need for public health action to tackle systemic racism and its impact on mental health disparities.
A systematic review of 23 primary studies found a positive association between racial/ethnic discrimination and psychosis risk. The largest effect sizes were observed in non-clinical settings, suggesting that experiences of racism may play a role in the development of psychosis.
A new study found a correlation between sugary drink consumption and depression symptoms in women, suggesting the influence of the intestinal microbiome. The researchers identified an increased number of Eggerthella bacteria in women with high soft drink intake.
A recent study from the University of Georgia found that living in neighborhoods with lower incomes and high crime rates is associated with a 79% higher rate of psychotic disorders. This suggests that environmental factors can play a significant role in shaping an individual's risk for developing these conditions.
Dr. Camilo de la Fuente-Sandoval has developed a groundbreaking approach to schizophrenia treatment prediction using neuroimaging and comprehensive clinical care. His team's research reveals elevated glutamate levels in the associative striatum that normalize with effective antipsychotic treatment.
Researchers at the Institute for Basic Science have discovered that excessive GABA produced by astrocytes impairs fear extinction in PTSD. A new brain-permeable drug called KDS2010 has reversed PTSD-like symptoms in mice, providing a promising therapeutic approach.
A recent study suggests that virtual reality therapy is effective in treating psychosis, working faster than current cognitive behavioral therapy. The treatment involves exposing patients to simulated social situations to reduce avoidance behavior and anxiety.