In a large study of 1,584 adults with chronic kidney disease, finerenone was shown to significantly slow the decline in kidney function compared to placebo. The drug also reduced cardiovascular disease risk and protein excretion in urine by over 40%.
Researchers used RNA therapy to target a genetic mutation causing heart failure, reducing protein aggregation and improving cellular abnormalities. The study provides insight into the biological mechanisms underlying treatment response and may accelerate the development of personalized treatments for genetic heart disease.
Researchers discovered a low dose of digoxin reduces heart failure-related deaths and hospitalizations by 19% and 25% respectively, making it an inexpensive and safe treatment option.
A recent study from the Universitair Medisch Centrum Groningen found that daytime liver transplants can be safely performed using prolonged hypothermic machine perfusion, with comparable post-transplant outcomes to traditional methods. This technique has increased flexibility for surgeons and improved patient care.
A new study presents positive results for finerenone, a drug that blocks aldosterone receptors, in patients with type 1 diabetes and chronic kidney disease. The drug reduces protein excretion in urine by about a quarter, indicating reduced kidney damage and improved function.
A long-term study found that machine perfusion of deceased-donor kidneys improved transplant outcomes by preserving kidney function for up to 10 years after transplantation. The method has become the preferred organ preservation technique globally due to its superior results.
A large international study found that additional ultrasound measurements to assess placental function can help determine the best course of action for pregnant women experiencing reduced fetal movement. The study showed that this approach leads to fewer complications during delivery and improves fetal outcomes.
A recent study suggests that virtual reality therapy is effective in treating psychosis, working faster than current cognitive behavioral therapy. The treatment involves exposing patients to simulated social situations to reduce avoidance behavior and anxiety.
A recent study published in The Journal of Prevention of Alzheimer's Disease found that evening people experience a greater rate of cognitive decline over time. This decline is attributed to unhealthy behaviors such as smoking and poor sleep habits, which can be mitigated by working with one's natural chronotype.
Researchers at Universitair Medisch Centrum Groningen use machine learning to distinguish between tremor and myoclonus, two types of involuntary movements. This distinction is crucial for treatment, as approaches vary widely between the disorders.
The UMCG's perfusion technique has led to a record number of liver transplants in the Netherlands and is gaining international attention. With the protocol now open to every transplant center worldwide, more organs can be made suitable for transplantation, resulting in better patient outcomes.
The FORESIGHT consortium aims to improve drug development through advanced nuclear and optical imaging techniques, AI expertise, and infrastructure. This will enable more efficient tracking of drug behavior in the body and better development of imaging biomarkers.
A study conducted by Hiddo L. Heerspink at the University Medical Center Groningen found that Ozempic reduced protein in urine by 52% and decreased kidney inflammation by 30%, as well as lowering blood pressure and reducing a key measure of heart failure
The PsyPal study will investigate psilocybin therapy's effectiveness in easing psychological distress in patients with incurable diseases. The trial aims to treat over 100 patients across four clinical sites, using a combination of psychotherapy and pharmacotherapy.
Researchers at UMCG have successfully performed liver transplants after prolonged preservation using a perfusion machine, showing similar outcomes to immediate transplants. The new method allows for safer and more efficient liver transplantation during the day, reducing complications and mortality rates.
Scientists conducted whole-body PET scans using a radioactively labeled antibody tracer against CD8+ T-cells before and after starting immune checkpoint inhibitors. The results showed heterogeneous and dynamic responses among patients, revealing the complexity of the immunotherapy response.