Researchers developed a groundbreaking approach to prioritize schizophrenia-associated genes by analyzing genetic data from over 102,000 individuals. This study uncovered 641 previously unrecognized genes associated with schizophrenia, shedding light on the complex interactions between distant genetic variants.
The Lieber Institute is developing a new tool called GRAPE that combines generative and predictive AI to find new, more effective treatments for brain disorders such as schizophrenia. The institute is utilizing AWS gen AI and compute services to advance research and store its massive collection of genomic and other data in the cloud.
Researchers are developing centrally acting catechol Omethyltransferase (COMT) inhibitors to treat cognitive impairment in certain neuropsychiatric disorders. The Lieber Institute's collaboration with Boehringer Ingelheim is exploring novel treatments for these impairments, which affect millions of people worldwide.
The Lieber Institute will use the grant to develop a new generative AI approach called GRAPE to create new drugs for treating schizophrenia and other mental illnesses. The tool will design molecular structures based on known gene expression patterns, aiming to mitigate the combined effects of hundreds of risk genes.
The study found that people of African ancestry are more likely to experience Alzheimer's disease and stroke, while being less likely to manifest Parkinson's disease. Genetic ancestry was found to influence gene expression in the brain, with 15% of variation attributed to environmental differences.
A new study found that over 100 genes linked to schizophrenia risk are associated with the placenta, not just the brain. This could lead to new prevention strategies targeting placenta biology, allowing for early interventions and potentially changing the course of developmental disorders.
Researchers at the Lieber Institute for Brain Development have found that neuronal cells are unable to precisely control levels of dopamine, leading to a genetic mechanism that controls dopamine flow. This study confirms that dopamine is a causative factor in schizophrenia, shedding light on a long-held hypothesis.
A comprehensive study published in Nature Neuroscience has pinpointed significant differences in gene expression in two key regions of the brain of individuals with bipolar disorder. The findings suggest that bipolar disorder may stem from chemical and structural changes in brain cells, impairing communication between brain cells.
A new study uses stem cells to predict schizophrenia symptoms, opening the door to personalized medicine. The researchers found that neurons derived from patients' own stem cells predicted psychosis and cognitive deficits with high accuracy.
A new study reveals that genetic predisposition for depression combined with exposure to high-particulate-matter air pollution greatly elevates the risk of depression. The study found that the combination of genes and air pollution has a multiplier effect on the risk of depression, suggesting potentially widespread brain effects.
Neuroscientists at Lieber Institute for Brain Development discover similar cell types across human and mouse brains associated with reward and addiction. The study provides molecular profiles of cell types in key regions, including the nucleus accumbens and amygdala.
The Lieber Institute for Brain Development (LIBD) has been awarded a $200,000 grant by the Pennington Family Foundation to investigate the factors contributing to varying outcomes in individuals with autism spectrum disorder. The study aims to identify biological associations that can improve treatment strategies and prevent long-term ...
The Lieber Institute for Brain Development is conducting a multi-site research effort to investigate the role of non-inherited genetic mutations in schizophrenia, specifically somatic mosaicism. The project aims to identify causes of neurodevelopmental disorders and guide treatment development.
The Lieber Institute for Brain Development won the grand prize at the National Collegiate Conference for Mahima Sukumar's research on electroconvulsive therapy. The study found that ECS can spur hippocampal neurogenesis, improving behavioral symptoms and brain structural changes associated with major depression.
Using state-of-the-art sequencing technology, researchers identified thousands of differences in gene expression across six life stages and found that genes containing these regions were crucial to the maturation process of neurons during fetal development. The study's findings suggest a 'signature' found in cells from the earliest sta...