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Science News Archive April 1998


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Complicated Hip Surgery Benefits From 3-D Models

A study at Washington University School of Medicine found that 3-D models of the pelvis are more accurate than X-ray images in preparing surgeons to revise hip replacements. This added information helps with crucial planning stages for complicated surgeries, reducing complications and improving patient outcomes.

SourceWashU Medicine·JournalJournal of Computer Assisted Tomography·DateApr 30, 1998

R-Type Channels - A New Type Of Calcium Channels Controlling Signal Transduction Between Neurons In The Brain

Researchers found that R-type channels control transmitter release in presynaptic terminals, contributing to fine-tuning synaptic activity. These high-voltage-activated channels are resistant to known blockers and have been identified through simultaneous recordings of Ca2+ influx and EPSC evoked by a single action potential.

SourceMax-Planck-Gesellschaft·JournalProceedings of the National Academy of Sciences·DateApr 29, 1998

First Top Operations Research Award To South American Company: Finalists Include Major Co's And Small Southern School District

Bosques Arauco's winning study utilizes operations research systems to improve efficiency and have a positive impact on forest plantations. The award recognizes outstanding work in operations research that has had a significant impact on the performance of the client organization, with notable annual savings.

Smart Concrete May Mean Less Road Closures

Researchers at U of T's Institute for Aerospace Studies have developed a smart structure on the Leslie Street bridge, lining columns with fibre-optic sensors and wrapping them with lightweight synthetic materials. The sensors precisely measure corrosion and hold the structure together, reducing road maintenance and closures.

New Tuberculosis Vaccine Candidate Developed: Improved Delivery Of Antigens By Current Vaccine BCG (Bacille Calmette-Guérin)

Scientists have developed a new TB vaccine candidate that uses recombinant BCG strains to secrete pore-forming listeriolysin, improving its ability to stimulate CD8 T cells. This could lead to better protection against M. tuberculosis infection and potentially halve the estimated 2050 global TB cases.

SourceMax-Planck-Gesellschaft·JournalProceedings of the National Academy of Sciences·DateApr 28, 1998

New Clue To apoE Function

Researchers have generated mice with human apoE3 or apoE4 genes, showing that apoE3 promotes nerve cell outgrowth while apoE4 does not. This study provides new insights into the biological effects of apoE variants and may offer a common mechanism for their adverse effects on neurodegenerative diseases.

Altered Neural Circuitry May Contribute To Disturbances In Cognitive Functions In Schizophrenia, Say Pitt Researchers

Researchers found that a specific component of neural circuitry in the prefrontal cortex is altered in most people with schizophrenia, leading to disturbances in complex thinking processes. The study suggests that this alteration may be a specific brain disturbance in the disease process of schizophrenia.

SourceUniversity of Pittsburgh Medical Center·JournalProceedings of the National Academy of Sciences·DateApr 28, 1998

Scientists At The Scripps Research Institute And R.W. Johnson Pharmaceuticals Develop New Antibacterial Agents

Researchers at Scripps Research Institute and R.W. Johnson Pharmaceuticals have developed a new class of antibacterial agents that inhibit two-component signal transduction systems, a key regulatory mechanism in bacterial virulence. These inhibitors show promise as a potential tool against antimicrobial-resistant pathogens.

SourceScripps Research Institute·JournalProceedings of the National Academy of Sciences·DateApr 28, 1998

Earlier Human Speech?

A team of researchers from Duke University found that the hypoglossal canal, which controls tongue movement, is larger in humans and Neanderthals than in apes and proto-humans. This discovery challenges the theory that human speech may not have arisen until around 40,000 years ago.

SourceDuke University·JournalProceedings of the National Academy of Sciences·DateApr 27, 1998

Human Clinical Trial Of Edible Vaccine Works

A human clinical trial of an edible vaccine has shown promising results, indicating that consumption can result in immunity to specific diseases. The vaccine was tested on volunteers who ate genetically altered potatoes and showed a significant immune response, with antibodies found in both blood and stool samples.

SourceCornell University·JournalNature Medicine·DateApr 27, 1998

First Human Trial Shows That An Edible Vaccine Is Feasible

Researchers have shown that an edible vaccine can safely trigger significant immune responses in humans. Ten of the 11 volunteers who ingested transgenic potatoes had fourfold rises in serum antibodies, and six developed intestinal antibodies. The study demonstrates a potential solution for reducing vaccine burden in developing countries.

Poetically Timed With Spring, Budding Yeast Yield Possible Insight Into Male Fertility--And Infertility

Researchers at UCSF have identified a critical gene involved in yeast spore development that may also play a role in human sperm development. The study found that a gene called NDT80 stimulates the synthesis of proteins necessary for DNA division, and its malfunction can cause permanent arrest in sperm development.

SourceUniversity of California - San Francisco·JournalMolecular Cell·DateApr 23, 1998

Before It's Off The Ground: Better Analyzing Proposed Technologies In Aviation, Aerospace; Preview At Montreal Convention

The Aviation System Analysis Capability (ASAC) is an integrated suite of models and databases that assesses the impact of new technologies on air transportation efficiency and safety. Developed by Logistics Management Institute, ASAC assists researchers in air traffic management analysis and aircraft technology analysis.

Penn State, PENNDOT Forge $15 Million Agreement

Penn State's Pennsylvania Transportation Institute (PTI) will conduct research, education, and technology transfer programs for PennDOT through the five-year, $15 million agreement. PTI will also assist in assembling focused teams from universities and colleges to support PennDOT's projects.

Fat Is Back, Healthy Diets Need Fat

A new University of Michigan study challenges traditional low-fat diet recommendations, finding that a more diverse and varied diet is associated with better mental health and quality of life. The research suggests that some fat in the diet can be beneficial when balanced with greater dietary diversity.