A University of Michigan team discovered that vascular endothelial growth factor (VEGF) helps blood vessels survive and proliferate in the face of nutrient depletion. This mechanism is thought to support tumor growth, leading researchers to explore strategies for inhibiting VEGF to starve tumors.
A gene knockout study has found that inactivating the Bax gene in female mice sustains ovarian function into advanced age. The research reveals that aged Bax-deficient mice maintain hundreds of ovarian follicles with functioning cells but are unable to ovulate or become pregnant.
Exercise can reverse age-related decline in lung capacity, increase muscle strength, and improve mobility. Regular physical activity also reduces the risk of disability and cardiovascular diseases, such as coronary artery disease and heart attacks.
The study reveals the first detailed structure of a protein involved in regulating the body's day/night rhythms, shedding light on how melatonin is produced in response to darkness. The breakthrough may pave the way for the development of new drugs to fight jet lag and serotonin-related diseases like depression.
Research reveals that specific growth factors can speed up muscle regeneration and quicken healing in animal models. The findings hold promise for treating various types of muscle injuries in humans, including those affecting athletes who risk ending their careers due to disabilities caused by muscle injuries.
Researchers developed a sensitive and accurate probe to measure cartilage damage, using ultrasound and load cell units. The probe can be used arthroscopically, allowing for precise assessment of cartilage thickness and mechanical strength before surgery.
A preclinical study published in Nature Medicine demonstrated that Immunex's TRAIL molecule suppresses tumor growth and induces complete remission in a high proportion of treated mice. The study shows promise for the treatment of various cancers, with the potential for minimal toxicity.
Researchers discovered a novel family of cell surface proteins that regulate nerve cell connections by inducing synapse formation. The Neuroligin/b-Neurexin junction is the core of this process, forming a transsynaptic cell-adhesion complex that initiates protein-protein-interaction cascades.
A new study found that older adults with chronic illnesses can benefit from wellness programs regardless of whether they are conducted in a classroom setting or at home. The programs produced significant improvements in anxiety and depression symptoms, as well as reductions in medical symptoms and better sleep quality.
Researchers at The Hospital for Sick Children have successfully used biological engineering to prevent the closing of the ductus arteriosus, a key passage between the heart and lungs. This breakthrough approach could lead to a more effective and safe way to help infants with severe heart problems survive.