The Notch signaling pathway is a key regulator controlling the proper development of many different cell types. In mice without Jagged2, there is a significant increase in hair cell density and a decrease in supporting cells.
A new longitudinal study found that working mothers do not have a significant negative impact on their children's development. The research, based on the National Longitudinal Survey of Youth, analyzed data from approximately 12,600 individuals and found no significant differences between children of employed and non-employed mothers.
A new study by Ohio State University proposes five research areas to understand why men and women respond differently to autoimmune diseases. The task force aims to uncover the cellular mechanisms behind hormonal effects and identify genetic factors that may contribute to the diseases.
A field trial in rural Nepal found that women taking vitamin A or beta-carotene supplements had a 40% lower risk of death from pregnancy compared to those not receiving the supplements. Vitamin A deficiency plays a critical role in maternal mortality, with rates often 50-100 times higher than in industrialized countries.
A mathematical model resolves a scientific debate on the origins of modern placental mammals, suggesting that a 65-million-year gap in the fossil record is unlikely due to incomplete preservation. The study finds that the quality of the mammalian fossil record is more consistent with genetic data than previously thought.
Researchers found that Chlamydia proteins can trigger an autoimmune response in the host, leading to inflammation of the heart. The link between Chlamydia and heart disease appears to involve an autoimmune disorder, with similar proteins on the pathogen's surface matching those found in human heart muscle.
A new retinal birefringence scanner can measure eye fixation independent of head position, allowing doctors to diagnose amblyopia in young children. The device has the potential to revolutionize communication and daily living for people with disabilities.
A Cornell University study found that middle school students who used an adjustable computer tray improved their posture and reduced their risk of musculoskeletal problems. The improvements were statistically significant for the forearm, neck, wrist, and trunk, but only modestly beneficial.
Researchers at Harvard Medical School have identified a key pathway linking the growth cone's membrane receptor to actin, the final agent of change. The study reveals an uninterrupted chain of signaling events that enables neurons to transmit information from the membrane to the cytoskeleton.
The US lacks preparedness for bioterrorism attacks, according to a recent report by Dr. D.A. Henderson. The country is particularly vulnerable to anthrax and smallpox, which are identified as top bioweapon threats. The report calls for improved training, diagnostic techniques, and vaccine development to address this growing concern.
A new chemical sequence has been uncovered, casting doubt on long-held equilibrium theory and clearing the way for kinetic chemistry. The finding breaks the strong bond between carbon and oxygen atoms under intense radioactivity conditions.
Researchers from Wharton and UCLA suggest that shoppers consume more items purchased on sale at local stores to maximize value. The study also proposes a series of questions for shoppers to help them make informed purchasing decisions.
A Massachusetts Institute of Technology professor has developed a quick and easy test that can analyze thin films used in microelectronics components using an optical method. The device, which uses short laser pulses to generate ultrasonic waves, can measure film thickness to within one layer of atoms in one second.
A new study by the NHLBI suggests that black patients with congestive heart failure are at a higher risk of death and disease progression compared to white patients. The study found significant racial differences in survival rates among patients treated with an ACE inhibitor.
A rigorous evaluation of the hospitalist model is necessary to assess its impact on patient outcomes, costs, and provider satisfaction. The UCSF researchers recommend a comprehensive evaluation framework that includes process and outcome measures.
Researchers at Advanced Viral Research Corp. discovered that Reticulose markedly decreases the production of CCR5 receptors in CD4 positive T-lymphocytes, increasing resistance to HIV infection. This finding may enhance the effectiveness of AIDS cocktails and pave the way for combination therapy.
The President's Information Technology Advisory Committee recommends increasing funding for long-term research programs and computing infrastructures. The committee highlights four areas deserving of increased research funding, including software development and high-end computing.
Climate forecasts can have a mixed impact on different groups, with benefits for large fishing companies and losses for small-scale fishermen. Researchers are calling for better dissemination of climate information to address these issues.
Researchers have developed a new method to engineer glass that can withstand stress without catastrophic failure, reducing the variability in strength. This new approach creates internal compressed layers that stop crack propagation, making the glass more consistent and reliable.
Geneticists at Duke University have discovered the functional interaction between myc and ras, two cancer-related genes. The study found that mutated ras causes myc protein to accumulate in cells, enhancing its growth-promoting abilities.
A team led by Owen Sexton successfully repopulated ponds with wood frog and spotted salamander egg masses, resulting in healthy and thriving populations. The reintroduction showcases the importance of habitat preservation and genetic similarity in facilitating amphibian dispersion and adaptation.
Campylobacter is a leading cause of food poisoning, but lacked a reliable test until now. Researchers have developed a quick DNA test that can identify the bacterium in eight hours, and a scanner to detect faecal contamination on meat.
A new sign language called thumbcode allows users to type 30 words per minute, compared to 60 words per minute for touch typists. The device-independent language uses hand positions to represent characters and can be used with gloves or video cameras.
A US team, led by MIT, has completed a 40-ton magnet that will be used to test the world's most powerful pulsed superconducting magnet. The combined magnet weighs over 150 tons and is part of an international collaboration to demonstrate nuclear fusion as an energy source.
Researchers created a computational model to capture the process of one protein interfering with another's folding. This reveals the mechanisms behind 'protein adultery', where amino acids from different proteins link, causing diseases like Alzheimer's and mad cow syndrome.
An asteroid approximately 30-50 metres across has been discovered in an orbit close to Earth's, likely originating from the Moon. The object's unusual nearly circular orbit is unlike most comets and asteroids that cross the Earth's orbit.
The editorial reviews the effects of moderate alcohol consumption on stimulating appetite and food intake. It highlights the need for long-term studies to understand its impact on body weight.
A study of 52 healthy volunteers found that a single pre-luncheon drink of wine or beer delayed mealtime satiety and increased 24-hour calorie intake compared to non-alcoholic drinks of equal calories. This suggests that alcohol consumption before lunch may play a role in weight gain among moderate drinkers.
A study by researchers at UCSF Medical Center found that the electrocardiogram is highly inaccurate for patients with left bundle-branch block (LBBB), leading to under-treatment. This affects approximately 100,000 Americans with LBBB who experience myocardial infarction every year.
The US National Park Service faces challenges in managing wildlife populations due to conflicting goals and limited information. Adaptive management is proposed as a solution to resolve these issues. The study of ecological systems reveals new insights into what may be ecologically appropriate decisions regarding park management.
Researchers at Washington University School of Medicine found a strong link between genes and the accumulation of extra belly fat and insulin resistance. The study suggests that people with certain genetic traits are more likely to develop type II diabetes and abdominal visceral fat, even if they follow healthy lifestyles.
The Susan G. Komen Breast Cancer Foundation is now accepting applications for its 1999 National Grants program, offering over $11 million in funding for groundbreaking research and education. The program aims to eradicate breast cancer as a life-threatening disease by advancing research, education, screening, and treatment.
Researchers isolated a gene that enables plants to absorb iron from the soil. The finding has significant implications for addressing global malnutrition and food security. By understanding how plants process iron, scientists can develop more efficient ways to fortify crops with this essential nutrient.
Researchers analyzing humpback whale calls with information theory claim the animals may have a hierarchical grammar. The study measured entropy in the songs, finding predictable sequences of sounds that hint at complex communication.
A diet rich in phytosterols reduces testosterone levels and activity of enzymes that metabolize testosterone into more active forms. The study suggests a potential link between plant-based fats and lower rates of hormone-dependent cancers.
A study of 42 women found that maternal folate status during extended lactation was sustained by supplementing with 1 mg folic acid per day. This supplementation helped maintain plasma and milk folate levels as well as hematocrit, but had no effect on unsupplemented women.
Research suggests that older people's tolerance for rock music is lower due to physiological changes, such as presbycusis, which affects hearing. Additionally, emotional factors play a role in auditory perception, with older adults potentially being more irritated by rock music due to unfamiliarity.
The Virginia Tech Center for Transportation Research is developing an integrated traveler information system, called Travel Shenandoah, for the Shenandoah Valley region. The system will provide comprehensive traffic and travel conditions information to travelers, while also supporting VDOT's efforts to work with the private sector.
Teenagers who use substances to manage stress may be more likely to develop impulsivity disorders. Those who don't exhibit this coping mechanism are less prone to substance abuse and addiction.
A recent study found that many American students consider geography their least favorite subject, often due to inadequate teaching methods and low teacher training. Active learning approaches, such as field trips and hands-on activities, are shown to improve students' attitudes towards the subject.
A study of 3000 children aged 5-17 found a clear relationship between abdominal fat and abnormal serum lipids and insulin levels. This suggests that childhood obesity may predict later development of diabetes and heart disease.
A new University at Buffalo study found that body mass index, refined sugar, and saturated fat intake are directly associated with the formation of gallstones. Conversely, physical activity and a diet high in monounsaturated fat and insoluble dietary fiber were protective against gallstones.
A survey of consumers found that Americans prefer beef over emu due to its gamey flavor, although it is a healthier option. Emu was rated lower in tenderness and overall acceptance compared to turkey and beef.
The Ablatherm device has shown local disease control in approximately 80% of cases, with a complete response in 56% and partial response in 24%. The treatment is minimally invasive and can be repeated if necessary, but may have some adverse effects.
Researchers propose new explanation for proton mobility, revealing complex behavior of hydrated protons. The findings could impact understanding of biological processes and reactions involving aqueous proton diffusion.
A Cornell University study suggests that chelation therapy used to treat lead poisoning in children may have adverse effects on the developing immune system. The therapy, DMSA, was found to impair immune function in offspring of pregnant rats who received the treatment during pregnancy.
Researchers identified five brain areas activated during sexual arousal, including the inferior temporal cortex and right orbitofrontal cortex. The study used positron emission tomography to map brain activity while subjects watched different films, providing insights into the neurophysiological bases of human sexuality.
A landmark study involving women with invasive cervical cancer showed that adding chemotherapy to radiation therapy significantly improves survival rates and disease-free survival. The study found that 73% of patients who received both treatments survived for at least five years, compared to 58% of those given only radiation.
UC Engineers create RACE, a technique that redesigns computer hardware to adapt to user demands. The approach results in significant speed boosts for applications like image processing, enabling desktop computers to approach supercomputer speeds.
A new study published by the American Psychological Association found that most parents do not intervene when their children squabble, even if they believe nonintervention is ineffective. Contrary to self-reports, parents often use passive nonintervention more than active management techniques.
A new form of herpesvirus has been identified as the cause of nearly a dozen young North American zoo elephant deaths. The virus, found to be latent in most African elephants, can spread to Asian species through transmission from infected African elephants in zoos. Early detection and treatment with antiviral drugs can save lives.
Researchers used 'silencing genes' cloned from electrically quiet human heart tissue to quiet firing nerve cells, demonstrating a potential gene therapy approach for conditions marked by excessive nerve excitability. The system was fine-tuned with an insect hormone-based control switch, allowing for temporary silencing of nerve cells.
Researchers found that brief exposure to high temperatures reduces potassium outflow from locust neurons, allowing them to fly normally after recovery. This discovery may have adaptive significance for heat-shocked animals.
A Johns Hopkins Medicine program offered HIV testing to emergency department patients, identifying nearly 6.4% of those tested as positive. The study found that voluntary screening improved early detection rates, particularly among high-risk groups such as males and blacks, who had higher rates of HIV positivity.
Researchers at Michigan Technological University are developing a technology to divert salt cake, an aluminum by-product, into valuable feed stock materials for the manufacturing of concrete products. This will ease material supply pressure and improve productivity in the concrete, mining, and construction industries.
Researchers found that Montserrat's volcanic ash contains high concentrations of cristobalite, a mineral linked to lung disease silicosis. The study suggests that living near the volcano poses a health risk, and future studies aim to determine acceptable levels of exposure.
Scientists have isolated two novel proteins expressed in cells specifically geared to the sense of taste, which are believed to be the first taste receptors. These candidate taste receptors resemble those that mediate sensory processes such as vision and olfaction and are positioned in specific cells on the tongue.
A team of scientists from Columbia University warns against incorporating spiritual interventions into medical practice due to methodological flaws in studies. Despite acknowledging comfort provided by religious activities, they argue that these should not be promoted as a means to improve health.
Scientists isolate UFD1 gene, linked to cardiac and facial anomalies in children with 22q11 deletion syndrome, a condition affecting one in 4,000 births. The study suggests that dysregulation of this gene leads to the development of heart and craniofacial structures.
Researchers have identified a gene, Irx4, that regulates the formation of heart chambers in vertebrates. The discovery provides new insights into cardiac development and opens up opportunities for discovering other genes involved in this process.