Scientists at University of Wisconsin-Madison uncover new process to produce lovastatin, a natural substance that lowers cholesterol in humans. The discovery may lead to more potent and affordable drugs through genetic engineering.
The AAPS International Workshop on Individual Bioequivalence aims to review available criteria, discuss their pros and cons, and explore various points in drug development and approval. The workshop will focus on evidence for/against a Subject by Formulation interaction, statistical issues, and FDA strategy.
Researchers discover that iron minerals in sediment protect marine organisms from extreme arsenic levels. The study suggests that natural processes can be harnessed to develop new methods for treating arsenic-tainted waste.
Researchers at the University of Florida have found that fibromyalgia is caused by a neurological abnormality, where the body overreacts to repetitive stimulation. This discovery aims to improve diagnostic tests and treatments for the chronic illness, affecting an estimated 3.7 million Americans.
Researchers found progeria cells have low catalase and glutathione peroxidase activity, making it hard to remove toxic peroxides. Reintroducing these enzymes could halt or reverse the problem using adenovirus gene transfers.
Research finds that noncompliance with prescribed antihypertensive drugs leads to approximately half of the failures in controlling high blood pressure. A special electronic medication container, eDEM Monitor, identifies clinically unrecognized noncompliance.
Researchers at Massachusetts General Hospital have developed a new approach to bone marrow transplantation that induces mixed chimerism in four patients with treatment-resistant non-Hodgkin's lymphoma. Two patients achieved long-term remission without significant graft-versus-host disease, a dangerous complication of the procedure. The...
Researchers at UT Southwestern Medical Center have discovered a nuclear receptor, FXR, that controls bile acids and cholesterol production. The finding has important implications for developing drugs to control dietary cholesterol in humans.
Biofilm bacteria are a common cause of persistent infections, such as ear infections and cystic fibrosis pneumonia. Recent advances in understanding biofilms may help develop new therapeutic agents to control these infections.
Researchers will discuss cellular interactions in prostate cancer, new gene discoveries, and techniques for measuring patient outcomes. The symposium also features presentations on experimental agents, immunotherapies, and alternative therapies for treating prostate cancer.
The AGU Spring Meeting will feature new press conferences on Leonid Meteors, which created a temporary lunar atmosphere, and Yucca Mountain as a potential site for long-term nuclear waste storage. The sessions will also include discussions on Mars Global Surveyor findings and the impact of magnetic storms on Earth.
A study of over 50,000 transplant recipients found that kidney transplants from living donors are more cost-effective than dialysis treatments. The total cost of care within five years is roughly $47,000 less for living donor transplants compared to dialysis.
A Penn State-led study found lower concentrations of a stress hormone in pregnant teens are linked to greater numbers of depression and conduct disorder symptoms. The hormone, corticotropin releasing hormone (CRH), is associated with emotions and behavior during pregnancy.
A national survey found that nearly half of American women (45%) regularly cross their legs, despite being aware of the negative effects on circulation. The study also revealed that leg crossing is often a habit, comfort-driven behavior, and a matter of politeness.
Research found depressed mothers' flat-pitched speech hampers infant learning, leading to delays in acquiring language and cognitive milestones. Infants who heard low- or moderate-depression voices spent more time observing a checkerboard pattern.
A meta-analysis of 37 diet intervention studies found that reducing dietary calories, saturated fat, and cholesterol has a positive effect on serum lipids and cardiovascular risk. The study suggests that adopting healthier eating habits can be an effective way to lower the risk of cardiovascular disease.
A study published in Molecular Cell reveals that the mutated tumor suppressor gene ARF prevents cellular transformation by blocking p53 degradation, allowing it to stop tumor cell growth. Researchers found that mutations in ARF's Exon 2 are linked to cancer, impairing its ability to localize and block p53 export.
A longitudinal study found that impulsive children are more prone to injuries, with those who overestimate their physical abilities experiencing more medical attention. The research suggests targeting vulnerable temperaments in injury prevention programs.
Research by Hirokazu Yoshikawa found that welfare recipients who received high levels of educational, job training, and center-based child-care assistance had higher earnings and better math and verbal achievement scores. The long-term support service approach also benefited the children themselves.
Research finds that nurturing and emotionally responsive parents, consistent discipline, and positive expectations for children's future are key factors in helping kids thrive in poor urban environments. Parents of resilient children reported better mental health and more support from friends and family.