Research at AAPS PharmSci 360 reveals that heat and reapplication significantly increase oxybenzone absorption, potentially affecting safety and toxicity. The study aims to establish an in vitro-in vivo correlation and inform maximum UV filter levels.
Researchers developed a targeted therapy that enhances fracture repair in vivo, reducing healing time by 60% without impacting surrounding healthy tissue. The therapy, DAC, was found to double bone density and improve treatment intervals, offering potential benefits for the orthopedic community.
Researchers found that widely used naloxone nasal spray and injection products retain high potency and stability beyond their labeled expiration dates. This study suggests extending shelf-life could aid in increasing medication availability, particularly during the ongoing opioid epidemic.
Researchers developed activatable theranostic nanoplatforms that can highlight tumor cells during surgery using near-infrared fluorescence. These nanoparticles also demonstrated effective phototherapy to eliminate hard-to-remove tumors without harming healthy tissue.
Researchers have designed second-generation vaginal films that can provide extended release and improve mucoadhesiveness for up to seven days, addressing issues with current HIV prevention methods. These films use a combination of modified natural polymer and functional biopolymer to deliver antiretroviral drugs.
Researchers developed a bone-targeted nanoparticle that delivers chemotherapy directly to bone lesions, reducing tumor size and pain. The targeted nanoparticles showed a strong burst release of cabazitaxel and increased binding to bone compared to non-targeted nanoparticles.
Researchers developed a novel gene therapy that lasts for over eight months, reducing methamphetamine in the brain and its stimulant effects. The therapy generates antibodies against meth, preventing it from reaching the brain.
Research finds that the Zika virus can survive on hard, non-porous surfaces for up to eight hours, especially when associated with blood. However, commonly used disinfectants such as isopropyl alcohol and quaternary ammonium/alcohol are effective in killing the virus in a short period.
A new study presents a promising treatment for tuberculosis by delivering a commonly used drug to the lungs, which is more effective than oral administration at a fraction of the dose. This approach has the potential to reduce toxicity and improve patient outcomes.
Researchers have developed a non-invasive breathalyzer device that detects acetone levels in the breath to monitor blood glucose levels. The device shows clear correlations between blood glucose levels and breath acetone, and could be a great improvement for people with diabetes.
A study published in The AAPS Journal suggests that medication degradation does not differ significantly between space and Earth. Nine medications were analyzed after being stored for up to 11 months in space, with some remaining viable beyond their expiration dates.
Researchers have discovered a long-acting enzyme that rapidly and safely metabolizes cocaine, potentially providing a treatment option for cocaine overdose. The enzyme, E12-7Fc-M3, has been shown to eliminate cocaine from the bloodstream for extended periods of time.
Research on biodegradable nanomedicine shows promise in selectively destroying ovarian cancer cells left behind after surgery. The technology uses nanoparticles to provide real-time imaging and phototherapy treatment during surgery, achieving complete tumor eradication in mice with no adverse effects.
Researchers have developed a radiotherapeutic bandage that has shown promise as an alternative therapy for squamous cell carcinoma (SCC) in an animal model. The bandages, which are made with nanoparticles containing inactivated radioactive material, can be individually tailored and manufactured on a large scale.
Researchers have developed an intestinal patch device containing insulin that can be swallowed as a capsule, demonstrating efficacy in managing blood glucose levels in diabetic rats. The patches showed excellent mucoadhesive strength and released insulin within five hours, reducing blood glucose levels significantly.
Researchers unveiled innovative approaches to cancer treatment and malaria vaccination at the 2015 AAPS National Biotechnology Conference. Dual antibody-coated nanomaterials show promise in capturing circulating tumor cells, while penfluridol suppresses pancreatic tumor growth through autophagy-mediated apoptosis.
Researchers have developed a novel prochlorperazine nasal spray formulation as a potential new treatment for migraines. The product has been found to remain stable for up to 120 days with minimal degradation, demonstrating its effectiveness in treating migraine patients.
Scientists have developed a topical microbicide loaded with hyaluronic acid nanofibers that could potentially prevent HIV transmission. The delivery system is triggered by semen fluid and provides prolonged retention at the target site, reducing discomfort.
A recent study developed an AAV-based medication that offers substantial protective effects for patients attempting to cease methamphetamine use. The treatment, which tightly binds and sequesters meth away from its sites of action in the brain, is non-addicting and suitable for use in combination with existing behavioral therapies.
A nasal vaccine in development has been shown to provide long-term protection for non-human primates against the deadly Ebola virus. The vaccine platform has significant global implications in controlling future outbreaks, which could have a fatality rate as low as 25-90%.
Researchers are developing a new, freeze-stable tetanus vaccine using lipid nanoparticles and a hollow microneedle system. The delivery device can target specific areas of the skin, increasing vaccine efficacy.
The American Association of Pharmaceutical Scientists recognizes outstanding researchers in biotechnology with various awards, including the AAPS Excellence in Ligand Binding Assays Award and the Innovation in Biotechnology Awards. These honors celebrate groundbreaking contributions to pharmaceutical biotechnology.
Researchers developed a first-of-its-kind microbicide gel formulation that delivers antiviral products to both the vagina and rectum, showing promise for HIV prevention. The DuoGel contains IQP-0528 and has been shown to prevent HIV-1 infection in vaginal and rectal tissues.
Researchers have developed a novel topical therapy targeting genetic abnormalities in deeper skin layers to improve psoriasis symptoms. The new treatment, Dual-F-NALP, has shown promising results by reducing inflammation and suppressing immune hypersensitivity.
A new compound has been found to inhibit cognitive impairment in animal models of Alzheimer's disease, showing a 60% improvement in learning and memory. The research uses the Endothelin system to target potential treatments for AD.
Researchers have developed a novel, non-invasive monitoring device that uses multilayer nanotechnology to detect acetone levels in the breath of diabetics, correlating with blood-glucose levels. This technology aims to improve patient compliance and quality of life for people living with diabetes.
A new intravaginal ring has been developed to deliver tenofovir and levonorgestrel, providing dual protection against HIV and unintended pregnancy. The ring shows promising results in preclinical trials, with local levels of tenofovir similar to those achieved with a gel.
This year's AAPS Fellows were recognized for their research and scholarly contributions in various fields of pharmaceutical sciences, including immunology, drug delivery, and clinical pharmacology. Notable recipients include Sathy Balu-Iyer, who developed a mechanistic model to understand immunogenicity of biotherapeutics.
Researchers Leaf Huang, Sukyung Woo, Shyh-Dar Li, and Raj Suryanarayanan received awards for their groundbreaking work on non-viral gene therapy, tumor evasion mechanisms, nanomedicine, and physical pharmacy. Their research holds promise for future development of clinically effective gene and anti-cancer therapies.
Researchers have developed a novel vaccine delivery system that mimics pathogens to stimulate the immune system without causing infection. The technology uses inulin acetate from plant fibers, showing promise for preventing viral diseases such as influenza, with an estimated cost of one or two dollars per dose.
This year's AAPS National Biotechnology Conference award winners have made significant contributions to the field of biotechnology, including the development of novel drug delivery systems and innovative approaches to protein-matrix interactions. The awards recognize excellence in research, innovation, and education.
Two Chicago high school students, Ayana Jamal and Ariella Hoffman-Peterson, presented their research on reducing the effects of Fetal Alcohol Syndrome (FAS) and understanding its genetics. Their work, conducted with a university professor, explored using retinoic acid as a potential treatment.
Researchers have developed a novel compound from vegetable sources that demonstrates superior anticancer activities, particularly against triple-negative breast cancer. The orally active compounds could offer safer and more effective treatment options for patients.
Researchers developed a medicated chewing gum formulation that improves patient compliance and faster absorption through the cheek, alleviating motion sickness sooner. Dimenhydrinate-based gum has great potential for commercialization and can be used to incorporate other active ingredients with objectionable taste into chewing gum.
A novel 90-day intravaginal ring has been developed to deliver tenofovir, the only topical prophylactic shown to reduce HIV transmission, for up to 90 days. The ring overcomes limitations of standard technology and can be modified to deliver multiple drugs.
A novel drug mimics a naturally occurring molecule found in coffee and blueberries, increasing survival in animal models after radiation exposure. The treatment is non-invasive and can be applied directly to the skin, providing an effective solution for treating radiation exposure.
A new dissolvable oral strip has been developed to immediately relieve pain from burns caused by hot foods and liquids. The strip, containing benzocaine and a therapeutic polymer, is applied directly to the burned area and quickly dissolves for instant pain relief and promotes healing.
AAPS honors top scientists in pharmaceutical sciences, recognizing their contributions to drug development, nanotechnology, and education. The awards celebrate innovative research on cell interactions with drugs and cancer treatment.
The American Association of Pharmaceutical Scientists (AAPS) has announced its 2012 Fellows, recognizing individuals for their outstanding contributions to the field. Alekha K. Dash and Glen S. Kwon are among those recognized for their research in novel drug delivery systems and cancer treatment.
Researchers at Mercer University are developing an oral vaccine that can be delivered in spherical bead-like particles to enhance innate immune recognition, offering a cost-effective alternative to current options. The vaccine aims to prevent meningitis and ovarian cancer recurrence by generating immunity against specific bacteria.
Researchers have developed a potent compound that selectively kills cancer cells while leaving healthy ones intact. This breakthrough has the potential to revolutionize leukemia treatment and could be a game-changer for patients with this life-threatening disease.
A novel study demonstrates that nanoparticles can retain osteoarthritis drugs in the knee joint, increasing their duration of action. This technology, when used with current or new osteoarthritis drugs, may allow patients to receive injections every three months instead of once a week.
A new transdermal patch has been developed to deliver HIV medication over seven days, offering a more convenient and affordable option for patients. The patch shows significant potential in reducing the number of pills patients need to take daily, as well as decreasing shipping costs.
Researchers have developed a novel oral treatment for leishmaniasis, showing a significant decrease in infection after less than five days of treatment. The treatment is tropically stable and less toxic than current IV therapy, offering hope to millions of people infected worldwide.
Researchers from top institutions receive awards for their work on ligand-binding assays, biotechnology innovations, and cancer treatment delivery. The American Association of Pharmaceutical Scientists recognizes excellence in these areas.
Researchers are developing an oral vaccine for cervical cancer and a combination prostate cancer vaccine, aiming to improve vaccination accessibility and affordability. The vaccines use nanoparticle-based Human Papillomavirus (HPV) formulations, potentially reducing costs and enabling mass vaccinations.
A new dry powder HPV vaccine offers improved effectiveness and lower costs by targeting mucous membranes directly, reducing contamination risks. This innovative delivery method aims to expand HPV vaccination access to more people globally, particularly in developing countries.
Researchers have developed an inhalable dry powder antibiotic targeting TB, potentially reducing treatment time from 6-12 months to under a year. The novel treatment aims to distribute antibiotics directly to lung lesions, increasing targeted doses and minimizing side effects.
A new inhalable dry powder treatment for lung cancer has been shown to significantly increase survival rates, with over 80% of mice surviving for more than 90 days. The treatment method is also less invasive than traditional options, reducing the risk of side effects and improving overall patient outcomes.
The American Association of Pharmaceutical Scientists (AAPS) has named 18 individuals as its 2010 Fellows, honoring their remarkable scholarly and research contributions. The new fellows include researchers who have made significant advances in drug delivery, pharmacokinetics, and cancer therapy.