Elias J. Corey has developed a new method for synthesizing ecteinascidin and phthalascidin, two drugs estimated to be at least 100 times more powerful than Taxol in inhibiting tumor cell growth. The findings have shown promising results in soft-tissue sarcoma treatment and could lead to faster availability of these life-saving drugs.
Scientists at Bristol-Myers Squibb identified a novel class of phosphodiesterase inhibitors that act on the same target as sildenafil, showing improved efficacy and selectivity in treating erectile dysfunction. The new compounds were found to be more potent and selective than sildenafil against various forms of the enzyme.
The American Association for the Advancement of Science is hosting a conference to discuss current ethics codes, societal efforts, and ways to improve them. The conference will analyze survey outcomes and develop a research agenda to enhance collaboration in promoting research integrity.
The Albert B. Sabin Heroes of Science Awards recognize individuals who have made significant contributions to biomedical research, including vaccine development and transplant surgery. This year's awardees include Dave and Lynn Frohnmayer, Maurice R. Hilleman, Francis Daniels Moore, Ruth L. Kirschstein, and John Edward Porter.
A recent study found that attending religious services is associated with lower likelihoods of voluntary sexual activity in adolescents. Spiritual interconnectedness and importance of religion also play a role in delaying sexual activity.
Two UC San Francisco scholars analyze a 10-year study on second-hand smoke and cancer, finding the tobacco industry launched an unprecedented misinformation campaign to undermine its findings. The campaign was aimed at slowing down smoking restrictions in European markets.
Researchers have discovered that stimulating nerves can alter cortical responses, leading to potential therapeutic approaches for stroke victims. By bypassing damaged brain areas, patients may regain at least some movement control.
Researchers successfully differentiated human placental cells by adjusting gap size in a fibrous-bed bioreactor, mimicking the body's natural process. The breakthrough may aid organ production for transplantation and has implications for tissue engineering and cancer research.
Researchers found that combretastatin A-4 prodrug significantly enhances the effectiveness of standard chemotherapy agents in laboratory animals. Combining the drug with chemotherapy resulted in a 10 to 500 times increase in tumor cell death, compared to using chemotherapy alone.
New polymers enable polymeric electro-optic modulators to translate electrical signals into optical signals at rates of up to 100 gigabytes per second, increasing information-processing speeds by 10 times those of current electronic devices.
A Harvard study challenges conventional wisdom, suggesting that online retailers can charge higher prices due to reduced price competition. The study reveals that consumer loyalty and convenience of the internet enable firms to increase prices, leading to higher profits.
BioNumerik reports success with its engineered cancer agents, demonstrating reduced toxicity while preserving antitumor activity. The company plans to initiate Phase 3 trials for BNP7787 and expand clinical trials for Karenitecin BNP1350.
The University of North Carolina at Chapel Hill has launched a new traveling science laboratory that brings state-of-the-art equipment and teaching tools to North Carolina schools lacking resources. The bus features equipment for wet lab experiments, Internet exploration, and curriculum materials.
Adding acetone to composting method dissolves chunks of carcinogenic substance, allowing microbes to break it down. Microbial populations thrive under modified conditions, degrading explosive in just one day.
Scientists have identified a family of candidate genes in humans and mice that code for receptors detecting bitter and sweet tastes. The discovery provides new tools to trace the wiring of the taste perception pathways into the brain, shedding light on how we perceive different tastes.
Researchers have created a device that converts electric signals into optical transmissions at 100 gigabytes per second, eliminating download time and increasing efficiency. The breakthrough technology has the potential to transform fiber optic telecommunications and enable applications such as aircraft navigation and smart cars.