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Science News for May 21, 2000


Northwestern scientists shed new light on neurodegenerative diseases

Scientists at Northwestern University discovered that polyglutamine aggregates are toxic and can bring healthy proteins to aggregate with them. The growth of these aggregates can be suppressed by molecular chaperones called heat shock proteins. This finding provides a new model for understanding the common pathology of neurodegenerativ...

SourceNorthwestern University·JournalProceedings of the National Academy of Sciences·DateMay 21, 2000

AVAX Technologies' O-Vax™ cancer vaccine induces positive immunological and clinical outcomes in patients with advanced ovarian cancer

The data from an ongoing Phase 1/2 trial of O-Vax in patients with advanced ovarian cancer indicates that the vaccine induces a positive immunological response, as measured by a delayed type hypersensitivity test. Favorable clinical responses were also observed, including complete regression of tumors and normalization of CA-125 levels.

Pay attention to potassium channels! First steps in the molecular identification of SK channels and their role in neuronal signal encoding.

Scientists at Max Planck Institute discover novel potassium current activated by calcium, shaping neural signal frequency. SK channels play a crucial role in neuronal adaptation, influencing brain function and learning. The study resolves a long-standing controversy between electrophysiology and apamin-binding studies.

SourceMax-Planck-Gesellschaft·JournalMolecular and Cellular Neuroscience·DateMay 21, 2000