Research at the University of Michigan found a 30% higher concentration of signaling cells in people with bipolar disorder, which could explain and treat manic depression. The discovery highlights the disorder's genetic and biological roots, offering new avenues for understanding and treatment.
Lehman et al. show that PGC-1 is limiting for mitochondrial proliferation in cardiac muscle, directing changes in mitochondrial population across cells. Overexpressing PGC-1 increases fatty acid oxidation capacity and coupled OxPhos, but constitutive expression leads to dilated cardiomyopathy.
A new study reveals that free radicals, generated by the macrophage enzyme NADPH oxidase, are essential for the development of alcoholic liver disease. The researchers found that mice lacking this enzyme were resistant to liver injury and had lower levels of covalent adducts in their bile.
Researchers found that alcohol feeding impaired osteoblast function and led to increased bone turnover, contributing to bone fragility. In contrast, mice lacking the interleukin-6 (IL-6) gene had better maintained bone mass and reduced fractures.
Scientists have developed genetically-altered mice that resist diet-induced obesity and insulin resistance by producing uncoupling protein-1 in muscle tissue. This protein burns excess energy as heat instead of storing it as fat, mirroring the effects of exercise on weight loss.
Researchers discover SLPI protein promotes healing in non-healing wounds, reversing tissue destruction and hastening recovery. The study's findings may lead to new treatments for delayed wound healing in the elderly.
Two MS clinical trials halted due to adverse effects confirm the targeted peptide plays a role in the disease. The studies suggest that lower doses are better than higher doses, and immunological tests can determine how targeted therapies work in patients.