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Science News Archive 2001 - Page 45


Page 45 of 47

Obese children more prone to asthma

A study of nearly 10,000 children in the UK found that obese children are at greater risk of developing asthma. The researchers discovered a significant association between weight and respiratory symptoms, with the heaviest children more likely to experience wheezing and asthma attacks.

SourceCenter for Advancing Health·JournalThorax·DateJan 16, 2001

Researchers release results of study showing patients undergoing stem-cell transplantation live longer than those undergoing marrow transplantation

A study led by Dr. William Bensinger found that patients undergoing stem-cell transplantation lived longer than those receiving marrow transplants, especially for high-risk blood cancers. The study also showed lower rates of acute and chronic graft-versus-host disease with stem cells.

SourceFred Hutchinson Cancer Center·JournalNew England Journal of Medicine·DateJan 16, 2001

Biochemist finds flexibility in key HIV protein

A University of Cincinnati biochemist has discovered that the V3 loop region of the HIV gp120 protein is structurally flexible, changing its shape as needed to bind to host cells. This finding rules out using a fixed structure as a target for anti-HIV drugs, making it harder to develop effective treatments.

SourceUniversity of Cincinnati·JournalJournal of Biological Chemistry·DateJan 15, 2001

Too much of a good thing

Research reveals CPY26 degrades retinoic acid to establish uneven distribution, crucial for normal embryonic development. Elevated RA levels in Cpy26 mutant mice lead to severe developmental defects, highlighting the enzyme's protective role.

SourceCold Spring Harbor Laboratory·JournalGenes & Development·DateJan 14, 2001

Atomic structure identified for gene-regulating molecule: Broad implications for cancers, autoimmunity, developmental disorders

Researchers have identified the three-dimensional atomic structure of a critical gene-regulating molecule, revealing its importance in human diseases such as cancers, autoimmune disorders, and developmental disorders. The discovery could lead to the development of new treatments and therapies for these conditions.

SourceThe Wistar Institute·JournalThe EMBO Journal·DateJan 14, 2001

Getting older and feeling weaker?

As people age, they experience a decrease in muscle strength, but an increase in endurance. To address this issue, Maury Nussbaum and Laura Wojcik are conducting a study to understand how tasks can be adjusted to accommodate older workers' work capacity.

Exposure to environmental tobacco smoke associated with respiratory problems for children

Children exposed to environmental tobacco smoke are at increased risk for asthma and wheezing, with effects strongest among youngest children. Exposure also associated with school absences and low lung function in older kids, highlighting the importance of preventing smoking exposure through home and public restrictions.

SourceCenter for Advancing Health·JournalArchives of Pediatrics and Adolescent Medicine·DateJan 13, 2001

Researchers design new way to squelch errant enzymes

Scientists have developed a novel approach to inhibit protein kinase enzymes, which play a crucial role in triggering cancers, hardening of the arteries, and autoimmune diseases. The researchers' bisubstrate analogs effectively prevent these enzymes from working, offering a promising therapeutic strategy for various diseases.

SourceJohns Hopkins Medicine·JournalNature Structural & Molecular Biology·DateJan 11, 2001

Stalking a Parkinson’s protein

Researchers have discovered a crucial genetic element that regulates alpha-synuclein protein activity, which is involved in both inherited and non-inherited forms of Parkinson's disease. By identifying this element, scientists hope to gain insights into the underlying mechanisms of the devastating disease.

SourceCold Spring Harbor Laboratory·JournalGenome Research·DateJan 11, 2001