A phase II study found that DiaPep277 treatment maintained insulin production in patients with early type 1 diabetes. The treatment also reduced the need for insulin therapy and altered immune response patterns.
Researchers at NIAID and NCI discovered a quick and simple method to assess drug efficacy by measuring viral load after just one week of therapy. This approach has the potential to prevent HIV drug resistance and improve treatment outcomes for patients.
Researchers create self-assembled nanofibers resembling collagen fibrils in real bone, enabling mineralization and promoting cell attachment. The synthetic nanofibers offer potential applications in bone fractures, tissue regeneration, and electronics.
A new study by the University of North Carolina at Chapel Hill found that only 3.1 percent of North Carolinians are talking on cell phones while driving at any given time. The prevalence rate varied by region, with higher rates in the Piedmont and lower rates in the mountains and coastal plain.
A study found that depressed patients are more than twice as likely to die or be readmitted for cardiac causes after CABG surgery. Depression is also associated with a significant independent risk of adverse cardiac events.
A new study found that early assessment of HIV-1 antiretroviral drug efficacy can predict long-term effectiveness. Patients with a continuous decline of HIV-1 concentrations within 0.72 log by day 6 after treatment initiation are likely to experience poor long-term responses.
Researchers at Stanford and UCSF have identified osteopontin as a key gene in the progression of multiple sclerosis, with findings suggesting its expression levels are related to disease severity. The study also revealed that osteopontin-deficient mice experienced significantly less severe symptoms and higher remission rates.
Researchers have determined the atomic structure of the Arp2/3 complex, a protein responsible for initiating actin filament growth in moving cells. This discovery provides insights into cellular movement mechanisms and has implications for understanding various biological processes, including immune responses and neural development.
Researchers found that DiaPep277 modulates the immune system to prevent autoimmune diabetes progression. The study showed significant increases in C-peptide levels and reductions in insulin requirements among patients receiving DiaPep277.
Researchers at Hadassah-Hebrew University Medical School and Peptor Ltd. successfully arrested the progression of Type I diabetes in newly diagnosed patients using DiaPep277, an experimental drug that alters immune cell behavior.
A new study published in The Lancet reveals that pegvisomant normalized IGF-I concentrations in 97% of patients with acromegaly after 12 months of treatment. Patients experienced improved symptoms and a better quality of life, highlighting the potential benefits of this innovative drug.
Researchers at Ohio State University found a link between major stressors during pregnancy and the development of autism in children. The study, which included over 200 mothers, showed that stress levels for mothers of autistic children were nearly twice those of other mothers.
A woman convicted of murdering three children by suffocation shares her perspective on how intense grief and a desire for control led to her actions. The authors argue that empathy from professionals could have prevented these tragedies.
Researchers found that people who felt a sense of purpose in life were more likely to experience well-being and less fearful of death. In contrast, extrinsically religious participants tended to fear death and avoid thinking about it. The study suggests the need for intrinsic motivation through spiritual nurturing and self-reflection.
A new suite of experiments will be delivered to the International Space Station by Space Shuttle Endeavour, broadening scientific research onboard the orbiting space laboratory. The experiments are expected to lead to insights in various fields such as bone disorder treatments, plant growth, and cancer cell formation.
A recent study by the American Academy of Periodontology found that 48% of teeth receiving periodontal surgery improved prognosis, while only 12% in non-surgical treatment groups did. The study emphasized the importance of individual teeth assessment for optimal results.
Researchers created a tiny computer using DNA molecules and enzymes, performing a billion operations per second with high accuracy. The device can be programmed to perform simple tasks and may pave the way for future computers that can operate within the human body.
A new study published in Psychosomatic Medicine found that women with higher educational attainment have less calcification of the arteries, indicating a lower risk of developing heart disease. The analysis of 308 postmenopausal women revealed an inverse linear trend between calcium deposits and education level.
A study of 633 HIV-positive participants found that sociodemographic factors significantly affect their nutritional adequacy. Gay men, those with higher household incomes and educational attainment, were more likely to meet the Recommended Daily Allowances for nutrients. In contrast, individuals with lower incomes, fewer children at ho...
A study published in the American Journal of Clinical Nutrition found that obese women converted carbohydrates to fat at a faster rate than lean women. This increased conversion was observed even when both groups were overfed with carbohydrate-rich diets, suggesting an intrinsic genetic potential for de novo lipogenesis.
The UCLA Basic Plasma Science Facility has been awarded a $4.8 million grant to conduct controlled experiments on plasma, a fourth state of matter. The Large Plasma Device (LAPD) machine allows physicists to create and analyze superheated, energized gas, with potential applications in fusion energy, computer chips, and waste destruction.
Severe periodontal disease poses significant threats to pregnant diabetics, exacerbating the condition and pregnancy outcomes. The American Academy of Periodontology recommends routine periodontal exams for pregnant diabetic women.
The novel depicts institutional and domestic abuse against children, including Oliver's mistreatment in a workhouse and Nancy's abuse by her pimp Bill Sykes. Dickens identifies recognized parental risk factors for abuse, such as substance abuse, domestic violence, and mental health problems, which are now acknowledged by modern research.
Researchers found that astronauts' endogenous circadian pacemaker (ECP) loses its influence after about 90 days in space, leading to reduced sleep quality and duration. This could jeopardize performance on longer missions like those to Mars.
Researchers at UCSD and VA San Diego Healthcare System discovered a natural antibiotic peptide called cathelicidin, which inhibits microbe growth and plays a crucial role in mammalian innate immunity. The study provides hope for developing new treatments and a blood test to identify individuals susceptible to bacterial infections.
A questionnaire surveyed junior doctors in two London teaching hospitals and found that nearly all were aware of post-exposure prophylaxis (PEP) but many lacked knowledge on its use. The study highlights the need for improved education on PEP among medical professionals to prevent occupationally acquired HIV infections.
A study found that ethnic differences affect the relationship between family environment and teen gang involvement, with black youth benefiting from more controlling parents and white/other youth increasing their involvement with gangs. Gang intervention programs should address both peer and parent relationships to be effective.
A scoring system characterized the men from pessimist to optimist, with optimistic men having a lower risk of coronary heart disease. Despite this protective effect, the researchers found no difference in mortality rates between optimistic and pessimistic men.
A recent study by Ohio State University researchers found that gay men tend to weigh the benefits and drawbacks of revealing their HIV status, with over half disclosing to family and 63% telling friends. The top reasons for disclosure included keeping others safe and seeking understanding.
The US FDA has approved Tracleer (bosentan) tablets as the first oral treatment for patients with pulmonary arterial hypertension. The medication works by blocking the effects of endothelin on blood vessels, improving exercise capacity and reducing symptoms. Regulatory reviews are ongoing in several countries.
Researchers found that people are more willing to take risks when confident in their knowledge and less likely to do so when unsure. This discovery has significant implications for various decision-making processes.
Simon C. Moss, a UH professor, has spent 40 years researching atomic-scale defects and their impact on materials properties. His work has led to breakthroughs in semiconductors, alloys, and thin films, earning him the Von Hippel Award.
Researchers at Johns Hopkins have developed a potential new screening test for prostate cancer by measuring the level of GSTP1 methylation in tissue samples. High levels of methylation were detected in 91.3% of early-stage cancers and 53.6% of precancerous lesions, suggesting its potential as an early diagnostic marker.
A new Stanford University study analyzed the costs and benefits of two treatments: implantable cardioverter defibrillators (ICDs) and the drug amiodarone. ICDs were found to be the most effective in preventing sudden cardiac death, but also came with the highest costs. Amiodarone produced intermediate benefits and costs.
A survey of over 400 doctors found that nearly a third would assist with lethal injections, highlighting the need for education on ethical guidelines and professional obligations. The study's authors warn that physicians' personal opinions on capital punishment may not align with their professional duties.
A team from Arizona State University has questioned the evidence for bacterial life in a Martian meteorite, citing limitations in microscope technology and data selection. The researchers argue that the shapes of magnetite crystals found in the meteorite are not uniquely identifiable with bacteria.
Researchers identified a mutated WFS1 gene responsible for low-frequency sensorineural hearing loss, which can lead to severe hearing aids requirements. The discovery may be common in the general population and could connect with other conditions like Meniere's Disease.
A new pilot study aims to investigate whether treating periodontal disease can reduce the risk of heart attacks. The three-year study will follow approximately 900 patients who have had a heart attack or are at high risk of one, comparing those who receive aggressive treatment for gum disease with those who do not.
A new study found that children from poor families with depressed mothers experience delays in cognitive and motor development, while middle-class households offer some protection. The effects of maternal depression on boys and girls differ, with moderate depression in affluent families resulting in lower cognitive scores.
The TIMED mission will study the Mesosphere and Lower Thermosphere/Ionosphere region, crucial for understanding space weather's effects on communications and satellite tracking. Ground-based instruments will be used to conduct a global study of this area.
Researchers measured the force required to overcome tissue-needle connection during acupuncture needling, finding a significant pullout force when needles were rotated. The study suggests that layers superficial to muscle may be involved in the body's response to acupuncture, with future research focusing on connective tissue's role.
A Virginia Tech team has won a grant to develop mathematically rigorous decomposition theories for solving large-scale design problems on massively parallel supercomputers. The project aims to reduce communication bottlenecks and improve concurrency in the design process.
Individuals with severe inattention and hyperactivity symptoms may use tobacco as self-medication to manage their symptoms. The study suggests that screening participants in smoking cessation programs for these symptoms could identify smokers who need additional intervention and tailor treatments to address their specific needs.
A NASA-funded study found that glacier melting can shut down North Atlantic Deep Water production, leading to a reduced Gulf Stream and cooling Western Europe. The study suggests that freshwater additions from increased rain and snow could cause this phenomenon in the future.
A new study from the University of Toronto shows that consuming carbohydrate, fat and protein drinks of equal calories improves verbal recall in elderly individuals. The positive effects on memory are explained by an evolutionary perspective, suggesting specific types of food energy enhance specific aspects of brain function.
The University of Colorado at Boulder has acquired two state-of-the-art electron microscopes, enabling researchers to image cellular structures in three dimensions at unprecedented resolution. This advancement is made possible by a suite of complementing computers that run programs developed by CU-Boulder researchers.
Researchers from the University of Pennsylvania have identified a gene called CREB that plays a role in regulating rest's rejuvenating effects. The study found that CREB activity is inversely related to the physiological urge for sleep and that blocking this activity increases the need for sleep after a period of wakefulness.
A new study found that 41% of physicians would perform at least one action proscribed by the AMA's ethics guidelines, while 25% would perform five or more actions. The study suggests that some physicians are morally confused about their role in capital punishment.
The University of Michigan School of Education has received a $175,000 grant from the Goldman Sachs Foundation to evaluate and support programs promoting educational excellence globally. The program focuses on developing academic abilities and entrepreneurial talents in underrepresented youth.
Researchers at the University of Michigan successfully grew new, mature blood vessels in live animals by implanting scaffolds that delivered critical growth factors. The innovative approach, reported in Nature Biotechnology, has potential medical applications for alternatives to heart bypass surgery and treatments for vascular disease.
Physicians who participate in executions do so out of a sense of citizen obligation, but this involvement mostly advances pro-death penalty political purposes. Medical professionals have long opposed physician participation in executions due to ethical concerns.
A new study reveals that HIV-specific CD4+ T cells persist in infected individuals, but high virus levels suppress their proliferative response. The research provides clues on how the virus manipulates the immune system for its own survival and challenges the notion of long-term nonprogressors.
Researchers have discovered that antibodies attacking DNA in people with lupus can also target molecules controlling glutamate activity, leading to neuron death and possible cognitive symptoms. This finding suggests a potential pathway for neurological complications and may lead to new therapeutic options.
Researchers at Women's and Children's Hospital in Adelaide have developed a way to safely use Human Immunodeficiency Virus Type 1 (HIV-1) to transfer therapeutic genes into human cells. This method has wide applicability for various human genetic diseases and is currently being tested on animal models before moving to human trials.
Research by Susan M. McHale found that children who spend more time on structured activities like hobbies and sports tend to have better academic, emotional, and behavioral development. In contrast, excessive outdoor play or unstructured free time may lead to poorer grades and behavior issues.
Researchers discovered a link between the CFTR gene and increased susceptibility to respiratory infections in cystic fibrosis. They found that altered CFTR can change the internal chemistry of lung cells, making them more attractive to certain bacteria.
A new study finds that even modest increases in family economic resources improve cognitive development, language abilities, and social behavior in young children from poor families. The study discovered a correlation between income-to-need ratios and developmental outcomes in children from birth to age 3.
A team of researchers has identified a novel gene, Lpp1, that is mutated in mice with severe spina bifida. This discovery provides new insights into the genetic basis of the condition and may lead to the development of new therapies to prevent it.
Researchers find HIV attachment to rafts is crucial for replication, and cholesterol-lowering drugs may help disrupt this process. Depleting cholesterol from rafts using compounds significantly reduces HIV's ability to infect new cells.
MetaPhore will develop and test a highly active SOD mimetic to protect heart tissues from damage. The research aims to provide additional mechanistic information on the role of superoxide in reperfusion injury, which may also apply to other ischemic events.