The TALENT trial assesses Tarceva's value in NSCLC treatment, showing promising anti-tumor activity. Additionally, a Phase Ib study evaluates Tarceva's feasibility in combination with chemotherapy for advanced breast cancer.
Norman Pace's innovative work on microbial diversity and biochemical reactions has revolutionized the field. He is one of 23 recipients of the prestigious 2001 MacArthur Fellowship, recognizing his significant contributions to science.
Researchers describe a new cause of respiratory failure in newborns and report a virulent Beijing strain causing a 'microepidemic' of TB on Gran Canaria Island. Exercise-induced oxidative stress may exacerbate chronic obstructive pulmonary disease, according to studies published in the American Thoracic Society Journal.
Scientists develop 'smart' polymer drug carriers that target diseased cells, improving treatment outcomes for cancer, AIDS, and other diseases. The technology also enables controlled release of drugs over days, weeks, or years.
Researchers will study 12 astronaut crew members before, during and after space missions to assess cardiac mass, compliance and relaxation. Findings may help prevent cardiac atrophy and arrhythmias in individuals confined to long-term bed rest or with conditions associated with cardiac stiffness.
Researchers have identified a subset of genes in Pseudomonas aeruginosa that behave differently when the bacteria exists as a biofilm. These findings may lead to the development of new therapies targeting antibiotic resistance in biofilms. The study found that certain genes were repressed or activated in response to antibiotic treatmen...
A team of researchers from the University of Michigan has created an ultrafast X-ray switch, enabling them to study the movement of constituent atoms and obtain information about molecular dynamics. The technology could be used to probe complex systems like proteins and study shock waves in materials.
The Suncoast Developmental Center will analyze data on patient falls and medication errors among elderly patients to improve patient safety. Researchers aim to identify checks and balances in the healthcare system to prevent or reduce mistakes.
Chyba, a renowned astrobiologist, has been awarded a 2001 MacArthur Fellowship for his groundbreaking work on understanding life on Earth. He will receive a $500,000 stipend to support his research on the origins of life and potential threats to human civilization.
Cancer patients' dietary needs vary according to disease stage, with underweight patients benefiting from fatty foods and those well-recovering advised on traditional healthy diets. The study found that nearly two-thirds of patients changed their eating habits since diagnosis, with most taking nutritional supplements.
The study confirms a suspected global epidemic of childhood obesity, with higher rates in the US compared to Russia and China. Obesity prevalence varies by socioeconomic status and geographic location, with urban areas and affluent families more likely to be affected.
The US FDA's priority review process for cancer drugs is significantly faster than its European counterpart, EMEA. In contrast to the EMEA's average approval time of over two years, the FDA approves cancer drugs on average within six months.
Two groups of researchers identify how anthrax toxin destroys cells and how to prevent it. They discovered a protein on the surface of animal cells that acts as a receptor for the toxin, and a way to attach the toxin to its target molecule inside cells, leading to cell death.
Celera Genomics has adopted Aura's OPUS software to streamline its development processes, saving time and resources. The partnership demonstrates the practical applications of innovative technologies developed for space exploration.
Researchers at Newcastle University are using satellites to measure 'bouncing' landscapes, which can affect the accuracy of large construction projects. The study aims to improve the accuracy of surveying data by 10 times, reducing costs by a significant margin.
Researchers have identified the anthrax toxin receptor, a single protein that allows the toxin to enter host cells. The discovery may lead to the development of new treatments for anthrax infection by blocking the toxin from entering cells.
The top countries in academic paper production are US, Italy, UK, Japan, and France. The study analyzed papers published between 1995-1999 and found that North America produced more phase I studies while Europe dominated phase III studies. Italy's performance was attributed to its large number of physicians involved in cancer treatment.
A recent study published in American Journal of Clinical Nutrition found that energy consumption from carbohydrates, proteins, and fats enhances memory performance in healthy elderly individuals. The researchers discovered that fat improved attention while protein enhanced recall over time.
A study found that consuming cocoa and dark chocolate slowed LDL oxidation by 8% and boosted total antioxidant capacity. However, experts stress the importance of a balanced diet that includes a variety of whole foods to support overall cardiovascular health.
Researchers found that consuming flavonoid-rich chocolate can increase HDL cholesterol and slow down LDL oxidation. This effect may contribute to a reduced risk of cardiovascular disease.
Scientists have sequenced the 'CT18' strain of Salmonella typhi, resistant to cheap antibiotics, and developed new treatment methods. The research provides crucial information on disease spread and mechanisms, potentially leading to a vaccine that can be affordable for everyone.
A new computer tool forecasts individualized treatment outcomes and risk assessments for patients with breast cancer. The program provides easy-to-read reviews of different treatment options, helping patients make informed decisions about their care.
A new 'double suicide gene' therapy has shown promise in treating prostate cancer by carrying pairs of fused genes directly into cancer cells and inducing self-destruction. The technique achieved "greater levels of targeted cytotoxicity" than single suicide gene therapy, with minimal toxicities reported among patients.
A study published in the American Journal of Clinical Nutrition found that elderly subjects had a lower white blood cell count increase after refeeding, indicating impaired immune function. This suggests that poor nutritional status in elderly patients may amplify the risk of infection or disease.
The Chernobyl nuclear disaster has led to a significant increase in thyroid cancer cases, particularly among children and young adults who were exposed to fall-out. The risk of thyroid cancer continues to rise, with the highest rates seen 15-19 years after exposure.
The rate of prostate cancer diagnosis has increased significantly, with only 3-5% of newly diagnosed patients having advanced disease. However, the impact of this shift on mortality rates is uncertain, as PSA screening can lead to over-treatment and unnecessary aggressive treatment.
A study of 96 elderly women found that high caffeine intake (over 300mg/day) accelerates bone loss, especially in those with the tt VDR genotype. Moderate caffeine consumption is not linked to increased bone loss, and doctors recommend adequate calcium and moderate caffeine for their patients.
Geologist Edward Keller has discovered a lost island, Isla Calafia, submerged for over 13,000 years under the Santa Barbara channel. The island, 31 miles long and three miles wide, rises about 660 feet from the bottom of the channel and is bordered by two major earthquake faults.
Cornell University has received a $150,000 grant from Microsoft to develop language-based security for mobile code. The new technology aims to protect computers from viruses and malicious code downloaded from the internet.
Researchers have identified Candidatus Endobugula sertula bacteria in Bugula neritina as the likely source of the anti-cancer compound Bryostatin 1. The study provides a new experimental system to unlock the potential of bryostatin drugs.
Researchers successfully used isolated limb perfusion to treat 51 patients, saving 44 limbs and enabling radical resection of residual tumors. Patients maintained over 80% of pre-operative activities post-surgery.
Researchers identified genetic basis of two rare disorders, familial cold autoinflammatory syndrome (FCAS) and Muckle-Wells syndrome, linked to mutations in the cryopyrin protein. The study sheds light on the role of cryopyrin in orchestrating immune defenses and may lead to a better understanding of related autoimmune diseases.
The American Chemical Society's Industrial Innovation Awards recognize the team's discovery of a novel formula that activates antibacterial ingredients in Dial Complete hand soap, allowing it to kill germs in under 30 seconds. This breakthrough technology has significant implications for public health and hygiene.
Researchers at University of Pennsylvania School of Medicine have discovered a pattern to protein manufacture in the hippocampus, which may help explain how memories are stored. The study found that protein synthesis in dendrites is exponentially faster than in the cell body, with specific patterns emerging.
A new approach reduces lymph node removal in breast cancer patients, reducing surgical trauma and complications. The technique uses a radioactive tracer to locate the sentinel node, allowing for targeted biopsy and minimizing false negatives.
Researchers at AgraQuest have developed a natural pesticide called Serenade that targets various fungal and bacterial diseases. It is highly effective and nontoxic to humans, birds, fish, and beneficial insects, making it suitable for integrated pest management systems.
A randomized, double-blind trial found colesevelam significantly lowered mean LDL levels by up to 18% without serious adverse events. This effect was independent of sex or age, making colesevelam a useful therapeutic alternative for patients with mild to moderate primary hypercholesterolemia.
A team of researchers using the XMM Newton satellite detected X-ray emissions from a supermassive black hole, indicating it is spinning and emitting energy through a complex magnetic field system. This discovery provides new insights into the behavior of supermassive black holes and their role in galaxy formation.
Researchers found that 27% of special education students had tics, compared to 20% of regular students. Early recognition and treatment can improve performance and social development for affected children.
Researchers found that destroying two controller proteins restricts DNA replication to a single copy, maintaining genome integrity. Cells with mutant proteins produce excessive DNA, reflecting the importance of these proteins in controlling genome duplication.
Researchers using NASA's Chandra X-ray Observatory have discovered a probable pulsar at the center of a 1,600-year-old supernova. The finding provides evidence for an associated pulsar and allows for detailed study of the supernova remnant. This discovery helps connect pulsars with massive stars from which they formed.
Graduate students report high satisfaction with program freedom but low satisfaction with teaching and career services. Strategies for improvement include student involvement and information on program outcomes.
A new study has found that small head circumference coupled with the ApoE e4 gene variant significantly increases the risk of developing Alzheimer's disease. The research suggests that having a large 'brain reserve' may protect against the disease, with head circumference being one way to measure brain reserve.
A pioneering combination of radiotherapy and chemotherapy has shown promising results in treating common cancers, including cervical, testicular, ovarian, bladder, and small cell lung cancer. Survival rates have increased by up to 18% with combined treatment, outperforming traditional radiotherapy alone.
PNNL scientists are working on a massive energy reserve that could keep America powered into the next century. They're also developing a 30% lighter windshield prototype with optimal safety properties. Additionally, researchers have created a diagnostic system to monitor rooftop air-conditioning units and improve energy efficiency.
The UrbanSim project will use advanced software to create realistic animated streetscapes showing the potential impact of current decisions on urban development. The system will integrate data from various sources, including demographic and economic information, to provide a comprehensive understanding of long-term effects.
A study of 114 patients with primary head and neck cancers found that photodynamic therapy achieved an overall response rate of 91% after two years, with 85% showing complete tumor elimination. The treatment also produced high one- and two-year overall survival rates of 90% and 81%, respectively.
Professor Julian Peto warns that current data protection legislation is hindering cancer research by withholding medical records and tissue samples. Researchers face obstacles in tracking disease development and identifying genetic factors due to lack of access to historical data.
Researchers at University of Pennsylvania successfully inserted a foreign gene into male mouse spermatogonial stem cells, achieving high efficiency and expression. The breakthrough enables the creation of transgenic individuals in various species, paving the way for studying human diseases.
Researchers found a significant drop in deaths from meningococcal disease, with a death rate of just under 9% among children admitted between 1995 and 1998. The authors attribute the decline to increased awareness of the disease, improved treatment delivery, and the introduction of the meningococcal C vaccine.
Researchers found a significant decline in meningitis deaths among children, attributed to improvements in intensive care and treatment. The study revealed a 59% reduction in fatality rates over five years, with most cases resulting from septicaemia.
Research suggests that people with left-handed families tend to have superior episodic memory due to increased inter-hemispheric interaction. This is because their brain hemispheres work together more actively to process and store memories, leading to improved recall of events.
A study of 4,910 four-year-old twins found that genetic factors account for the largest share of asthma prevalence, with genes contributing 68% and environment accounting for just 13%. Environmental factors such as family diet and air pollution are likely to be much less important than genetic make-up.
A study published in the Archives of Disease in Childhood found that the Men C vaccine is safe for infants, with minimal adverse events reported. The vaccine was administered to almost 3000 infants between 2-5 months old and showed no serious adverse events, with only mild side effects such as swelling and redness at the injection site.
Virginia Tech Transportation Institute (VTTI) has been awarded a $3 million grant to study driver behavior leading up to crashes and near-crashes in Northern Virginia. The project aims to provide detailed data on events leading up to crashes, bridging gaps in knowledge about pre-crash and conflict behaviors of drivers.
A team of scientists from Texas A&M University has developed a mathematical model to better understand wildlife habitats and interactions. The model uses equations to describe how animals and plants live, grow, and interact with each other in different environments.
Researchers at Texas A&M University have made a precise measurement of solar neutrinos, resolving a long-standing puzzle. By studying the proton transfer reaction, they found that the number of solar neutrinos is lower than expected by around 20 percent compared to previous calculations.
Hochella will analyze samples from acid-mine drainage sites in Germany and the US using advanced equipment to develop better models of metal transport. This work aims to improve understanding of toxic-metal-bearing phases and their distribution in drainage systems.
A study of internists found that physicians often do not follow best practices due to concerns about patient individuality. The study suggests that noncompliance with guidelines can be a valid reflection of questions about their usefulness and applicability.
A recent analysis published in The Lancet suggests that routine breast cancer screening through mammography may not be effective in reducing deaths. The study found that the two best trials failed to show an effect of screening on deaths ascribed to breast cancer after 13 years, and that screening leads to more aggressive treatment.