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Science News for September 6, 2001


First high-resolution structure of a membrane transporter solved at The Scripps Research Institute—a weapon against cancer and antibiotic-resistant bacteria

Researchers at Scripps Research Institute have solved the first high-resolution structure of a membrane transporter, which can help design new drugs against antibiotic-resistant bacteria and certain cancer cells. The breakthrough could lead to increased efficacy of chemotherapy agents.

SourceScripps Research Institute·JournalScience·DateSep 6, 2001

Cell-cell communication in the flower is unlocked

Researchers have discovered how plants' self-incompatibility works on a molecular level, revealing highly specific lock-and-key interactions between pollen and stigma. This breakthrough could enable genetic engineers to short-circuit reproduction and increase genetic variability in crops like tomatoes and rice.

SourceCornell University·JournalScience·DateSep 6, 2001

Structure of key protein involved in cancer, osteoporosis and foot-and-mouth disease finally solved

The MGH research team has solved the structure of an integrin receptor, a key protein involved in diseases such as tumor angiogenesis, breast cancer metastasis, and osteoporosis. The finding may help develop strategies to target these diseases with novel anti-angiogenic, anti-inflammatory, anti-viral, and anti-osteoporosis drugs.

SourceMassachusetts General Hospital·JournalScience·DateSep 6, 2001

Biologists find a gene required for tolerance of heavy metals, previously known only in plants, in an animal

Biologists at the University of Pennsylvania have discovered a biochemical pathway in animals responsible for detoxification of heavy metals. The discovery establishes a firm basis for determining its ubiquity in other animals and clarifies how animals eliminate, sequester and metabolize heavy metals.

SourceUniversity of Pennsylvania·JournalJournal of Biological Chemistry·DateSep 6, 2001