Researchers found that eczema patients have impaired immune response, preventing adequate antimicrobial peptide production in their skin. This deficiency may lead to increased susceptibility to skin infections, such as staphylococcus aureus and herpes simplex.
Researchers at Ohio State University have created a new method for shaping metal using magnetism, eliminating the need for industrial lubricants. The 'bump forming' technique increases the depth of metal parts by up to 47% while reducing production costs and environmental impact.
The study reveals how SATB1 regulates gene transcription by remodeling chromatin and positioning nucleosomes. In thymocytes, SATB1 brings specific enzymes to the IL-2Ra gene site, regulating its activation and repression.
The U-M Bioterrorism Preparedness Initiative has received a $1 million grant from the Centers for Disease Control and Prevention to develop web-based training for over 9,000 public health workers in Michigan. The initiative aims to improve the state's public health system's ability to prevent and respond to infectious disease outbreaks.
A team of researchers from Duke University has made significant breakthroughs in understanding the mechanism of FTase, a key player in cancer development. The study revealed that FTase doesn't release its product until another substrate molecule arrives, suggesting a new role for the enzyme beyond molecular seamstressing.
A study by Arlene M. Fiore and colleagues suggests that reducing manmade methane emissions could have a greater impact on global ozone levels than reducing nitrogen oxide emissions. This reduction in methane would also help decrease greenhouse warming and surface air pollution.
A study of German children found that exposure to airport noise was linked to reading deficits and impaired long-term memory. However, the effects were reversible once the local airport closed, suggesting that a quieter environment can mitigate the negative impacts of noise on children's cognitive abilities.
The grant will develop new technologies to study G protein-coupled receptors and transcription factors, crucial for physiological responses. Researchers aim to create flat panels with multiple GPCRs to quickly assess drug candidates' effects.
The six-year project MIDUS II aims to understand the complex relationships between psychosocial factors and physical health in people aged 35-85. Researchers will collect data through interviews and questionnaires to identify genetic differences influencing health and well-being.
A survey of 3,457 Americans found that elderly Medicare beneficiaries experience better satisfaction with their coverage, including improved access to care and reduced out-of-pocket costs. In contrast, privately insured individuals reported more problems with accessing necessary services and paying medical bills.
A study by Dr. Ninh T. Nguyen found that surgeons with over 75 procedures performed laparoscopic gastric bypass had fewer complications, shorter hospital stays, and reduced operative times. Patients who were male or older were more susceptible to postoperative problems.
Buprenorphine, a medication related to morphine, has been approved for treating heroin and prescription painkiller addiction in office-based settings. Physicians will need minimum eight hours of training and obtain waiver to prescribe controlled substances.
Researchers have found a new avenue of HIV damage that affects the structure of CD4 T cells, making it impossible for them to function normally. This discovery may lead to improved disease staging and therapy, as therapies targeting inflammation and scar tissue accumulation could enhance current antiviral treatment.
A new phase III multi-national European trial involving 618 patients with advanced non small-cell lung cancer found that cisplatin and paclitaxel improved survival rates compared to carboplatin and paclitaxel. The study suggests that cisplatin-based chemotherapy remains the preferred standard treatment for lung cancer in Europe.
A team led by Purdue University's David Sanders has developed a promising system to deliver genes to diseased liver and brain cells using a modified Ross River Virus (RRV) as a Trojan horse. This approach avoids the harmful side effects associated with other retroviruses, bringing gene therapy closer to treating human diseases.
Researchers at Baylor College of Medicine trained macaque monkeys to recognize changes in a display screen, rewarding them with juice for correct responses. The study found that neurons in the visual cortex increased activity when an event was likely to occur, allowing primates to develop expectations and prepare accordingly.
The ribosome recycling factor plays a crucial role in protein synthesis by disassembling the ribosomal complex after protein completion. Researchers believe RRF could be targeted for new antibiotic development to combat bacterial resistance.
The NHLBI has funded new heart health education projects in high-risk communities across the US, with a focus on reducing cardiovascular disease and stroke deaths. The projects will employ creative approaches to engage communities, including training peer health educators and conducting awareness-raising town-hall meetings.
New research has solved a long-standing mystery about DNA unzipping, revealing that it requires at least two proteins working together. The study found that if one protein falls away, the process stops and DNA reverts to its zipped state unless another protein joins in.
Researchers found that EZH2 expression was significantly higher in metastatic prostate cancer tissue compared to localized prostate cancer. A future test for high levels of EZH2 protein could serve as a red flag for physicians to identify men with the most aggressive form of the disease.
Amanda Fisher has been awarded the prestigious EMBO Gold Medal for her exceptional work in European molecular biology. The award recognizes her achievements as a role model for scientists in Europe.
Dr. Berger's lab will expand its studies of idiopathic prostatitis and explore potential solutions using Botox and genetic stress factors. The grant will help develop a working model explaining the disease's puzzling manifestations.
A study by Northeastern University's David DeSteno reveals that both men and women experience more distress from sexual than emotional infidelity. The findings challenge long-held evolutionary theories on jealousy.
NASA's Public Health Applications Program aims to provide public health agencies with innovative technologies, data, and satellite-based tools to combat the disease. The program helps identify environmental indicators, predicts disease outbreaks, and informs mosquito surveillance efforts.
The Navy has built an Air-Sea Interaction Tower to measure atmospheric and ocean conditions, including temperature, humidity, and wave height. The tower will provide better weather forecasts, enabling the avoidance of storms and saving lives.
The Navy is using immersive simulation training, known as 'visceral reality,' to challenge fresh recruits through realistic and intense scenarios. This new approach aims to better equip sailors to deal with combat situations, providing a more effective training evolution.
The Max Planck Institute for Radioastronomy has determined the sizes of four of the largest and most distant minor planets in our solar system. The diameters range between 700 and 1200 km, providing new insights into the Kuiper belt's structure and potential origin of planetary systems.
Women with stage IIIb cervical cancer may benefit from different treatments depending on the spread of their disease, according to a new study. The research found that women whose cancer had not spread to lymph nodes had the highest survival rates, while those with upper chest lymph node involvement typically died within months.
A large multicenter clinical trial will randomly assign patients with tibial fractures to either reaming or non-reaming surgical groups. Surgeons will assess participants at six weeks, three months, and one year to determine the success of the operation.
Researchers from Newcastle University successfully classified 70% of River Ouseburn water samples by measuring natural fluorescence, which could aid in detecting organic pollutants. The 'glowing' technique uses spectrophotometry to fingerprint dissolved organic matter in rivers.
A University of Pittsburgh study found a marker for blood clots in patients experiencing cardiac arrest outside the hospital. The researchers identified increased clotting in veins, which worsens with longer cardiac arrest duration.
A recent study using MRI scans found that children with ADHD showed smaller brain volumes in all regions compared to their peers. The researchers suggest that the disorder may be caused by genetic factors rather than medication use.
Researchers at Ohio State University Wexner Medical Center have been awarded a $9.5 million grant to study the innate immune system and develop new cancer therapies. The project will explore how targeted therapies can be more potent in the presence of certain agents, and will involve multiple clinical trials and laboratory projects.
New data confirm KEPPRA's sustained antiepileptic effect over 7.13 years, with a high retention rate of 54.3%. The incidence of adverse events is similar to previous studies, ensuring the safety and tolerability profile for KEPPRA.
The University of Illinois Chicago is developing a new model for dental education to address disparities in oral health care, increasing the diversity of the dental workforce. The program will provide community-based experiences and full scholarships to recruit minority and low-income students.
The University of Pittsburgh Cancer Institute has discovered three proteins present in liver tissue from colon cancer patients that are not found in normal liver tissue. The findings hold promise for developing a more sensitive tumor marker for early detection and predicting potential recurrence.
Researchers investigate potential link between low-level exposure to zeranol and breast cancer risk. The study explores the biological effects of zeranol, a synthetic non-steroidal agent used in cattle feed, on human breast tissue.
Researchers from the University of Pittsburgh found that shocking the heart after prolonged cardiac arrest can cause further damage, highlighting the need for alternative treatment options. The study suggests that waiting a few minutes before defibrillation may be a more effective approach.
A new study confirms that children with ADHD have smaller brains than those without the disorder, but found that stimulant medications do not affect brain size. The research, led by Dr. F. Xavier Castellanos, also showed that brain development in children with ADHD is normal and healthy.
Sydney Brenner's groundbreaking research on Caenorhabditis elegans revealed genes controlling human processes, while his contributions to molecular biology and systems biology paved the way for major discoveries. His work at the Molecular Sciences Institute continues to advance our understanding of biological systems.
A lunar solar power system, proposed by Criswell, could supply up to 20 terawatts of electricity to Earth, enough for a population of 10 billion. The system would harness just one percent of the moon's solar power and beam it back to receivers on Earth via microwave beams.
A study published in Psychological Science found that German children exposed to airport noise showed significant declines in reading and memory abilities. However, these effects were reversible once the local airport closed, indicating that exposure to chronic noise can have serious health and learning impacts on children.
The genome sequence of Shewanella oneidensis reveals its ability to remove toxic metals like chromium and uranium from the environment. Scientists have discovered a new bacterial phage that may enable genetic manipulation of Shewanella for specific bioremediation projects.
Researchers at Cold Spring Harbor Laboratory have discovered a new breast cancer gene called DBC2, which is associated with sporadic breast cancer. The study shows that the Dbc2 protein kills cancer cells or stops them from growing, making it a promising target for treatment.
The University of Houston is developing blueprints for Texas spaceports and a Mars colony, aiming to provide a less expensive alternative to government-run facilities. The program will consider factors such as propulsion systems, habitat design, and radiation protection, with the goal of creating a sustainable human presence on Mars.
Peter Rensberger has been recognized with the American Chemical Society's James T. Grady-James H. Stack Award for Interpreting Chemistry for the Public. The award aims to promote outstanding reporting that fosters a public understanding of chemistry, chemical engineering, and related fields.
A study published in Neurology found that opioid medications effectively relieve postherpetic neuralgia (PHN) pain without significant side effects, with 54% of patients preferring opiates over antidepressants. The research suggests opioids are a good alternative for patients not responding to other types of pain medications.
Research by Dr Jackie Sheehan and colleagues found that anxiety over labour unrest is holding back SOEs from completing layoffs, with workers instead being moved into new sub-companies or retrained. Despite reduced government interference, significant state controls remain in place.
According to a recent report from Conservation International, 25 primates are now threatened with extinction, with Asia accounting for almost 45% of the world's most endangered primates. Habitat loss and hunting are major factors in the decline of these species, and urgent conservation action is required to prevent extinctions.
Researchers from Johns Hopkins University and National Institutes of Health found opioids to be highly effective in reducing pain in PHN patients, while causing no appreciable cognitive decline. The study's results provide convincing evidence for the use of opioids as an alternative treatment option for neuropathic pain.
The Timbot robotic model monster truck is developing software that could guide unmanned vehicles like cars, buses, or aircraft in the future. It supports 'graceful degradation' by adapting to changes in its environment and prioritizing critical functions.
Researchers developed a mechanical system that stimulates muscle activity in the legs by mimicking natural sensory input, which could aid astronauts and bed-ridden patients. The technology uses plungers to push against the bottom of the foot in specific patterns, generating enhanced neuromuscular activity.
Researchers at the University of Houston are developing methods to manufacture huge solar cell arrays on the moon using materials from lunar soil. The goal is to generate enough electricity to supply a lunar base or colonies, as well as beam electricity back to Earth for use in local grids.
The University of Houston has a rich history of space research, with contributions to NASA's Exobiology Program and the National Space Biomedical Research Institute. Researchers are planning to go back to the moon and Mars to develop space outposts.
Researchers at the University of Illinois have created synthetic cytochromes by designing a small cyclic peptide that binds to iron millions of times more strongly than without it. This peptide's unique structure enables it to facilitate electron transport across cell membranes, potentially leading to effective antibiotics.
The University of California, Riverside will receive a $4.9 million grant to develop a program that improves teacher subject knowledge and student achievement in mathematics. The program aims to increase math achievement by 25% among 10,000 students in grades 4-8 through targeted instructional strategies.
Researchers found that statins modify immune system molecules involved in MS progression, exhibiting potent anti-inflammatory effects. Statin therapy may serve as a useful standalone or add-on treatment for patients with MS.
A team of researchers reanalyzed the data from Boas' 1912 study on cranial measurements, finding that genetic factors dominate variation in head shape. The study's results contradict Boas' claims that environmental influences are the primary driver of cranial plasticity.
Researchers found that combining whole brain radiation with stereotactic radiosurgery improved survival rates by one to two months for patients with single brain metastases. Those with multiple metastases showed some improvement in survival, but not as much, and added medications may further enhance treatment outcomes.
A large study found that African American infants who slept on their stomachs were at more than twice the risk for SIDS compared to those sleeping in other positions. The research also highlighted disparities in healthcare recommendations and access to information about safe sleep practices among different racial groups.