Seyferth's research focuses on creating new molecules through the use of organometallic compounds. He has made significant contributions to the field of organometallic chemistry, including the development of methods for synthesizing complex compounds such as drugs and adhesives.
The American Academy of Ophthalmology has awarded Special Recognition Awards to Mr. McManus for his dedication to vision research, and Dr. Jones and Dr. Brown for their innovative research and humanitarian efforts. The awards recognize their contributions to the field of ophthalmology.
Dr. Rawal has developed a rapid and straightforward reaction that can assemble pieces of complex molecules with high accuracy. This innovation is expected to improve the performance of anticancer drugs like vincristine, which has been used successfully in treating childhood leukemia.
Two collaborative research projects on drug addiction and postpartum depression have been awarded funding. The studies will investigate sex-based differences in gene expression and the effect of estrogen on treatment response.
Dale J. Kempf, Daniel W. Norbeck, and Hing L. Sham receive award for developing Kaletra, the first HIV protease inhibitor approved for use in children as young as six months old.
Researchers create experimental model of a non-equilibrium system to test the soundness of temperature in a continuously shaken container of tiny beads. They find that temperature follows the expected rules, suggesting that essential information can be extracted from disordered motion in dissipative systems.
A chemist's research creates tools to make complex drugs more efficiently, with potential breakthroughs in anti-cancer treatments. His work has led to licenses for pharmaceutical companies to study promising drug candidates.
The Wyeth Pharmaceuticals team is being recognized for their role in developing the first combined pneumococcal vaccine for infants, Prevnar. The vaccine has dramatically advanced the health and well-being of children worldwide by preventing serious diseases such as meningitis, bacteremia, and pneumonia.
A renowned chemist has synthesized epothilone, a compound derived from bacteria, promising to replace taxol in treating cancer. His successful 25-step synthesis has garnered interest from pharmaceutical companies, paving the way for potential clinical trials and widespread use.
The Pfizer Inc team won the Heroes of Chemistry award for developing Neurontin, a medication controlling seizures in children. This breakthrough led to improved quality of life for many children with epilepsy, demonstrating the valuable role chemists play in improving lives.
The American Academy of Ophthalmology is honoring Dr. Demorest, Dr. Scott, and Dr. Stambaugh for their significant contributions to ophthalmology. They are recognized for their clinical, educational, and research achievements, as well as their leadership positions in the field.
The UGA research team has identified a molecular key to cell division, which could lead to new targets for cancer therapeutics. The study found that cyclin-dependent kinases drive the mitosis process and that molecules called oncogenes and tumor suppressor genes are controlled by novel mechanisms.
Researchers have discovered that microRNAs play a crucial role in controlling plant growth and development by regulating cell division and leaf shape. The study found that a specific microRNA called "Jaw" targets messenger RNAs involved in preventing excessive cell division, leading to abnormal leaf shapes.
A study of 817 patients who underwent bypass surgery found that treating depression could significantly reduce mortality rates. Patients with moderate to severe depression at baseline and those with mild depression sustained from initial to six-month assessment were more than twice as likely to die than patients who were not depressed.
Researchers uncover unexpected new role for GATA-3 in hair follicle development, shedding light on parallel molecular cues between skin and immune systems. GATA-3-deficient mice exhibit severe structural anomalies in hair development, including bent whiskers and irregular thickenings.
A recent study found that the French eat smaller portions compared to Americans, which may contribute to their lower obesity rates and healthier diets. The researchers examined portion sizes at restaurants in Paris and Philadelphia, as well as single-serve foods sold in supermarkets.
Faculty members Krishnamurthy and Keogh receive funding to improve wireless network efficiency and develop efficient algorithms for analyzing sequential data. Their research has potential applications in disaster recovery, finance, industry, and more.
Research by Dean Krahn and colleagues found that moderate drinking had no significant effect on cognitive ability in middle-aged adults, contrary to previous studies. The study used an extensive database of over 10,000 participants who completed cognitive tests at different stages of life.
The URI Metcalf Institute has awarded fellowships to two minority journalists, Rodriguez and Ortiz, to develop story ideas and receive scientific training in marine and environmental science. The fellowship aims to increase the number of minority journalists trained in science who report on science-based news.
Researchers aim to better understand the nuances of language comprehension in individuals with right hemisphere stroke, which often affects word meanings and phrases. The study will use MRI scans to determine if lesion location impacts communication deficits.
Researchers at Weizmann Institute have identified a new principle guiding brain memory systems, explaining inconsistencies in previous studies. This discovery may lead to the development of new methods for wiping out unwanted memories and treating psychological trauma.
Researchers analyzed TES observations and found trace amounts of carbonate minerals in Martian dust, indicating a thin atmosphere interacting with dust. The discovery contradicts the idea of past oceans on Mars and suggests a climate history dominated by ice and frozen water.
A team of researchers has discovered that injecting radioactive glucose can selectively kill cancer cells without harming healthy tissues. The treatment exploits the fact that cancer cells use more glucose than normal tissue, allowing for targeted delivery of radioactivity.
A study by NIH/NIEHS has identified a mouse gene linked to hydrocephalus, a common birth defect. The research team cloned the defective gene, which affects cerebrospinal fluid drainage, and found it causes classic symptoms of hydrocephalus in mice.
Scientists at Emory University Health Sciences Center have identified a new sperm protein called SED1 that plays a critical role in the initial association between sperm and egg during fertilization. Mice without this protein had reduced fertility despite normal sperm characteristics, highlighting its importance in successful binding.
A post-hoc analysis of the LIFE study found a close to 50% risk reduction in sudden death among losartan-treated diabetic patients compared to those treated with atenolol. Lars Lindholm comments that the results are exploratory and require confirmation.
Researchers discovered that the brain can associate certain stimuli with food consumption when hungry, but not after eating. This association is linked to brain regions involved in conditioning and reward pathways.
A study of Santa Cruz, Bolivia, found that replacing tropical forests with crops can increase daytime temperatures and decrease nighttime temperatures. This occurs because crops are less efficient at cooling the air through transpiration, a process where water evaporates from leaves during photosynthesis.
Researchers at Duke University Medical Center found that depression is a strong independent risk factor for death in patients undergoing coronary artery bypass surgery. Depression was associated with a doubling of the risk of death during the follow-up period, regardless of other factors.
The US is responsible for 23% of global greenhouse-gas emissions. The editorial emphasizes the need for changes in law and tax incentives to persuade citizens to use fewer fossil fuels and adopt recycling initiatives.
A genetic dictionary has been developed to understand the role of newly identified genes and their functions, which can aid in identifying unknown genes involved in cell division and cancer. The dictionary is based on gene activity data from four organisms and provides a context for understanding genetic words.
Researchers at Cornell University have confirmed a theory about how a protein complex known as FACT helps cells read their genetic code. By studying the activation of a heat-shock gene in fruit fly cells, they found that FACT and other proteins quickly move to chromosomal sites where transcription occurs.
A new combination cancer-killing drug regimen has shown promising results in extending patient survival, with 16% tumor shrinkage and 35% stable disease progression after six months. The orally administered treatment has been well-tolerated and offers a more convenient option for patients compared to traditional IV chemotherapy.
A post-hoc analysis of the LIFE study found that losartan significantly reduced sudden cardiac death in diabetic patients with hypertension and left ventricular hypertrophy compared to atenolol. The results showed a nearly 50% risk reduction in sudden death for losartan-treated patients.
This special issue aims to expand knowledge on drug supply and trafficking by providing accessible information to academic researchers. The articles cover various aspects of the topic, including a case study of a middle market drug broker and a conceptual framework for action against drug supply.
Researchers isolated a honeybee gene called csd, revealing that female bees have two different versions of the gene that form an active protein triggering female development. This discovery explains how male and female bees develop from fertilized and unfertilized eggs, respectively.
Researchers found that a combination of low-dose spiral CT and selective use of PET can effectively detect early-stage lung cancer in high-risk individuals. The study showed that lesions up to 5mm can be safely followed up after 12 months without major risks of progression.
Researchers found a clear association between ocean tides and ice stream motion in West Antarctica. The study discovered that a one-meter tide variation can cause an ice stream to halt and then accelerate rapidly.
A newly discovered gene, Stb8, has been found in bread wheat species to be resistant to Septoria tritici leaf blotch, a fungus causing significant yield losses worldwide. The gene's longer duration of effectiveness compared to previous genes may make it a valuable addition to breeding programs.
Researchers found that the HIV vpr gene exploits the normal repair process of cells to stop vital white blood cells from replicating, thus disabling the immune system. The study suggests a possible treatment for AIDS-related immune-system damage using medicines that prevent the human ATR gene from being activated by HIV's vpr gene.
Research at UCSF found that patients taking 80% or more of their antiretroviral medications developed twice as many resistance mutations as those taking less than 40%. Despite this, excellent adherence remains the best way to prevent HIV/AIDS and prolong life with resistant virus.
A recent study has found that 18F-FDG PET scans are more accurate than CT scans in predicting post-therapy Hodgkin's disease relapse. The diagnostic accuracy of 18F-FDG PET was 92%, while CT results were only correct in 56% of cases.
Researchers found steady, light rain in central Pacific during El Niño, which differs from thunderstorms. This type of rain affects air movement and jet stream patterns, leading to improved rainfall forecasts worldwide.
Researchers have discovered microRNA JAW that controls the development of flat leaves, a key characteristic in capturing sunlight and energy. The study reveals the importance of microRNA regulation in plant morphology, paving the way for new avenues in agricultural advancements.
Researchers found a common gene, Bric-a-brac2, responsible for diverse pattern and color pigmentation across 13 fruit fly species. The study suggests that similar genetic mechanisms govern body plans in related animals.
Studies with yeast prions show that small mutations can cause transmission barriers, potentially explaining species barriers for mammalian prions. The findings suggest a new approach to treating disorders like Alzheimer's by influencing toxic protein folding.
Researchers have mapped the location of a dominant signaling molecule on proteins, which causes cancer and diabetes when it goes awry. The discovery allows scientists to block aberrant binding and treat diseases by designing drugs that target specific phosphate bonding patterns.
A new study has found that mobile magma plumes, rather than stationary hotspots, are responsible for the formation of islands and subsurface mountains in the Pacific Ocean. This discovery challenges traditional theories of tectonic movement and sheds light on climate changes recorded in ancient rocks.
Dronabinol significantly reduced agitation in 66% of Alzheimer's patients and improved functional status in 69%, while also addressing weight loss. These findings suggest dronabinol as a potential treatment option for managing behavioral symptoms in patients with Alzheimer's disease.
Researchers found that most hydrogen eliminated from atmosphere goes into ground, highlighting importance of understanding soil destruction. Soil uptake of hydrogen is estimated to be as high as 80 percent, suggesting microbes use it for biological functions.
A study at the Salk Institute found that children with Williams syndrome exhibit unique social behavior patterns, including high scores on tests measuring social interactions. Genetic screening revealed that one gene may be responsible for this hyper-sociability in some individuals, suggesting a potential genetic link to the disorder.
A new study aims to investigate how physicians treat end-stage heart failure patients, focusing on the use of inotropic drugs. The research hopes to provide a framework for selecting care options, including palliation, for older heart failure patients near the end of life.
A study by researchers at the University of Pennsylvania School of Medicine found that 53% of computer searches for 'no prescription codeine' lead to illegal opiate sales sites. The sites often require minimal information and can be accessed from outside the US, posing a significant risk to public health.
The Bechtel Foundation has donated $300,000 to support the development of an atomic testing museum at the Desert Research Institute's Frank H. Rogers Building. The museum will feature exhibits on the Cold War role of the Nevada Test Site and traveling exhibits from the Smithsonian Institution.
A study published in JAMA found that children on the ketogenic diet for six months had significantly elevated cholesterol and triglyceride levels, but these levels often normalized after treatment cessation. The researchers suggest that the diet should remain a treatment option despite short-term lipids elevation.
Research reveals Borneo's elephants are genetically distinct from other Asian elephants, suggesting they may have parted ways 300,000 years ago. This classification changes the focus of their conservation, as their habitats are increasingly disrupted by human expansion.
A study found that physicians often fail to discuss out-of-pocket costs with patients, leading to financial burden and skipped medication. Discussing costs can make a difference, enabling physicians to seek less expensive alternatives.
Researchers found that postmenopausal women with a higher body mass index have an increased risk of breast cancer due to elevated estrogen levels. In contrast, heavier men under age 60 or those with family history of prostate cancer may experience lower risks of developing the disease.
Researchers from deCODE Genetics and the University of Oxford found that genetic drift, not admixture, has shaped Iceland's gene pool. The study suggests that small effective population size and relative isolation have contributed to Iceland's unique genetic characteristics.
A 1,500-year-old underground tomb was discovered by Field Museum archaeologists beneath a palace-like residence in El Palmillo, Oaxaca. The tomb, remarkably well-preserved due to its subfloor location, contained three human remains with high-status signs, ceramic vessels, and red paint-covered bones.