Researchers used radiation to activate receptors in tumor blood vessels, enabling targeted delivery of anti-cancer drugs. The approach showed promising results in reducing side effects and delaying tumor growth.
Researchers found a link between alcohol intake and endocannabinoid-like brain compounds in mice, suggesting a potential target for medication development. The study's findings parallel observations in humans, with age-dependent decline in alcohol preference and reduced CB1 receptor signaling.
A researcher at the University of Toronto has developed a method to automatically remove the unsightly scarlet spots, known as red-eye, from digital images. The software isolates the reddened areas of the eyes and replaces them with natural eye color, providing a convenient solution for consumers.
A study on breast cancer treatment found that many women do not receive adjuvant chemotherapy as recommended, with age being a significant factor. In contrast, women with known heart disease are at high risk of future heart events but often lack preventive treatments, highlighting the need for better care coordination.
A recent Canadian Medical Association Journal investigation found that a massive heroin seizure had no impact on drug prices or overdose rates. Heroin prices actually decreased after the shipment was intercepted, raising questions about the effectiveness of supply-side interventions in controlling Canada's illicit drug epidemic.
Researchers found that intensive blood pressure control reduces cardiovascular events in patients with diabetes and PAD. The study suggests aggressive blood pressure management is particularly beneficial for the diabetic population, even among those with low ankle-brachial index.
A study of Canadian children with shaken baby syndrome found nearly 20% died, 55% suffered lasting neurologic injuries, and 65% experienced visual impairment. The authors estimate at least 40 cases occur annually, calling for further research on prevention strategies.
A new study reveals that sentinel lymph node mapping can be safely performed on patients with melanoma in the delicate head and neck area, allowing for early detection of cancer spread. The technique has been shown to accurately stage patients and identify those who need further treatment, potentially improving survival rates.
A University of Toronto researcher is studying how the Cherokee people responded to forced removal, with a focus on accommodationist writers and resistant voices. His book aims to acknowledge the history of removal and its impact on Cherokee literature.
Researchers found that cancer cells can migrate through protein matrices by reverting to a more rounded shape, allowing them to continue moving even when inhibitors are present. This 'salvage' pathway could be targeted by new drugs to combat cancer spread.
A new antibody library developed by PNNL scientists can identify antibodies in days, reducing labor costs and improving the design of medical treatments. The library, which contains 1 billion human antibodies, uses a yeast surface display method to quickly screen for useful antibodies.
Researchers found that exposing rats to low levels of carbon monoxide significantly reduced intimal hyperplasia and leukocyte accumulation, indicating a protective effect against arteriosclerosis. The study suggests potential therapeutic benefits for treating vascular diseases.
Scientists have achieved germline transmission of 'gene knockdown' in mice by using genetic engineering to create mouse embryonic stem cells targeted with RNAi. This enables the manipulation of gene activity in specific tissues and allows for switching on and off at any time during development or adulthood.
The US Navy is developing new antifouling hull coatings inspired by nature, using complex nanometer-scale patterns to prevent barnacles from attaching. These coatings have shown exceptional low settlement rates in early experiments, promising a reduction in fuel costs and frequent cleaning needs for Navy ships.
UAF Institute of Arctic Biology researcher comments on a Science article about patterned ground, a process of self-organization in nonliving things. The research highlights the emergence of intricate patterns in Alaskan mountain ranges and North Slope, without predicting or natural selection.
Researchers have found a novel group of bacteria in tropical ocean sediments that produce molecules with potential in treating infectious diseases and cancer. The discovery has opened up a new source for drug discovery, with thousands of strains available.
Researchers have developed a new technology using adaptive optics to improve diagnosis of eye diseases. The technology enables doctors to see individual cells in the retina, allowing for early detection and treatment of conditions such as glaucoma and age-related macular degeneration.
Researchers collected and analyzed a record-breaking ice core in the St. Elias range, providing insights into the North Pacific Decadal Oscillation (PDO). The PDO is a 20-30 year climate cycle affecting weather across North America, with cool and warm phases centered in the North Pacific.
Researchers identified a protein called CUGBP2 that regulates the production of COX-2, a key culprit in arthritis and cancer. When CUGBP2 levels are high, it triggers cancer cell death by inhibiting COX-2 production.
The book is a comprehensive guide to the flora of the Caribbean, featuring over 700 underwater color photographs and detailed information on 565 species of marine plants. The award recognizes the widespread need for this reference among students, researchers, and reef managers.
A recent study published in the American Journal of Medical Genetics found a significant association between SIDS and a gene regulating serotonin uptake. The study identified an increased frequency of the L allele in SIDS cases versus controls, suggesting a potential genetic risk factor for the condition.
The study reveals that health and socio-economic factors have a natural impact on quality of life in early old age. Having control over work choices also significantly affects quality of life, with those who choose to retire or work beyond normal retirement age enjoying better lives than those with limited options.
Researchers studied DNA sequences to understand co-evolutionary system between ants, garden fungi and parasitic fungal weeds. They found that the system has been locked in an evolutionary 'arms race' for millions of years.
A breakthrough discovery by Saint Louis University researchers reveals how the protein Bre1 functions in normal cells, shedding light on its role in cancer development. The study suggests that understanding this protein's regulation of gene expression could lead to new ways to block cancer-causing pathways.
The study aims to identify disease-fighting fungi and understand their role in nutrient cycling. By analyzing multiple genes and structural characteristics, researchers will create a database to distinguish between beneficial and harmful fungal species.
A recent study by Max Planck Institute researchers found that in mutualistic interactions between species, the faster-evolving species may actually lose out. The slow-moving species can gain an advantage when both are generous and coordinate their strategies, whereas quickly evolving species tend to adapt to slow evolvers' needs.
Nei's work has developed statistical methods to study genetic diversity, evolutionary relationships, and species divergence. He pioneered the neighbor-joining method for constructing phylogenetic trees, widely used worldwide.
Researchers developed a numerical model that explains the emergence of various patterns, including stone circles and labyrinths, through the interaction of two mechanisms: lateral sorting and squeezing. The relative strengths of these processes, along with factors like soil compressibility and stone size, determine the resulting pattern.
Researchers at McGill University have discovered a molecule that accelerates wound healing, providing a potential treatment option for millions of Americans suffering from burns and chronic skin ulcers. The growth factor progranulin has been shown to improve skin repair, offering new hope for individuals affected by these conditions.
Scientists found that the embryo uses L-selectin on its surface to bind with carbohydrate molecules on the uterine wall, leading to a complete stop and attachment. This discovery may provide information useful for treating infertility and potentially offer insight into preeclampsia.
Researchers found leptin significantly correlates with reduction in food intake and weight loss prior to developing EAE symptoms. Modulating leptin concentration through dietary approaches may have potential utility in treating MS and other autoimmune diseases.
A cross-sectional study of Tibetan adults found that low back pain is a significant problem, impairing health and productivity. Effective interventions, such as safer back positioning and flip-charts, can help reduce the burden of low back pain in rural societies.
A study published in Science reveals that Toxoplasma parasites can rapidly adapt to new hosts, allowing them to infect a wide range of animal species and spread worldwide. This discovery raises the possibility of other parasites undergoing similar changes, potentially presenting new threats of infection.
A rapid diagnostic test for plague has been developed to detect antigens at low concentrations within 15 minutes of infection. The test is 100% sensitive and reliable, detecting more infections than conventional laboratory assessments and providing opportunities for bioterrorism preparedness and response.
Research at the University of Minnesota suggests that magnetic field lines, similar to a slinky, can produce energy waves that accelerate electrons toward Earth. These waves are sufficient to power auroras, which occur in ring-shaped patterns around the poles.
Researchers have discovered a new source of stem cells in the umbilical cord, which can be obtained through a non-invasive method. The cord matrix stem cells have been shown to differentiate into neurons and glia, exhibiting telomerase activity and producing nerve-cell specific traits.
Researchers have made significant progress in understanding the effects of HIV protease inhibitors on atherosclerosis, as well as exploring novel gene therapies for epidermolysis bullosa. Additionally, studies on CXCR4/CXCL12 interaction reveal new insights into hematopoietic stem cell mobilization.
Researchers found that a molecular sticking process stops the embryo's journey along the uterine wall and starts attaching it to the wall, creating a sticky environment. The discovery of L-selectin protein helps to understand human embryo implantation and may prove useful to treat infertility.
Columbia University has established a new cross-disciplinary graduate program with a $2.9 million NSF grant, focusing on applied mathematics and Earth sciences. The program aims to equip students with both mathematical skills and deep understanding of environmental issues.
The UCSB team has developed a reversible switch for surface design, allowing for dynamic regulation of macroscopic properties. The technology uses alkanethiolates to create nanometer-thin interfaces that can be controlled as a function of space and time.
The Office of Naval Research is developing a suite of technologies to help sailors and Marines avoid mines during amphibious landings. The systems, including Moving Map, Augmented Reality Visualization, and Expeditionary Warfare Decision Support System, aim to reduce the risk of accidents by providing real-time navigation data.
Scientists have discovered that ancient birds used a unique 'wing-assisted incline running' behavior to help them climb vertical surfaces, which may be the key to explaining how dinosaurs learned to fly. This behavior, found in modern-day birds, involves rapid movement of the front appendages to gain foot traction as it climbs.
The Navy's new concept, FORCEnet, focuses on integrating long-haul networks, knowledge management tools, and wireless technologies to support warfighters in the field. This initiative aims to provide real-time information advantage and enhance combat operations.
A new study reveals persistent gender inequalities in the Philadelphia region, with women facing lower median incomes and overrepresented in low-paying jobs. The report also highlights the disproportionate burden of caring labor on women, which contributes to their lower earnings.
A survey of 1,069 high school students found that teens consider 'avoiding environments with alcohol' and 'talking with friends or other informal supports' as effective strategies to cut back on drinking. Formal counseling was more useful for quitting than reducing drinking, according to the teens.
Scientists at British Columbia's Children's Hospital reveal a method for directly measuring the level of self-destructive white blood cells in mouse blood, distinguishing those that go on to develop diabetes from those that do not. The technique may also be used to detect other autoimmune disorders.
Researchers at MIT create a switchable surface that can change from water-attracting to water-repelling by applying an electric field, with potential applications in drug delivery and biomedical engineering. The surface's properties are controlled using conformational transitions, allowing for reversible modification.
Researchers found that recombinant activated factor VIIA significantly reduced blood loss during abdominal prostate removal surgery. Patients given the drug required no blood transfusions, whereas those receiving placebo did.
A new study from the Liverpool Diabetic Eye Study has proposed optimal screening intervals for diabetic eye disease, based on incidence data. The findings suggest that patients with no baseline retinopathy should be screened every 3 years, while those with background retinopathy can be screened annually.
Researchers have identified two microorganisms, Fusarium and Pandoraea spp., that can degrade the toxicity of endosulfan, a persistent organic pollutant. This breakthrough offers a potential solution for detoxifying contaminated sites, reducing toxic residues in soil.
Scientists discovered that early mammals used epipubic bones to stiffen their bodies during trotting steps, allowing for increased mobility and locomotor efficiency. This finding suggests that the development of these bones contributed significantly to the evolution of mammals.
Research suggests that taking dietary supplements of L-arginine and antioxidants like vitamins C and E may lower the risk of atherosclerosis and heart disease. The treatment reduced inflammation and increased production of eNOS, a molecule that prevents blood clots.
The Kavli Institute will bring together top minds in particle astrophysics and cosmology to tackle fundamental questions about the universe. The institute will focus on areas like dark matter, black holes, and hidden space-time dimensions.
A new study by Brigham Young University researchers found that walking stick species re-evolved wings after losing them 50 million years earlier. The discovery raises questions about the basics of evolutionary theory and suggests that complexity can be maintained over tens of millions of years.
A NASA study found that lightning strikes in multiple locations, with 35% of recorded flashes striking the ground in two or more places. On average, each cloud-to-ground flash struck the ground in 1.45 separate places, increasing the risk of being struck by 45%.
A UMass study suggests that greenhouse gases were the primary driver behind the rapid formation of Antarctica's ice sheet, contradicting a long-held theory on plate tectonics. The researchers used computer simulations to recreate the world 34 million years ago and found that a drop in carbon dioxide levels triggered the glaciation.
Researchers gather data from an unusual storm over the Amazon rainforest to analyze the storm's inner workings, revealing a two-phase process where both precipitation forms at lower altitudes and higher in the atmosphere. The study provides new insight into storm intensity and hazards, which should be avoided by aircraft.
Scientists at North Carolina State University developed a remote sensing technique to accurately time nitrogen fertilizer applications in wheat, resulting in an 86% success rate across various environmental conditions. This technology allows growers to make informed decisions that balance profitability and environmental stewardship.
Researchers studying the common Australian gecko Christinus marmoratus have found a protein growth factor that contributes to its ability to quickly regenerate its tail after losing it. This discovery is encouraging for treating human lymphoedema, but more research is needed.
Researchers found that herpes viruses use a viral protein called mK3 to hide from the immune system by marking MHC class 1 molecules as waste. This study provides insights into basic cellular processes and offers novel strategies for understanding viral infections.