A new study by Saint Louis University researchers found approximately 7.8 million Americans living with hyperhidrosis, which can cause anxiety, depression, isolation, and reduced quality of life. The study also revealed that axillary hyperhidrosis affects 4 million Americans, leading to feelings of less confidence and frustration.
Researchers at Duke University have successfully redesigned sensor proteins that can detect a range of molecules, including explosives like TNT and neurotransmitters. This breakthrough could lead to new technologies for monitoring diabetes and locating underwater robots.
A European study of over 20,000 deaths in six countries found that end-of-life decisions were common, with administration of drugs to hasten death varying significantly between countries. The study highlights the need for further exploration of end-of-life care practices and attitudes towards physician-assisted death.
The study reveals that nitric oxide alters protein interactions, leading to new insights into the underlying causes of disease and potential new therapies. The findings suggest that NO regulates a broad spectrum of cellular reactions, potentially underlining some disease symptoms.
A new study has found that a weekly regimen of paclitaxel and carboplatin is well-tolerated and effective in treating advanced non-small cell lung cancer. The treatment resulted in a response rate of 32% and median survival time of 49 weeks, with fewer side effects compared to standard regimens.
Researchers link tooth loss to subclinical atherosclerosis and increased carotid plaque buildup. The study suggests that chronic infection or inflammation of the gums may contribute to tooth loss.
A study by Frits Rosendaal and colleagues found that haemophilia carriers have a significantly lower risk of ischaemic heart disease, with a 36% decrease in overall mortality. This reduction in blood clotting may offer protection against heart attacks and has implications for future prevention strategies.
Researchers at UGA have identified a lipid-protein duo causing massive stem cell death during brain development, but also hinting at potential recovery mechanisms for devastating diseases like Alzheimer's and Parkinson's. The study reveals that this 'deadly couple' leads to the survival of cells destined to form neurons.
A study in Japan found that consuming raw Japanese deer meat may transmit Hepatitis E virus (HEV), a rare liver disease. The infected deer meat tested positive for HEV RNA, suggesting an animal route of transmission. This discovery adds the Sika deer to the list of foods with a risk of transmitting HEV.
Researchers have developed a DNA-based test to accurately distinguish great white sharks from other species, even when only dried fins or meat are available. This new test will help conservationists and fisheries managers better regulate and protect great whites, a species that has declined by up to 79% in the northwestern Atlantic.
Max Planck researchers found that reducing SK3 channel production in the hippocampus of aged mice prevented learning and memory deficits. The study provides new insight into the mechanisms of age-related cognitive decline and suggests a potential therapeutic approach.
A new gene expression profile test could identify which breast cancer patients are likely to respond to chemotherapy, helping reduce unproductive treatment and toxicity. The test uses biopsy samples from primary tumors before treatment and measures the tumor's response to docetaxel.
The Salk Institute's latest study, led by Joseph Ecker, provides a detailed map of Arabidopsis genes and their functions. The team has also identified key molecular pathways involved in ethylene gas signaling, which is crucial for plant growth, yield, and drought tolerance.
A study published by the American Sociological Association finds that campaign contributions and lobbying have limited impact on policy, with party lines and ideology playing a greater role. The average PAC donation to candidates is $1,700, which is not enough to win significant influence.
Researchers discover that the HAP1 protein plays a crucial role in brain damage caused by Huntington's disease. The protein's interaction with mutant huntingtin leads to apoptosis in neurons, particularly in the hypothalamus. This finding offers new hope for therapeutic strategies aimed at bolstering HAP1 function.
A recent study confirms oxaliplatin's safety in treating advanced colorectal cancer, with low rates of high-grade gastrointestinal side effects. The treatment regimen, combined with fluorouracil and leucovorin, showed improved results in patients who had previously failed first-line chemotherapy.
Research reveals that intense atmospheric jets triggered by strong winds can drive convection in the North Atlantic Ocean. This process increases the number of convection sites from two to three, significantly impacting the Atlantic climatic system.
Scientists have inactivated almost three-quarters of all genes in the genome of Arabidopsis thaliana, creating a public database of genome-wide gene mutations. The study provides significant new information on the function of individual and groups of genes.
Peter Lynds' paper challenges assumptions about determined instantaneous physical magnitude and time, proposing a necessary trade-off between precisely determined physical values and continuity through time. He addresses long-standing issues in physics, including cosmology and the role of imaginary time.
Innovation in biomedical research is being stifled by pharmaceutical companies' increased risk aversion. Small biotech firms, often spun off from universities, are taking on more risk to develop new drugs.
Researchers used transgenic mice to study CA4P's effect on choroidal neovascularization, finding it suppressed development and induced partial regression of established CNV. CA4P joins a growing list of drugs with potential as prophylactic agents for retinal and/or choroidal neovascularization.
A research team led by H. Ronald Kaback solved the three-dimensional structure of the bacterial membrane transport protein lacose permease (LacY), shedding light on its mechanism and function. The resulting structure revealed intricate interactions between amino acids, sugars, and protons, providing crucial insights into membrane trans...
A study published in Journal of Bone and Joint Surgery found that lengthening the Achilles tendon can reduce the recurrence of diabetic foot ulcers by up to 75% after seven months. The procedure, which involves stretching the tendon and immobilizing the foot for six weeks, also requires caution to prevent increased stress on the heel.
Scientists discovered protein chromodomains that recognize and bind to specific histone modifications, enabling the regulation of gene expression. This breakthrough could lead to improved treatments for cancer by targeting epigenetic mechanisms.
Researchers can now study specific gene function in Arabidopsis by quickly searching for and ordering genetically modified plants with knocked-out genes. Over 21,700 genes were identified as having been turned off using insertional mutagenesis, representing a significant advancement in understanding plant genome functions.
Anthony Hyman, group leader at Max Planck Institute of Molecular Cell Biology and Genetics, wins prestigious EMBO Gold Medal. His research focuses on microtubules' role in cell division, shedding light on their dynamics and functions.
A report by U of T professors Anthony Doob and Cheryl Webster finds that harsher sentences do not reduce crime, citing the likelihood of apprehension as a key factor. The researchers argue that more resources are needed for social and educational programs to help children and youth thrive in school and prevent crime.
Researchers at The Wistar Institute have discovered a new mechanism for gene silencing that involves multiple enzymes and histone modifications. This discovery could lead to the development of new cancer therapies by re-silencing inappropriately activated genes.
A study by Dr. Joel Ray found that folic acid fortification has no immediate effect on the incidence of Trisomy 21 (Down Syndrome) in Canada. Research suggests that genetic mutations may occur before fetal development, making folic acid supplementation less effective in preventing the condition.
Researchers from Imperial College London and UCLA have visualized the structure of lactose permease, an enzyme in E. coli that pumps lactose into cells. The structure data reveals a possible mechanism of action for this protein family, which plays critical roles in depression, stroke, and diabetes.
The US Navy is developing a powerful free-electron laser that can transmit infrared light for use in ship-defense systems. The laser has the capability of generating extremely short pulses, sub-picosecond pulses, and breaking records for tunable high-average power lasers.
Researchers found that in-car traffic guidance systems cause a temporary increase in accident risk after drivers are informed of traffic congestion and change their routes. However, the accident risk drops significantly when safety measures such as route selection criteria are added to the system.
Research by Richard Mattes and Corinna Alper found that regular peanut consumption reduces the risk of cardiovascular disease without causing significant weight gain. The study involved three trials where participants added peanuts to their diet, with no increase in body weight detected despite adding 500 calories a day.
A recent CDC study reveals that elderly individuals are at a higher risk of severe complications from dengue infection, including hospitalization and hemorrhagic fever. Clinicians must conduct thorough clinical examinations to avoid delayed diagnosis and treatment, which can lead to further complications.
A study by James Lloyd-Smith and colleagues found that hospital-wide infection controls are crucial in preventing disease transmission. The research highlights the importance of general infection control measures over specific precautions for known cases, particularly in developing countries where resources may be limited.
Researchers have successfully expressed a variant of the maize anthranilate synthase (AS) gene in soybean seeds to increase tryptophan content. The modifications aim to improve the nutritional value of soybeans, but further testing is needed to confirm results.
Recent studies highlight the importance of addressing weight concerns without stigmatizing obese patients. The American Thoracic Society Journal reports on innovative approaches to weight loss treatment and sheds light on previously unexplored phenomena such as chimerism in human lung tissue after stem cell transplantation.
MaNIS improves access to natural history specimen data, facilitating conservation hotspot identification, ecosystem change monitoring, disease tracking, invasive species management, and biodiversity studies. The distributed database network provides researchers with millions of specimens' information online.
A NASA scientist has discovered a new species of organism that thrives in a salty, alkaline environment without oxygen. The Spirochaeta americana microorganism can survive in conditions inhospitable to humans and is of great interest to astrobiologists studying the possibility of life on Mars.
Researchers found a strong association between increased hostility and depressive symptoms and elevated IL-6 levels in healthy men. These findings suggest that psychological factors may contribute to the development of heart disease through inflammation. Further studies are underway to investigate this relationship in women.
Researchers have created a triple-transgenic mouse that exhibits both plaque and tangle lesions, allowing them to study the relationship between the two and develop drugs targeting both. This model could lead to a single class of drugs for treating both inherited and sporadic forms of Alzheimer's disease.
Johns Hopkins researchers found deformation twinning in nanocrystalline aluminum, explaining how it deforms under high loads. This discovery will help build models to predict the performance of these materials in real-world devices.
Researchers found an inverse relationship between Pin1 abundance and degenerative damage susceptibility. Pin1-deficient mice developed a neurodegenerative disease similar to Alzheimer's, highlighting the protein's role in regulating proteins critical for cell division.
Researchers at UCLA created a 30-cm diameter plasma laser by applying a nonuniform magnetic field. Meanwhile, scientists have made rapid advances in detecting dark matter using weak gravitational lensing experiments. A paper also examines the emerging behavior of complex systems in electronic bidding on online auction sites like eBay.
The Binding Interface Database is an extensive, searchable internet site that brings together all known information on protein interactions. The database currently contains 245 interacting protein pairs and over 1,500 key interaction areas, providing a valuable resource for researchers to study complex biological systems.
Researchers have identified a system in a mutant arabidopsis that signals cells to pause during stressful situations, allowing plants to regulate themselves and adjust before growth resumes. This discovery may lead to breeding plants with improved stress handling techniques and enhanced drought tolerance.
A new study published in the New England Journal of Medicine found that paricalcitol, a newer vitamin D formulation, has a significant impact on improving survival rates among dialysis patients. The study showed a 16% better survival rate for patients taking paricalcitol compared to those taking calcitriol.
A recent study by North Carolina State University researchers found that a gene variant in the Dopa decarboxylase enzyme is associated with variation in fruit fly lifespan. The study's results suggest that this genetic variation may also play a role in human longevity, with potential implications for pharmacological interventions to im...
A study published in the journal AIDS found that HAART therapy can significantly prolong survival for AIDS patients with central nervous system lymphoma, with median survival of at least 22 months. This is a significant finding, as previously diagnosed patients had only a few weeks to months after diagnosis.
A recent study suggests that rising ozone levels could lead to a significant loss of $21 million annually in US soybean production over the next 30 years. Researchers found that soybeans suffer from reduced photosynthesis and biomass, resulting in fewer seeds and pods, and decreased seed weight.
A three-year study of 193 healthy older adults found that social environment, including home and family, was the most important factor in determining quality of life. Good mental faculties and personal optimism also played a significant role.
Researchers found that top managers skillfully manipulate director selection to create an image of board independence while retaining a supportive board that seldom challenges their decisions. The study suggests giving stockholders more direct representation on boards to prevent corporate fraud and deception.
A boy was diagnosed with acquired osteopetrosis after being given high doses of bisphosphonates to treat weak, painful bones. The condition results from excessive bone formation and can lead to fractures., Researchers emphasize the importance of carefully monitoring medications like bisphosphonates, especially in children.
Transgenic rice seeds expressing a thermotolerant and bi-functional starch hydrolase produce high-protein flour and sugar syrups. The unique feature of heat-activated rapid autodrolysis eliminates the need for commercial enzymes, improving efficiency and production cost.
The Protein Data Bank has released the three-dimensional structure of the SARS virus protease, which will accelerate the search for effective treatments. The rapid processing enabled by PDB's technology will enable more efficient paths to developing drugs for treating SARS.
This study found that elevated tropospheric ozone concentrations inhibit photosynthesis in soybeans, leading to decreased growth and yield. The results suggest a potential annual loss of $21 million for the US soybean industry based on current production levels.
Researchers have found that the enzyme Pin1 plays a crucial role in protecting neurons from age-related degeneration and tangle formation in Alzheimer's patients. By understanding how Pin1 works, scientists hope to develop new therapies to prevent or slow down neurodegenerative processes.
A study by Taiwanese researchers found that swimming exercises can improve bone density and mechanical properties in growing rats, similar to weight-bearing exercise. However, the benefits of non-weight-bearing exercises like swimming on long bone biomechanical properties were not significant.
Self-referred whole-body CT scanning has grown rapidly, with 88 imaging centers nationwide and prices ranging from $795 to $1,215. Researchers caution that the technology's effectiveness is uncertain and potential risks include radiation exposure and false-positive results.
A study of college smokers found that many reported feeling 'invulnerable' to the negative health effects of smoking, despite recognizing general risks. The survey also revealed that these smokers often underestimate their own personal risk and may not associate certain respiratory problems with smoking.