Researchers at Purdue University have successfully crystallized a fat-soluble protein using a synthetic detergent and synthetic fat, overcoming a 20-year hurdle. This breakthrough could lead to significant advances in understanding diseases by studying the structure of these proteins.
A study found that pediatricians prescribe medication for pediatric insomnia more frequently than previously thought. The likelihood of prescribing medication is higher in children with ADHD and special needs. Behavioral therapy or failed treatments are often combined with sleep medications.
The study found that voice recognition technology has reduced report time turnaround from 133 hours to 66 hours, with preliminary reports available within 14 hours. However, technical issues such as freezing and interfacing problems with RIS systems have led to decreased productivity and satisfaction among radiologists.
Children from lower-income families are more likely to have access to vision care, while those from higher-income families face barriers due to private insurance or lack of coverage. Cultural and social factors also play a role in disparities in eye care services.
A recent study found that people with atopic dermatitis or eczema, and their household contacts, are at increased risk of complications from smallpox vaccination. The study suggests that the screening process may not be effective in identifying individuals who should not receive the vaccine.
A new study found that violent music lyrics can increase aggressive thoughts and feelings in college students, even when humorous lyrics are used. The research controlled for factors such as individual personality differences and musical style, suggesting a potential link between exposure to violent content and aggression.
A combination of celecoxib and a common cream used to treat nonmelanoma skin cancer was found to be up to 35% more effective in reducing skin tumors than using the cream alone. The researchers hope to reduce side effects while increasing efficacy by exploring different treatment regimens.
Researchers at Children's Hospital of Philadelphia and University of Pennsylvania have successfully delivered RNA payloads to immune cells called CD40-activated B cells, which stimulated the production of cytotoxic T lymphocytes. This finding could form the basis for a cancer vaccine that stimulates the body's existing immune system.
Researchers at Brenner Children's Hospital have developed a new gene therapy technology that uses highly efficient protein delivery to correct mitochondrial defects. This approach has the potential to prevent or treat genetic diseases like SIDS and TFP deficiency in infants, as well as heart and brain diseases later in life.
Researchers at Cardiff University have discovered a gene, MBD2, essential for bowel cancer cells to grow but dispensable in normal cells. This finding suggests that drugs targeting MBD2 could prevent human bowel cancer without harming normal cells.
A new study by Cincinnati Children's Hospital Medical Center found that frequent school changes are an independent predictor of behavioral problems in children. The study involved 3,285 children between the ages of 5 and 14, who were more likely to experience behavioral issues if they attended multiple schools.
Children from low-income families have lower birth weights and are shorter in stature than higher-income peers by age one. Proper nutrition through breast milk is crucial for healthy growth, while early introduction of baby food can hinder development.
A recent study conducted at Cincinnati Children's Hospital Medical Center found that approximately one in five mothers who visited the pediatric emergency department or a well-child clinic had depression. The study also revealed that 76% of these mothers reported difficulty caring for their children due to their depressive symptoms.
A new device, Vigilance', has been shown to significantly reduce microbial contamination in neonatal intensive care units, sparing premature infants from infection-causing organisms. The device uses ultraviolet germicidal irradiation and decreased the risk of chronic lung disease and hospital stays.
A recent UB study found that childhood obesity is on the rise, associated with multiple medical consequences including type 2 diabetes. The study suggests that early intervention at preschool level can help prevent obesity-related issues.
A study of pediatric residents found that sleep deprivation significantly impair their ability to drive safely, with difficulty maintaining lane position and speed. Researchers suggest implementing strategies like planned naps and taxi services to mitigate the effects of fatigue on resident safety.
A study by Brown University found that medical residents feel unprepared to break bad news to kids and parents due to inadequate training. The residents ranked their comfort levels in sharing bad news with pediatric patients as lower than with adult patients.
A study found that 40% of children with ADHD responded well to lower doses of medication paired with a placebo, showing equal control over symptoms and fewer side effects. The researchers aim to explore mechanisms and establish clinical applications for this treatment approach.
A Wake Forest researcher has identified a syndrome that causes brain malformations, leading to death in premature infants. The malformations were found using ultrasound and MRI scans during autopsies of premature infants who died soon after birth.
A new mutation, R245X, has been identified as a significant cause of USH1 in the Ashkenazi Jewish population. Early diagnosis through molecular screening can lead to earlier intervention, including cochlear implants and ophthalmologic evaluations, improving the quality of life for affected children.
A growing number of supercities, with over 200 globally, are located near major fault lines and could face devastating earthquakes. The number of fatalities from building collapses during earthquakes has increased four-fold since the 17th century due to urbanization.
Researchers found lasting cognitive deficits in individuals who started smoking marijuana before age 17. Those who began using marijuana at a younger age performed significantly worse on tests assessing verbal functions compared to those who started later or used it sparingly.
A recent study published in the Journal of Developmental and Behavioral Pediatrics suggests that bedwetting may be associated with low socioeconomic status in children. The research found that almost 39% of children with bedwetting problems came from low socioeconomic backgrounds, compared to 23% of non-bedwetters.
Researchers used fruit flies to study how age affects meiosis, a specialized cell division that gives rise to eggs and sperm. The study found that as fruit fly eggs 'age', errors in cell division increase, mirroring the phenomenon in humans, where birth defects like Down syndrome rise with maternal age.
The study found that lobeline decreases METH self-administration without inducing reward, indicating its potential as a useful pharmacological treatment. Lobeline also did not alter METH-induced reinstatement of drug-seeking behavior or affect dopamine levels in the brains of rats.
Scientists from University of Ulster's Geophysics Research Group warn of substantial loss of life possible in Bingol city after Thursday's earthquake, citing increased seismic risk. The team identified two highly stressed areas on the East Anatolian Fault Zone as most likely locations for future large events.
Researchers monitored brain activity in rats to understand how cues contribute to drug relapse. They found that rapid dopamine release occurs in response to cues associated with cocaine, initiating drug-seeking behaviors. This study provides new insights into the neural mechanisms underlying cocaine addiction.
Researchers found that cocaine-exposed mice had significantly larger tumors and higher IL-10 concentrations than saline-treated mice. Administration of anti-IL-10 antibody reversed the tumor growth-promoting effects of sigma ligand agonists.
Researchers found that black infants born in the summer and fall had lower birth weights than those born in the winter and spring. Additionally, early infancy weight gain was significantly lower for black and Puerto Rican infants born during the fall compared to those born in the spring and summer.
Studies suggest atypical antipsychotics like Clozaril and Seroquel may have a protective effect against diabetes in patients with schizophrenia and bipolar disorder. Researchers recommend routine screening for diabetes, hypertension, and obesity in mentally ill patients.
Researchers have discovered a genetic link between specific mutations in the Dnchc1 gene and selective death of motor neurons, causing diseases like ALS. The study provides new insight into the pathogenetic mechanism underlying MND.
Religious leaders and experts discuss the moral standing of human embryos created from mammalian stem cells, citing concerns over personhood and dignity. They argue that traditional views on fertilization and conception are challenged by the possibility of creating life without gametes.
A team of researchers found that the absence of a specific gene, Ink4d, causes progressive hearing loss in mice by triggering the death of sensory hair cells. This finding suggests that humans with similar genetic mutations may be more susceptible to hearing loss due to trauma.
Researchers documented how HIV enters human T cells, where it multiplies and subverts the immune system, using time-lapse microscopy. The study reveals that HIV exploits the dendritic cell's special relationship with T cells to gain entry and launch its assault.
A recent study found that leptin levels dropped significantly during fasting periods, leading to reduced testosterone levels and slowed metabolism. The study also showed that leptin plays a crucial role in regulating the reproductive axis and thyroid function in humans.
Researchers found that wearing surgical masks significantly reduces the risk of SARS transmission for healthcare workers. In contrast, staff members who did not wear masks were more likely to contract the disease despite following other safety protocols.
Researchers at St. Jude Children's Research Hospital have identified a critical role for the gene Prox1 in regulating the development of the retina, ensuring proper formation and organization of complex tissue. The study found that Prox1 directs progenitor cells to stop multiplying, resulting in a precise ratio of horizontal cells to r...
A study by Lancaster University found that strong local campaigns significantly increase constituency turnout and results in marginal seats. Campaign intensity was key to Labour's success, with their targeted efforts leading to higher turnouts in target seats.
Researchers at Cedars-Sinai Medical Center found that patients with hereditary BRCA-associated ovarian cancer respond better to chemotherapy, leading to improved survival. The study suggests that platinum-based chemotherapy may be more effective for these patients, and this finding may enable physicians to better plan treatment.
The study reveals that the NF2 gene's protein, merlin, organizes cellular structures facilitating cell-to-cell communication and plays a crucial role in tumor development. Loss of merlin function may contribute to cancer progression and metastasis, providing potential therapeutic targets for NF2-associated cancers.
A study by Makrina Savvidou and colleagues found that impaired placental blood flow precedes pre-eclampsia in pregnant women. Raised concentrations of asymmetric dimethylarginine (ADMA) are strongly associated with reduced arterial dilation and increased risk of pre-eclampsia.
Researchers at Johns Hopkins University warn of automated web forms being exploited for mass unwanted catalogs and postal disruptions. They propose technological fixes to prevent such attacks, including altering online form coding and implementing human verification steps.
A new study using satellite data found a global warming trend of 0.16°F per decade, closer to surface warming and computer-model simulations. The analysis improved upon previous results, accounting for errors in radiation sensor heating and satellite orbit drift.
A study by Brown University researchers found that economic incentives and conservation policies contributed to an increase in forest cover in rural India. The growing demand for forest products was met by planting new trees rather than exploiting existing forests.
A new study published in The Lancet found that a high-fibre diet was associated with a lower risk of colorectal adenoma and colon cancer. Participants who consumed the most fibre had a 25% lower risk of developing adenoma compared to those who consumed less fibre.
A new early-warning system designed for southern California could give people up to 40 seconds of advanced notice of major earthquakes, allowing them to take shelter or evacuate. The system uses low-energy P-waves that travel faster than damaging S-waves and can provide precious seconds to react.
Scientists identify key amino acid sequence responsible for activating GPIIb-IIIa molecule, a crucial component of platelet function. This discovery provides new insights into how integrins on cells throughout the body may function.
A new study found that antibodies in female mice attached to their babies' cells stimulate a T-cell response, leading to ovarian destruction and inflammation. The researchers suggest that exposure to the mother's antibody during critical periods of development is crucial for avoiding autoimmune disease.
Researchers found that seal pups can recognize their mothers' calls within two to five days after birth, a crucial skill for finding each other among hundreds of fur seals. This quick recognition is essential due to the mother leaving her pup on land while she forages at sea.
A study found that mice genetically engineered to lack a molecule called Stem Cell Antigen-1 (Sca-1) experienced normal bone development but exhibited decreased bone mass and brittle bones as they aged. The researchers believe that defective maintenance of stem cells may contribute to age-related osteoporosis in humans.
Researchers at Purdue University have developed a new diagnostic method that uses a vibration-based technique to test the structural integrity of composite military materials. The method can detect damage caused by small impacts and has been shown to be sensitive enough to detect damage even in areas where other techniques cannot.
The Cornell center will focus on high-energy density plasmas, developing diagnostic devices and studying extreme conditions such as plasma jets and X-pinch point imaging sources. The research aims to create hot, dense plasmas that can produce neutrons associated with nuclear fusion.
The article reports on the release of the first peer-reviewed SARS genome sequence, confirming a new variety of coronavirus and providing insights into the virus's molecular components. The genomic sequence is expected to aid in the diagnosis, treatment, and prevention of SARS.
MIF is a crucial intermediary in uncontrolled inflammation and impaired wound healing. In estrogen-deficient mice, MIF expression increased, leading to excessive inflammation and delayed healing. Therapeutics that inhibit MIF may accelerate wound healing.
Researchers at the University of Pennsylvania have successfully produced mouse eggs from embryonic stem cells outside the body, showcasing their totipotent capabilities. This breakthrough could lead to new methods for producing embryonic stem cells artificially, potentially sidestepping ethical concerns.
Researchers Scott Curtis and Bob Adler found a significant pattern of alternating rainfall for El Niño since 1979. This discovery may help scientists improve rainfall forecasts around the globe during an El Niño event.
A study found that enhanced counseling and support interventions significantly reduced depression symptoms in caregivers, with benefits sustained over a 5-year period. The intervention involved individual and family counseling sessions, as well as ongoing support groups.
A Scripps Institution of Oceanography professor and his colleague revisit the famous Miller experiment to recreate a prebiotic soup that may have been present on early Earth. The report traces the history of the experiment and highlights its significance in transforming the study of life's origin into a respectable field of inquiry.
Researchers found that individuals with at least one copy of the klotho gene variant KL-VS are almost twice as likely to have undetected atherosclerosis. Lifestyle changes can modify this risk, suggesting genetic testing may be considered.
Researchers are studying how our brains perceive and process facial features to understand face recognition. They believe that well-formed and well-known objects like faces are perceived in parallel processing, while difficult patterns may be processed serially.