Researchers stiffened a critical protein 'death domain' to target and destroy leukemia cells, showing promise for novel cancer treatments. The approach uses natural sequences to develop highly specific drugs, potentially unlocking new therapies.
Giles is a leading researcher in computational science, focusing on high-performance parallel computers and algorithm development. His work aims to bridge the digital divide by promoting diversity in computing and access to technology.
The Geisel School of Medicine at Dartmouth calls for national collaboration on medical education research to establish evidence-based standards. Researchers propose borrowing models from patient care studies, using epidemiology and observational strategies to improve teaching methods.
A study published in Physical Review E found that a loss of just 2% of US power grid substations can cause catastrophic failure. Researchers identified high-load transmission substations as critical points, emphasizing the need for increased redundancy and distributed generation.
Researchers have identified stem cells in skin that can self-renew and differentiate into multiple cell types, offering new insights into regenerative medicine. The discovery holds promise for treating hair loss and wound healing.
Researchers at Penn State have created a new method to speed up the process of capturing carbon dioxide from combustion gases using serpentine minerals. This innovative approach significantly reduces the time required for sequestration from geologic timescales, making it a promising solution for mitigating climate change.
Researchers have found evidence of a chimp-sized hominid walking upright on two legs in Kenya's Tugen Hills, dating back to 6 million years ago. The fossil shows a thinner neck connecting the ball to the shaft, indicating an early transition to bipedalism.
Researchers discovered that controlling temperature and daylight regulated bulb growth, allowing for flowering and seed production in garlic plants. This breakthrough opens possibilities for genetic diversity, pest resistance, and improved yields.
A five-year head-to-head trial of three common anti-epileptic drugs will enroll 439 children aged two to 13. The study aims to determine the best initial medicine for childhood absence epilepsy, which affects 10-15% of all epilepsy cases in children.
Researchers found that Neanderthals experienced periods of starvation and nutritional stress, but to a lesser extent than modern Inuit who used more advanced technology. Tiny grooves in tooth enamel served as markers of these episodes.
Researchers at the University of Pennsylvania have successfully spun carbon nanotubes into usable fibers using a technique developed by Rice's Richard E. Smalley. The resulting fibers exhibit good mechanical and electrical properties, but modest thermal conductivity.
Researchers isolated stem cells from the bulge of hair follicles in hairless mice, finding two distinct populations that can produce hair follicles. These stem cells also showed 'stemness' genes, indicating their ability to self-renew and differentiate into various cell types.
USC researchers detail process of beak formation in journal Science, identifying BMP4 as a major mediator of beak shape. The study sheds light on how different bird species develop uniquely shaped beaks reflecting their ecological niches.
The Lancet's editorial advocates for animal research to improve human health and develop new medicines, despite potential controversy. The journal emphasizes the need for scientific justification and responsible animal care in experiments.
Researchers find that simple vesicles with genetic material grow and compete for resources, challenging current theory on cell evolution. The study suggests that the presence of RNA is key to driving cellular growth and competition.
Health experts emphasize the need for stronger health systems to achieve improved health outcomes, but agree that a more manageable approach is needed. Disease-specific interventions can deliver quicker results, yet may lead to duplication and disruption, while system-wide approaches build benefits over time, but are less manageable.
Yale researchers found strong clinical evidence to support treating systolic blood pressure of at least 160 mm Hg in older adults. Treatment decisions should prioritize patient preferences and tolerance of therapy due to limited evidence on benefits.
Researchers have discovered a small, Smac-like molecule that can encourage the death of cancer cells without harming normal cells. The compound mimics the natural protein Smac, which normally regulates cell death in healthy cells.
Researchers at Rice University have successfully produced macroscopic single-walled carbon nanotube fibers with high strength and conductivity. The discovery has the potential to revolutionize industries such as aerospace and energy by creating ultra-strong, smart materials.
Researchers analyzed tiny meteorite grains to determine the formation of aluminum oxide in AGB stars. The study found that both crystalline and amorphous forms are produced, clarifying observations and refining condensation modeling.
Researchers observe supersolid behavior in solid helium-4, where a small fraction of atoms exhibit zero friction and nonclassical rotational inertia. The discovery challenges the accepted picture of crystalline solid 4-He and forces theorists to revise their understanding of quantum mechanics.
The research project aims to identify tick genes that spread serious illnesses, such as Lyme disease. By analyzing the genome data, scientists hope to develop vaccines to block transmission of microbes that cause tick-borne illnesses.
Researchers developed a novel peptide compound that triggers apoptosis in cancer cells, overcoming key obstacles associated with short peptides. The hydrocarbon-stapled alpha-helix peptide, SAHB, is more resistant to degradation and can be taken up by cells, making it a promising therapeutic agent.
Pulmonary fibrosis occurs when normal lung tissue is replaced with thick scar tissue, impairing oxygen flow. Researchers have discovered that TGF-beta causes apoptosis in epithelial cells before fibrosis develops, paving the way for potential treatments by blocking cell death.
A rapid review of the Atkins diet suggests that it can lead to significant weight loss in the short-term, with individuals on the low-carbohydrate diet losing more weight than those on an energy-restricted low-fat diet. However, long-term effects and potential health risks remain uncertain, highlighting the need for further research.