The study reveals two molecular pathways controlling the organization of the nucleolus, a critical organelle that manufactures ribosomes, and heterochromatin, which mediates gene silencing. These findings have implications for understanding genome stability and its relation to human disorders like birth defects and cancer.
Scientists have identified nine new genetic mutations in cancer cells that make patients more likely to respond to bortezomib, a common multiple myeloma treatment. These findings may help physicians tailor treatment to individual patients, increasing the effectiveness of the drug.
A novel regimen of three chemotherapy drugs resulted in a significant clinical response in patients with previously untreated chronic lymphocytic leukemia (CLL). The treatment showed promise for high-risk patients, with no age restrictions, and minimal side effects.
A Pittsburgh-based research team has created an innovative ink-jet system to print bio-inks that direct muscle-derived stem cells to differentiate into both muscle and bone cells. This technology could revolutionize the design of replacement body tissues, benefiting millions of people with damaged tissues due to various conditions.
A genome-scale map of genetic variation in the malaria parasite has been completed, revealing nearly 47,000 specific genetic differences among parasites worldwide. This study provides a critical foundation for dissecting the functions of important parasite genes and tracing the global spread of malaria.
A massive effort to sequence and compare complete or partial genomes of Plasmodium falciparum has revealed nearly 47,000 genetic variations. This data will help researchers understand the parasite's evolution and study malarial drug resistance. New antigens identified may be potential targets for new therapeutics or vaccines.
A new study found that the loss of PTEN function in glioma cells leads to high levels of B7-H1 expression, making it harder for T-cells to kill cancer cells. This discovery may have implications beyond brain tumors and could affect the effectiveness of emerging therapies.
The Hammersmith Hospitals NHS Trust and Imperial College London have been awarded Biomedical Research Center status, guaranteeing £19.5m annual funding for the next five years. This partnership aims to translate scientific research into benefits for patients, making West London a leading centre for UK biomedical research.
A large study of Australian women found that epidurals during labor and birth are associated with decreased rates of breastfeeding in both the short-term and long-term. Women who had epidurals were more likely to experience difficulty breastfeeding and give up breastfeeding before six months compared to those without analgesia.