A study of 50 patients with treatment-resistant lupus found an overall 5-year survival rate of 84% after autologous hematopoietic stem cell transplantation (HSCT). The longest continuous duration of remission was 7.5 years, with a 2% treatment-related death rate.
A study of 208 patients treated at Bellevue Hospital from 1990 to 2003 found that most had minor injuries, but some suffered severe amputations or died. The researchers identified a pattern between economic downturns and increased subway accidents, suggesting that slowing down trains could reduce the severity of injuries.
Chronic oil pollution has been a long-standing problem along the Atlantic Coast in Brazil, Uruguay and Argentina. Researchers found that Magellanic penguins, appearing in high numbers among oiled seabirds, are particularly affected by the pollution.
Scientists at Tel Aviv University build a system to create plasma fireballs similar to natural ball lightning, providing insight into the phenomenon. Meanwhile, researchers at Purdue University simulate how to make liquids drip from an opening even without gravity's tug, potentially leading to new applications for printing and microsca...
Scientists at Berkeley Lab create porous scaffolding-like material that mimics nacre's structure, exhibiting four times greater strength than current materials. The composite could foster bone tissue regeneration and improve artificial joints.
Minister Gehrer addresses key challenges in European R&D, including the timing of the new Framework Programme and the need for a strategy to stimulate innovation. She also emphasizes the importance of reducing red tape and promoting entrepreneurship and risk-taking through life-long learning.
A recent study found that discontinuing antidepressant medication during pregnancy can lead to a higher risk of depression relapse compared to continuing treatment. The study, which enrolled 201 pregnant women, suggests that women taking antidepressants who anticipate pregnancy should discuss the risks and benefits with their doctors.
A study published by Northwestern Memorial HealthCare found that high-dose chemotherapy and autologous stem cell transplant can result in disease remission and improvement or salvage of residual organ function in the majority of patients with life-threatening lupus. The treatment's lower toxicity rate compared to previous studies may b...
Researchers found that timely diagnosis of diabetes improves blood pressure control, glucose management, and overall health outcomes. Studies also suggest that reengineering primary care practice through practice redesign may be necessary to substantially improve chronic illness care.
Researchers found that STAT1 expression was lower in SCCHN tumors than in normal tissue, and increasing STAT1 expression led to suppressed tumor growth. The study also suggests that STAT1 works as a tumor suppressor for SCCHN cells, but when its expression is lowered, SCCHN tumors grow.
Researchers found that people tend to use apologies and concessions in intimate relationships, while excuses are less effective. The study also revealed that the context of the situation influences the chosen strategy, with serious offenses generating additional apologies and concessions.
New research reveals the Drosophila homolog of the mammalian UNR protein as a co-factor required for SXL-mediated repression of msl-2 translation. This mechanism prevents dosage compensation in female cells, highlighting an essential role for the UNR protein in maintaining sex-specific regulation.
Research found no significant association between hospital case volume and short-term mortality after ovarian cancer surgery. However, patients treated by gynecologic oncologists had the best outcomes and lowest mortality rates. Long-term outcomes were slightly more favorable for high-volume hospitals, but this difference was modest.
A study in South Africa found that implementing a blood safety program, including education and targeted outreach, significantly reduced the prevalence of HIV-1 in blood donations. The program resulted in a 50% decrease in HIV-1 positivity rates over two years.
Researchers found that STAT1 is a critical survival pathway in head and neck cancer, with increased levels leading to diminished and dying cancer cells. Therapeutic strategies to restore its functioning may be beneficial for patients, potentially improving treatment outcomes and survival rates.
A new study using bone SPECT test shows that the test can identify patients with lower back pain who would benefit from facet joint injections, leading to significant pain reduction and cost savings. The test can help doctors avoid unnecessary injections in patients who may not respond well to them.
African remains found in Campeche, Mexico, provide earliest physical link between the African Diaspora and the New World. The discovery, dating back to the late-16th century, sheds light on the early transatlantic slave trade.
Researchers found that early identification of patients who would benefit from non-surgical treatment improved survival rates. The study, published in the Journal of Clinical Oncology, showed a significantly better cure rate when matching the right treatment to the patient's tumor biology.
Scientists found that RNAi machinery plays a role in maintaining telomere length by regulating retrotransposon transposition. Mutations in key components of the system increase telomere element transposition.
Researchers detected lower gray matter density in brains of patients with Type 1 diabetes, associated with poorer glycemic control and depression. The study opens up new approaches to understanding the central nervous system in diabetes.
The five-year data demonstrate long-term efficacy and reliability of MAL-PDT for treating superficial and nodular basal cell carcinomas, with superior cosmesis compared to cryotherapy. The treatment was found to be non-inferior to surgery in relation to initial response rates, but with significantly better cosmetic outcomes.
An undergraduate researcher at Williams College has discovered the specific mechanism mice use to enter torpor, a state that enables them to survive fasting periods. The study found that replacement of epinephrine and adrenaline in the peripheral nervous system determines whether an animal enters torpor.
University of Illinois researchers Gustavo Gioia and Pinaki Chakraborty explain the behavior, which was previously unknown. The findings provide a new way to calculate friction forces along rough walls.
Researchers use confocal laser scanning microscopy and Raman spectroscopy to analyze ancient microorganisms in Martian rocks, revealing insights into biochemistry and degradation over millions of years. The techniques allow scientists to view fossils in three dimensions, providing new evidence for the search for life on Mars.
A study on rural families in Michigan explores the challenges faced by wage-earning women due to economic restructuring, highlighting the importance of addressing child care needs and increasing access to secure employment with benefits. The research emphasizes the need for new education delivery modes to empower these populations.
In a study published in Biology Letters, researchers found that male monkeys of two species experience a 10% weight gain when their mates are pregnant. This gain is likely due to hormonal changes, including increased prolactin and estrogen levels. The study's findings could provide insights into human fathering behavior and motivate me...
Researchers have developed a new method of lie detection using brain MRI, which can accurately identify deception in 92% of cases. The test measures brain activity, eliminating the limitations of traditional polygraph tests.
A study published in JAMA found that pregnant women with major depression are at a high risk of relapse if they discontinue antidepressant medication. The research highlights the need for accurate information and treatment guidelines to help clinicians make informed decisions about managing depression during pregnancy.
The NYAS China Conference showcased groundbreaking research on chemical biology, infectious diseases, genomic medicine, and neuroscience. Experts discussed innovative approaches to drug development, disease treatment, and brain growth, highlighting the importance of global collaboration.
Researchers found that language affects perception in the right half of the visual field, but not in the left. The study suggests that linguistic differences can sharpen visual distinctions in the right visual field.
Researchers at UCSB discovered a genetic pathway that could lead to new treatments for ADPKD. The polycystin-1 protein plays a key role in the disease, and its inhibition may have beneficial effects. This finding opens up new avenues for drug development.
A new device called DLS-PM measures the quality of blood platelets, allowing for longer storage and improved matching with patients. This innovation has the potential to increase the availability of platelets globally, particularly in crisis situations.
Researchers identified a new gene associated with Charcot-Marie Tooth disease, a rare inherited neurological disorder. This discovery may lead to better understanding of how nerves function and improved diagnostic possibilities for CMT sufferers.
Biobullets, tiny microcapsules that release potassium chloride, have been developed to combat zebra mussels. The new method poses little threat to other marine animals and is faster than existing methods, making it a promising solution to the ongoing problem.
Scientists uncover the final steps of retrotransposon replication, revealing how they integrate into human genomes and contributing to genetic disease and genome expansion. The study sheds light on the mechanism behind the accumulation of millions of 'junk' genes.
Researchers found that sediment-filled basins in subduction zones can strengthen the edge of the plate above, increasing the likelihood of large earthquakes. The Cascadia subduction zone is particularly prone to severe shaking due to its forearc basins, which can be up to 3 miles deep.
A University of Kentucky researcher has identified bioactive fragments of complement C3 and C5 as causal markers of age-related macular degeneration (AMD) progression. These components stimulate the development of wet AMD, and their presence in drusen may indicate high risk for progression.
A study by University of Iowa authors found that consumers have a bias for the whole, preferring larger bills due to processing fluency. This affects their willingness to use smaller bills, as they associate value with larger bills.
A new study reveals that ads comparing two brands are effective when people use analytical processing, but not as effective when they use imagery processing. The authors found that comparative ads provide explicit comparisons among brands and encourage consumers to compare product characteristics across brands.
Researchers found consistent differences between Singaporeans and Americans regarding brand associations, with implications for consumer behavior across diverse cultures. The study highlights the need for more research on the impact of self-view on brand evaluation.
A recent study published in American Journal of Roentgenology found that CT enteroclysis can detect complications like fistulas, abscesses, and tumors superior to conventional enteroclysis. This imaging method also detects minimal mucosal changes, a sign of early stage Crohn's disease, with no disadvantages.
A new study has found that people's eating habits are influenced by their previous meals, with breakfast having the strongest effect. The study suggests that instead of setting daily nutritional goals, focusing on multi-day goals can help individuals approach dinner with a different set of habits and improve overall clarity.
A new web model of influenza-host lifecycles will help scientists understand how the virus interacts with its host, enabling the design of more effective anti-viral drugs. The Reactome database outlines a typical virus life cycle and will be updated as research becomes available.
Researchers found that consumers can be influenced to favor a market leader by altering the order of information. By focusing on whole brands rather than individual features, subjects became more objective and less swayed by early positive information.
A recent study compares the Primary Care Clinician Plan carve-out organization with MassHealth-contracted managed care organizations, finding identical cost per person after adjusting for population differences. The report concludes that the behavioral health carve-out provides good value to Commonwealth and MassHealth members.
Researchers have discovered that CRPS-I patients exhibit reduced small-fiber nerve endings, leading to abnormal neural function and increased sensitivity. The study provides an identified cause for the condition, shifting its classification from 'psychosomatic illness'.
A Rice University student has developed a simple and eco-friendly method to create tiny hollow spheres called microcapsules. This breakthrough is expected to have significant applications in various industries, including medicine and pharmaceuticals.
A new study by Leah D. Whigham and colleagues found that the human adenovirus Ad-37 causes obesity in chickens, while other viruses like Ad-36 and Ad-5 have been linked to human obesity. More research is needed to determine if these viruses contribute to human obesity.
Researchers are working on a three-year €2.5 million project to isolate and expand mesenchymal stem cells from cord blood for use in therapies. The goal is to create viable new medical uses for these stem cells, which could be used to repair bone defects and fractures.
Research shows that a unique brain region acts as an integrative centre, modifying pain sensations when people are thirsty. Elite athletes can push through normal thresholds of pain and thirst due to their ability to balance this 'priority switch',
Researchers found that a one-mile stretch of National Forest significantly reduced chemical pollutants and improved bacterial populations in a stream. The study suggests that undeveloped forest sections can mitigate the effects of urbanization on water quality.
A new report finds that the drug meloxicam is safe for vultures and effective in treating livestock, providing a potential solution to combat diclofenac's devastating effects on vulture populations. The three endangered species of Asian vultures are critically close to extinction due to diclofenac use.
Researchers at the University of Minnesota have discovered post-perovskite in the D'' layer surrounding Earth's core, explaining its unusual seismic properties. This finding sheds new light on the Earth's evolution and aging processes, offering insights into the planet's history.
The study found that infant transplant patients resisted infections despite having low T cell counts, a crucial component in fighting viruses and cancer tumors. This discovery could lead to improved treatments for AIDS, cancers, and diseases of aging related to declining immune function.
Researchers found that different types of negative emotions trigger distinct preferences in decision-making. Anxiety prefers safer options with control, while sadness favors more rewarding and comforting choices. Even when the cause of negative emotions is known, decisions related to that cause can still be affected by the emotions.
Grande-Allen's team aims to identify specific drug therapies for patients with valve disease by recreating conditions such as neurohormone buildup and serotonin levels. The bioreactor will simulate mechanical stimulation and fluid movements found inside a living heart.
Researchers used NASA's TRMM satellite data to analyze temperature changes inside hurricanes, providing clues about storm transformations. The study sheds light on the stages of extra-tropical storms and helps forecasters better understand hurricane development.
Researchers found that shelter dogs with behavioral issues were more likely to be reported as aggressive or fearful when owners believed their responses would be shared with staff. Honest owner assessments can help shelters identify troubled dogs and provide better care for both animals and potential adopters.
Researchers at Argonne's Structural Biology Center have contributed their 1,000th protein structure to the Protein Data Bank, providing insight into cellular behavior, disease origins, and biomolecular interactions. The achievement highlights advances in technology and data analysis.
A common molecular signature of miRNA expression has been identified in solid tumors, providing insight into gene regulation and potential new approaches for diagnosis and treatment. This finding confirms the importance of microRNAs in growth and survival across species.