Lack of key enzyme associated with development of rare tumor
Researchers discovered a link between phosphodiesterase 11A enzyme deficiency and the development of rare tumors in patients with adrenal disorders. The study found four patients with mutant copies of the PDE11A gene, leading to higher levels of cyclic nucleotides that may stimulate tumor growth.
SourceNIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development·JournalNature Genetics·DateJun 11, 2006