Researchers have developed a completely penetrant mouse model of head and neck squamous cell carcinoma, recapitulating the human disease at both pathological and molecular levels. The model enables testing of combinations of targeted therapies and prevention approaches for HNSCC.
A groundbreaking study by OHSU researcher has created the world's first animal model that mimics human head and neck cancer at both pathological and molecular levels. This model enables researchers to screen for novel therapeutic approaches, potentially leading to improved treatment options for this often deadly disease.
A national survey of junior tennis coaches found that over half of parents have a positive influence on their children's development, but more than a third are harmful. Coaches identified excessive focus on winning, unrealistic expectations, and criticising as common problems, scoring them highly in terms of seriousness.
Cardiovascular disease costs UK economy £29 billion a year, with healthcare expenses representing 60% of the total. The largest component was hospital inpatient care, which accounted for nearly two thirds of NHS expenditure on cardiovascular diseases.
Women who balance work and family responsibilities are more likely to report good health, with those who have been home-makers for short periods showing the lowest rates of obesity. Analysis suggests that adopting multiple roles may be a contributing factor to overall well-being rather than a cause of poor health.
Researchers have discovered that frog proteins can rescue mouse embryonic stem cells from dividing without limit, highlighting an ancient mechanism that may hold the key to understanding human disease. The study also shows that mammals have adopted this function from amphibians, suggesting a long history of stem cell regulation.
Researchers at Boston Children's Hospital have isolated a previously unknown molecule called oncomodulin that stimulates axon regeneration in the optic nerve. The discovery offers new possibilities for treating conditions such as glaucoma, stroke, and spinal cord injury.
Researchers discover non-coding RNA transcript Kcnq1ot1 is essential for paternal-specific gene silencing in mice. The study suggests that mammals have co-opted multiple transcriptional regulatory mechanisms to control imprinted genes, supporting the idea that imprinting evolved gradually over time.