A team of Canadian and American researchers has identified the role of SHP-1 in regulating blood glucose levels and insulin sensitivity. The study used genetically modified mice to demonstrate that SHP-1 inhibition can improve glucose metabolism at the liver and muscle levels, potentially leading to new treatments for type 2 diabetes.
Researchers found no link between a fatty diet and an increased risk of skin cancer. In fact, patients who had previously been diagnosed with a skin cancer other than melanoma even had a lower risk of getting a further non-melanoma skin cancer if they reported consuming more fat.
Experts estimate that cost-effective retrofits could reduce energy use in China, India, and Brazil by at least 25%, while advanced technologies could reduce projected CO2 emission growth by 16%. Unlocking today's potential savings requires simple, highly cost-effective renovation projects to identify and eliminate energy waste.
Health researchers across Canada will investigate social determinants of health, ethnic influences on aging, and disparities among Aboriginal peoples, children, rural youth, seniors, and sexual minorities. The research aims to improve the lives of vulnerable Canadians and build stronger communities.
Researchers found correlations between DNA variants in the D4 receptor gene and self-reported sexual desire, arousal, and function. Variants affecting dopamine levels were shown to influence sexual behavior.
A new study by Princeton University researchers found that stocks with easily pronounced names tend to perform better in the short term. The effect was strongest shortly after initial public offerings (IPOs), with fluently named stocks earning up to $333 more than disfluent ones over a year.
Young Bamileke immigrants from Cameroon are using unorthodox methods to become rich, going against the general ethics of their community. The government's reluctance to address 'feymania' is undermining efforts to control corruption and criminality, strengthening the country's negative image abroad.
Researchers have identified over 1400 proteins in liver cells of mice, mapping their locations in ten different compartments. The study's findings show that around 40% of these proteins also appear in other cell organs, suggesting a high degree of conservation across species.
A team of researchers from Munich discovered a cellular mechanism that protects against tumours by controlling the Bcl-3 oncogene. The study identified Cyld as a potential tumour suppressor, which can accumulate around the nucleus and prevent Bcl-3 from entering it.
Youth with bipolar disorder show increased brain activity when rating hostile faces, indicating difficulty processing emotional cues. This finding may help refine diagnosis and understanding of the underlying brain mechanisms.
A Queen's University study discovered a new heterodimer formed by COX-1 and COX-2 enzymes in genetically modified mice. This finding may impact the development of alternative anti-inflammatory drugs, potentially reducing cardiovascular risks associated with existing pain medications.
Researchers have discovered a promising drug target, LipB, essential for M. tuberculosis survival and replication. The protein's structure has revealed its activity in activating cellular machines driving the bacterium's metabolism.
Scientists find VIAAT enables joint storage of GABA and glycine in vesicles, refuting dogma that GABA release is crucial for nerve cell growth. VIAAT mutant mice develop normally despite GABA and glycine release elimination.
Researchers found that a bacterial parasite, Pasteuria ramosa, produces intermediate levels of virulence to maximize spore production and host fitness. This tradeoff between host and parasite fitness has important implications for public health strategies to contain emerging parasitic diseases.