Researchers at Oklahoma Medical Research Foundation discovered that ApoE4 attaches to a receptor on brain cells, leading to protein fragment formation and cell death. This finding may lead to new pathways for developing Alzheimer's therapeutics.
ConocoPhillips has established a $22.5 million eight-year research program at Iowa State University focused on developing biorenewable fuels technologies, including ethanol and biodiesel from organic materials. The program aims to promote energy diversification and reduce greenhouse gas emissions.
Researchers report on patients who suffered toxic side effects from taking excessive doses of niacin, a common vitamin used to pass urine drug tests. The study warns against this practice due to the risks of liver toxicity, hypoglycemia, and other serious health issues.
A recent study by Dr. Jesús Gómez-Zurita and collaborators found that phytophagous leaf beetles (Chrysomelidae) radiated independently of their host plants, with origins dating back to the late Cretaceous period. This challenges the long-held coevolution hypothesis, suggesting a more complex evolutionary process.
A Chinese online tool for assessing depression has been found to be both accurate and reproducible, offering a potential solution for identifying the growing number of people suffering from depression. The Internet-based Self-assessment Program for Depression (ISP-D) was tested on 579 subjects, revealing that 31% had major depressive d...
The LHC Theory Initiative has announced its first-ever $40,000 graduate fellowship awards to stimulate young talent in particle physics. The recipients, Randall Kelly and Jonathan Walsh, will use the funds to support their research on higher-order corrections and simulation tools.
Researchers at Johns Hopkins have identified a protein required for neighboring cells to fuse and become one super cell. The Solitary protein coordinates the movement of molecular delivery trucks and marks where the cell barrier needs to be broken, directing the building of a delivery road.
A new experimental flu vaccine produced using insect cells has shown promising results in early testing, demonstrating safety and immunogenic response in healthy adults. The vaccine, made using recombinant DNA techniques, offers a potential alternative to traditional egg-based vaccines.
A study found vulnerabilities in premature infants' brains similar to those in mature brains, but also identified a significant difference that suggests different treatments are needed. Damage occurs mainly in white matter, which connects brain regions, and can lead to behavioral problems and developmental delay.
The report estimates that nearly 60% of people with type 2 diabetes have at least one serious health complication, including heart disease, stroke, and chronic kidney disease. Estimated annual healthcare costs for a person with type 2 diabetes complications exceed $10,000.
Researchers found that for people with a specific genetic variant, dietary fat intake was not significantly associated with body mass index (BMI) or risk of obesity. However, consuming monounsaturated fatty acids (MUFAs) like olive oil may help lower the likelihood of obesity in these individuals.
Scientists found strong evidence that a major earthquake can cause a nearly immediate increase in regional volcanic activity. The intensity of two ongoing eruptions on Indonesia's Java Island increased sharply following a powerful earthquake, and the increased activity persisted for about nine days.
Researchers discovered a key gene, NALP1, associated with vitiligo and other autoimmune diseases. The gene controls the innate immune system and may help trigger these conditions.
A recent study failed to validate the association of 85 genetic variants with increased risk for acute coronary syndromes (ACS), including heart attack and angina. The research included 811 patients with ACS, but found no conclusive evidence supporting the use of these gene variants as risk factors in clinical care.
A recent study by University of Missouri-Columbia law professor Philip Peters found that juries often side with doctors over patients in medical malpractice cases. The research suggests that defendants' hired experts are more successful at persuading juries, leading to better outcomes for them.
Researchers discovered that prolonged exposure to antibiotics triggers a genetic response in E. coli, resulting in increased efflux pump activity and altered outer membrane porin protein levels. This study highlights the critical role of genetic adaptation in antibiotic resistance.
Scientists from Wake Forest University School of Medicine found that stress hormone epinephrine can cause changes in prostate and breast cancer cells, making them resistant to cell death. This link between stress and cancer has been suggested but previously unexplored, with potential implications for patients and researchers.
FSU is leading a collaborative project to create high-resolution digital images of 100,000 plant specimens from the East Gulf Coastal Plain. The project aims to enhance biodiversity documentation and provide online access to botanical information.
Ancient farmers in Mexico cultivated early forms of maize around 5,300 B.C., 1,200 years earlier than previously thought. This finding expands knowledge on the transition to agriculture in Mesoamerica and sheds light on the rise of complex societies.
The Indian biotech sector is poised to revolutionize the industry with its innovative products, strategies, and manufacturing capabilities. The sector has already made significant impacts on drug prices, reducing costs by up to 90% for some generic biopharmaceuticals.
Researchers propose two models to study social science aspects of malaria in pregnancy, considering factors in prevention and treatment. The models aim to improve malaria control and prevention strategies during pregnancy.
A significant number of Canadian-educated physicians practice in the US, contributing to the shortage. Practitioners from rural areas could alleviate shortages by returning to Canada.
Researchers at Mount Sinai School of Medicine have developed a new imaging technology using multi-detector computed tomography (CT) and a novel contrast agent N1177 to detect high-risk plaque. This may help physicians diagnose a heart attack before it occurs, preventing cardiac events.
Researchers found that modified bone marrow cells reduced MS symptoms, nerve damage, and increased tissue debris clearance when injected into mice with EAE at disease peak. The study opens up further research avenues for human multiple sclerosis treatment.
Researchers from the University of Pittsburgh have developed a new approach to online communication called FaceAlive Icons, which uses personalized images to convey emotions. The program allows users to alter their facial expressions and improve personal communication in emails, text messages, and online forums.
Researchers developed a tool to analyze brain folds using computer graphics techniques, providing insights into cortical development. The model may serve as a biomarker for early diagnosis of autism and other neurological diseases.
Researchers are investigating a genetically modified variant of Avian Newcastle disease virus to treat human prostate cancer. The virus is designed to replicate only in the presence of prostate-specific antigen, found exclusively in cancerous cells.
Virginia Tech researcher Patrick Schaumont is developing a methodology to create secure embedded system designs. His goal is to protect sensitive information stored on portable computers, including access codes and high-resolution photographs.
A meta-analysis of 10 previous studies found that consuming cocoa products reduces systolic and diastolic blood pressure, comparable to the effects of blood pressure-lowering medications. However, drinking tea was not associated with a reduction in blood pressure in any of the trials.
A new study has found that calorie-restricted diets with low or high glycemic loads result in comparable long-term weight loss. Participants lost an average of 8% of their original body weight, regardless of diet type, after one year on a 30% calorie-restricted diet.
Researchers at Virginia Tech are developing an instrument to study the chemistry of gases that decompose chemical and biological warfare agents on surfaces. The goal is to predict the fate of these gases on various surfaces, including metal, metal-oxide, and polymeric materials.
A systematic review of studies published over four decades confirms that good doctor-patient communication significantly impacts patient outcomes, including resolution of chronic headaches and improved blood pressure readings. The review highlights the importance of clarifying instructions and checking for understanding to ensure effec...
Researchers found humpback whales migrating up to 8,300 kilometers to warmer waters during winter, with the longest distance recorded at 5,100 miles from Central America to Antarctica. The study validates a long-held assumption about humpback whale migration patterns.
The new technology significantly improves the accuracy of radiologist interpretation by aligning 3D medical images in three-dimensional space. This enables quicker diagnoses and treatment for patients with diseases like cancer, reducing wait time and anxiety.
Researchers at the University of Utah Health have made a significant breakthrough in understanding the origins of synovial sarcoma, a deadly cancer that affects young adults. By engineering mice to develop this cancer, scientists discovered that it originates from muscle cell precursors known as myoblasts.
A detectable PSA level is first indicator of recurrent prostate cancer after radical prostatectomy, with a doubling time of less than three months indicating imminent death from prostate cancer. Patients with longer doubling times are at significant risk for disease recurrence and cancer-specific death.
Researchers at UCSD School of Medicine have identified two variants of the natural tumor suppressor enzyme PHLPP, which control three different disease pathways. The findings suggest that therapies targeting PHLPP1 could improve insulin regulation in diabetes, while therapies targeting PHLPP2 could enhance cell survival in heart and ne...
Researchers found cases of MRSA infectious keratitis following refractive surgery in patients with no known exposure to healthcare facilities. Colonization of MRSA is common, especially among those exposed to healthcare settings.
Researchers analyzed data from 397 adults and children, finding that most asthma flare-ups led to step-up in medication doses. Fewer patients experienced step-down therapy changes when symptoms subsided, highlighting the need for more flexible treatment approaches for asthma patients.
Researchers successfully transplanted a single donor cornea into three patients with different eye conditions, demonstrating the feasibility of customized component corneal transplantation. The procedure allows for optimal use of available donor tissue, particularly in countries with limited quality and quantity of donor corneas.
The invasive grass Microstegium vimineum can impede the regeneration of woody species in southern US forests by blocking sunlight and seeds. Researchers found that M. vimineum biomass increased significantly after forest canopy disturbances, leading to a decline in native species richness.
Researchers at the University of Illinois Chicago found that knocking down a specific RNA-binding protein can inhibit ovarian tumor cell growth and invasiveness. The study suggests this protein could be a new target for diagnosis or treatment of ovarian and other cancers.
A study by Pittsburgh scientists found that female stem cells have a greater ability to regenerate skeletal muscle tissue than male cells. The researchers isolated female and male muscle-derived stem cells and tested their regenerative capabilities in dystrophic mice. Female stem cells were more efficient at regenerating skeletal muscl...
A new study published in Forest Ecology and Management found that logging after a wildfire can lead to high fuel accumulation, regardless of whether the site is logged or unlogged. The research showed that logging residue contributed to four times more fine fuels on the ground, while logging caused fewer snags and large woody debris.
A new study found that doctors are treating patients with early symptoms of a heart attack with the same level of urgency as those with later-confirmed cases. This suggests that doctors are using alternative data sources, such as patient history and electrocardiogram results, to make treatment decisions.
The new guidelines recommend measuring waist circumference in all adults to assess risk of cardiovascular disease and diabetes. Health professionals are advised to incorporate this measurement into their toolkit for managing overweight and obese patients.
A recent study by Drs. John Ioannidis and Thomas Trikalinos found that many meta-analyses employ asymmetry tests to detect publication bias, but these tests are often not statistically valid. As a result, the findings of these meta-analyses may be misleading or incorrect.
Researchers create combination proteins that trigger a stronger immune response against Lyme disease, potentially leading to more effective vaccines. The new proteins can also be used as diagnostic reagents to distinguish between disease-causing and harmless strains of bacteria.
The Scripps Research Institute study provides new evidence that Nod1, a key player in the human immune system, shares similarities with plant Resistance proteins. These proteins protect plants from various pathogens, revealing a common regulatory pathway between humans and plants.
Dr. Yueh-Lin Loo at the University of Texas at Austin has developed a plastic with changeable conductivity, which can be altered during manufacturing to meet the needs of future electronic devices. This breakthrough could lead to flexible, inexpensive wiring in products such as military camouflage and foldable electronic displays.
The article examines the definition of pedophilia, characteristics of offenders, recidivism rates, and potential treatments. Researchers discuss how to determine pedophilic behavior and the impact of mandatory reporting laws on victims and abusers.
A recent study found that one-third of ovarian cancer patients in the US fail to receive recommended comprehensive surgical treatment. Factors associated with undertreatment include age, race, and insurance status. The study highlights the need for increased access to specialized care from gynecologic oncologists.
Researchers discovered that a single adenine deletion in a bacterial promoter can lead to reduced heat-shock gene expression in aphids, affecting their tolerance to high temperatures. This mutation appears to confer a selective advantage under cooler conditions, allowing it to be maintained in populations.
A new study found that Hispanic women are diagnosed with more advanced and aggressive breast cancers at a significantly younger age than non-Hispanic women, even when controlling for healthcare access. The research suggests that biological or genetic factors may be driving these racial differences in disease presentation.
A Cornell University study found that graduate students ate 27% less chicken wings when they could see leftover bones accumulating on their table, compared to tables where food was cleared. The study suggests using environmental cues like empty glasses or bottles to curb overeating and overdrinking at social gatherings.
A study found that people who smoked and drank coffee were less likely to develop Parkinson's disease, which may be due to genetic or environmental factors. However, the risks of smoking and caffeine consumption should not be taken to avoid the disease.
Researchers at Jefferson University identified a protein called Akt1 that plays a crucial role in helping breast cancer cells spread. The finding could lead to the development of new drugs targeting this protein, potentially slowing or stopping the growth and progression of breast cancer.
A study of 2,000 US physicians found that two-thirds believe experiencing illness increases patients' awareness of religion and spirituality issues. Most physicians (85%) believe the influence of religion and spirituality is generally positive, but few think it changes medical outcomes.
Patients undergoing minimally invasive lung cancer surgery experience shorter hospital stays and accelerated recovery times compared to traditional open surgery. This approach also improves chemotherapy delivery, reducing delays and increasing treatment efficacy.
A new study suggests that tropical rainforests are crucial in slowing down global warming, while planting trees in mid- and high-latitude locations could exacerbate climate change. The research confirms that forests in these regions would not only fail to mitigate the effects of global warming but also potentially increase temperatures.