Researchers produced human cardiomyocytes from hESCs using a sequential, directed differentiation protocol that did not rely on serum or feeder cells. Echocardiography showed attenuation of left-ventricular end-diastolic and end-systolic diameters in animals receiving cardiomyocytes compared to control groups.
A new nasal spray treatment has been shown to be safe and effective in rapidly treating cluster headaches, considered the most painful type of headache. The study involved 52 people with cluster headaches who used zolmitriptan nasal spray or placebo to treat 151 separate attacks.
Researchers compared gene expression in the frontal cortex of cirrhotic and non-cirrhotic alcoholics, finding widespread effects on cellular pathways related to cirrhosis. This suggests that heavy drinking can cause more brain damage in individuals with liver scarring.
A six-year study of almost 35,000 children reveals no change in developmental levels despite new early years initiatives. The research highlights the need for high-quality evidence-based policy implementation and monitoring.
Researchers at George Mason University found that zinc deposits are hallmarks of age-related macular degeneration (AMD), a condition affecting millions of Americans. The study suggests that excessive zinc intake may contribute to AMD progression.
Researchers at the University of Helsinki discovered that tightly organized epithelial cells can suppress malignant cell proliferation, with a focus on the LKB1 tumor suppressor gene. The study found that epithelial cells lacking LKB1 protein form disorganized structures enabling cancer genes to drive proliferation.
A growing trend in oropharyngeal cancers is attributed to HPV infection, especially in younger males. This emerging epidemic warrants the exploration of HPV vaccine efficacy and safety in male populations.
A study published in the journal Immunity reveals that a toxin released by bacteria causes severe bleeding in the lungs, making infections deadly. The discovery provides a better understanding of what makes major global bacterial infections deadly and may lead to new treatments.
Researchers find Apert's syndrome is perpetuated due to mutant cells out-replicating normal cells in testes, leading to higher transmission rates. The single base-pair mutation occurs at a frequency 100-1000 times higher than predicted standard mutation rate.
Researchers found that HIV reduced population growth in worst-affected areas by two-thirds, but the overall population continues to grow, with a higher crude death rate and lower birth rate in the presence of HIV.
Scientists discovered that genetic variations do not negatively affect the efficacy of fluvastatin in renal transplant patients. Additionally, researchers created synthetic lipids called pseudoceramides to treat skin diseases and found them to significantly increase protein production when skin cells differentiate.
A new study found that 1 in 20 North Carolina men who have sex with men reported using crystal methamphetamine, increasing the risk of spreading HIV and other STDs. Meth use is associated with inconsistent condom use, STD infection, HIV positivity, and erectile dysfunction treatment.
A survey of 25,000 WTC rescue and recovery workers found a 3.6% rate of new asthma, 12 times higher than expected for the adult population. Respirator use was associated with lower rates of newly diagnosed asthma, but not all worker groups showed significant protection.
Astronomers have used XMM-Newton and Suzaku to measure the diameters and masses of neutron stars, confirming Einstein's predicted distortion of space-time. The technique involves observing the iron lines produced by hot atoms swirling around neutron stars.
Long-term memory retrieval in abstinent alcoholics shows lower brain activity in key regions, indicating latent lesions or subclinical pathology. This suggests that brain damages from alcohol use can occur without apparent cognitive impairments.
Researchers have cloned a novel aluminum-tolerant gene in sorghum, providing insights into how specialized proteins can boost aluminum tolerance in crops. The new genetically-engineered sorghum lines are expected to increase food production on marginal soils in developing countries.
New research from UCLA finds that fireproofing homes dramatically reduces the spread of forest fires. By fireproofing not just their own homes but also those of their neighbors, individuals can help limit the damage and preserve entire neighborhoods.
The technology produces hydrogen by adding water to an alloy of aluminum and gallium, with the gallium component hindering the formation of an oxide skin that prevents oxygen from reacting with aluminum. This allows for the reaction to continue until all the aluminum is used to generate hydrogen on demand.
Research suggests that human testes can multiply mutations, making it easier for disease-causing genes to be passed to offspring. This phenomenon could explain why certain genetic disorders, such as Apert syndrome, occur more frequently than expected.
A research team has found ancient bacteria with active and living DNA, marking the oldest finding of organisms containing life on Earth. The discovery sheds light on cell aging and regeneration processes.
The American Chemical Society presents groundbreaking research on the biotechnology of health and wellness, including a study that reveals 'good' cholesterol can be bad for the heart. Additionally, scientists uncover new information about HDL cholesterol's protein composition, which could lead to more accurate lab tests and life-saving...
Scientists detected a long-term increase in tropical rainfall, with the rainiest years since 2001. The increase is attributed to a warming trend, which enhances evaporation and allows more moisture to form clouds.
Dr. Svetlana Sukhishvili has been awarded a National Science Foundation grant to direct the 'Materials World Network' project. The project will collaborate with researchers from Moscow and Stevens Institute of Technology to develop responsive micelles at surfaces.
Researchers find that HSP 90 inhibitors can degrade proteins perpetuating inflammation, restoring lung function and reducing blood vessel leakage in ICU patients. The study suggests a potential new treatment for sepsis using these cancer-fighting compounds.
A research letter investigates the feasibility of self-collected HPV specimens for testing among women at high risk of cervical cancer. The study found that outreach nurses were able to recontact 81.4% of participants who tested positive and referred them for further testing.
Researchers at University of Pennsylvania devise nanoscale system to observe how individual cells react to external forces. The study shows that cells respond to outside forces and demonstrate a remote response from the cell’s internal forces., The findings prove useful for understanding tissue growth, function, and disease.
Scientists have created a new theory on how to create transistors for quantum computers using photons. The transistors can process optical signals and enable the development of supercomputers that can solve extremely complicated tasks.
Researchers developed a method to create cardiac muscle cells from embryonic stem cells, which then survived and thrived in damaged rat hearts. The treatment showed promise in improving heart function and thickness of walls after a heart attack.
The new guidelines aim to reduce ambiguity and capture necessary information from experiments to provide a deeper level of understanding. They have been implemented in public repositories such as ArrayExpress, IntAct, and PRIDE, enabling easier identification and use of relevant data.
Researchers identified a protein signal that prevents neural stem cells from becoming neurons, shedding light on the maturation process of stem cells. The discovery could simplify stem cell isolation and potentially have implications for treating nervous system damage.
A new UCLA study found that women exposed to high levels of air pollution in Los Angeles County were more likely to have preterm babies. The research, which analyzed data from over 2,500 births in 2003, controlled for other risk factors and found a significant link between air pollution exposure and increased preterm birth rates.
A study by Cardiff University scientists suggests that human activities such as deforestation and poaching are driving the decline of the giant panda population. The research finds that conservation efforts should focus on habitat restoration and protection to ensure the species' survival.
Scientists at Einstein College of Medicine have discovered the secret behind people living to 100 or more: favorable “longevity” genes that protect against disease-causing genes. The novel method used by researchers could lead to new drugs to protect against age-related diseases, including cardiovascular disease and diabetes.
The Los Angeles basin has entered a relatively quiet period of seismic activity, with smaller and less frequent earthquakes reported over the past thousand years. The study's findings suggest that seismic clusters in the Mojave Desert alternate with periods of calm in the urban fault network.
Researchers found that rhesus macaques increase grunts and girneys when interacting with babies, suggesting a way for females to elicit attention and encourage behavior in infants. These vocalizations may also facilitate interactions between females with babies, promoting social tolerance.
Scientists have developed algorithms to enable the 19 individual mirrors of NASA's James Webb Space Telescope to function as one telescope, allowing for sharper images and detection of distant galaxies. The 'Wavefront Sensing and Controls' system was tested successfully on a scale model and through computer simulations.
Oklahoma State University has received $1.5M in NSF grants to acquire two new instruments: a field emission environmental scanning electron microscope and an LTQ mass spectrometer. These instruments will enhance research capabilities in areas of interest to industry, government, and other universities.
Researchers at Rice University have developed a way to package radioactive particles inside DNA-sized carbon tubes to target tiny tumors. The alpha-emitting nanocapsules are designed to deliver a single, direct hit to cancer cells, making them potentially more effective than traditional beta-particle radiation.
Associate Professor Jennie Ching-I Tsao of the UCLA Pediatric Pain Program has been selected as a winner of the Mayday Pain & Society Fellowship. The program provides tools and skills to advocate for better treatment of pain, including media communication and policy engagement. Tsao's research focuses on biopsychosocial models of pain ...
Researchers have created 'pro-chelators' that can selectively bind to potentially destructive forms of iron in the brain, reducing oxidative stress and cell damage associated with these diseases. The iron-binding agents are designed to target only harmful iron species, allowing benign forms to carry out vital functions.
A meta-analysis of 17 studies found that calcium supplementation reduced fracture risk by 24% in individuals with high compliance rates. Vitamin D supplementation also showed significant benefits, with a 16% reduction in bone loss at the spine.
Researchers at Monash University uncover a molecular arms race between bacteria and the human immune system, revealing perforins as key players in defense against bacterial toxins. The discovery could lead to new ways to fight disease, including infectious diseases and transplantation rejection.
Researchers are working on a £18 million project to change the social habits of living cells, which could help fight diseases like cancer and diabetes. By adjusting cell networking, they aim to reduce disease occurrence and improve health outcomes.
PCOS is characterized by multiple health complications, including menstrual dysfunction, infertility, hirsutism, and metabolic syndrome. Research focuses on identifying the primary cause of PCOS, which may be linked to defects in the ovary, hypothalamic-pituitary axis, or abnormal insulin activity.
A long-term study published in The New England Journal of Medicine reveals that bariatric surgery reduces mortality in severely obese patients by 29%. The researchers found that the actual weight loss is less important than the surgery itself in reducing risk, opening up new possibilities for treatment development.
Researchers found that light trucks, including SUVs and minivans, produced 0.5-0.6% more toxic air pollutants than conventional cars in a downtown Baltimore parking garage. The study provides new insights into the health risks of vehicle-related air pollution in urban settings.
The Woods Hole Oceanographic Institution (WHOI) has been awarded a $97.7 million contract to support the development and installation of coastal and global components of the National Science Foundation's Ocean Observatories Initiative (OOI). The partnership includes Scripps Institution of Oceanography and Oregon State University, aimin...
The quality of giant bluefin tuna caught in the Gulf of Maine has declined significantly since the early 1990s, with potential changes in food sources and reproductive patterns. Researchers found that the condition of those fish caught is of much lower quality, with reduced fat content and a leaner appearance.
For the first time since their discovery in 1977, astronomers have observed a Uranus ring crossing and detected significant changes in the rings' arrangement. The observations used advanced telescopes and revealed new details about the fine dust that permeates the rings, including a previously unseen outer ring.
A new study suggests that homosexual civil unions may have existed in France six centuries ago, challenging common assumptions about the history of same-sex relationships. The affrèrement, a medieval legal contract, provided a framework for non-nuclear households and shared characteristics with marriage contracts.
A Carnegie Mellon scientist has developed a new method to characterize large viral particles and proteins using a mass spectrometer. This breakthrough enables researchers to study intact protein complexes in seconds, paving the way for rapid disease diagnosis.
The University of Alaska Fairbanks has received funding for the first phase of the Alaska Region Research Vessel's construction, supporting research in high latitudes and facilitating global ocean science collaborations. The $123-million vessel will be capable of breaking ice up to 2.5 ft thick and accommodate 26 scientists and students.
Researchers found that mice lacking a critical component of the retinal clock exhibit abnormal gene activity and defective electrical responses, but their eyes appear normal. The study suggests that the retina's autonomous circadian clock plays a crucial role in visual processing.
A new study suggests that inhaling nitric oxide during liver transplantation can decrease hospital stay time and improve liver function. The authors found increased levels of nitrite in circulation, which may mediate the beneficial effects of NO inhalation.
Astronomers found a gigantic hole in the Universe, spanning nearly a billion light-years, empty of stars, galaxies, gas, and dark matter. The void's existence was confirmed by studying data from the NRAO VLA Sky Survey, which revealed a significant drop in galaxy count in a region southwest of Orion.
A study found that morbidly obese mice can gain protection against diabetes by consuming excess calories without developing insulin resistance. The key hormone adiponectin plays a crucial role in this process, and its abundance helps store excess fat in the right places.
A study by Andrea Dietrich at the American Chemical Society meeting found that cPVC has a low odor potential, while HDPE had the highest odor production. The researchers also discovered that certain types of plastic piping can leach organic compounds into drinking water.
Researchers at University of Wisconsin-Madison discovered that Viagra significantly boosts the release of key reproductive hormone, offering potential new insights into male fertility and sexual health.
Money illusion refers to the phenomenon where people base their decisions on nominal values rather than real value, leading to irrational behavior in markets. Experimental evidence shows that firms are reluctant to cut prices during deflation due to money illusion, but more willing to increase prices during inflation.
Researchers found that FTY720 prevents disease in mouse models of leukemia caused by the cancer protein BCR-ABL. Nitric oxide inhalation also accelerates restoration of liver function after transplantation, reducing hospital stay times.