A study of postmenopausal women has found that infection with four known gum-disease-causing bacteria is associated with more severe oral bone loss. The two most prevalent pathogens were P. gingivalis and T. forsythensis, found in 15.1% and 37.9% of the participants.
A phase 2 trial found that denosumab reduced the progression of bone erosion in patients with rheumatoid arthritis. The treatment group experienced significant reductions in erosion scores, even as early as six months, compared to the control group.
Recent studies have shed light on the origins and purpose of pride, a complex emotion linked to achievement-oriented ideas like accomplishment and confidence. People who feel authentic pride tend to score high on extraversion and genuine self-esteem.
Two studies identify smoking, low formal education, and glucose tolerance as independent predictors of rheumatoid arthritis. Smoking is associated with a higher risk, while better glucose tolerance is linked to a lower risk, suggesting alternative mechanisms may be at play.
Researchers found that COPD patients exhibit greater arterial stiffness, especially those with osteoporosis. This early sign of aging may contribute to the increased risk of cardiovascular disease in these patients.
The Infectious Diseases Society of America has released a new blueprint to prevent tens of thousands of deaths and illnesses caused by vaccine-preventable diseases. The blueprint aims to improve vaccination rates among adults and adolescents, with a focus on increasing access to vaccines for underserved populations.
Researchers found bone marrow-derived endothelial progenitor cells (EPCs) play a critical role in early stages of tumor progression. Eliminating EPCs stops cancer growth by preventing blood vessel formation.
A long-term study validates Georgia's vehicle emissions inspection program, reducing emissions by half since the late 1970s. Newer fuels and cleaner vehicle models have also contributed to the decline in emissions, making the inspections program a cost-effective solution.
Research at the University of Pittsburgh School of Medicine suggests that chemotherapy must target a subset of cancer stem cells to be effective in treating lung cancers. Cancer stem cells, similar to normal stem cells, can resist multiple drug resistance transporters, making them resistant to conventional therapies.
A study published at EULAR 2007 found that longer-term breastfeeding is associated with a lower risk of developing rheumatoid arthritis in mothers. The study, which involved 136 women with RA and 544 controls, suggested that naturally-induced hormones during breastfeeding may offer protective benefits against the disease.
A content analysis of newspaper stories on organ and tissue donation found 57% positive and 14% negative articles. The most frequently referenced topics were kidneys, post-transplantation health, and the critical shortage of organs.
The UK's escalating waste problem can be tackled by changing buying habits and attitudes to consumption. Social marketing techniques can encourage people to reduce their consumption and lower waste output.
The Damon Runyon Cancer Research Foundation has renewed its investment in young clinical cancer investigators, providing $2.25 million to support the development of their cancer research programs. Five new awardees will receive funding to investigate various types of cancer, including leukemia, lymphoma, and esophageal cancer.
Researchers found that Phaeocystis globosa can change its colony formation based on the presence of nearby grazers, enhancing or suppressing colonies to avoid being eaten. This complex defensive behavior has implications for global climate change, as Phaeocystis blooms play a key role in the carbon cycle.
A new survey of 2,082 nurses found that more than a quarter suffered from insomnia, with significant effects on medication dispensing errors, charting deviations, and falling asleep at work. Despite the impact, only 30% sought professional care to address their insomnia.
Studies demonstrated that ROZEREM did not impair middle-of-the-night balance, mobility or memory performance in patients with chronic insomnia. The medication's unique mechanism of action targets the suprachiasmatic nucleus, which regulates the sleep-wake cycle, and showed no evidence of abuse potential.
Research suggests that consuming three units of alcohol per week may reduce the risk of developing rheumatoid arthritis, with higher doses providing greater protection. Moderate alcohol consumption also appears to counteract the negative effects of smoking and genetic predisposition.
Researchers used genome sequencing to detect rare viral mutations and found that low-frequency resistant HIV strains can lead to premature therapy failure. The study aimed to determine if patients who fail treatment early were initially infected with drug-resistant strains.
A European multinational study showed that tocilizumab improved symptoms in 43.9% and 22% of patients with rheumatoid arthritis, with a 70% improvement observed in over one-fifth, according to the first phase III trial results.
Researchers found that elevated pepsin levels, a marker for gastric aspiration, are associated with acute rejection of lung transplants. Prolonged exposure to stomach fluids may contribute to lung injury and increase the risk of rejection.
Kurt C. Stange has been named an American Cancer Society Clinical Research Professor, a prestigious award recognizing his innovative research on cancer prevention and treatment. The five-year grant will support work to identify emerging models of personalized, integrated care.
Endurance exercise experts recommend limiting fluid intake during prolonged activities to prevent exercise-induced hyponatremia (EAH), a potentially lethal water intoxication. Excess drinking can lead to diluted sodium levels in the blood, posing risk to athletes engaging in 4-hour or longer endurance events.
Researchers developed artificial blood vessels from muscle-derived stem cells and a biodegradable polymer, exhibiting extensive remodeling and blockage-free performance in rat models. The findings have significant implications for treating heart and kidney disorders with 'off-the-shelf' vascular grafts.
Johns Hopkins scientists discovered blood-dwelling proteins CCSA-3 and CCSA-4 that accurately identify colon cancer and precancerous polyps. The researchers were 100% accurate in identifying existing cancers and correctly identified individuals with advanced precancerous polyps, suggesting a potential less invasive screening test.
A retrospective study identified rare drug-resistant HIV variants in blood samples from an earlier clinical trial using ultra-deep sequencing. The findings suggest that even low-level mutations can lead to early treatment failure, highlighting the need for improved resistance testing methods.
The University of Delaware has received a $11 million grant from the NIH to conduct translational research on osteoarthritis, focusing on tissue mechanics and biomechanics. A unique mentoring program will also support women biomedical researchers at UD.
Patients with ankylosing spondylitis who received REMICADE showed significant improvement in spinal mobility and reduced spinal inflammation over two years. This study found that REMICADE-treated patients experienced sustained reductions in spinal inflammation, as detected by magnetic resonance imaging (MRI), compared to placebo group.