A study reveals that genetic differences in Japanese and US patients with non-small cell lung cancer affect how well they respond to chemotherapy drugs like paclitaxel and carboplatin. The research found that specific gene variations, such as CYP3A4 and ERCC2, influence treatment outcomes.
A new study developed a simple marker that allows urologists to identify men at risk for high-grade prostate cancer, even after a negative initial biopsy. This finding could reduce overtreatment and unnecessary biopsies while improving patient outcomes.
A study of 519 patients found no benefit in overall survival from pre-operative chemotherapy for nonsmall cell lung cancer. Neo-adjuvant therapy did result in tumor down-staging and improved response rates, but its use should be targeted towards specific patient subgroups.
A new genomic test can identify specific patterns among thousands of genes to determine the precise pathways that led to lung cancer. Researchers found that tumors with defects in certain pathways responded well to targeted therapy, offering a potential alternative to traditional chemotherapy.
Pazopanib demonstrated high response rates of 27% and stable disease in 46% of patients with advanced renal cell carcinoma (RCC). In ovarian cancer, pazopanib showed biological activity in 41% of evaluable patients. These findings support further investigations into pazopanib's therapeutic potential.
Researchers at Duke University Medical Center found that flaxseed supplementation significantly slows prostate tumor growth in men scheduled for surgery. Flaxseed's omega-3 fatty acids and lignans appear to play a crucial role in halting cancer cell proliferation.
A Phase III study suggests ALIMTA-carboplatin may deliver less toxicity than GEMZAR-carboplatin, offering comparable quality-of-life benefits and survival data. The combination also appears to benefit from a lower toxicity profile.
A Phase II clinical trial at M.D. Anderson Cancer Center found dasatinib achieves complete cytogenetic response in 77-95% of newly diagnosed CML patients, compared to historical data on imatinib. The rapid response rate suggests dasatinib may be more effective as a first-line treatment for CML.
A multicenter Phase II study of enzastaurin as a second- or third-line treatment for NSCLC found a median progression-free survival of 1.9 months and an overall survival rate of 46.3% at 12 months. The most common toxicity was fatigue.
Researchers found that patients with higher levels of protein S-100 in their serum samples had a greater likelihood of melanoma returning after treatment. The study identified S-100 as a potential biomarker for predicting disease recurrence and stratifying patients into those more or less likely to relapse.
A predominantly Western diet high in red meat, fatty foods, refined grains, and desserts is associated with faster cancer recurrence and lower overall survival rate in stage III colon cancer patients. In contrast, a prudent diet rich in fruits, vegetables, poultry, and fish does not significantly influence cancer recurrence or mortality.
The OHSU Cancer Institute study found that sipuleucel-T vaccine slowed the rate of rise of serum PSA in exploratory analyses, but did not significantly delay cancer progression. The treatment also showed a favorable safety profile with common side effects like fatigue and chills.
Researchers have described the function and range of possible mutations of the FANCD2 gene, a key player in Fanconi anemia. The study reveals that FANCD2 patients experience more severe symptoms due to its vital role in genome stability and development, highlighting the need for early diagnosis and treatment.
New evidence from Mexico's Central Balsas valley links crop domestication in the New World to local environmental history. Agriculture originated during a warm, wet period following the last ice age, and its effects on the environment are still evident today.
A blood test detecting tumor-related proteins may help monitor treatment effectiveness and predict cancer recurrence. Patients with low protein levels were more likely to remain in remission, while those with high increases were at higher risk of cancer return.
A survey of over 500 US healthcare centers found that VA hospitals more frequently adopted recommendations for preventing central venous catheter infections, including maximal sterile barrier precautions and chlorhexidine gluconate use. This may be attributed to centralized purchasing and communication within the VA.
Carola Wenk, a UTSA computer science professor, has been awarded a $400,000 NSF grant to study geometric shape handling in theory and practice using GPS technology. She aims to develop real-time traffic estimation and prediction systems for San Antonio.
New research shows that cigarette smoke can cause changes in the DNA sequence of sperm cells, altering the genetic composition of offspring. The study found that male mice exposed to cigarette smoke had higher rates of genetic mutations than non-smoking mice, with the duration of exposure increasing the likelihood of damage.
A new test for diagnosing TB has been developed, offering a quick and simple alternative to existing methods. The test involves taking three sputum samples from a patient over the course of one day, enabling the detection of traces of mycobacterium tuberculosis with high accuracy.
The wild tiger's population has declined by 41% over the past decade due to habitat loss and trade in tiger parts. Successful conservation programs, such as those in India and Nepal, have shown promise in protecting the species.
A recent literature review and formal classification of sleep-related disorders associated with abnormal sexual behaviors and experiences have been published. These disorders, referred to as 'sleepsex' or 'sexsomnia', can cause disturbing and embarrassing symptoms, and may lead to delays in seeking help due to fear of judgment.
A new study finds that people with Alzheimer's disease experience accelerated cognitive decline after being placed in a nursing home. However, those with prior adult day care experience fare better during the transition. The research suggests that experience in day care programs may help prepare individuals for institutional living.
The article highlights protocols for characterizing epigenetic marks in native chromatin, investigating embryogenesis in Xenopus laevis, and cloning techniques. These methods provide insights into gene activity, cellular reprogramming, and disease states.
Researchers are testing an oral insulin capsule taken by mouth once a day to delay or prevent type 1 diabetes in people at risk. The study's goal is to identify ways to rein in the autoimmune attack on beta cells, potentially preventing the disease.
Researchers at Jefferson Medical College found that a natural substance secreted by fat cells can protect blood vessels from inflammation, a factor in heart disease. Harnessing adiponectin's properties may someday help protect against blood vessel damage in patients with obesity and diabetes.
A MU physicist argues that the Lunar Laser Ranging (LLR) technique is not effective in measuring the gravitomagnetic field. The LLR method relies on processing data with two sets of mathematical equations, but it can introduce errors due to gauge freedom and insufficient analytic control.
A community intervention campaign in Herkimer County increased comfort with breastfeeding in public, from 54% to 69% among men and 35% to 46% among women. The project aims to reduce obesity risk in infants through improved cultural acceptance of breastfeeding.
Researchers have discovered six new antitumor compounds that are more effective against cancerous cells while minimizing harm to healthy cells. The study, conducted at the University of Granada, uses a new technique called Microarrays to identify the effects of drugs on genes.
Researchers at St. Jude Children's Research Hospital discovered that cancer cells can increase GAPDH production to counteract the backup self-destruct program CICD, allowing them to survive and thrive. The finding suggests that blocking this enzyme could kill abnormal cells, providing a basis for novel anti-cancer drugs.
A recent study published in the SLEEP journal found that patients with severe obstructive sleep apnea (OSA) who used continuous positive airway pressure (CPAP) for longer periods at night experienced improved daytime functioning and reduced sleepiness. The study, conducted by Dr. Terri E. Weaver, suggests that a greater percentage of p...
A team of biomedical engineers developed a computer model that uses Bayesian math to explain how the brain anticipates new motor skills. The model is based on similar learning patterns in humans and can predict the best ways to teach new movements, potentially helping stroke patients and designing physical therapy regimens.
A nationwide research study is being conducted at Case Western Reserve University School of Medicine to determine the safety and effectiveness of a new smallpox vaccine. The vaccine, IMVAMUNE, contains a weakened form of the live-virus, which may minimize side effects for all individuals, including those with compromised immune systems.
Researchers found that pregnant women's exposure to the flu vaccine stimulates the development of immune cells in their babies. The study used a new technique to detect antigen-specific T cells and showed that B and T cell responses occur in utero following maternal vaccination against influenza.
Researchers developed a smaller gene therapy vector to deliver a radioprotective enzyme systemically, sparing healthy tissue from radiation damage. The minicircle plasmid conferred undiminished radioprotection to cells, suggesting improved treatment outcomes for cancer patients.
Cornell researchers identified a dozen triterpenoids in apple peel with potent anti-proliferative activities against human liver, colon, and breast cancer cells. The compounds may be responsible for the anti-cancer properties of whole apples.
Cornell researchers identified a genetic mutation in orange cauliflower that allows it to hold more beta-carotene, a precursor to vitamin A. This finding may lead to more nutritious staple crops by increasing their ability to store beta-carotene.
A recent study found that a key inflammatory regulator in the brain acts as a protector against Alzheimer's disease, helping to remove toxic clumps called plaques. The research used genetically engineered mice with pinpoint control over inflammation levels, revealing that higher IL-1beta activity actually reduced plaque buildup.
Researchers will identify Alternaria fungus antigens responsible for chronic sinusitis and its link to asthma. The goal is to develop new treatments and understand disease mechanisms.
Researchers employ a module-based systems theory approach to explore the design principles of signal transduction and transport receptors. The study reveals that endocytosis and other receptor/ligand properties can be described by just a few control parameters, including avidity and consumption.
The partnership aims to create programs and provide grants that support tangible improvements in access to and delivery of cancer care, particularly for disparities and clinical trials. The initiative also focuses on solutions to the projected shortfalls of the oncology workforce and addresses the unique needs of cancer survivors.
Dr. Gianni Bonadonna's innovative adjuvant treatment of breast cancer using CMF chemotherapy significantly reduced disease recurrence and death over 30 years. The new Gianni Bonadonna Breast Cancer Award and Fellowship supports emerging researchers in breast cancer, honoring his legacy and impact on the field.
Researchers have identified C-reactive protein (CRP) as a strong indicator of survival for men with advanced prostate cancer. The study found that higher levels of CRP are associated with shorter survival and lower response to chemotherapy.
A Pitt School of Medicine study published in the American Journal of Psychiatry found that adding a medication to a standard treatment regimen for major depressive disorder in the elderly improves chances of recovery. The study showed that recovery rates increased from 40% to 60% when adding a second drug to the treatment.
A retrospective study of 700 patients found that HIV-infected individuals had significantly higher TB relapse rates compared to those without the virus. The study also showed that shorter treatment regimens may lead to more frequent relapses in HIV-infected patients.
Researchers found that nearly 7% of children who didn't drink sugar-sweetened beverages between meals were overweight at 4½ years old, compared to 15.4% of those who consumed them frequently. The American Dietetic Association also issues updated guidelines encouraging environmentally responsible nutrition practices.
Scientists at the University of Liverpool discovered that humans' ability to walk upright developed from ancestors foraging for food in forest tree tops. They found that this trait evolved before walking on all fours on open land, and was later adapted for life on the ground.
Patients with liver cancer undergoing chemotherapy who have high serum levels of hepatitis B virus (HBV) DNA are at risk of developing severe hepatitis, which is associated with poor survival. Researchers found that a pre-chemotherapy HBV viral load above 10^5.65 copies per milliliter was linked to poorer outcomes.
A study published in Aging Cell found that male mice fed a normal diet and NDGA showed significantly longer survival than control mice. However, no significant difference was observed in female mice. The researchers are now conducting further studies to confirm the results and determine the potential of NDGA as an anti-aging agent.
Research shows that police officers outperform community members and students in shoot/no-shoot simulations, with reduced biases against unarmed Black targets. Training improves sensitivity to weapon presence and speed in decision-making.
Researchers found that patients with obstructive sleep apnea (OSA) have higher levels of dead cells from the lining of their blood vessels, which may explain why they are at a higher risk for cardiovascular disease. Treatment with nasal CPAP reduced levels of these cells.
Patients with stage four cancer have less quality sleep, which is linked to functional performance, mental health, and pain status. Poor sleep quality can be a critical factor in cancer treatment, highlighting the need for effective symptom management.
Researchers detected anti-Fluzone antibodies in 40% of cord blood specimens, establishing B and T cell responses to antigens occur in utero following maternal vaccination. This finding has significant implications for understanding when immune responses to environmental exposures begin.
Researchers developed a treatment strategy for hereditary inclusion body myopathy, a rare muscle disease, based on clues from transgenic mice. The approach also may benefit patients with certain kidney disorders.
A team of researchers from Penn State created a viscoelastic mixture that exhibits fluid-like behavior at slow speeds, solid-like behavior at intermediate speeds, and heals itself after tearing. The study provides new insights into how materials switch between these states.
Researchers at UCSC have achieved atomic spectroscopy on a chip, enabling compact and portable applications in laser frequency stabilization and quantum information processing. The technology has potential implications for gas detection sensors and quantum optics experiments.
Scientists have observed paxillin moving from cell surface hubs to the nucleus, highlighting its role in signaling and controlled cell growth. This discovery sheds light on paxillin's interactions with other proteins and its potential involvement in diseases such as cancer.
Two Lilly studies analyzed data from African-American and Hispanic patients with non-small cell lung cancer (NSCLC), suggesting race may not significantly impact treatment efficacy. The studies provided insight into the safety profiles of ALIMTA and GEMZAR in diverse populations, paving the way for further research.
Researchers from NIST, NTT Corp., and Stanford University have set a record for sending 'quantum keys' over a 200-kilometer fiber-optic link. The experiment demonstrated the feasibility of practical inter-city terrestrial quantum communications networks and long-range wireless systems using communication satellites.
The co-infection of HIV and viral hepatitis is a growing concern, with recent studies showing increasing rates of liver disease and related deaths among those with HIV. Hepatologists are discussing the best approaches to treating these patients, including the use of new agents and consideration of liver transplantation.
Researchers found that consuming high amounts of vitamin B6, B12, and folate from food reduced the risk of pancreatic cancer by 59%, 73%, and 81% respectively. In contrast, multivitamin use was associated with a higher risk of developing the disease.