A large multicenter study examined circulating tumor cells in patients with metastatic colorectal cancer, showing their predictive value for survival and cancer progression. Patients with fewer than 3 CTCs had superior median survival times compared to those with detectable CTCs.
A team of researchers discovered a receptor molecule for serotonin plays crucial roles in fear responses to ambiguous stimuli in mice. The hippocampus brain region is involved in processing and assessing value of stimuli, making it easier to interpret situations as threatening.
The drug lapatinib has modest but real activity against brain metastases, shrinking tumors and slowing disease progression in some breast cancer patients. The study's findings suggest that the drug should undergo further testing as a treatment for breast cancer with brain metastases.
Michael R. Zalutsky received the award for his significant contributions to medical science, especially in using molecular targeting to combat cancer. His research has had a substantial impact on therapeutic nuclear medicine and its applications.
Early metabolic imaging with PET accurately identifies patients responding to chemotherapy for esophageal cancer, noting a remarkably favorable outcome for metabolic responders. This study supports the use of PET-response-guided treatment to tailor multimodality therapy based on tumor biology.
A recent study published in Health Psychology by the American Psychological Association found that young adults with a short temper tend to have compromised lung function. Higher levels of general frustration were also associated with statistically significant reductions in pulmonary function among Black and White women, as well as Bla...
Researchers discovered patterns of cellular activity that confer poorer prognoses in younger women with breast cancer, highlighting the need for age-appropriate targeted therapies. The study aims to identify effective treatments targeting these tumor cell activities in premenopausal women.
Researchers found a widening disparity in life expectancy between white and black women with advanced breast cancer, with median survival rates differing by up to 8.8% over the last two decades. Socio-economic factors, such as access to healthcare and treatment options, are suspected to be contributing factors.
Researchers have identified novel genetic mutations linked to hereditary diffuse gastric cancer, which are due to both independent mutational events and common ancestry. The study found that between 30% and 40% of families with a positive family history of gastric cancer will carry germline mutations in the CDH1 gene.
A five-year study found no significant increase in congestive heart failure among women treated with Herceptin and chemotherapy. The research team developed a prediction model to assess individual cardiac risk factors and personalize treatment.
Researchers found vorinostat's anti-cancer activity in patients with recurrent glioblastoma multiforme, with a 15% patient success rate and improved median overall survival. The study aimed to explore the novel application of vorinostat in targeting brain cancer.
A recent study published by researchers at Duke University Medical Center and The University of Texas M. D. Anderson Cancer Center has found that chemotherapy may actually enhance the effectiveness of cancer vaccines used to treat brain tumors. The process by which immune cells regenerate after being wiped out by chemotherapy makes the...
Adding radioimmunotherapy to chemotherapy increased complete response rates for patients with follicular lymphoma, a slow-growing type of non-Hodgkin's lymphoma. Over 90% of study patients responded completely to the treatment, with limited side effects.
A MUHC-led international team has identified the gene LCA5 as the cause of Leber Congenital Amaurosis, a condition affecting 200,000 worldwide. The discovery is part of efforts to fast-track a cure for this disease using gene therapy.
A recent study found that antidepressant sertraline does not improve symptoms or survival in advanced cancer patients without major depression. The researchers concluded that the overmedicalisation of these patients should be avoided, and treatment with sertraline should be reserved for cases with a proven indication.
A small group of Rochester breast cancer survivors experienced major improvements in memory, concentration and learning after taking modafinil for eight weeks. The study suggests the drug could provide relief to those suffering from 'chemo-brain', a persistent side effect of chemotherapy.
A Phase II study has shown that combining chemotherapy drugs with an antiangiogenic agent can significantly delay the spread of tumors in patients with metastatic melanoma. The treatment, which included paclitaxel and carboplatin with bevacizumab, prevented tumor growth for almost six months and improved survival rates.
Researchers developed a new imaging technique that combines functional and anatomical imaging to diagnose coronary artery disease more accurately. This 'synergy' approach uses software to integrate data from SPECT and CT angiography scans, providing clearer pictures of the heart muscle and coronary arteries.
A new study reveals that patients with localized prostate cancer are more likely to receive surgery if they see a urologist, while those who see a radiation oncologist and urologist tend to receive radiation therapy. The study suggests that men should seek a balanced perspective on treatment options from specialists.
Researchers at Mayo Clinic have discovered that low doses of gabapentin substantially reduce hot flashes in patients undergoing anti-hormonal treatment for prostate cancer. The study found that gabapentin reduced the frequency and intensity of hot flashes by up to 46% in men receiving androgen deprivation therapy.
Using metabolic imaging, UCLA researchers found that FLT-PET is a powerful predictor of treatment response and outcome in brain tumor patients. The study showed that FLT-PET imaging was predictive of patients' overall survival, with those who responded to drug treatment living three times as long as those who did not.
Researchers have developed small acoustic heat-engine devices that convert waste heat into sound and then into electricity. The technology shows promise for harnessing solar energy and cooling electronics, with plans to test the devices within a year at military radar facilities and universities.
A Dana-Farber study found that honest prognostic information can actually help parents feel more hopeful, not less. Parents who received extensive prognostic information were also more likely to report feeling hopeful, even when the child's prognosis was poor.
R. Edward Coleman received the award for his contributions to molecular imaging and nuclear medicine practice, particularly in advancing positron emission tomography (PET) for breast cancer, Alzheimer's, and brain tumors. His research has had a significant impact on medicine, and he is recognized as one of the best doctors in America.