Scientists have identified a key component of the body's response to allergens that can be targeted to reduce allergic reactions in mice. The research confirms that p110delta is a crucial player in allergic reactions and offers hope for therapies that target the real causes, not just symptoms.
The strength of spider silk lies in the specific geometric configuration of structural proteins, which have small clusters of weak hydrogen bonds that work cooperatively to resist force and dissipate energy. This structure makes spider silk as strong as steel, despite weaker hydrogen bonds.
A global threat map reveals that every square kilometer of the world's oceans is affected by human activities, with rising ocean temperatures being the most pervasive threat. The study found that almost half of all coral reefs have recently experienced medium- to high-level impacts, highlighting the urgent need for conservation efforts.
Scientists at UEA found intense rainfall events increasing in UK's winter and spring seasons, reversing summer trend. Heavy summer rainfall returns after 1990s decrease, impacting flood risk and extreme weather events.
Research has established Neowater's ability to refine the standard hybridoma production process, leading to enhanced yields of human monoclonal antibodies. The novel nanoparticle-doped water also stimulates new membrane formation, improving cell growth and proliferation rates.
A meta-analysis of 221 datasets found that a 5kg/m2 increase in BMI raises the risk of oesophageal adenocarcinoma, thyroid cancer, colon and kidney cancers in men, and endometrial, gallbladder, and oesophageal adenocarcinoma in women. The study also found stronger associations between increased BMI and colon cancer in men.
A newly sequenced genome reveals insights into the evolution from single-celled life forms to multicellular animals. Choanoflagellates, tiny planktonic organisms, are the closest living relatives of animals and hold key information about human history and the origins of life.
Researchers found a strong correlation between climate and genetic variations influencing metabolic syndrome risk, with some genes associated with cold tolerance having protective effects while others increase disease risk. Climate adaptations may have played a role in the emergence of metabolic disorders.
Researchers developed a new treatment strategy for serious Staph infections by blocking the production of a golden pigment that allows Staph to evade immune cells. The compound, BPH-652, is a cholesterol-lowering agent that targets a similar enzyme in humans.
A new study reveals that increased expression of the protein sFRP-1, an inhibitor of cell signaling through WNT proteins, is responsible for elevated intraocular pressure in individuals with glaucoma. Restoring WNT signaling may offer a novel treatment approach to manage the disease.
UCLA chemists have developed a new class of materials called zeolitic imidazolate frameworks (ZIFs) that can selectively capture carbon dioxide, storing it like a reservoir. ZIFs outperform current porous carbon materials, capturing five times more carbon dioxide and requiring less energy.
A Vanderbilt University team has discovered a protein that blocks the growth of 'staph' bacteria by sopping up manganese and zinc, offering a new way to treat infections. The protein, calprotectin, is naturally produced by immune cells in response to bacterial infections, making it a potential target for therapeutic interventions.
Researchers at IRB Barcelona have discovered a new control mechanism for genetic code translation in bacteria, which differs from humans. This discovery strengthens the theory that the initial genetic code evolved separately in distinct branches of life, highlighting the plasticity and complexity of the genetic code.
Researchers at Saint Louis University find that immune cells with pro-survival proteins accumulate in the bodies of patients with lupus, contributing to disease progression. The team aims to develop a therapy that blocks these proteins to restore balance in the immune system.
Researchers at Stanford Medicine used hypnosis to help doctors diagnose the cause of seizure-like events in children. Eight out of nine cases were found to be non-epileptic, caused by psychological stress, which require a different treatment approach than true epileptic seizures.
A randomized controlled trial found that multiple-dose activated charcoal has no effect on mortality in patients who have poisoned themselves with toxic pesticides or plants. The study involved over 4600 patients and showed no differences in mortality rates between those who received activated charcoal and those who did not.
Researchers found a biomarker that identifies men with a five-fold increased risk of prostate cancer recurrence if their tumors show silencing of the CDH13 gene. The study, which examined DNA methylation changes in 151 research subjects, suggests a potential tool to improve prediction accuracy and inform clinical practice.
The discovery of the double planet system provides crucial evidence for the presence of multiple planet systems similar to our own solar system. The findings suggest that if OGLE-2006-BLG-109L is typical, it is possible that other systems have Jupiter- and Saturn-sized planets.
Researchers have discovered a peptide in scorpion venom that controls chloride channel movement, potentially treating cystic fibrosis. The novel GaTx1 peptide could inhibit CFTR channels, increasing water production and thinning mucus in airway cells.
A new global map tracks human influences on marine ecosystems, revealing that coral reefs are in trouble and few blue spots on the planet are pristine. The study suggests that about 41% of oceans bear a serious human footprint, with areas like the North Sea and Caribbean Sea showing deepest impacts.
Researchers discovered a correlation between pre-treatment biopsy samples and post-treatment positive biopsies in high-risk prostate cancer patients. This information can help doctors tailor radiation treatment to reduce recurrence rates.
A Yale University study suggests that compromised DNA repair processes may lead to widespread mutations and an increased risk of cancer. The research found that the immune system's somatic hypermutation process, which introduces random mutations in B cells' antibody genes, is a key factor in the development of lymphoma.
A 18-month study explores the relationship between environment perception and physical activity in Hispanic fifth graders, examining how moms' views influence child behavior. The UH-PEAK study uses innovative technology to track daily activity and gather data on safe spaces for play.
A preventive nutrition intervention program targeting all children at risk is more effective than a traditional 'recuperative' model in reducing undernutrition. The study found significant differences between the two models, with stunting and wasting lower in preventive communities by 4-6 percentage points.
A new technique developed at Yale School of Medicine promotes rapid bone formation by removing bone marrow and injecting a hormone, offering a promising alternative to current treatments for weakened or fractured bones. The study, conducted in mice, shows that this procedure creates new bone tissue with improved biomechanical properties.
Researchers found that a single PSA test before age 50 can predict advanced prostate cancer up to 25 years later, helping identify high-risk men for targeted screenings. The study analyzed blood samples from over 160 men with advanced prostate cancer and a similar cohort without cancer.
A genetic variant in the Reelin gene significantly increases the risk of developing schizophrenia in women, according to a recent genome-wide association study. The study analyzed DNA from patients with schizophrenia and healthy controls across multiple populations, identifying a common variant that affects women only.
A new model system has enabled scientists to conduct powerful genetic studies directly in the parasite Toxoplasma gondii, leading to a better understanding of its biological processes. This discovery could provide valuable leads on how to stop parasite growth and prevent diseases affecting millions of people.
Research at the University of Leeds shows that humans follow crowds without realizing it, with just 5% of individuals influencing the group's direction. This study has major implications for directing large crowds in disaster scenarios and organizing pedestrian flow in busy areas.
A study by Charlotte Radiology found that single reading of screening mammograms with computer-aided detection (CAD) is more efficient and yields higher sensitivity than double reading. The use of CAD resulted in a lower recall rate compared to double reading, making it an effective alternative for increasing sensitivity.
The NIH and EPA have formed a collaboration to improve the safety testing of chemicals using high-speed screening robots and cells. This new approach aims to generate data more relevant to humans, reduce animal testing, and increase the number of chemicals tested.
Researchers found a single PSA test can predict advanced prostate cancer with high accuracy, allowing for targeted screening and potentially reducing overdiagnosis. The study revealed that men with higher PSA levels are at increased risk of developing advanced cancer, highlighting the potential for early detection to improve outcomes.
A new system of planets has been discovered with striking similarities to our Solar System, revealing giant planets that favour family groups over lone objects. The discovery uses a world-wide net of telescopes and challenges the single-life theory of gas-giant planets.
Studies show that stylasterids, or lace corals, diversified in deep waters before launching successful invasions of shallow water habitats. This contradicts the long-established theory that corals and other marine animals evolved in shallow water.
Researchers have discovered a multi-planet system with two large planets similar to Jupiter and Saturn, suggesting that planetary systems like our own may be common in the Milky Way galaxy. This is the first discovery of its kind, using a new gravitational microlensing technique.
Researchers at Yale University have received a $4 million NIH grant to study new biomarkers for detecting acute kidney injury (AKI) after cardiac surgery. The goal is to develop an earlier and more accurate diagnosis, reducing mortality rates.
Scientists discovered that HOXA11, a homeobox gene, is essential for the development of uterosacral ligaments, which are weakened in women with pelvic organ prolapse. In another study, researchers found that increased expression of the WNT antagonist sFRP-1 contributes to elevated intraocular pressure in glaucoma patients.
A new study provides a global-scale map of human impact on marine ecosystems, revealing 40% of the world's oceans are heavily affected. The research highlights the cumulative effect of activities such as fishing, climate change, and pollution, with some areas experiencing dramatic degradation.
DNA traceability technology requires access to DNA from cloned animals for verification and tracing. IdentiGEN founder Patrick Cunningham advocates for public DNA access to assure consumers about product origins.
Researchers at Rockefeller University have identified a crucial signaling molecule, BMP6, that maintains cross-talk between skin cells controlling hair growth. This finding suggests that dermal papilla cells receive signals from their microenvironment to regulate key genes and features.
Astronomers have discovered a solar system nearly 5,000 light years away with scaled-down versions of Jupiter and Saturn. The planets are similar in size to our own, suggesting that planetary systems like ours may be more common than previously thought.
A new study suggests that smokers may benefit from earlier colon cancer screening due to their increased risk of developing the disease. The research found that current smokers were diagnosed with colon cancer approximately seven years earlier than people who never smoked.
Patients with severe acute pancreatitis who received probiotics had higher mortality rates than those receiving a placebo. The study suggests that probiotics may not be effective in preventing infectious complications and modulating the immune system in these patients.
Researchers at NIH have successfully treated a patient with a rare disorder using cancer drug imatinib, which is also effective against systemic mastocytosis and chronic basophilic leukemia. The study's findings offer new treatment options for patients with these complex conditions.
Neil deGrasse Tyson, director of the Hayden Planetarium, has been recognized for his efforts to popularize science and technology through various outreach initiatives. He will receive the AAAS Public Understanding of Science & Technology Award, which acknowledges his dynamic leadership in engaging the public in science.
A small clinical trial found that rituximab dramatically reduced inflammatory lesions and clinical symptoms in patients with relapsing-remitting MS. The study suggests that therapies targeting B-cells may provide an important treatment strategy for multiple sclerosis.
Robert Watson, a renowned climate scientist, has been recognized for his outstanding contributions to promoting international scientific cooperation. He is being awarded the AAAS International Scientific Cooperation Award for his work on environmental and sustainable development.
Researchers investigate anorthosites as a forgotten source of planetary magnetic anomalies, finding strong signatures of the Earth's magnetic field direction in ancient rocks. Another study proposes that gas hydrates in shallow marine sediments are the dominant source of methane in ice core records. A third study explores the feasibili...
The American Institute of Physics awarded prizes to four winners for their outstanding science writing. Quantum mechanics expert Tim Folger won for his article on the effect of gravity on a speck of dust, while physicist James Trefil received an award for explaining dark matter and dark energy in the universe's future.
Research published by the American Academy of Neurology found that smoking marijuana can have a harmful effect on cognitive skills in people with multiple sclerosis. The study also showed a significant association between marijuana use and emotional problems such as depression and anxiety.
The American Society for Cell Biology (ASCB) is launching a program to support young researcher parents, providing $18,000 'New Scholars' grants to cover childcare expenses during the Annual Meeting. This initiative aims to increase women's participation in science and address family care issues as a barrier to career development.
Researchers using Chandra X-ray Observatory data have reported a possible detection of a binary star system that was later destroyed in a supernova explosion. The new method provides great promise for finding the detailed origin of these cosmic events.
A new five-year study aims to identify modifiable beliefs and behaviors that boost memory performance in middle-aged and older adults. By assessing psychological and physiological pathways, researchers hope to develop effective interventions to reduce distress, impairment, and dependence.
Engineers at the University of Leeds have developed a new device that uses a specially-woven web to assist weak hearts, increasing internal pressure to improve blood flow. The web-based device eliminates the need for life-long drug therapy and reduces the risk of blood clots.
Researchers at Northwestern University found that physical attractiveness is equally important for both men and women, while earning power also plays a significant role. The study suggests that people may not know what they initially value in a romantic partner, leading to discrepancies between stated preferences and actual choices.
Researchers discovered over 100 mutant genes that allow the social amoeba Dictyostelium discoideum to cheat on spore production. This challenge evolutionary theory and suggests a constant battle between 'cheaters' and non-cheaters, with adaptations driving evolution.
A University of Illinois study found that exercise-trained mice had fewer gallstones than sedentary mice, with improved cholesterol levels and increased bile acid solubility. The researchers identified potential mechanisms to explain this link, providing new insights into the benefits of physical activity for reducing gallstone formation.
Researchers at Rhode Island Hospital found that routine screening for carbon monoxide poisoning can detect life-threatening cases in emergency room patients. The study screened over 14,000 patients and identified 11 unexpected cases, highlighting the importance of universal screening to prevent further exposure.
A genome-wide search for social genes has found that Dictyostelium discoideum have more than 100 genes regulating their cooperative behavior. Cheating mutations were identified in over 100 genes, highlighting the complex mechanisms behind social cooperation.
Research suggests that powerful individuals are less receptive to new ideas when they feel confident in their own opinions. Conversely, when made to feel powerless, they pay closer attention and weigh arguments more carefully. By temporarily reducing power, leaders can increase the likelihood of persuasion.