Researchers at M. D. Anderson Cancer Center found that EGFR stabilizes a protein channeling glucose to cancer cells, saving them from starvation. This discovery may require targeting both EGFR's growth-inducing kinase activity and its glucose-related role to effectively treat epithelial cancers.
Researchers discover that myoepithelial cells play a critical role in regulating breast tumor progression and can act as 'gatekeepers' for the transition from in situ to invasive carcinoma. Understanding their pathways may open new avenues for cancer therapy and prevention.
Researchers found that EGFR stabilizes sodium/glucose transporter 1 to maintain adequate glucose levels in cancer cells, preventing autophagic cell death. This study suggests that inhibiting both EGFR-mediated SGLT1 stabilization and EGFR kinase activity may be necessary for eradicating epithelial tumors.
A study published in Functional Ecology reveals that plants producing high-quality pollen have closer relationships with pollinators, which is crucial for the survival of certain bumblebee species. The research found that plants relying on insects for pollination produce pollen with 65% more protein than those not reliant on insects.
A retrospective chart review of 4,000 premature infants found that 50% who received Synagis had lower RSV hospitalization rates than those without the medication. The study's lead author believes physicians' clinical judgment should be relied upon for high-risk patient care.
Breast cancer patients with a history of mood and anxiety disorders are more likely to develop posttraumatic stress disorder (PTSD) after diagnosis. The study found that 16% of breast cancer patients developed PTSD within 18 months of diagnosis, with women having previous mood disorders being over twice as likely to develop the condition.
Researchers identified BILBO1 as crucial for Flagellar Pocket formation in trypanosomes. The protein is essential for the structure's functions, including endo- and exocytosis. Inhibition of BILBO1 function is fatal to the parasite.
A study published in the EMBO Journal reveals that distinct signaling pathways between neighboring cells regulate cell division. Notch and Wnt/Wingless pathways control proliferation through gene effectors dMyc and bantam, which instruct E2F to activate the cell division machinery.
The EuroQUAM inauguration conference in Barcelona showcased cutting-edge results in cold quantum matter, a field with applications in high-precision measurement and quantum information. The conference aimed to stimulate collaborations between experiment and theory, highlighting the high quality of research in Europe.
Researchers at the University of Helsinki have identified a novel mechanism by which harmless colon polyps acquire malignant tumor properties, driven by abnormal PROX1 protein production. Removing PROX1 from cancer cells reverses their malignant behavior, suggesting it as a promising target for future therapies.
Research has found a significant association between the tachykinin receptor 3 gene and both alcohol and cocaine dependence. The study, conducted in European American families, identified seven DNA sequence variations within the TACR3 gene as having a strong link to AD and co-existing cocaine dependence.
A new study has identified several unexpected barriers to children's physical activity at child care centers, including flip flops, mulch, and parental concerns about weather conditions. The study found that these barriers prevent many children from engaging in essential gross motor skills development.
A research team led by M. D. Anderson Cancer Center scientists created a whole-organ genomic survey to chart the molecular journey from normal cell to invasive cancer in bladder tissue. They identified a crucial new category of genes, known as 'forerunner genes,' that launch the process of cancer development.
A study by Duke University Medical Center found that adolescent rats who demonstrated a taste for alcohol after only three nights of drinking were likely to become the biggest drinkers later on. The research suggests that early drinking patterns may be set and targets efforts to prevent alcoholism in these individuals.
Scientists found tiny airborne carbon cenospheres near an asteroid impact site, formed when carbon deep in the Earth's crust was vaporized and created new structures in the atmosphere. The discovery suggests environmental circumstances were less dramatic than previously thought, challenging the long-held fire-on-Earth hypothesis.
A study published by the American Academy of Neurology found that people with shorter arms and legs may be at a higher risk for developing dementia later in life. The association between short limbs and dementia risk may be due to poor nutrition in early life, affecting limb growth.
A new study led by Dana-Farber Cancer Institute researchers found that abnormal surrounding cells cause the walls of the ducts to deteriorate, enabling tumor cells to escape. The discovery may lead to screening tests and treatments targeting genetic abnormalities in cells lining the ducts.
Conservation efforts in Madagascar could avert catastrophic biodiversity loss with pro-active programs. The country harbors
Companies like UCB Pharma and CeeTox are using cell-based assays to assess the toxic characteristics of small molecule compounds. This early identification can improve clinical trial results and reduce the time to market.
A study found that low vitamin D levels and high parathyroid hormone levels are associated with depression in older adults. The researchers measured blood levels of vitamin D and parathyroid hormone and assessed symptoms of depression among 1,282 community residents.
A study published in Proceedings of National Academy of Sciences identifies the erythropoietin (EPO) gene as a contributor to increased risk of severe diabetic eye and kidney diseases. The research highlights the importance of considering blunting EPO's effects in future therapeutic strategies, such as anti-VEGF therapy.
The American College of Physicians issues guideline for screening osteoporosis in men over 65, emphasizing regular assessments with DEXA scans. A study finds little difference in fracture prevention between osteoporosis drugs risedronate, raloxifene, and alendronate.
A randomized trial found that exclusively breastfed children scored an average of 7.5 points higher on verbal intelligence tests and 2.9 points higher on non-verbal intelligence tests compared to formula-fed children. Teachers also rated these children significantly higher academically in reading and writing.
A study of over 43,000 Canadian patients reveals that two commonly used ACE inhibitors, enalapril and captopril, are associated with a 10-15% increase in mortality compared to ramipril for older adults with congestive heart failure. The authors recommend considering alternative treatments due to the higher mortality risk
Researchers have designed an RFID testbed that can measure hundreds of radio frequency identification tags simultaneously. The system allows for rapid testing of new antenna configurations and enables the evaluation of different signaling schemes without fabricating new chips or constructing multiple antennas.
A Phase 3 study demonstrated that motavizumab reduced hospitalizations due to RSV by 83 percent and lower respiratory infections requiring outpatient management by 71 percent. The study involved 1,410 full-term healthy infants less than six months of age and confirmed high rates of serious RSV disease in this population.
A new study found that increasing alcohol outlet density in a suburb leads to rising rates of violence. Hotel pubs and bars drove violence in inner-city areas, while packaged liquor outlets were more significant in suburban areas.
Researchers at UTMB have developed a promising antiviral therapy against RSV using custom-designed molecules that target the genetic machinery of the virus. These 'morpholino oligomers' show minimal toxicity and significantly reduce RSV replication in cell culture and mouse experiments.
A recent study reveals that nearly one-third of US parents have low-level knowledge of typical infant development, resulting in impaired parent-child interactions. This false parenting assumption can rob kids of cognitive stimulation, as parents often misinterpret behaviors and set unrealistic expectations for their child's growth.
A study found that children's blood lead concentrations at age 6 are associated with reduced IQ and gray matter volume in the prefrontal cortex, highlighting a critical period of vulnerability. Research suggests that even lower levels of lead exposure can result in measurable deficits in cognitive development and behavioral problems.
A team of researchers led by the US Department of Energy Joint Genome Institute has analyzed the genome of Trichoderma reesei, a champion biomass-degrading fungus. The study found that despite its reputation, T. reesei employs a surprisingly minimal repertoire of genes to break down plant cell walls.
Preliminary research suggests that high-risk women with breast cancer who don't have a BRCA1/2 mutation may be at a higher risk of developing a second breast cancer. The study supports the use of prophylactic mastectomy as an option for these women, but raises questions about the role of sentinel node biopsy.
Researchers have discovered a unique genetic profile associated with alcohol-induced heart failure, which could enable earlier diagnoses and monitor clinical outcomes. The study's findings offer new hope for addressing this condition, particularly when caught early through aggressive intervention.
Leptospirosis is a major public health problem in South East Asia and South America, with over 500,000 severe cases every year. Researchers have discovered that bacteria can form biofilms, which protect them against harsh conditions and make them more resistant to antibiotics.
Princeton engineers have created a process that can literally melt away tiny defects on microchips, enabling precise shaping of components without increasing fabrication cost. The method, called Self-Perfection by Liquefaction (SPEL), uses a light pulse from an excimer laser to guide the resulting flow of liquid into desired shapes.
A team of researchers has decoded the genetic sequence of Tricoderma reesei, a fungus that can break down plant fibers into simple sugars. This finding could unlock possibilities for industrial processes that convert corn, switchgrass, and cellulose-based waste into ethanol.
Bubonic plague bacteria produce excessive aspartic acid due to missing enzyme, contributing to its high lethality. Researchers found that a single genetic mutation in Yersinia pestis leads to this imbalance.
Researchers found substantial increases in drinking and alcohol dependence among women, particularly white and Hispanic women, between 1991 and 2002. The study suggests that social acceptability of women's drinking increased, leading to a rise in alcohol dependence, especially among those who drank.
A study by Cincinnati Children's Hospital Medical Center found that 90% of high-cost hospitalizations for young children were linked to influenza. The researchers also identified that 65% of high-cost visits required ICU stays, emphasizing the importance of immunizing children with high-risk conditions.
Researchers have identified a gene sequence associated with an expanding waist line, weight gain, and insulin resistance, affecting half of the UK population. The sequence is more common in Indian Asians than Europeans, providing a possible genetic explanation for the high levels of obesity and diabetes in this group.
Researchers at EMBL and CNRS identified the key protein domain responsible for binding to host RNA molecules, allowing the virus to multiply. The PB2 cap-binding site is a promising target for designing mimics of the cap that would inhibit viral replication.
A recent study found that US mothers are less likely to vaccinate their youngest daughters against human papillomavirus virus (HPV), even though the vaccine is recommended for girls aged 11 and 12. The researchers identified key factors associated with intention to vaccinate, including beliefs about HPV vaccination and perceived benefits.
A study published in The Lancet Neurology found that cilostazol is as effective as aspirin in preventing recurrent stroke, but causes fewer bleeding events. This suggests that cilostazol could be a more effective and safer alternative for Chinese patients with ischemic stroke.
Researchers at Baylor College of Medicine found that the association between Nanog and Oct4 proteins with transcription repression complexes determines embryonic stem cell fate. The complex, called NODE, contains histone deacetylases that control gene expression.
Researchers Philip A. Beachy and Clifford J. Tabin received the 2008 March of Dimes Prize for their work on hedgehog genes and their role in embryonic development, including limb formation and organ development.
The Nix protein plays a crucial role in the maturation of red blood cells by facilitating autophagy, a process that removes damaged organelles like mitochondria. This regulation is essential for maintaining cellular quality and preventing anemia.
A recent study published in Nature Genetics has identified two new genetic variants associated with fat mass, weight, and risk of obesity. The variants, located near the MC4R gene, act in addition to previously described FTO gene variants, resulting in an average increase of 3.8 kg (or 8.5 lb) in weight.
A new study using adolescent rats has found that early exposure to alcohol during adolescence can quickly lead to heavy drinking patterns. Researchers examined the characteristics of rats that developed problem drinking behaviors and found that novelty seeking and stress responsiveness were not related to drinking outcomes.
Researchers found that 10.1% of US children use cough and cold medications in a given week, with decongestants and antihistamines being the most commonly used active ingredients.
Research from the University of Rochester Medical Center reveals that uninsured children in middle-class families are just as likely to go without health care as those in poorer families. Nearly 3 million children had no medical care and no prescription use for a full year, according to an analysis of nationally representative data.
A new study found that interior renovation of older housing is associated with a modest increase in children's blood lead levels and long-term health risks. To reduce the risk, parents can take precautions such as wearing personal protective devices and hiring contractors with lead safety training.
A study of over 3,000 older adults found that those taking multiple anticholinergic medications experienced worse physical function, similar to someone three to four years older. The researchers recommend careful consideration when prescribing these medications to older adults due to the potential effects on their physical function.
Treatment advances for fibroids and endometriosis aim to preserve reproductive potential while treating these conditions. Novel conservative approaches, including medical treatments and non-invasive procedures, are now available, offering women more choices during menopause.
Two studies by Cincinnati Children's Hospital Medical Center found that children whose parents lose or change jobs are more likely to experience unmet healthcare needs and have interrupted insurance coverage. This can lead to poor health outcomes, including unfilled prescriptions and a lack of regular healthcare access.
A team of researchers has cloned nearly all predicted human protein kinase genes in functional form, providing a valuable resource for studying kinase signaling networks. This achievement has significant implications for understanding the mechanisms of various cancers and identifying promising therapeutic targets.
Researchers found that diatoms store phosphorus in polyphosphate and apatite forms, and transport it to the ocean floor. This discovery sheds new light on the ocean's phosphorus cycle.
A recent study led by Northwestern Memorial physician Virginia Kaklamani suggests that variations of the adiponectin gene may increase a woman's risk of developing breast cancer. This discovery could lead to the development of a genetic testing model to predict breast cancer risk more accurately.
The Solar Probe mission will study the streams of charged particles emitted by the sun, exploring the processes that heat its corona and produce solar wind. The spacecraft will zip past the sun at speeds up to 125 miles per second, gathering data on magnetic fields, energy flow, and energetic particle formation.
Childhood pneumonia is a leading killer of children worldwide with over two million deaths annually. Proven preventive measures include vaccination, exclusive breastfeeding, zinc supplementation, and controlling indoor air pollution.
A randomized controlled trial confirms the efficacy of the ketogenic diet in reducing epileptic seizures in children with drug-resistant epilepsy. The study found significant seizure reductions in children assigned to the ketogenic diet, compared to those on a control diet.