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Science News for November 13, 2008


JCI online early table of contents: Nov. 13, 2008

New research reveals that alkaline pH activates TRPA1 protein in human cell lines and mouse nerve cells, causing pain sensation. The study suggests a potential link between TRPA1 activation and human alkaline pH-related pain sensations, contributing to the understanding of pain mechanisms.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateNov 13, 2008

Proton therapy and concurrent chemotherapy may reduce bone marrow toxicity in advanced lung cancer

Researchers found that proton therapy with concurrent chemotherapy significantly reduced bone marrow toxicity in patients with locally advanced non-small cell lung cancer, improving treatment efficacy and patient outcomes. The study suggests proton therapy as a safer option for vulnerable patients, including children and the elderly.

Acrylic glass made of sugar

Scientists have discovered an enzyme that can convert sugars into a precursor of acrylic glass, a plastic used in various applications. This breakthrough could make the production of acrylic glass more environmentally friendly and potentially increase its demand in the coming years.

SourceHelmholtz Association·JournalMicrobiology·DateNov 13, 2008

Cigarette smoke could alter shape of heart

Researchers found that cigarette smoke exposure in rats leads to significant changes in the left ventricle's shape and increased levels of activated enzymes. Norepinephrine levels also rise in response to cigarette smoke, suggesting a link between stress hormone release and cardiovascular damage.

SourceUniversity of Illinois Chicago·JournalEuropean Journal of Heart Failure·DateNov 13, 2008

Raising alcohol taxes reduces deaths

A new study published in the American Journal of Public Health found that raising alcohol taxes immediately reduces the number of deaths from alcohol-related diseases. The study shows that two to four times more lives can be saved through tax increases compared to other prevention efforts.

SourceBurness·JournalAmerican Journal of Public Health·DateNov 13, 2008

Obama and health: Change can happen

The Lancet Editorial suggests that President-elect Barack Obama's administration should prioritize health system strengthening to address the uninsured US residents. The plan includes payment choices, universal children's health insurance, and pre-existing condition coverage.

SourceThe Lancet_DELETED·JournalThe Lancet·DateNov 13, 2008

Corralling the carbon cycle

Researchers have made a breakthrough in understanding how plants absorb and release carbon dioxide, a vital step in understanding the impact of climate change. By measuring carbonyl sulfide, a compound consumed by plants during photosynthesis, scientists can now quantify gas flow into plants.

NCAR installs massive digital storage library from sun microsystems for climate and weather records

The new system, AMSTAR, will provide NCAR with up to 30 petabytes of storage capacity and enable scientists to conduct increasingly sophisticated computer studies of Earth's climate. The system is based on the Sun StorageTek SL8500 Modular Library and will allow NCAR to store its valuable scientific data for the next 15-20 years.

Cancer treatment may result in bone loss

A new cross-Canada study found that breast and prostate cancer treatment can cause significant bone loss, affecting up to 46,000 people each year. The researchers discovered that medications called bisphosphonates can help combat osteoporosis and fractures in cancer patients.

SourceUniversity of Montreal·JournalJournal of Clinical Oncology·DateNov 13, 2008

How cockroaches keep their predators 'guessing'

Researchers found that cockroaches choose between four primary escape routes at fixed angles from threats, avoiding predictability and allowing them to stay one step ahead of predators. This study challenges the idea that 'unpredictable' behavior is random, suggesting instead that animals may be choosing between multiple strategies.

SourceCell Press·JournalCurrent Biology·DateNov 13, 2008

The protein TRPA1 feels the pain of alkaline pH

New research reveals that alkaline pH activates TRPA1 protein in human cell lines and mouse nerve cells, leading to pain sensation. The study suggests that activation of this protein might be the mechanism underlying some human alkaline pH-related pain sensations.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateNov 13, 2008

Novel regulatory step during HIV replication

Scientists have identified a crucial role for sulfonation in HIV replication, finding that inhibiting this pathway can compromise viral gene expression and render host cells resistant to infection. This discovery provides a promising new target for HIV/AIDS therapy.

SourceSalk Institute·JournalPLOS Pathogens·DateNov 13, 2008

Arsenic linked to cardiovascular disease at EPA-regulated drinking water standards

Researchers at the University of Pittsburgh discovered that exposure to EPA-approved levels of arsenic in drinking water can lead to cardiovascular disease by closing pores in liver blood vessels. The study found that mice exposed to arsenic had impaired sinusoidal cell functions, leading to a loss of nutrient exchange and waste removal.

SourceUniversity of Pittsburgh Schools of the Health Sciences·JournalJournal of Clinical Investigation·DateNov 13, 2008

Female embryonic sexual development driven by universal factor

A gene essential for organ growth also regulates female but not male embryo sexual development, supporting a controversial hypothesis about mammalian sexual development. Researchers found that beta-catenin acts as an internal regulator of the pathway, which includes Wnt4 and R-spondin1 genes, leading to the formation of ovaries.

SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalHuman Molecular Genetics·DateNov 13, 2008

Fish choose their leaders by consensus

Stickleback fish follow a consensus decision-making process to choose their leader, prioritizing size, fatness, and health. As group size increases, accuracy improves, but occasional errors occur due to submission to peers and cascades of incorrect decisions.

SourceCell Press·JournalCurrent Biology·DateNov 13, 2008