Scripps researchers develop first definitive study of 2-AG's activity after discovering MAGL-specific inhibitor JZL184, reducing pain in mice and inducing effects associated with cannabinoid receptors. This breakthrough could lead to new treatments for chronic pain, obesity, anxiety, and depression.
Researchers found that bavituximab, a PS-targeting antibody, can cure lethal virus infections in animal models of cytomegalovirus and Lassa fever. The drug showed potent anti-viral activity and may represent a new class of drugs for treating viral infections.
Researchers at the University of Bonn found that the brain's 'wiring' plays a significant role in shaping personality traits and behavior. Individuals with well-developed neural connections between the ventral striatum and hippocampus tend to be more open to new experiences and seek out challenges.
A multidisciplinary approach predicts the immunity of a vaccine based on gene expression patterns and T cell responses. The study successfully predicted immunity in up to 90% accuracy using the yellow fever vaccine as a model.
Research suggests melatonin therapy may prevent ocular inflammation in uveitis, reducing symptoms and protecting the blood-ocular barrier. Melatonin treatment has anti-inflammatory effects, potentially benefiting patients with chronic uveitis.
Researchers use supercomputers to model air flow around golf balls, optimizing dimple size and pattern for lower drag. The study reveals the physics of a flying golf ball with unprecedented detail, paving the way for future improvements in ball design.
Hybrid plants exhibit increased growth and biomass due to the increased expression of genes involved in photosynthesis and starch metabolism during the day. This connection between circadian clock regulators and growth vigor could lead to new methods for increasing biomass crops for biofuels and improving food yields.
Researchers propose a new model to improve existing standards by capturing the multi-dimensional experience of new teachers, highlighting the importance of emotional and relational aspects in their development. The study found that support from colleagues and availability of teaching materials are key factors in job satisfaction.
Researchers from Queen Mary University of London have improved their understanding of how magnetic information is lost in devices similar to hard drive read-heads. The findings, published in Nature Materials, could lead to the development of more efficient and powerful data storage technologies.
UT Southwestern researchers have developed a new strategy for broad-spectrum anti-viral drugs that targets a lipid molecule on infected cells, triggering the immune system to attack and destroy infected cells. The treatment, bavituximab, shows promise in treating viral diseases, including Lassa fever and cytomegalovirus.