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Science News for August 21, 2009


Off-label use: Oft not evidence based

A recent national survey found that physicians inaccurately believed in the FDA approval status of 22 drug-indication pairs, including lorazepam for chronic anxiety and quetiapine for dementia with agitation. The study highlights the need for better methods to inform physicians about the level of evidence supporting off-label drug use.

SourceUniversity of Chicago Medical Center·JournalPharmacoepidemiology and Drug Safety·DateAug 21, 2009

Ghostwriting documents now fully available on PLoS Medicine Web site

The PLOS Medicine journal has made all 1500 ghostwriting documents publicly available, revealing a coordinated campaign by Wyeth and medical writing companies to promote hormone drugs. The editors call for action to eradicate ghost-writing, including retraction of papers and investigation by academic institutions.

SourcePLOS·JournalPLOS Medicine·DateAug 21, 2009

Impaired transport in neurons triggers prion disease

A new study reveals that impaired axonal transport in neurons is a key factor in the development of prion diseases. The research shows that clinical symptoms correlate with reduced axonal transport in specific brain centers, providing new insights into the disease.

SourcePLOS·JournalPLOS Pathogens·DateAug 21, 2009

Gene discovery reveals a critical protein's function in hearing

Researchers identified a new protein that protects sensory cells in the ear, crucial for maintaining potassium balance and preventing intoxication. The study found mutations in the claudin-9 gene lead to functional defective sensory cells, highlighting the importance of this protein in hearing.

SourcePLOS·JournalPLOS Genetics·DateAug 21, 2009