Cancer cells have been found to rarely undergo explosive divisions, with resulting daughter cells often surviving only a few days. The extra centrosomes cause an unequal pull on some chromosomes, leading to chromosomal instability and irregular numbers of chromosomes.
Researchers found that certain genetic mutations known to extend the lifespan of C. elegans roundworms induce somatic cells to express genes allowing reproductive germline cells' immortality. This discovery may lead to therapies protective against age-related decline in other tissues.
Researchers have for the first time visualized the three-dimensional structure of a crucial subcomplex of the nuclear pore complex (NPC), a fundamental innovation in multicellular life. The findings support a common architecture between NPCs and coated vesicles, revealing an ancient evolutionary connection.
A new study finds that optimal medical therapy is equally effective as revascularization procedures like bypass surgery or angioplasty in lowering the risk of death and cardiovascular events in patients with diabetes and stable coronary heart disease. Insulin-providing and insulin-sensitizing drugs are also shown to be equally effective.
Researchers found that routine diabetes screenings can lead to significant cost savings for healthcare systems. The study suggests that screening and preventive management can be a cost-effective approach to managing the disease.
Researchers identified a gene involved in inflammatory response that could hold key to treating CML, a lethal cancer. A drug combination targeting this gene showed improved therapeutic effect on CML in mice.
A landmark study found that prompt bypass surgery has the same five-year survival rate as drug therapy alone for patients with type 2 diabetes and stable heart disease. In contrast, bypass surgery lowered the risk of subsequent major cardiac events, particularly in those with severe heart disease.