Researchers found omacetaxine killed 90% of leukemic stem cells in vitro and prolonged survival in test animals with resistant CML. The findings may open the door to developing a curative treatment strategy for some patients with CML.
Researchers discovered that second chromosomes in bacteria are formed from plasmids, challenging current understanding of genome evolution. The study provides a general model for how multichromosomal architectures evolved in the Rhizobiaceae family.
A pilot study found potentially hazardous chemicals in hospital cleaning products, including quaternary ammonium chlorides and glycol ethers. The study highlights the importance of protecting workers and others from exposure to cleaning hazards, particularly in poorly ventilated spaces.
A new study reveals that dust storms and volcanic eruptions have a significant impact on the Atlantic Ocean's temperature. The researchers used satellite data and climate models to find that changes in African dust storm and tropical volcano activity account for about two-thirds of the upward trend in recent decades.
Tiny, toxic protein particles severely disrupt neurotransmission and inhibit delivery of key proteins in Alzheimer's disease. The particles inhibit neurons from communicating with each other and with other target cells in the body.
Research suggests that global warming will worsen health problems like heat-related mortality and diarrheal diseases due to climate change. The US needs an estimated $200 million in annual funding to study these impacts and develop protective measures.
A team of scientists has developed a new method to create stem cells with embryonic-like properties without using viruses, which can trigger cancer. This approach imports necessary genes on a small DNA circle and naturally disappears from the cell population over time.
Dr. Nick Harvey received the 2009 ESCEO-IOF Alliance for Better Bone Health Young Investigator Award for his study on indices of intrauterine growth predicting postnatal development of skeletal size and volumetric density. The award recognizes outstanding research based on fetal growth measurements made between 19 and 34 weeks gestation.
A new study found a positive link between high levels of zopiclone in the blood and impaired driving assessments. Researchers also noted that drivers with zolpidem had no such association, suggesting that these substances have varying abuse potentials.
Researchers use Ocean Acoustic Waveguide Remote Sensing (OAWRS) to observe mass migrations of hundreds of millions of fish, revealing critical population density triggers synchronized movement. This breakthrough confirms theories about large groups of animals and provides valuable information for conservation of marine ecosystems.
A randomized trial found that frequent treatment of children under 10 years old with azithromycin can decrease infection prevalence in older individuals and adults, demonstrating herd protection. Treatment frequency four times a year is comparable to treating the entire population once a year.
Researchers at UW-Madison have developed a new method to generate induced human pluripotent stem cells (iPS) without using viral vectors or exotic genes. This breakthrough removes key safety concerns and genetic artifacts that could compromise therapeutic safety or skew research results.
Charles Summers, a University of California entomologist, has won the prestigious Woodworth Award for his contributions to entomology. He developed economic thresholds and management strategies for various crops, reducing pesticide use and improving yields.
Martin Cohn, a UF developmental biologist, has been named an HHMI Early Career Scientist for his groundbreaking work on limb development and evolution. His research has led to new insights into the formation of human problems such as birth defects.
Researchers at Emory University have discovered that DNA repair enzymes can relocate to specific areas of the cell in response to oxidative stress, which is linked to various human diseases. This finding could lead to the development of anti-cancer drugs that target DNA repair mechanisms.
Researchers found specific gene variations affect lung function growth and susceptibility to environmental insults. Variants in GST genes correlated with poorer lung function and greater susceptibility to damage from maternal cigarette smoke during pregnancy.
Researchers at Duke University have developed a new MRI signaling method that can visualize molecular changes inside the body, which may signal health problems such as cancer. This technique uses hyperpolarization to detect signals from molecules besides water, allowing for earlier diagnosis and treatment of various health conditions.
A Mayo Clinic study reveals that 60% of retired National Football League (NFL) linemen suffer from sleep disordered breathing, with an average of 18.1 episodes per hour.
A study published in Physical Therapy found that directing attention to external effects of movement improves postural stability in patients with Parkinson's disease. This strategy may help reduce falls and improve mobility for those affected.
Researchers have found a protein in tick saliva that works as a complement inhibitor, improving the health of rats with mild and severe models of myasthenia gravis. The protein, rEV576, may have therapeutic value in human myasthenia gravis and could offer a new treatment option with reduced side effects.
A new study published in Biological Psychiatry found that modafinil can reduce weight gain associated with olanzapine treatment. The study showed that subjects receiving olanzapine and modafinil experienced less weight gain than those receiving only olanzapine.
The University of Texas M. D. Anderson Cancer Center has launched a new graduate program focusing on understanding and attacking cancer metastasis. The program, supported by a highly competitive grant from the University of Texas System, aims to improve basic understanding of cancer spread mechanisms.
A new study published in PLOS Computational Biology found that the most useful information for face recognition comes from eye images, which provide the least 'noisy' result. The study analyzed over 800 male and female face images to understand why our brains prefer a coarse resolution for face recognition.
Removing non-native trout from mountain lakes reverses their impact on aquatic insect populations. Aquatic insect abundance increases quickly after trout removal, but suspension of stocking alone is ineffective in restoring insect numbers.
The Status of the Geoscience Workforce 2009 Report provides comprehensive insights into the geosciences workforce, education, and economic dynamics. The report details demographics by age, race, gender, and industry type, as well as student and research funding statistics.
Researchers at the University of Rhode Island have discovered a biochemical mechanism that explains how protein tyrosine kinases, such as Src and Fibroblast Growth Factor Receptor families, sense and respond to oxidative stress signals. This understanding may help in designing targeted therapies for specific cancers.
Researchers have identified a viral protein, VP16, as the molecular key that prompts herpes simplex virus to exit latency and cause recurrent disease. The study provides a molecular target for designing improved HSV vaccines and treatments, which could also be used in cancer therapy.
Braunschweig Helmholtz researchers found that host genetic factors significantly impact the progression of influenza A virus infections. The study discovered strong differences in disease outcomes among mice with genetically identical immune systems, suggesting a genetic basis for varying responses to the flu virus.
Researchers at Scripps Research Institute have discovered the structure of P-glycoprotein, a protein responsible for cancer cell resistance to chemotherapy. The study provides valuable insights into how P-gp transports substances out of cells and may lead to the design of more effective drugs.
A new study has found that large size and fast bite were the main reasons for the extinction of certain fish 65 million years ago. Today, these same features characterize large predatory fishes that are in decline and at risk of extinction themselves.
Researchers found that 89% of patients treated with catheter-based therapy (CBT) showed significant improvement in neurologic disability and NIHSS score. CBT may be an effective alternative for ischemic stroke patients ineligible for intravenous thrombolysis, with potential benefits including earlier treatment windows.
Researchers found female termite primary queens can produce both sexually and asexually reproducing babies, mostly growing into queen successors with no inbreeding risk. Asexual reproduction allows colonies to grow faster while maintaining genetic diversity.
Researchers found two common SNPs associated with poorer lung function in children, which may alter SOD3 expression levels. This study identifies a genetic target for healthy lung development during childhood, potentially leading to the development of medication to foster optimal lung growth.
A new EU report emphasizes the importance of integrating climate change policies with economic and social issues to achieve effective climate action. The study assesses the degree of climate policy integration in six European countries, revealing significant potential for improvement.
Scientists have created a new low-calorie, low-sugar vegetable juice by fermenting vegetables with lactic acid-producing bacteria. The process significantly removes sugar while retaining nutritional content, making it suitable for diabetics and pre-diabetic individuals.
Patients with moderate to severe COPD show altered breathing and swallowing coordination even during normal eating. The study found that COPD patients swallow more often at the end of exhalation, a pattern that disrupts safe swallowing.
A recent study published in PLOS Pathogens has revealed that a majority of the global population has been infected with three recently discovered human polyomaviruses, including KIV, WU, and MCV. The study, which tested over 2,200 anonymous donor blood samples, found that infection with these viruses occurs early in childhood.
A new study published in Menopause: The Journal of the North American Menopause Society found that transdermal estrogen delivery may not increase the risk of blood clots in postmenopausal women, unlike oral delivery. The study suggests that transdermal HT delivery may be a safer alternative for some women.
Whitehead Institute member Peter Reddien has been awarded an Early Career Scientist position by the Howard Hughes Medical Institute (HHMI), providing him with a six-year funded research program. He will investigate regeneration in planaria flatworms, a project that aligns with HHMI's goals to support innovative and creative science.
Research suggests that aspirin can reduce the risk of polyps forming in the colon or rectum, a precursor to colorectal cancer. Studies have shown mixed results regarding the optimal dose and duration of use, but experts call for more evidence on the effects of aspirin on cancer.
The new technique manipulates parahydrogen to create molecules that are easier to detect in MRI scans, allowing for faster and more accurate diagnoses of various medical conditions. This technology has the potential to replace current imaging technologies using radioactive substances or heavy metals.
A study by Wagner and Oehlmann analyzed mineral waters for estrogenic chemicals, detecting contamination in 60% of samples. Plastic bottle water showed higher levels than glass-bottled water, with more embryos developing in New Zealand mud snails exposed to plastic bottles.
A long-term study found that adults with a history of anorexia nervosa are more likely to experience mental health issues. The research, published in the British Journal of Psychiatry and International Journal of Eating Disorders, also showed improved reproductive outcomes for those who had recovered from anorexia.
Scientists have found nanoparticles in cosmetics and sunscreens can be toxic to microbes, reducing survival rates. A new biosensor has been developed to detect nanoparticles, warning of potential danger to aquatic life.
Researchers found that many Hispanics were misclassified in a 'some other race' category, leading to incorrect projections of racial diversity. The study suggests that Americans may struggle to accurately report their ancestry due to generational memory loss and stigma around interracial relationships.
Researchers at Rensselaer Polytechnic Institute have discovered that incorporating treated carbon nanotubes into epoxy composites can significantly improve toughness and crack resistance. The study found a five-fold reduction in crack growth rate when subjected to repetitive stress.
Researchers Harmit Singh Malik and Toshiyasu Taniguchi receive HHMI funding for their innovative work in evolutionary biology and cancer genetics. Malik studies genetic conflicts in cells, while Taniguchi investigates DNA repair pathways to combat drug resistance.
Research suggests taking public transit can help individuals meet daily physical activity requirements by up to three times. Short walks during transit trips contribute to this increased activity level.
Two NYU School of Medicine researchers, Iannis Aifantis and Jeremy S. Dasen, have been recognized as Early Career Scientists by the Howard Hughes Medical Institute for their groundbreaking research in cancer biology and neuroscience. They will receive a six-year appointment and funding to further explore their areas of research.
A new study reveals that climate change is drastically reducing daddy long legs populations, which in turn affects the food supply of upland birds such as golden plovers. The drop in cranefly larvae can lead to starvation and death for many chicks.
Dr. DeBose-Boyd, an associate professor of molecular genetics, will receive $1.5 million in funding to support his innovative cholesterol research directions. His work focuses on regulating and controlling cholesterol production, with potential implications for preventing and treating heart disease.
The newly formed National Bioethics Committee for research of Gabon will review clinical trial protocols, ensuring the safety and well-being of African study participants. The committee's establishment marks a significant step towards strengthening ethics review capacity in Africa.
Three Editorials in The Lancet focus on inadequate conditions for US migrant detainees, the need for tailored disease-prevention programs, and the recent Danish decision to award compensation to breast cancer sufferers who worked night shifts. Pope Benedict XVI's comments on AIDS are also criticized for distorting scientific evidence.
A noninvasive finger sensor test is highly predictive of major cardiac events for people at low or moderate risk. The EndoPAT test measures blood flow and identifies endothelial dysfunction, a condition that can lead to atherosclerosis and cardiovascular problems.
UK astronomers successfully observed the asteroid 2008 TC3 using the William Herschel Telescope on La Palma, collecting data that helped predict its impact and study its rare F-class composition. The results demonstrate the importance of asteroid research in mitigating potential impacts.
Scientists have developed a technology that can convert mechanical energy from body movements into electric energy, which can be used to power electronic devices without batteries. The new 'nanogenerator' has potential applications in defense technology, environmental monitoring, biomedical sciences, and personal electronics.