A Phase II trial found that sunitinib was not effective in patients with papillary renal cell carcinoma, highlighting the need for new therapies for this rare subtype of kidney cancer. The study suggests differences in response between clear- and non-clear cell subtypes.
A new study published in PLoS ONE has mapped the spawning habitat of bluefin tuna in the Gulf of Mexico, revealing two major hotspot regions where bycatch occurs. These findings suggest that spatial management techniques can protect western Atlantic bluefin tuna on their breeding grounds without compromising the yellowfin tuna fishery.
A student at the University of Sheffield designed a mobile bicycle-powered water pump, called bicibomba movil, to improve irrigation and water distribution for rural residents in Guatemala. The machine can achieve a flow rate of 40 liters per minute on flat ground and has been produced in regular production since its creation.
The DFG approved twelve new Collaborative Research Centres to explore various research topics including the molecular interactions of immune response in pneumonia, innovative programming techniques, and materials for bone regeneration. The new centres aim to advance our understanding of complex phenomena and develop new therapies.
Researchers found that pancreatic cancer patients with circulating tumor cells tend to have worse outcomes, and some types of cells may predict poorer survival. The presence of MUC1 protein-expressing circulating tumor cells is particularly associated with shorter overall survival.
A pilot study found increased tendon ruptures in women taking statins, prompting a larger study to confirm the findings. The MSU team will analyze over 100,000 participants to assess the effects of statin dose, duration, and type on tendon rupture risk.
A Durham University researcher has developed a new notation system for African drums, allowing people to learn and perform unique rhythms worldwide. The system is used in a song called 'Vuma! Unity, harmony, goal!' promoting rhythm and unity for World Cup success.
A UBC researcher has discovered what makes Rembrandt's portraits so captivating by recreating four of the artist's most famous works using computer-rendering programs. The study found that viewers fixated on specific areas of the face, such as the eyes, and preferred portraits with 'eye guiding narrative' techniques.
Women who have had a bilateral oophorectomy tend to have smaller tumors and have their tumors detected by mammography rather than physical exam. However, hormone therapy after surgery wipes out any difference in tumor size or detection method.
A study of nearly 45,000 patients found that many with HIV in the US and Canada do not receive care early enough, resulting in lower CD4 cell counts. This delay increases the risk of clinical disease progression and ongoing transmission.
The MBARI AUV is equipped with 'gulper' samplers that can collect up to ten 1.8-liter water samples while traveling through the water or within an oil plume. The vehicle's AI software helps it map boundaries and take samples outside the plume.
A new study published in Springer's journal Behavioral Ecology and Sociobiology found that men perceive vocal masculinity as a strong indicator of dominance, but it does not influence their attentiveness to rivals' voices. The researchers also discovered that testosterone levels are linked to dominance ratings.
Research from Fox Chase Cancer Center shows that patients with stage IIIA non-small cell lung cancer (NSCLC) who receive surgery, particularly lobectomy, have increased overall survival rates. This is in contrast to those who received chemoradiation alone.
Researchers used techniques similar to pharmaceutical sales reps to educate doctors on treatment guidelines, resulting in a 8.6% increase in recommended diuretic prescriptions in counties with high academic detailing activity.
Scientists have discovered a group of four proteins responsible for generating Helicobacter pylori's characteristic curvature, enabling its survival in the acidic stomach environment. Laboratory-engineered mutant strains lacking these proteins fail to twist properly and are unable to colonize the stomach.
Rice researchers found that starving cells in slime mold have an advantage, pushing those that eat into selfless sacrifice. The study reveals a surprising strategy for survival and reproduction in single-cell organisms.
Dr Pellegrini's research focuses on HIV, tuberculosis, and how the human immune system responds to these infections. His work aims to develop therapies that target the host immune system to eradicate chronic infections.
A study at Henry Ford Hospital found that the newer left ventricular assist device HeartMate II has a significantly lower risk of infection than its predecessor, the HeartMate I XVE. The new device is smaller and uses synthetic ruby bearings lubricated by blood itself, reducing the risk of infection by 75%.
Researchers at NIST used neutron beams to study magnetite nanoparticles, revealing a complex interaction between the inner 'core' and outer 'shell'. The discovery could lead to new tools for controlling particle behavior in data storage and biological applications.
Researchers at the University of Pittsburgh have discovered a genetic mutation linked to lymphatic dysfunction, which could lead to a first-ever target for drug therapy for lymphedema. The study identified mutations in the GJC2 gene that impair cell signaling, leading to fluid accumulation and tissue swelling.
A nearly 2,300-person study by the University of Minnesota definitively links indoor tanning to increased risk of melanoma, with frequent users facing a 74% higher likelihood. The study found that risk is associated more with how much a person tans and not the age or device type.
Researchers have discovered a direct relationship between a psychiatric disorder and the immune system, specifically microglia cells derived from bone marrow. Bone marrow transplants cured mutant mice with compulsive hair-pulling behavior, suggesting potential new treatments for obsessive-compulsive disorder.
A study by University of Illinois professors found that those who ask themselves whether they will complete a task tend to do better than those who tell themselves they will. This phenomenon has implications for cognitive, social, and clinical psychology, as well as education and work settings.
Researchers have found a key interaction between the Notch signaling system and the BCL6 gene that may be responsible for certain cancers developing. This discovery could lead to a better understanding of cancer formation and potential treatments.
A genetic analysis reveals that flu strains in the US don't disappear at the end of winter, but instead migrate to South America and other parts of the world. This knowledge has implications for public health efforts, including antiviral use and vaccination programs.
Groundwater experts propose using deeper aquifers for irrigation, pumping high volumes of water from wells can pull down arsenic-contaminated water. Scientists recommend retesting existing deep wells on a regular basis to ensure quality. Filtration and alternative methods are used in countries without deep aquifers.
Researchers at Michigan State University discovered that shiny black solar cells lure water insects away from critical breeding areas. Applying white grids or other methods can break up polarized reflection of light, making it less attractive to mayflies and other aquatic insects.
A new trial found that supervised injectable heroin leads to larger reductions in street heroin use compared to injectable or oral methadone. The RIOTT trial showed that treatment with supervised injectable heroin resulted in significantly lower use of street heroin within six weeks.
Researchers explore alternative visual strategies to engage the public with climate change, highlighting the need for inspirational motifs and renewable energy icons. Climate scepticism and knowledge gaps pose significant challenges in addressing climate change, requiring creative communication approaches.
Researchers discovered that methamphetamine enhances memory in pond snails, allowing them to recall learned behaviors despite being immersed in de-oxygenated water. This finding may provide insights into the mechanisms of human addiction and how memories are formed.
Researchers developed a novel imaging system to visualize T-cell actions in animal models, providing insights into immune responses and transplant outcomes. The study revealed a clearer understanding of the balance between protective and destructive T-cells in transplanted tissue.
A team of researchers has made the first detailed observations of 'halo' gas clouds in our Galaxy, finding they contain hydrogen gas 700 times the mass of the Sun. These clouds are linked to earlier star formation and can fall back into the main body of the Galaxy, recycling material.
Dr. Henry Gabelnick was awarded the lifetime achievement award at the 6th International Microbicides Conference for his dedication to developing microbicides. He has contributed significantly to the field through research on preclinical algorithms and primate models.
Researchers have developed a way to use Rice University's light-activated nanoshells as building blocks for complex structures that can trap, store and bend light. These materials have unique optical properties, making them suitable for applications such as ultrasensitive biological and chemical sensors.
Researchers at the University of Sheffield have found that mortality rates from alcohol-related diseases are over four times higher in deprived areas compared to less deprived areas. Deaths from such diseases are increasing despite public awareness campaigns, highlighting the need for targeted policies to reduce harm caused by alcohol.
A recent University of Missouri study found that food insecurity and hunger among children persist even in households with food stamps and other forms of assistance. Informal food supports through churches and food pantries are related to improved child food security.
A low-pressure area, System 90E, is developing in the Eastern Pacific with strong thunderstorms and cold cloud tops, indicating a potential tropical cyclone. The system is expected to continue consolidating over the next 24-36 hours with a good chance of development within the next 24 hours.
Seventy percent of Madagascar's species live in the forests where critically endangered rosewood trees are found. The Malagasy government lacks effective enforcement, allowing for lucrative illegal logging and tree trade with China.
The Rice University-led Environmental Toxicology and Chemistry journal has released a special virtual edition making 25 previously published studies on the Exxon Valdez oil spill available for free. The collection provides insights into the occurrence, fate, and effects of oils and oil spills in the environment.
Researchers at Henry Ford Hospital found that a continuous flow left ventricular assist device (LVAD) improves function on the right side of the heart, reducing central venous pressure and pulmonary artery pressures. The study, which monitored 41 patients, also showed significant improvements in measures related to tricuspid regurgitat...
Researchers at NC State are creating a comfortable and functional leather HazMat boot that meets both criteria. The new boots use special materials that repel toxic chemicals, making them easy to clean and decontaminate.
UK researchers have discovered electrically charged ash in the plume of Iceland's Eyjafjallajokull volcano. The finding contradicts models and adds a new dimension to understanding volcanic plumes' impact on air travel. Detailed measurements reveal self-renewing charge within the plume, which affects particle behavior and growth.
NASA's Aqua satellite captures infrared image of System 93W, showing a comma-like area of showers and thunderstorms with two areas of strong convection. Forecasters predict a good chance for development in the next 24 hours as the system moves southeast of Hong Kong.
A recent study suggests that N-terminal pro-brain-type natriuretic peptide (NT-pro-BNP) is not a reliable biomarker for cardiac dysfunction in dialysis patients. Instead, high NT-pro-BNP levels are more closely associated with fluid overload and require adjustment of dry weight to prevent complications.
Two new UCSF studies detail the wide reach of the tobacco industry and its influence on young people, military veterans, and national healthcare reform. The analyses reveal industry 'youth smoking prevention' tactics and efforts to defeat healthcare reform under President Clinton.
Plectasin disrupts the forming of the cell wall in bacteria, preventing division and ultimately leading to bacterial death. Despite its potential, the authors caution that no permanent solution exists to antibiotic resistance.
Scientists at Cornell University found that compounds in Guatemalan potato moth larvae saliva increase photosynthesis and starch production in commercial potato plants, resulting in bigger tubers. Yield increases were observed when 10-50% of potatoes were infested, with marketable yields doubling or tripling.
A seven-year experiment shows that pond communities bear a lasting imprint of random events in their past. The study reveals that low-productivity ponds are predictable, while high-productivity ponds exhibit more stochastic behavior, where history matters more.
A new treatment stimulates the host immune system to destroy invading microbes, protecting against tularemia and other disease-causing bacteria. The therapy has broad usage and potential for future use as a treatment alternative to antibiotics.
Researchers will screen thousands of drug candidates for therapeutic benefits in mice, zebra fish, and human cell lines. The goal is to find compounds that can delay or prevent bone marrow failure and cancer in Fanconi anemia patients.
A new study reveals that abandoning traditional beliefs in local Islamic Saints is linked to agricultural expansion and the introduction of new sheep breeds, affecting agro-pastoral resource management. The research highlights the importance of individual religious beliefs in shaping environmental practices.
Researchers found that CDP-choline can reduce cell death and ceramide levels, preventing damage when exposure to alcohol is stopped. The study suggests a potential preventive measure for fetal alcohol syndrome.
Scientists argue that Ardipithecus ramidus, a human ancestor, lived in tree or bush savannas with 5-25% tree cover, not dense woodlands. The claim challenges the savanna hypothesis, which suggests that the expansion of savannas prompted the evolution of bipedalism.
Researchers discovered that low-intensity ultrasound therapy can improve the survival and function of tissue grafts after surgery. The treatment increased cellular activity, reduced waste buildup, and enhanced molecular motion, leading to better outcomes for patients undergoing various surgical procedures.
Researchers used nondestructive evaluation techniques to analyze ancient coins minted by King Agrippa I and II. The study revealed that the copper used in the coins likely came from mines previously thought not to have been opened until a century later, suggesting a closer relationship between the Romans and the region.
A recent study in Hong Kong found that fear of the H1N1 virus prompted residents to adopt preventive behaviors such as frequent hand-washing (47% reported washing hands >10 times/day) and wearing face-masks. These behaviors can play a crucial role in controlling pandemic influenza.
Researchers at UCLA Medical Center found antiviral therapy during compensated cirrhosis to be the most cost-effective approach for treating HCV patients with advanced liver disease. Treatment initiated before progression to more advanced liver disease resulted in improved survival and decreased costs compared to other strategies.
Research found that sarcopenia, low skeletal muscle mass and strength, is associated with insulin resistance and high blood-sugar levels in both obese and non-obese individuals. Muscle mass and strength are crucial in preventing type 2 diabetes.
A research team from NIST and NIH developed a technique to rapidly optimize 3D cell growth media to meet the developmental needs of specific cell types. They found that cells prefer softer environments for development, but those in stiffer gels are more active in building bone tissue.
Researchers develop scalable devices exhibiting customizable optical properties using a bottom-up approach inspired by nature. The findings showcase potential applications in sensitive sensors, detectors, and invisibility cloaks, and demonstrate the possibility of manipulating artificial molecules to create desired optical properties.