Researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases have identified a key player in muscle repair: the gene Ezh2. By activating this gene, satellite cells may proliferate and compensate for underlying defects, potentially increasing quality of life for individuals with degenerative diseases.
Researchers identified networks of genes crucial for healthy heart formation, shedding light on congenital heart disease. MicroRNAs regulate gene expression and dosage, and the study provides insights into the genetic mechanisms underlying fetal-heart development.
Cardiac specialists will use new guidelines to determine who should receive a mechanical heart-pumping device. The guidelines have the potential to change clinical practice patterns for patients with severe heart failure. Dr. Morgan's presentation at the ISHLT annual meeting in San Diego highlights the importance of these changes.