Researchers at Goethe University Frankfurt have created two interlocking rings of DNA, measuring 18 nanometers in size, which are suitable as components of molecular machines. The catenan structure is freely pivotable and can be used to arrange and study proteins or other molecules that are too small for direct manipulation.
A two-pronged educational program at Emory Healthcare significantly improved leaders' and frontline staff's knowledge of quality principles. The program also led to successful design and launch of QI projects, with many projects sustained up to one year after completion.
Researchers found that glaucoma patients worried about going blind, managing their condition, and affecting their families. They also valued peer support and internet information, but often struggled to understand it due to declining vision.
A recent study found that Delhi's radical changes in air quality regulations had a substantial positive effect on the health of city residents. The research used remote sensing imagery to measure the effects of air quality on health, and found that poorer men exhibited significant negative relationships between ambient air and respirat...
A new study by the USDA found that pistachios contain fewer calories per serving than previously thought, supporting weight management and heart health. Pistachios are also rich in fiber and protein, making them a nutritious snack option.
An international team identified a genetic mutation responsible for a hereditary neurological disorder affecting members of a Palestinian family. The researchers used a combination of genome sequencing technology and disease-network analysis to pinpoint the causative mutation, which is found in approximately 1 in 200 Palestinians.
The number of AIDS-defining cancers decreased, while non-AIDS-defining cancers increased significantly between 1991-2005. Lung cancer emerged as the most common malignancy in people with HIV but not AIDS.
A new study from Monell Center reveals that bitter taste can cause people to report nausea and display stomach activity similar to actual nausea. The body anticipates the consequences of food we eat, responding to toxic tastes with a protective mechanism.
A new MRI study published in Radiology suggests that automated brain volume measurements can predict future memory decline in elderly people with normal cognitive ability. The study found high accuracy rates when considering multiple brain regions, including the temporal and parietal lobes.
A survey of US primary care physicians found that making treatment recommendations changes the way physicians think about medical decisions. In scenarios involving colon cancer and avian influenza, physicians chose different treatments for themselves versus those they recommended to patients.
Researchers studied three species of shootingstars to understand their response to global warming. They found that some species migrated while others adapted in place, with rare species exhibiting distinct genetic histories. This study provides valuable clues for predicting how plants will respond to climate change.
Researchers from US and Iran develop framework to identify cyber-terrorists through web mining and honeypot traps. The framework aims to trace cyber terrorists in real-time, making arrests before debilitating attacks occur.
The new citrus variety KinnowLS developed at UC Riverside is extremely sweet, juicy, and visually appealing, with only 2-3 seeds per fruit. This breakthrough variety has the potential to revolutionize citrus production in India and Pakistan, where it can be grown in hot climates.
Researchers at University of Michigan have developed a novel gene therapy, NP2, that shows promise in providing substantial pain relief for patients with unrelenting cancer-induced pain. The study demonstrates the safety and efficacy of NP2 in reducing pain by up to 80% over four weeks.
A recent study published in Current Biology reveals that the taste of something extremely bitter can cause nausea and stomach churning, regardless of whether it's swallowed. The researchers found that the body anticipates toxins or anti-nutrients and prepares for them by responding with nausea and stomach contractions.
Researchers found that the process of repairing damaged DNA repeats can lead to cell death in yeast, providing insight into neurodegenerative diseases. The study suggests that expanded DNA repeats can be toxic to cells, contributing to disease progression.
An international team of scientists used a powerful synchrotron X-ray technique to observe muscle protein changes inside intact and contracting muscle cells. The results revealed the conformation of myosin molecular motors in resting muscles and the signalling pathway between actin and myosin filaments.
Research suggests Vitamin D supplementation improves vascular endothelial cell health, reducing cardiovascular disease risk in overweight African-American adults. The study found that supplementation with 60,000 IU monthly improved flow-mediated dilation, a key indicator of blood vessel health.
Hebrew University researchers have discovered a new mechanism by which tumor cells become invasive, involving a program of genes that confer invasive properties on epithelial cells. The study suggests that p53, a key tumor suppressor, may play a critical role in cancer prevention through its inhibition of cell invasion.
A new drug, DCC-2036, has shown potential in treating leukemia patients who have developed resistance to standard treatment. The study found that the drug was effective against human leukemia cells and prolonged survival in a mouse model of CML.
Researchers at UCSF have discovered a link between inflammation and the early formation of pancreatic cancer. They found that two molecular signals produced in the pancreas during inflammation can help initiate the early stages of cancer, while another protein may be a clinical indicator of cancer stage.
Researchers at UCSF found that older adults have difficulty switching between tasks due to brain network inefficiencies, affecting working memory and multitasking abilities. The study suggests that attention and memory interaction plays a crucial role in this process.
Researchers found that neutralizing C5a protein fragment can prevent cardiomyopathy in patients with sepsis, offering hope for stopping devastating effects of the disease. The study shows promise for developing new treatments to combat heart failure and improve survival rates.
A study comparing pelvic anatomy after robotic-assisted radical prostatectomy (RARP) and open prostatectomy found significant differences in pelvic distances. These findings may impact post-operative radiation therapy for patients requiring this treatment.
Research suggests that stress alters the balance of intestinal bacteria, leading to increased levels of immune biomarkers and priming the innate immune system. The study found that antibiotics can reduce this effect, highlighting the role of gut bacteria in modulating stress-induced immune responses.
The American Academy of Neurology has issued a new guideline on the most effective treatments for diabetic nerve pain. Pregabalin was found to be an effective treatment in improving quality of life, while several other treatments including gabapentin, valproate, antidepressants and opioids should also be considered.
Researchers at Berkeley Lab have created bilayered nanocrystals with multiple catalytic sites, enabling sequential and selective catalytic reactions. This approach could improve design of high-performance nanostructured catalysts for multiple-step chemical reactions.
A recent study reveals that antibiotic resistance genes can quickly spread between different types of bacteria using conjugative plasmids. The research found that these plasmids can adapt to various bacterial species and even combine with other plasmids, increasing the potential for gene transfer.
Italian researchers created space-like conditions in a vessel to confirm the behavior of astrophysical jets, which travel at high speeds and stretch across vast distances. The study found that these jets behave according to Newtonian Dynamics, confirming successful 3D simulations.
Scientists have successfully mutated specific genes of Chlamydia bacteria using a new approach called Targeting Induced Local Lesions in Genomes (TILLING). This breakthrough could lead to better understanding of the infections and develop new strategies to prevent and control them.
Antifreeze proteins have been found to bind to ice crystals through a specific mechanism involving hydrophobic and hydrophilic groups. This discovery may lead to the development of stronger, more versatile AFPs with commercial applications in various industries.
Researchers found periodontal ligament stem cells to be the most efficacious in treating advanced gum disease, outperforming other dental stem cell types. The study suggests PDLSCs may offer a new treatment option for periodontitis, a common cause of tooth loss worldwide.
Researchers at Nationwide Children's Hospital discovered two small molecule inhibitors that block STAT3, a protein linked to osteosarcoma. The study suggests these compounds may serve as a new, non-toxic treatment option.
Researchers discovered Camel-raised Nanobody agents that target breast cancer cells, offering a new approach to identifying effective treatments for individual patients. The 'Nanobodies' are robust, small, and easy to produce at low cost, making them a promising tool in the fight against breast cancer.
A study by Stanford scientists found a specific TB strain was unintentionally spread among indigenous peoples of western Canada, leading to epidemics decades later. Poor living conditions and malnutrition on reservations contributed to the outbreak.
Scientists discover that bacteria in wasp antennae produce a cocktail of antibiotics to protect against fungal threats, a strategy similar to human combination therapy. This finding has potential clinical benefits and may yield novel antimicrobial compounds useful for human medicine.
A literature review suggests that drinking 100 percent fruit juices may offer disease-fighting benefits similar to whole fruits. The review found a positive association between 100 percent juice intake and reduced risks for several chronic diseases, including cancer, cardiovascular disease, and cognitive decline.
Researchers discovered that sirolimus stabilizes lung function and improves quality of life in women with lymphangioleiomyomatosis (LAM), a rare lung disease. OHSU expert Alan Barker co-authored the study, which could also inform cancer treatment.
A new study suggests that Vitamin D supplementation can improve vascular endothelial cell function and flow-mediated dilation in overweight African-American adults. This improvement in cardiovascular health can decrease the risk of heart disease.
A recent study found no association between corticosteroid use during pregnancy and orofacial clefts in infants. However, dermatological corticosteroids were linked to an increased risk of cleft lip with or without cleft palate. The study's results add to the safety information for corticosteroids commonly used during pregnancy.
A major new study reveals that nitrogen pollution is costing Europe around £60-£280 billion annually, more than double the income gained from using nitrogen fertilizers. The report also identifies key threats, including toxic algal blooms, air pollution, and loss of plant diversity.
A new study published by NCI and CDC found a significant shift in the distribution of cancers in the HIV/AIDS population. Cases of AIDS-defining cancers decreased threefold between 1991-95 and 2001-05, while cases of other cancers increased tripled during the same period.
A new intensive diabetes education program has been shown to improve long-term blood sugar control in low-income, poorly educated diabetics. Participants who received the nine-session problem-solving course saw significant improvements in their hemoglobin A1C levels and reductions in high cholesterol and high blood pressure.
A study found that cultural differences in spontaneous trait inference, or inferring personality traits from behavior, are present in both behavioral and neural responses. This suggests that cultural influences shape our immediate responses to others' behaviors, rather than just intentional deliberate effort.
Researchers have developed conceptual tools to visualize warped space-time, discovering vortex lines and tendex lines that describe gravitational forces. These tools allow for a better understanding of black holes, gravity, and the universe, enabling predictions of gravitational waves and solving long-standing mysteries.
A study of 326 African American women found a high prevalence of central hair loss with clinical signs of scarring, linked to diabetes, bacterial scalp infections, and hairstyles causing traction. Hair styles associated with braids and weaves may lead to prolonged folliculitis and scarring.
Researchers found that low frequency sound causes severe lesions in cephalopod sensory organs, including statocysts. This damage can affect balance, spatial orientation, and other critical functions.
A Phase III clinical study found that laquinimod reduced annual relapse rates by 23% and disability progression by 36%. Laquinimod also slowed brain atrophy by 33%. The study involved 1,106 people with relapsing-remitting MS in 24 countries.
Scientists at Eindhoven University of Technology have developed a new transparent, conducting film made from commonly available materials, offering a rare metal-free alternative to indium tin oxide. The material, produced in water, has an important advantage over ITO: it is environment-friendly and suitable for flexible displays.
Researchers have found that obesity can impair the body's natural circadian rhythms, particularly in the cardiovascular system. The study suggests that this disruption can lead to a range of health problems, including impaired heart function and an increased risk of disease.
A new system allows for the measurement of power that cells employ to assemble into three-dimensional tissue. The research helps engineers evaluate how quickly cell types will combine into desired structures.
Researchers at WSU aim to uncover the biological cause of Gulf War Illness by studying genomic instability. High levels of chromosomal aberrations have been detected in GWI patients, similar to those found in cancer patients. The study may lead to a simple blood test for diagnosing GWI.
A new study from UCSF found that arthroplasty, a newer surgery for cervical disc disease, can restore range of motion and reduce repeat surgeries in younger patients. For people under 50 with the condition, arthroplasty is a viable option.
Researchers found no significant impact of hormonal status on eight voice parameters, contradicting previous studies. Voice samples taken at different points in the menstrual cycle showed consistent characteristics, regardless of hormonal phase.
Researchers analyzed genes from nine bee species, revealing unique genetic changes associated with eusociality in highly and primitively eusocial bees. These findings suggest that the evolution of eusociality is an independent process, shaped by distinct genetic signatures.
Researchers discovered that a tumor suppressor gene, p120, can actually contribute to cancer development when it's absent. In mice models, the loss of p120 led to hyperactivated immune systems and pro-tumor generating cells that promoted cancer growth.
A clinical study suggests that a specific combination of nutritional ingredients, including indole-3 carbinol and vitamin D, may increase the mean urinary concentration of 2-OHE in pre- and post-menopausal women by 110% and 88%, respectively. The supplement was well-tolerated with no adverse side effects.
Researchers from Wisconsin and Texas have identified two EET analogs that effectively lower blood pressure and reduce kidney injury in animal models of hypertension. The findings offer a promising avenue for the development of novel treatments for cardiovascular disease.
A systematic review of memantine trials found no evidence of benefit for patients with mild Alzheimer's disease, contradicting its frequent off-label use. Increasing acetylcholine levels appears to slow mental decline in AD, but current evidence is insufficient.
The article explores the complex topic of assessing quality of life in children with life-threatening conditions, highlighting personal essays from patients, parents, and caregivers. The pieces illustrate various challenges and perspectives on disabilities, emphasizing the importance of empathy and understanding in healthcare.