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Science News for August 15, 2011


Referring doctors increasingly aware of deep brain stimulation therapy; more work remains

Researchers found that while deep brain stimulation has increased acceptance among referring physicians for Parkinson's disease and other movement disorders, only half of recommended patients are appropriate candidates for immediate therapy. This suggests that physicians have become more aware and accepting of the treatment, but may re...

SourceCedars-Sinai Medical Center·JournalArchives of Neurology·DateAug 15, 2011

Could the Spanish flu devastate us again?

Researchers at Tel Aviv University have developed a unique computational method to analyze the H1N1 virus, identifying key mutation strategies that led to the 2009 pandemic. This method reveals crucial differences between the pandemic strain and common seasonal H1N1 strains, shedding light on potential vaccine development.

SourceAmerican Friends of Tel Aviv University·JournalProceedings of the National Academy of Sciences·DateAug 15, 2011

Decoding infidelity linked to Type 2 diabetes

A team of researchers has discovered that a genetic mutation in the CDKAL1 gene can lead to misreading of specific parts of the insulin-producing gene, resulting in decreased insulin production and impaired cell function. This finding sheds light on the underlying mechanisms of Type 2 diabetes.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateAug 15, 2011

Researchers map pathway of infection for a common, potentially life-threatening respiratory virus

Researchers at the University of Toronto have identified a new treatment target for human respiratory syncytial virus (RSV), a common cause of severe lung infections and estimated 10% of colds. The study found that RSV interacts with healthy cells by binding to a molecule called nucleolin, allowing it to decrease or increase infection.

SourceUniversity of Toronto·JournalNature Medicine·DateAug 15, 2011

Researchers demonstrate green tea is effective in treating genetic disorder and types of tumors

Researchers at The Donald Danforth Plant Science Center have discovered that green tea polyphenols can control a deadly congenital disease by hijacking the ADP activation site. This finding has also been validated in two types of tumors, glioblastomas and tuberous sclerosis complex disorder, suggesting potential for drug development.

SourceDonald Danforth Plant Science Center·JournalBiological Chemistry·DateAug 15, 2011

Nut-allergy sufferers face prejudice -- new study

A new study found that parents of nut-allergy sufferers often encounter hostility and scepticism from friends, family, and even restaurant staff, making it difficult to find safe environments for their children. The research highlights the need for better public education about the dangers of nut allergy.

SourceUniversity of Leicester·JournalChronic Illness·DateAug 15, 2011

Brand-conscious consumers take bad news to heart

A new study by University of Illinois marketing expert Tiffany Barnett White found that brand-conscious consumers view negative information about their beloved brands as a threat to their self-image. They defend the brand and re-write history to maintain a favorable self-evaluation, extending to multiple markets such as sports teams.

SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalJournal of Consumer Psychology·DateAug 15, 2011

Women's quest for romance conflicts with scientific pursuits, study finds

Research by University at Buffalo professor Lora Park found that women who prioritize romantic goals over academic pursuits exhibit less interest in STEM fields. Women's socialization to be romantically desirable conflicts with traditional masculine scripts for intelligence and achievement, leading to decreased math and science interests.

SourceUniversity at Buffalo·JournalPersonality and Social Psychology Bulletin·DateAug 15, 2011

Pitt cancer researchers find key oncoprotein in Merkel cell carcinoma

Researchers at the University of Pittsburgh Cancer Institute have identified the small tumor protein (sT) as the oncoprotein that triggers Merkel Cell Carcinoma (MCC), a rare but deadly skin cancer. The discovery could improve diagnosis and understanding of MCC, potentially shedding light on other cancers.

SourceUniversity of Pittsburgh Schools of the Health Sciences·JournalJournal of Clinical Investigation·DateAug 15, 2011

Lead poisoning from battery industry reported in developing countries

A study reports that children living near lead battery manufacturing and recycling operations in developing countries have significantly higher blood lead levels, associated with lifelong health problems. The industry is expected to nearly double in size over the next five to 10 years, posing significant risks to workers and communities.

SourceLaura Mecoy Communications LLC·JournalJournal of Occupational and Environmental Hygiene·DateAug 15, 2011

Better chronic pain management

Chronic pain affects an estimated 500,000 Canadians aged 12-44 and 38% of seniors living at home, highlighting the need for better care strategies. Experts recommend a broad approach to increase pain management expertise through education, technology, and supported self-care.

SourceCanadian Medical Association Journal·JournalCanadian Medical Association Journal·DateAug 15, 2011

Molecular delivery truck serves gene therapy cocktail

Researchers at UNC School of Medicine have devised a gene therapy cocktail that can treat some inherited diseases caused by misfolded proteins. The approach uses an adeno-associated virus (AAV) vector to deliver two payloads simultaneously: one disables the mutant protein and another provides a new gene to replace its activity.

SourceUniversity of North Carolina Health Care·JournalProceedings of the National Academy of Sciences·DateAug 15, 2011

Stem cells central to pathogenesis of mature lymphoid tumors

Research suggests that blood stem cells may play a role in the development of chronic lymphocytic leukemia (CLL), a cancer of mature white blood cells. CLL often begins with an asymptomatic proliferation of B cells called monoclonal B lymphocytosis (MBL). The study found that hematopoietic stem cells, which can give rise to any type of...

SourceCell Press·JournalCancer Cell·DateAug 15, 2011

JCI online early table of contents: Aug. 15, 2011

A study in mice found that a genetic variation in the CDKAL1 gene leads to misreading of insulin-producing genes, causing decreased insulin production and impaired cell function. Meanwhile, researchers discovered that breast cancer cells evade the antitumor activity of NK cells by modifying their environment.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateAug 15, 2011

Pre-pregnancy overweight may program teen asthma symptoms

Research published in Journal of Epidemiology and Community Health found a significant association between pre-pregnancy obesity and asthma-like respiratory symptoms in adolescents. Teenagers whose mothers were severely overweight before pregnancy were 20-30% more likely to wheeze or have asthma.

SourceBMJ Group·JournalJournal of Epidemiology and Community Health·DateAug 15, 2011

Male acts of bravery, risk display honor, increase accidental death

Men who live in states with a strong culture of honor are more likely to take risks and engage in aggressive behavior, leading to higher rates of accidental death. In rural areas, this culture can be even more deadly, with a 19% higher rate of accidental deaths compared to non-honor states.

SourceSAGE·JournalSocial Psychological and Personality Science·DateAug 15, 2011

Just 15 minutes of physical activity per day reduces risk of death by 14 percent and increases life expectancy by 3 years

A study published in The Lancet found that just 15 minutes of daily physical activity can reduce the risk of death by 14% and increase life expectancy by 3 years. This benefit applies to all age groups and both sexes, with a significant reduction in mortality rates from cardiovascular disease, diabetes, and cancer.

SourceThe Lancet_DELETED·JournalThe Lancet·DateAug 15, 2011

More evidence that caffeine lowers risk of skin cancer

A new Rutgers study found that applying caffeine directly to the skin may help prevent damaging UV light from causing skin cancer. The study, which involved genetically modifying mice with diminished ATR enzyme, showed that the modified mice developed fewer tumors and had reduced risk of invasive tumors compared to unmodified mice.

SourceRutgers University·JournalProceedings of the National Academy of Sciences·DateAug 15, 2011

Outcomes vary in global heart failure trials by geographic region

A study analyzing results from multiple international clinical trials of beta-blocker drugs found significant differences in survival rates among patients treated in different regions. US patients showed a lower survival rate compared to patients outside the US, while other countries demonstrated more substantial reductions in mortality.

SourceDuke University Medical Center·JournalJournal of the American College of Cardiology·DateAug 15, 2011

NYU Langone experts find MRI techniques can detect early osteoarthritis

Researchers at NYU Langone Medical Center have developed advanced MRI techniques that can detect subtle changes in joint cartilage microstructure, allowing for early diagnosis of osteoarthritis. These techniques enable physicians to shift the management of the disease from eventual joint reconstruction to long-term preservation.

SourceNYU Langone Health / NYU Grossman School of Medicine·JournalJournal of the American Academy of Orthopaedic Surgeons·DateAug 15, 2011

Bending light with better precision

Researchers have created a technique to control the speed and direction of light using memory metamaterials, which can repeatedly change their properties. This innovation enables the manufacture of Gradient Index of Refraction (GRIN) devices for imaging and communication technologies with unprecedented precision.

SourceAmerican Institute of Physics·JournalApplied Physics Letters·DateAug 15, 2011