A new study found a positive association between maternal IV fluids and newborn weight loss, suggesting that some weight loss in the first 24 hours may be due to hydration regulation rather than breast milk deficiency. The researchers recommend using weight measured at 24 hours post-birth as a baseline for assessing newborn weight loss.
Scientists at Gladstone Institutes have gained new insight into the delicate relationship between two proteins that regulate stem cells in the heart and may contribute to certain types of cancer. The study reveals an unexpected cross-talk between Notch and Beta-Catenin, which together control cell growth and fetal development.
Researchers discover that alpha-synuclein, key to Parkinson's disease, forms complex folded tetramers in healthy cells rather than a single, randomly-coiled chain. This finding challenges existing disease paradigms and suggests a new therapeutic approach.
A new study reveals that enhanced tree growth in tropical forests can stimulate soil micro-organisms, leading to the release of stored soil carbon. Researchers found that extra litterfall triggers a process called priming, which stimulates the decomposition of carbon stored in the soil.
A team of international scientists identified the protein TSLP as a key regulator of multiple allergic diseases, including eczema, food allergies, and asthma. They found that TSLP elicits the maturation of distinct basophils that promote allergic inflammation.
A new study found that high levels of fat interfere with key transcription factors, leading to diminished glucose sensing in pancreatic beta cells. This pathway is activated in type 2 diabetes and contributes to metabolic defects, including insulin resistance.
Researchers have discovered how butterflies mimic neighboring species to avoid being eaten by birds, using a 'supergene' that controls distinct wing-pattern forms. This phenomenon has puzzled scientists for centuries and is now understood to be controlled by a single gene change.
Researchers at Mount Sinai Hospital and University of Toronto identified the PTPN22 gene mutation's impact on immune cells, leading to hyper-immune responses and autoimmune disorders. The study's findings will help develop new diagnostic tests and targeted therapies for rheumatoid arthritis and other autoimmune conditions.
Researchers at Stanford University School of Medicine have developed a way to remove pluripotent human embryonic stem cells from their progeny before transplanted into patients. The technique uses antibodies to recognize and bind to only pluripotent cells, eliminating the risk of teratomas.
A five-year study found that rheumatoid arthritis patients are at higher risk of cardiovascular disease due to inflammation. Treatment with disease-modifying antirheumatic drugs (DMARDs) reduced the risk, while certain risk factors such as diabetes and high blood pressure predicted new events.
Researchers found that Salmonella cells use a beta form of amino acid lysine to cause illness, making it an attractive drug target. Deleting genes involved in this process or inserting alpha lysine instead renders the bacteria non-virulent and sensitive to antibiotics.