A new study found a possible link between resistance to immunomodulator therapy and the presence of protein cereblon. Lowering cereblon levels allows IMiDs to work properly, suggesting that other mechanisms may play a role in drug resistance.
Researchers discovered a mutation in the GATA6 gene linked to pancreatic agenesis, a rare condition where the pancreas fails to develop. This finding provides insight into how stem cells can be programmed to become pancreatic cells, potentially leading to new treatments for type 1 diabetes.
Researchers at Stanford University School of Medicine have identified the molecular pathway through which physical force contributes to scarring in mice. They found that blocking this enzyme can reduce inflammation and fibrosis, offering a potential new approach for treating fibrotic diseases such as pulmonary fibrosis and rheumatoid a...
A new treatment using leukemia patients' own infection-fighting cells appears to protect them from infections and cancer recurrence after fludarabine-based chemotherapy. With a restored immune system, patients can stop taking prophylactic antibiotics and may have prolonged progression-free survival.
A Phase I/II clinical trial for patients with relapsed or resistant chronic lymphocytic leukemia (CLL) showed impressive potential for PCI-32765, a B cell receptor inhibitor, achieving durable remissions and minimal toxicity. The study demonstrated six-month progression-free survival of 90-92%.
Researchers have developed a multi-purpose photonic chip that generates, manipulates, and measures entanglement and mixture on a tiny silica chip. This device can perform various experiments in a straightforward way using a single reconfigurable chip.
Researchers have discovered that cereblon expression is required for the anti-myeloma activity of lenalidomide and pomalidomide. This finding helps understand which patients may be more or less likely to respond to therapy, enabling the development of targeted treatments.
A Danish research team has developed a new DNA-based method to monitor rare and threatened animal species in freshwater environments, showing it can be effective even for extremely rare populations. The study found a clear correlation between DNA detection and population density, enabling the estimation of population sizes.
A randomized Phase III study found that repeated rituximab treatment at disease progression is just as effective as ongoing maintenance therapy in managing follicular lymphoma. The study suggests that an as-needed approach to treatment may be the preferred option for patients with low-tumor-burden FL, reducing healthcare costs and impr...
A phase Ib/II clinical trial reveals that PCI-32765 is highly active and well-tolerated in 61 relapsed CLL patients, with 70% achieving complete or partial remission after 10 months of treatment. The agent targets Bruton's tyrosine kinase, a key protein for CLL-cell survival.
Researchers develop tiny Stirling engine with a plastic bead that performs work and runs with the same efficiency as a macroscopic heat engine under full load. Microscopic processes cause the machine to run rough due to collisions with surrounding water molecules.
Scientists have elevated little-studied cellular mechanism sulfenylation to potential drug target by showing its importance in cell signaling and cancer. A new chemical probe allowed detection of minute differences in sulfenylation rates, revealing a key role for hydrogen peroxide in activating epidermal growth factor receptor.
Researchers evaluated the safety and efficacy of hydroxyurea therapy in pediatric patients with SCD and found that continued use of hydroxyurea was associated with lower rates of pain crises, episodic transfusions, and hospital admissions. The studies also showed high acceptance rates for hydroxyurea among families of children with SCD.
Researchers at Penn School of Medicine have developed a technique to expand immune cells in umbilical cord blood prior to transplants, leading to quicker immune system rebuilding and lower risk of infections. The method paves the way for future salvage therapy options and increased use of public cord blood banks.