The study found that octreotide induces caspase-mediated apoptotic pathway in HepG2 cells, supporting a receptor-mediated and mitochondrial-apoptotic pathway. This suggests that measurements of serum octreotide levels may be important for verifying optimal therapeutic drug concentrations.
A Boston College study found that Red Bull's brand identity affects consumers' behavior in video games, with some players speeding up and others crashing. The 'Red Bull effect' shows how non-conscious brand priming can shape consumer performance.
Cardiac resynchronization therapy significantly reduces mortality among patients with mildly symptomatic or advanced heart failure, improving long-term outcomes. The addition of CRT to optimal medical therapy or ICDs can be extended to a wider proportion of patients, benefiting the growing population affected by heart failure.
Research suggests that Tregs are involved in immune evasion of tumors and may be used as disease markers for gastric cancer. However, further studies are needed to confirm these findings.
Researchers developed computer-assisted diagnosis tools to grade Follicular Lymphoma samples more accurately and efficiently. The tools use high-resolution images and machine learning algorithms to identify malignant regions and classify disease grades, promising faster and more accurate diagnoses.
Ethicists call for UK legislation change to hold healthcare professionals accountable for patient neglect. Current law allows prosecution only when death results from serious error.
NASA's Terra satellite captured an image of Cyclone Yasi on Jan. 30 at 23:20 UTC, revealing a well-formed storm that appears to be strengthening. The cyclone is forecast to continue intensifying over the next 36 hours and make landfall just south of Cairns as a large system.
A multicenter study found that recalled Sprint Fidelis implantable cardioverter-defibrillator (ICD) leads failed at a higher rate in younger patients, women, and individuals with hereditary heart disease. However, the failure was not associated with death or serious injuries.
Researchers at the University of Warwick have developed a simple method to give microscopic polymer vesicles 'stealth' capabilities, allowing them to avoid the body's defenses while releasing drugs. The new armor is made from nanoparticles and has been successfully tested using a cryo electron microscope.
Researchers at SRNL are using patented microbes to break down chlorinated solvents in contaminated groundwater. The MicroCED mixture has shown promise in transforming lethal chlorinated ethenes into safe end products, potentially offering a cheaper alternative to energy-intensive cleanup methods.
Researchers studied physicians and scientists trekking to Mt. Everest Base Camp, finding extensive but reversible changes in heart function after exposure to low oxygen levels. The findings suggest that heart problems experienced by seriously ill patients may be reversible once oxygen levels are returned to normal.
Partnerships with major food companies bring funding and support, but may obscure health messages. Health charities must tread carefully to avoid brand co-branding and maintain public health focus.
Researchers found that R-spondin1 reduces GVHD by protecting intestinal stem cells, which help regenerate damaged tissues and reduce inflammation. The study's results suggest a potential therapeutic approach for human bone marrow transplant patients.
Researchers from the University of Southampton are conducting Phase II trials for a new DNA vaccine targeting chronic and acute myeloid leukaemia, two forms of bone marrow and blood cancer. The vaccine aims to strengthen patients' immune systems and improve treatment outcomes.
The Open Research Area Scheme in Europe has successfully funded joint projects addressing key social and economic issues like climate change, child welfare, and market uncertainty. Researchers will study public attitudes to climate change, critically review children's policies, and develop new forecasting methods for economic processes.
The study provides insights into how ants develop into queens or workers, shedding light on invasion biology and potential pest control methods. Analysis of the Argentine and red harvester ant genomes suggests chemical modification of DNA may play a key role in this process.
Researchers at Memorial Sloan-Kettering Cancer Center have developed a novel ultrasmall silica inorganic nanoparticle platform for targeted molecular imaging of cancer. The first-in-human clinical trial aims to evaluate the distribution, tissue uptake, and safety of the particles in humans using PET imaging.
Potential risks of sex in pregnancy include premature labour, pelvic inflammatory disease, and blood clots, but the evidence is often contradictory and limited. For low-risk women, frequent intercourse may increase the risk of premature labour, while restricted activity is recommended for those at high risk
Researchers used NASA's THEMIS spacecraft to track energetic particles in Earth's magnetic atmosphere during a substorm, gaining insights into their origin and behavior. The study supports the betatron acceleration model, which explains how electrons gain energy from changing magnetic fields far from the reconnection site.
A new method using MRI T2*-weighted imaging is proposed for assessing iron overload in beta-thalassemic patients. The results indicate that serum ferritin levels are not reliable for estimating iron stores, making MRI a more accurate and non-invasive option.
Researchers at Duke University Medical Center discovered that genetic mutations in brain tumors can alter their metabolism. This study found over 100 metabolites with altered concentrations in cells with the defective IDH1 or IDH2 genes, providing promising avenues for future research into new treatments.
A new study using brain scans found that neural reactions to pro-health messages can accurately predict smoking quit success. The researchers tested 28 heavy smokers and found that neural activity in the medial prefrontal cortex predicted behavior change, outperforming people's own self-reported estimates.
Recent research suggests that liver resection patients are at risk of developing hepatic vein thrombosis, which can lead to pulmonary embolism. The study reports two cases where thrombi formed in hepatic veins following surgery.
A recent study found that despite a significant decline in HIV infection rates, new cases of hepatitis C virus (HCV) infection have declined only slightly among injection drug users. The findings suggest that current prevention efforts must be intensified to reduce the risk of HCV infection, particularly among younger IDUs.
Researchers have shown that nanosilver is not a new discovery but has been used for over 100 years to prevent bacterial growth. Nanoparticles have different properties than larger particles, making them more reactive and toxic to bacteria.
Researchers at Scripps Research Institute successfully converted adult skin cells into beating heart cells through a direct reprogramming strategy, bypassing the need for embryonic-like stem cells. This breakthrough discovery has the potential to lead to new treatments for diseases such as heart disease, Parkinson's, and Alzheimer's.
Researchers found a discrete brain pathway that regulates vulnerability to nicotine addiction and identified the nicotinic receptor subunit α5 as a potential target for anti-smoking therapies. The study suggests boosting this subunit's expression may help individuals resist nicotine's addictive properties.
Researchers have discovered a new material, molybdenite, that can be used to make smaller and more energy-efficient electronic chips. Molybdenite has distinct advantages over traditional silicon or graphene for use in electronics applications.
Scientists have successfully designed a new type of antenna liner using metamaterials, which can enhance performance and reduce mass, leading to lower costs and increased efficiency in communications satellites. The design has overcome previous limitations of narrow bandwidth and high loss, making it suitable for real-world applications.
Researchers found that nestin recruits cdk5 to the muscle membrane, initiating dispersion and regulating neuromuscular junction formation. The study sheds light on signaling mechanisms connecting brain to muscle and may aid future treatments for neuromuscular diseases.
Researchers found that omega-3 deficient mice exhibited disturbed synaptic functions and emotional behaviors, including depression. The study suggests that chronic malnutrition during intrauterine development may influence synaptic activity involved in emotional behavior in adulthood.
A recent study by Washington University researchers discovered that fatty acid synthase and nitric oxide synthase enzymes interact in endothelial cells to cause blood vessel damage in diabetes. By understanding this mechanism, they hope to develop new treatments for vascular complications of the disease.
Researchers found that early puberty is associated with greater bone mass, while later puberty results in less, increasing the risk of fracture. This discovery has significant implications for adolescence growth and development, highlighting the importance of timing in shaping adult bone health.
A study from Henry Ford Hospital found that photodynamic therapy can preserve vocal cord function in patients with early-stage laryngeal cancer. The treatment, which uses a powerful laser and light-activated drug, showed consistent trends toward normal vocal cord vibration over several weeks and months.
A team of surgeons at Henry Ford Hospital has successfully removed a rare malignant immature teratoma from an adult's trachea and rebuilt the airway using tissue and bone from the patient's arm. The patient is now able to speak and swallow normally, with only a temporary tracheostomy tube used for breathing assistance.
Researchers at the University of Minnesota have developed a new approach to analyzing social networking interactions, considering time and space factors. This enables better understanding of leadership emergence, trust changes over time, and migration within communities online.
Researchers found that vitamin D-deficient mice had reduced lung volume, lower airway resistance, and smaller lungs compared to control mice. The study suggests a potential link between vitamin D deficiency and obstructive lung disease, highlighting the need for future studies on prevention and treatment strategies.
Research from Case Western Reserve University shows that helping others in the AA program can lead to improved sobriety and reduced depression. The 'helper therapy principle' helps individuals with a similar condition, reducing egocentrism and selfishness.
Researchers at Princeton University developed an air laser that can detect hidden bombs, pollutants, and greenhouse gases from afar. The new technique uses an ultraviolet laser pulse to generate an entirely new beam of light that interacts with molecules in the air, providing a powerful tool for remote measurements.
A study found that African American men avoid doctor visits due to stress and lack of practical advice. The study suggests that physicians need to provide more support and resources to encourage men to follow medical recommendations.
A new UT MD Anderson study finds that brief pre-surgery stress management training can improve immune outcomes and lower mood disturbances in men with early-stage prostate cancer. The study's results suggest that managing stress has biological as well as psychological benefits, which may have an effect on aspects of disease.
Researchers at University of Michigan and University of California, Irvine discover DNA's building blocks 'rock and roll,' forming alternative structures with Hoogsteen base pairs. These fleeting states contain new layers of information stored in the genetic code, shedding light on critical interactions between DNA and proteins.
Researchers at Indiana University School of Medicine have discovered a potential new anti-cancer treatment using the antibiotic tautomycetin, which targets the cancer-causing enzyme SHP2. This finding offers hope for developing effective treatments against various types of leukemia and solid tumors.
Researchers at McGill University Health Centre solved two cold cases using genetic studies, identifying a gene responsible for rare cancer and thyroid disease. The findings provided answers for families affected by the diseases, including information on screening tests and risk for future generations.
A team of researchers has created a 'reporter mouse' that can detect kidney damage in real-time by generating light, offering a potential solution to current diagnosis methods. The technique uses the NGAL protein, which can report toxic cellular stresses, and meets the criteria for a true biomarker.
A new study has identified the precise steps in the molecular evolution of Streptococcus pneumoniae, a major threat to global health. The research reveals that the bacterium's genetic makeup has undergone significant changes, with a likely birthplace in Europe and widespread spread across the globe.
A new study by Temple University psychologists Jason Chein and Laurence Steinberg found that the presence of peers heightens teens' sensitivity to rewards, leading them to take more risks. The researchers used fMRI to measure brain activity in adolescents, young adults, and adults while playing a simulated driving game.
BGU's green algae strain can produce up to 12-15% DGLA, a precursor for anti-inflammatory prostaglandin E1. The collaboration aims to optimize DGLA production and develop a commercial pilot plant, valued at $300 million by 2015.
A New York City College of Technology research team has developed a method to deflect asteroids using solar sail technology. The technique involves heating the surface of an asteroid to create a jet stream, which would alter its trajectory and potentially convert an Earth impact into a near miss.
Researchers found that Taxol, a cancer drug, can aid in the regeneration of nerve cells after spinal cord injuries. The drug stabilizes microtubules and prevents the production of inhibitory substances in scar tissue, allowing for better nerve cell growth.
A new appreciation of the ecology-evolution dynamic reveals that environmental factors can influence evolutionary changes and shape ecological traits. This emerging field of study highlights the interconnectedness between ecology and evolution, suggesting a feedback loop where ecological changes affect evolution and vice versa.
Researchers at UC San Diego School of Medicine identified defects in two signaling pathways, Wnt and PS-1, associated with Lesch-Nyhan Disease. These findings also suggest common mechanisms for cognitive and behavioral defects in Alzheimer's and Parkinson's diseases.
New research predicts increased frequency of drought in eastern Africa, exacerbating existing food shortages and population growth. Scientists link warming Indian Ocean temperatures to decreased rainfall in the region.
A large trial in Uganda found that treating pregnant women for worm infections increased their child's chances of developing eczema. The study supports the 'hygiene hypothesis', which proposes that exposure to infections can modify the immune system and protect against allergies.
Researchers from Lawrence Berkeley National Laboratory created a durable and efficient photocatalyst that can collect solar energy to extract hydrogen from water. The disorder-engineered nanocrystal absorbs infrared light, making it attractive for use in clean-energy technologies.
A new study published in the journal Drug and Alcohol Dependence found that retired NFL players misuse painkillers at a higher rate than the general population, with 7% currently using opioid drugs. The study also found that players who experienced undiagnosed concussions were more likely to misused opioids.
The SUNRAY project aims to identify new ways to address malnutrition in Africa, prioritizing research led by African researchers. The initiative will integrate nutrition research with other sectors to address root causes and avoid 'technical fixes'.
Research reveals that smoking habits are transmitted from mother to daughter and father to son, influencing the likelihood of nicotine addiction in offspring. The study found that socio-economic factors account for the transmission of these habits.
A large-scale experiment by UC Davis ecologists shows that environmental changes can alter how intact ecological communities function, affecting plant and animal species interactions. The study, led by Jonah Piovia-Scott, used seaweed to imitate climate change effects on Caribbean islands.
A large cohort study found that hormone therapy started at menopause increases breast cancer risk, particularly among women who start therapy before or soon after menopause. The study's results support previous findings and provide new insights into the relationship between timing of hormone therapy and breast cancer risk.